{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:37Z","timestamp":1784557237890,"version":"3.55.0"},"reference-count":48,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,29]]},"abstract":"<jats:p>\n                    <jats:italic>N<\/jats:italic>\n                    1-methylnicotinamide (MNAM), a product of methylation of nicotinamide through nicotinamide\n                    <jats:italic>N<\/jats:italic>\n                    -methyltransferase, displays antidiabetic effects in male rodents. This study aimed to evaluate the ameliorative potential of MNAM on glucose metabolism in a gestational diabetes mellitus (GDM) model. C57BL\/6N mice were fed with a high-fat diet (HFD) for 6 weeks before pregnancy and throughout gestation to establish the GDM model. Pregnant mice were treated with 0.3% or 1% MNAM during gestation. MNAM supplementation in CHOW diet and HFD both impaired glucose tolerance at gestational day 14.5 without changes in insulin tolerance. However, MNAM supplementation reduced hepatic lipid accumulation as well as mass and inflammation in visceral adipose tissue. MNAM treatment decreased GLUT4 mRNA and protein expression in skeletal muscle, where NAD+ salvage synthesis and antioxidant defenses were dampened. The NAD+\/sirtuin system was enhanced in liver, which subsequently boosted hepatic gluconeogenesis. GLUT1 protein was diminished in placenta by MNAM. In addition, weight of placenta, fetus weight, and litter size were not affected by MNAM treatment. The decreased GLUT4 in skeletal muscle, boosted hepatic gluconeogenesis and dampened GLUT1 in placenta jointly contribute to the impairment of glucose tolerance tests by MNAM. Our data provide evidence for the careful usage of MNAM in treatment of GDM.\n                  <\/jats:p>","DOI":"10.1530\/jme-23-0126","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T15:02:39Z","timestamp":1701270159000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":2,"title":["N1-methylnicotinamide impairs gestational glucose tolerance in mice"],"prefix":"10.1530","volume":"72","author":[{"given":"Xiaojing","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Institute of Neuroscience, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Institute of Neuroscience, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Basic Medicine, School of Medicine, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Institute of Neuroscience, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Institute of Neuroscience, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanglin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Institute of Neuroscience, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7359-4311","authenticated-orcid":true,"given":"Xiao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of China, Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Institute of Neuroscience, Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"IUBMB Life","first-page":"315","article-title":"The protein family of glucose transport facilitators: it's not only about glucose after all","volume":"62","author":"Augustin","year":"2010","unstructured":"Augustin R2010The protein family of glucose transport facilitators: it's not only about glucose after all. IUBMB Life62315\u2013333. (https:\/\/doi.org\/10.1002\/iub.315)"},{"key":"bib2","series-title":"Archivum Immunologiae et Therapiae Experimentalis","first-page":"127","article-title":"1-methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages","volume":"56","author":"Biedron","year":"2008","unstructured":"Biedron RCiszek MTokarczyk MBobek MKurnyta MSlominska EMSmolenski RT & Marcinkiewicz J20081-methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. Archivum Immunologiae et Therapiae Experimentalis56127\u2013134. (https:\/\/doi.org\/10.1007\/s00005-008-0009-2)"},{"key":"bib3","series-title":"Diabetes","first-page":"1272","article-title":"Placental adiponectin gene DNA methylation levels are associated with mothers' blood glucose concentration","volume":"61","author":"Bouchard","year":"2012","unstructured":"Bouchard LHivert MFGuay SPSt-Pierre JPerron P & Brisson D2012Placental adiponectin gene DNA methylation levels are associated with mothers' blood glucose concentration. Diabetes611272\u20131280. (https:\/\/doi.org\/10.2337\/db11-1160)"},{"key":"bib4","series-title":"Diabetes","first-page":"527","article-title":"Genetic nicotinamide N-methyltransferase (Nnmt) deficiency in male mice improves insulin sensitivity in diet-induced obesity but does not affect glucose tolerance","volume":"68","author":"Brachs","year":"2019","unstructured":"Brachs SPolack JBrachs MJahn-Hofmann KElvert RPfenninger ABarenz FMargerie DMai KSpranger J, et al.2019Genetic nicotinamide N-methyltransferase (Nnmt) deficiency in male mice improves insulin sensitivity in diet-induced obesity but does not affect glucose tolerance. Diabetes68527\u2013542. (https:\/\/doi.org\/10.2337\/db18-0780)"},{"key":"bib5","series-title":"Cochrane Database of Systematic Reviews","first-page":"CD011970","article-title":"Lifestyle interventions for the treatment of women with gestational diabetes","volume":"5","author":"Brown","year":"2017","unstructured":"Brown JAlwan NAWest JBrown SMcKinlay CJFarrar D & Crowther CA2017Lifestyle interventions for the treatment of women with gestational diabetes. Cochrane Database of Systematic Reviews5CD011970. (https:\/\/doi.org\/10.1002\/14651858.CD011970.pub2)"},{"key":"bib6","series-title":"Nature Reviews Endocrinology","first-page":"639","article-title":"Gestational diabetes mellitus: risks and management during and after pregnancy","volume":"8","author":"Buchanan","year":"2012","unstructured":"Buchanan TAXiang AH & Page KA2012Gestational diabetes mellitus: risks and management during and after pregnancy. Nature Reviews Endocrinology8639\u2013649. (https:\/\/doi.org\/10.1038\/nrendo.2012.96)"},{"key":"bib7","series-title":"Cell Metabolism","first-page":"213","article-title":"Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle","volume":"11","author":"Canto","year":"2010","unstructured":"Canto CJiang LQDeshmukh ASMataki CCoste ALagouge MZierath JR & Auwerx J2010Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metabolism11213\u2013219. (https:\/\/doi.org\/10.1016\/j.cmet.2010.02.006)"},{"key":"bib8","series-title":"British Journal of Pharmacology","first-page":"230","article-title":"1-methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2\/prostacyclin pathway","volume":"152","author":"Chlopicki","year":"2007","unstructured":"Chlopicki SSwies JMogielnicki ABuczko WBartus MLomnicka MAdamus J & Gebicki J20071-methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2\/prostacyclin pathway. British Journal of Pharmacology152230\u2013239. (https:\/\/doi.org\/10.1038\/sj.bjp.0707383)"},{"key":"bib9","series-title":"Journal of Hepatology","first-page":"1248","article-title":"NNMT aggravates hepatic steatosis, but alleviates liver injury in alcoholic liver disease","volume":"74","author":"Ding","year":"2021","unstructured":"Ding QMa YLai SDou X & Li S2021NNMT aggravates hepatic steatosis, but alleviates liver injury in alcoholic liver disease. Journal of Hepatology741248\u20131250. (https:\/\/doi.org\/10.1016\/j.jhep.2020.11.025)"},{"key":"bib10","series-title":"Developmental Cell","first-page":"661","article-title":"Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt","volume":"14","author":"Fulco","year":"2008","unstructured":"Fulco MCen YZhao PHoffman EPMcBurney MWSauve AA & Sartorelli V2008Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Developmental Cell14661\u2013673. (https:\/\/doi.org\/10.1016\/j.devcel.2008.02.004)"},{"key":"bib11","series-title":"Nature Reviews. Endocrinology","first-page":"535","article-title":"Physiological and pathophysiological roles of NAMPT and NAD metabolism","volume":"11","author":"Garten","year":"2015","unstructured":"Garten ASchuster SPenke MGorski Tde Giorgis T & Kiess W2015Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nature Reviews. Endocrinology11535\u2013546. (https:\/\/doi.org\/10.1038\/nrendo.2015.117)"},{"key":"bib12","series-title":"Annals of the New York Academy of Sciences","first-page":"21","article-title":"Insulin regulation of gluconeogenesis","volume":"1411","author":"Hatting","year":"2018","unstructured":"Hatting MTavares CDJSharabi KRines AK & Puigserver P2018Insulin regulation of gluconeogenesis. Annals of the New York Academy of Sciences141121\u201335. (https:\/\/doi.org\/10.1111\/nyas.13435)"},{"key":"bib13","series-title":"Nature Medicine","first-page":"887","article-title":"Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization","volume":"21","author":"Hong","year":"2015","unstructured":"Hong SMoreno-Navarrete JMWei XKikukawa YTzameli IPrasad DLee YAsara JMFernandez-Real JMMaratos-Flier E, et al.2015Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nature Medicine21887\u2013894. (https:\/\/doi.org\/10.1038\/nm.3882)"},{"key":"bib14","series-title":"Cell Stem Cell","first-page":"281","article-title":"Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction","volume":"29","author":"Janbandhu","year":"2022","unstructured":"Janbandhu VTallapragada VPatrick RLi YAbeygunawardena DHumphreys DTMartin EMMAWard AOContreras OFarbehi N, et al.2022Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction. Cell Stem Cell29281\u2013297.e12. (https:\/\/doi.org\/10.1016\/j.stem.2021.10.009)"},{"key":"bib15","series-title":"Diabetologia","first-page":"799","article-title":"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance","volume":"58","author":"Kannt","year":"2015","unstructured":"Kannt APfenninger ATeichert LTonjes ADietrich ASchon MRKloting N & Bluher M2015Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance. Diabetologia58799\u2013808. (https:\/\/doi.org\/10.1007\/s00125-014-3490-7)"},{"key":"bib16","series-title":"Scientific Reports","first-page":"8637","article-title":"NNMT activation can contribute to the development of fatty liver disease by modulating the NAD (+) metabolism","volume":"8","author":"Komatsu","year":"2018","unstructured":"Komatsu MKanda TUrai HKurokochi AKitahama RShigaki SOno TYukioka HHasegawa KTokuyama H, et al.2018NNMT activation can contribute to the development of fatty liver disease by modulating the NAD (+) metabolism. Scientific Reports88637. (https:\/\/doi.org\/10.1038\/s41598-018-26882-8)"},{"key":"bib17","series-title":"Nature","first-page":"258","article-title":"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity","volume":"508","author":"Kraus","year":"2014","unstructured":"Kraus DYang QKong DBanks ASZhang LRodgers JTPirinen EPulinilkunnil TCGong FWang YC, et al.2014Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature508258\u2013262. (https:\/\/doi.org\/10.1038\/nature13198)"},{"key":"bib18","series-title":"BMC Pregnancy and Childbirth","first-page":"494","article-title":"Prevalence and risk factors of gestational diabetes mellitus in Asia: a systematic review and meta-analysis","volume":"18","author":"Lee","year":"2018","unstructured":"Lee KWChing SMRamachandran VYee AHoo FKChia YCWan Sulaiman WASuppiah SMohamed MH & Veettil SK2018Prevalence and risk factors of gestational diabetes mellitus in Asia: a systematic review and meta-analysis. BMC Pregnancy and Childbirth18494. (https:\/\/doi.org\/10.1186\/s12884-018-2131-4)"},{"key":"bib20","series-title":"Journal of Endocrinology","first-page":"501","article-title":"A mouse model of gestation-specific transient hyperglycemia for translational studies","volume":"244","author":"Li","year":"2020","unstructured":"Li HYLiu YXHarvey LShafaeizadeh Svan der Beek EM & Han W2020A mouse model of gestation-specific transient hyperglycemia for translational studies. Journal of Endocrinology244501\u2013510. (https:\/\/doi.org\/10.1530\/JOE-19-0516)"},{"key":"bib19","series-title":"Journal of Hepatology","first-page":"882","article-title":"Hepatocyte-specific depletion of Nnmt protects mice from non-alcoholic steatohepatitis","volume":"77","author":"Li","year":"2022","unstructured":"Li DYi CHuang HLi J & Hong S2022Hepatocyte-specific depletion of Nnmt protects mice from non-alcoholic steatohepatitis. Journal of Hepatology77882\u2013884. (https:\/\/doi.org\/10.1016\/j.jhep.2022.03.021)"},{"key":"bib21","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"3112","article-title":"Serum N(1)-Methylnicotinamide is associated with obesity and diabetes in Chinese","volume":"100","author":"Liu","year":"2015","unstructured":"Liu MLi LChu JZhu BZhang QYin XJiang WDai GJu WWang Z, et al.2015Serum N(1)-Methylnicotinamide is associated with obesity and diabetes in Chinese. Journal of Clinical Endocrinology and Metabolism1003112\u20133117. (https:\/\/doi.org\/10.1210\/jc.2015-1732)"},{"key":"bib22","series-title":"Pharmacological Reports","first-page":"76","article-title":"Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis","volume":"61","author":"Mateuszuk","year":"2009","unstructured":"Mateuszuk \u0141Khomich TISlominska EGajda MWojcik LLomnicka MGwozdz P & Chlopicki S2009Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis. Pharmacological Reports6176\u201385. (https:\/\/doi.org\/10.1016\/s1734-1140(0970009-x)"},{"key":"bib23","series-title":"Nature Reviews. Disease Primers","first-page":"47","article-title":"Gestational diabetes mellitus","volume":"5","author":"McIntyre","year":"2019","unstructured":"McIntyre HDCatalano PZhang CDesoye GMathiesen ER & Damm P2019Gestational diabetes mellitus. Nature Reviews. Disease Primers547. (https:\/\/doi.org\/10.1038\/s41572-019-0098-8)"},{"key":"bib24","series-title":"JCI Insight","article-title":"SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside","volume":"6","author":"Mukherjee","year":"2021","unstructured":"Mukherjee SMo JPaolella LMPerry CEToth JHugo MMChu QTong QChellappa K & Baur JA2021SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside. JCI Insight6. (https:\/\/doi.org\/10.1172\/jci.insight.147193)"},{"key":"bib25","series-title":"Histochemistry and Cell Biology","first-page":"369","article-title":"Oxidative stress in the placenta","volume":"122","author":"Myatt","year":"2004","unstructured":"Myatt L & Cui X2004Oxidative stress in the placenta. Histochemistry and Cell Biology122369\u2013382. (https:\/\/doi.org\/10.1007\/s00418-004-0677-x)"},{"key":"bib26","series-title":"Journal of Cellular Physiology","first-page":"6386","article-title":"N1-methylnicotinamide (MNAM) as a guardian of cardiovascular system","volume":"233","author":"Nejabati","year":"2018","unstructured":"Nejabati HRMihanfar APezeshkian MFattahi ALatifi ZSafaie NValiloo MJodati AR & Nouri M2018N1-methylnicotinamide (MNAM) as a guardian of cardiovascular system. Journal of Cellular Physiology2336386\u20136394. (https:\/\/doi.org\/10.1002\/jcp.26636)"},{"key":"bib27","series-title":"Current Pharmaceutical Design","first-page":"800","article-title":"N1-Methylnicotinamide: is it time to consider it as a dietary supplement for athletes?","volume":"28","author":"Nejabati","year":"2022","unstructured":"Nejabati HRGhaffari-Novin MFathi-Maroufi NFaridvand YHolmberg HCHansson ONikanfar S & Nouri M2022N1-Methylnicotinamide: is it time to consider it as a dietary supplement for athletes?Current Pharmaceutical Design28800\u2013805. (https:\/\/doi.org\/10.2174\/1381612828666220211151204)"},{"key":"bib28","series-title":"Diabetologia","first-page":"2156","article-title":"Oxidative stress impairs nuclear proteins binding to the insulin responsive element in the GLUT4 promoter","volume":"44","author":"Pessler","year":"2001","unstructured":"Pessler DRudich A & Bashan N2001Oxidative stress impairs nuclear proteins binding to the insulin responsive element in the GLUT4 promoter. Diabetologia442156\u20132164. (https:\/\/doi.org\/10.1007\/s001250100024)"},{"key":"bib29","series-title":"Trends in Endocrinology and Metabolism","first-page":"340","article-title":"Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme","volume":"28","author":"Pissios","year":"2017","unstructured":"Pissios P2017Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends in Endocrinology and Metabolism28340\u2013353. (https:\/\/doi.org\/10.1016\/j.tem.2017.02.004)"},{"key":"bib30","series-title":"International Journal of Molecular Sciences","article-title":"The pathophysiology of gestational diabetes mellitus","volume":"19","author":"Plows","year":"2018","unstructured":"Plows JFStanley JLBaker PNReynolds CM & Vickers MH2018The pathophysiology of gestational diabetes mellitus. International Journal of Molecular Sciences19. (https:\/\/doi.org\/10.3390\/ijms19113342)"},{"key":"bib31","series-title":"American Journal of Physiology. Endocrinology and Metabolism","first-page":"E520","article-title":"NAD(+)-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism","volume":"315","author":"Porter","year":"2018","unstructured":"Porter LCFranczyk MPPietka TYamaguchi SLin JBSasaki YVerdin EApte RS & Yoshino J2018NAD(+)-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism. American Journal of Physiology. Endocrinology and Metabolism315E520\u2013E530. (https:\/\/doi.org\/10.1152\/ajpendo.00057.2018)"},{"key":"bib32","series-title":"Diabetes","first-page":"2951","article-title":"Gestational diabetes induces placental genes for chronic stress and inflammatory pathways","volume":"52","author":"Radaelli","year":"2003","unstructured":"Radaelli TVarastehpour ACatalano P & Hauguel-de Mouzon S2003Gestational diabetes induces placental genes for chronic stress and inflammatory pathways. Diabetes522951\u20132958. (https:\/\/doi.org\/10.2337\/diabetes.52.12.2951)"},{"key":"bib33","series-title":"Nutrients","article-title":"Diet and healthy lifestyle in the management of gestational diabetes mellitus","volume":"12","author":"Rasmussen","year":"2020","unstructured":"Rasmussen LPoulsen CWKampmann USmedegaard SBOvesen PG & Fuglsang J2020Diet and healthy lifestyle in the management of gestational diabetes mellitus. Nutrients12. (https:\/\/doi.org\/10.3390\/nu12103050)"},{"key":"bib34","series-title":"Physiological Genomics","first-page":"99","article-title":"A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human","volume":"29","author":"Salek","year":"2007","unstructured":"Salek RMMaguire MLBentley ERubtsov DVHough TCheeseman MNunez DSweatman BCHaselden JNCox RD, et al.2007A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. Physiological Genomics2999\u2013108. (https:\/\/doi.org\/10.1152\/physiolgenomics.00194.2006)"},{"key":"bib35","series-title":"Journal of Hepatology","first-page":"783","article-title":"ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development","volume":"73","author":"Song","year":"2020","unstructured":"Song QChen YWang JHao LHuang CGriffiths ASun ZZhou Z & Song Z2020ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development. Journal of Hepatology73783\u2013793. (https:\/\/doi.org\/10.1016\/j.jhep.2020.04.038)"},{"key":"bib36","series-title":"Pharmacological Reports","first-page":"483","article-title":"Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse","volume":"62","author":"Sternak","year":"2010","unstructured":"Sternak MKhomich TIJakubowski ASzafarz MSzczepanski WBialas MStojak MSzymura-Oleksiak J & Chlopicki S2010Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse. Pharmacological Reports62483\u2013493. (https:\/\/doi.org\/10.1016\/s1734-1140(1070304-2)"},{"key":"bib37","series-title":"Scientific Reports","first-page":"3016","article-title":"N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism","volume":"8","author":"Strom","year":"2018","unstructured":"Strom KMorales-Alamo DOttosson FEdlund AHjort LJorgensen SWAlmgren PZhou YMartin-Rincon MEkman C, et al.2018N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism. Scientific Reports83016. (https:\/\/doi.org\/10.1038\/s41598-018-21099-1)"},{"key":"bib38","series-title":"Genome Biology","first-page":"RESEARCH0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","unstructured":"Vandesompele JDe Preter KPattyn FPoppe BVan Roy NDe Paepe A & Speleman F2002Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology3RESEARCH0034. (https:\/\/doi.org\/10.1186\/gb-2002-3-7-research0034)"},{"key":"bib39","series-title":"Diabetes Research and Clinical Practice","first-page":"109050","article-title":"IDF diabetes atlas: estimation of global and regional gestational diabetes mellitus prevalence for 2021 by international association of diabetes in pregnancy study Group's criteria","volume":"183","author":"Wang","year":"2022","unstructured":"Wang HLi NChivese TWerfalli MSun HYuen LHoegfeldt CAElise Powe CImmanuel JKaruranga S, et al.2022IDF diabetes atlas: estimation of global and regional gestational diabetes mellitus prevalence for 2021 by international association of diabetes in pregnancy study Group's criteria. Diabetes Research and Clinical Practice183109050. (https:\/\/doi.org\/10.1016\/j.diabres.2021.109050)"},{"key":"bib40","series-title":"Pharmacological Reports","first-page":"86","article-title":"Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats","volume":"61","author":"Watala","year":"2009","unstructured":"Watala CKazmierczak PDobaczewski MPrzygodzki TBartus MLomnicka MSlominska EMDurackova Z & Chlopicki S2009Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats. Pharmacological Reports6186\u201398. (https:\/\/doi.org\/10.1016\/s1734-1140(0970010-6)"},{"key":"bib41","series-title":"Journal of Nutritional Biochemistry","first-page":"108377","article-title":"Depot-specific regulation of NAD(+)\/SIRTs metabolism identified in adipose tissue of mice in response to high-fat diet feeding or calorie restriction","volume":"80","author":"Wei","year":"2020","unstructured":"Wei XJia RWang GHong SSong LSun BChen KWang NWang QLuo X, et al.2020Depot-specific regulation of NAD(+)\/SIRTs metabolism identified in adipose tissue of mice in response to high-fat diet feeding or calorie restriction. Journal of Nutritional Biochemistry80108377. (https:\/\/doi.org\/10.1016\/j.jnutbio.2020.108377)"},{"key":"bib42","series-title":"Journal of Nutritional Biochemistry","first-page":"109296","article-title":"Both prolonged high-fat diet consumption and calorie restriction boost hepatic NAD+ metabolism in mice","volume":"115","author":"Wei","year":"2023","unstructured":"Wei XWei CTan YDong XYang ZYan J & Luo X2023Both prolonged high-fat diet consumption and calorie restriction boost hepatic NAD+ metabolism in mice. Journal of Nutritional Biochemistry115109296. (https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109296)"},{"key":"bib43","series-title":"Molecular Endocrinology","first-page":"325","article-title":"Loss of fatty acid binding protein 4\/aP2 reduces macrophage inflammation through activation of SIRT3","volume":"30","author":"Xu","year":"2016","unstructured":"Xu HHertzel AVSteen KA & Bernlohr DA2016Loss of fatty acid binding protein 4\/aP2 reduces macrophage inflammation through activation of SIRT3. Molecular Endocrinology30325\u2013334. (https:\/\/doi.org\/10.1210\/me.2015-1301)"},{"key":"bib44","series-title":"Human and Experimental Toxicology","first-page":"S666","article-title":"NAMPT-mediated NAD(+) biosynthesis suppresses activation of hepatic stellate cells and protects against CCl(4)-induced liver fibrosis in mice","volume":"40","author":"Xu","year":"2021","unstructured":"Xu LYang CMa JZhang XWang Q & Xiong X2021NAMPT-mediated NAD(+) biosynthesis suppresses activation of hepatic stellate cells and protects against CCl(4)-induced liver fibrosis in mice. Human and Experimental Toxicology40S666\u2013S675. (https:\/\/doi.org\/10.1177\/09603271211052991)"},{"key":"bib45","series-title":"Journal of Biological Chemistry","first-page":"32869","article-title":"Adipose tissue-specific inhibition of hypoxia-inducible factor 1alpha induces obesity and glucose intolerance by impeding energy expenditure in mice","volume":"285","author":"Zhang","year":"2010","unstructured":"Zhang XLam KSLYe HChung SKZhou MWang Y & Xu A2010Adipose tissue-specific inhibition of hypoxia-inducible factor 1alpha induces obesity and glucose intolerance by impeding energy expenditure in mice. Journal of Biological Chemistry28532869\u201332877. (https:\/\/doi.org\/10.1074\/jbc.M110.135509)"},{"key":"bib46","series-title":"Journal of Diabetes Research","first-page":"1080152","article-title":"N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation","volume":"2020","author":"Zhang","year":"2020","unstructured":"Zhang JChen YLiu CLi L & Li P2020N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation. Journal of Diabetes Research20201080152. (https:\/\/doi.org\/10.1155\/2020\/1080152)"},{"key":"bib47","series-title":"Scientific Reports","first-page":"3793","article-title":"HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs","volume":"4","author":"Zhao","year":"2014","unstructured":"Zhao TZhu YMorinibu AKobayashi MShinomiya KItasaka SYoshimura MGuo GHiraoka M & Harada H2014HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs. Scientific Reports43793. (https:\/\/doi.org\/10.1038\/srep03793)"},{"key":"bib48","series-title":"Redox Biology","first-page":"102135","article-title":"SOD2 in skeletal muscle: new insights from an inducible deletion model","volume":"47","author":"Zhuang","year":"2021","unstructured":"Zhuang AYang CLiu YTan YBond STWalker SSikora TLaskowski ASharma Ade Haan JB, et al.2021SOD2 in skeletal muscle: new insights from an inducible deletion model. Redox Biology47102135. 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