{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:15:50Z","timestamp":1792617350353,"version":"4.5.0"},"reference-count":63,"publisher":"Bioscientifica","issue":"4","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9,7]]},"abstract":"<jats:p>\n                    A deficiency in hydrogen sulfide has been implicated in the development and progression of diabetic chronic kidney disease. The purpose of this study was to determine the effect of diabetes on the H\n                    <jats:sub>2<\/jats:sub>\n                    S system in early-stage diabetic kidney disease. We characterised gene and protein expression profile of the enzymes that regulate H\n                    <jats:sub>2<\/jats:sub>\n                    S production and degradation, and H\n                    <jats:sub>2<\/jats:sub>\n                    S production capacity, in the kidney from 10-week-old C57BL6J\n                    <jats:italic>\n                      <jats:sup>db\/db<\/jats:sup>\n                    <\/jats:italic>\n                    mice (\n                    <jats:italic>n\u2009=\u2009<\/jats:italic>\n                    6), in age-matched heterozygous controls (\n                    <jats:italic>n\u2009=\u2009<\/jats:italic>\n                    7), and in primary endothelial cells (HUVECs) exposed to high glucose. In\n                    <jats:italic>db\/db<\/jats:italic>\n                    mice, renal H\n                    <jats:sub>2<\/jats:sub>\n                    S levels were significantly reduced (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.009). Protein expression of the H\n                    <jats:sub>2<\/jats:sub>\n                    S production enzymes was differentially affected by diabetes: cystathionine \u03b2-synthase (CBS) was significantly lower in both\n                    <jats:italic>db\/db<\/jats:italic>\n                    mice and high glucose-treated HUVECs (\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.0001;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0318) whereas 3-mercatopyruvate sulfurtransferase (3-MST) expression was higher in the\n                    <jats:italic>db\/db<\/jats:italic>\n                    kidney (\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.0001), yet lower in the HUVECs (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0001). Diabetes had no effect on the expression of cystathionine\n                    <jats:italic>\u03b3<\/jats:italic>\n                    -lyase (CSE) in the\n                    <jats:italic>db\/db<\/jats:italic>\n                    kidney (\n                    <jats:italic>P<\/jats:italic>\n                    = ns) but was associated with reduced expression in the HUVECs (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0004). Protein expression of degradation enzyme sulfide quinone reductase (SQOR) was significantly higher in\n                    <jats:italic>db\/db<\/jats:italic>\n                    kidney (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.048) and lower in the high glucose-treated HUVECs (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.008). Immunofluorescence studies revealed differential localisation of the H\n                    <jats:sub>2<\/jats:sub>\n                    S enzymes in the kidney, including both tubular and vascular localisation, suggestive of functionally distinct actions in the kidney. The results of this study provide foundational knowledge for future research looking at the H\n                    <jats:sub>2<\/jats:sub>\n                    S system in both kidney physiology and the aetiology of chronic diabetic kidney disease.\n                  <\/jats:p>","DOI":"10.1530\/jme-23-0065","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T07:52:31Z","timestamp":1694073151000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":4,"title":["Characterisation of the hydrogen sulfide system in early diabetic kidney disease"],"prefix":"10.1530","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-4848","authenticated-orcid":true,"given":"Caroline J","family":"Bushell","sequence":"first","affiliation":[{"name":"Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard G","family":"Forgan","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University, Waurn Ponds, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Aston-Mourney","sequence":"additional","affiliation":[{"name":"Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Connor","sequence":"additional","affiliation":[{"name":"Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean L","family":"McGee","sequence":"additional","affiliation":[{"name":"Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryony A","family":"McNeill","sequence":"additional","affiliation":[{"name":"Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Mitochondrion","first-page":"72","article-title":"Mitochondrion-driven nephroprotective mechanisms of novel glucose lowering medications","volume":"58","author":"Afsar","year":"2021","unstructured":"Afsar BHornum MAfsar REErtuglu LAOrtiz ACovic Avan Raalte DHCherney DZI & Kanbay M2021Mitochondrion-driven nephroprotective mechanisms of novel glucose lowering medications. 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