{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:19:44Z","timestamp":1784557184093,"version":"3.55.0"},"reference-count":113,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,12,12]]},"abstract":"<jats:p>The exact neural construct underlying the dynamic secretion of gonadotrophin-releasing hormone (GnRH) has only recently been identified despite the detection of multiunit electrical activity volleys associated with pulsatile luteinising hormone (LH) secretion four decades ago. Since the discovery of kisspeptin\/neurokinin B\/dynorphin neurons in the mammalian hypothalamus, there has been much research into the role of this neuronal network in controlling the oscillatory secretion of gonadotrophin hormones. In this review, we provide an update of the progressive application of cutting-edge techniques combined with mathematical modelling by the neuroendocrine community, which are transforming the functional investigation of the GnRH pulse generator. Understanding the nature and function of the GnRH pulse generator can greatly inform a wide range of clinical studies investigating infertility treatments.<\/jats:p>","DOI":"10.1530\/jme-23-0079","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T13:14:34Z","timestamp":1702386874000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":2,"title":["New methods to investigate the GnRH pulse generator"],"prefix":"10.1530","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-166X","authenticated-orcid":true,"given":"Deyana","family":"Ivanova","sequence":"first","affiliation":[{"name":"Department of Women and Children\u2019s Health, Faculty of Life Science and Medicine, King\u2019s College London, UK"},{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T","family":"O\u2019Byrne","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, Faculty of Life Science and Medicine, King\u2019s College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Advances in Experimental Medicine and Biology","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/978-1-4614-6199-9_16","article-title":"Electrophysiology of kisspeptin neurons","volume":"784","author":"Alreja","year":"2013","unstructured":"Alreja M2013Electrophysiology of kisspeptin neurons. 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