{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:19:03Z","timestamp":1784557143903,"version":"3.55.0"},"reference-count":55,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,6,4]]},"abstract":"<jats:p>\n                    The objective was to assess the potential differential effects of human versus mouse growth hormone\n                    <jats:italic>in vivo<\/jats:italic>\n                    , given that human unlike mouse growth hormone can bind prolactin as well as the growth hormone receptor. To this end, a transgenic CD-1 mouse expressing human but not mouse growth hormone was generated, and the phenotypes of male mice fed with a regular chow or high-fat diet were assessed. Pancreas and epididymal white adipose tissue gene expression and\/or related function were targeted as the pancreas responds to both prolactin and growth hormone receptor signaling, and catabolic effects like lipolytic activity are more directly attributable to growth hormone and growth hormone receptor signaling. The resulting human growth hormone-expressing mice are smaller than wild-type CD-1 mice, despite higher body fat and larger adipocytes, but both mouse types grow at the same rate with similar bone densities. Unlike wild-type mice, there was no significant delay in glucose clearance in human growth hormone-expressing mice when assessed at 8 versus 24 weeks on a high-fat diet. However, both mouse types showed signs of hepatic steatosis that correlated with elevated prolactin but not growth hormone RNA levels. The larger adipocytes in human growth hormone-expressing mice were associated with modified leptin (higher) and adiponectin (lower) RNA levels. Thus, while limited to observations in the male, the human growth hormone-expressing mice exhibit signs of growth hormone insufficiency and adipocyte dysfunction as well as an initial resistance to the negative effects of high-fat diet on glucose clearance.\n                  <\/jats:p>","DOI":"10.1530\/jme-24-0026","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T06:40:48Z","timestamp":1717483248000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":0,"title":["Increased capacity to maintain glucose homeostasis in a transgenic mouse expressing human but not mouse growth hormone with developing high-fat diet-related insulin resistance, hepatic steatosis and adipose dysfunction"],"prefix":"10.1530","volume":"73","author":[{"given":"Yan","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-9610","authenticated-orcid":true,"given":"Jessica S","family":"Jarmasz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakila","family":"Sultana","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Cordero-Monroy","sequence":"additional","affiliation":[{"name":"Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Albrechtsen Research Centre, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla G","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Albrechtsen Research Centre, Winnipeg, Manitoba, Canada"},{"name":"Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Zahradka","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Albrechtsen Research Centre, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissavet","family":"Kardami","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-5475","authenticated-orcid":true,"given":"Peter A","family":"Cattini","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"American Journal of Physiology","first-page":"E1309","article-title":"Defective prolactin signaling impairs pancreatic beta-cell development during the perinatal period","volume":"305","author":"Auffret","year":"2013","unstructured":"Auffret JFreemark MCarre NMathieu YTourrel-Cuzin CLombes MMovassat J & Binart N2013Defective prolactin signaling impairs pancreatic beta-cell development during the perinatal period. American Journal of Physiology305E1309\u2013E1318. (https:\/\/doi.org\/10.1152\/ajpendo.00636.2012)"},{"key":"bib2","series-title":"Diabetes","first-page":"2331","article-title":"Gestational diabetes mellitus from inactivation of prolactin receptor and MafB in islet beta-cells","volume":"65","author":"Banerjee","year":"2016","unstructured":"Banerjee RRCyphert HAWalker EMChakravarthy HPeiris HGu XLiu YConrad EGoodrich LStein RWet al.2016Gestational diabetes mellitus from inactivation of prolactin receptor and MafB in islet beta-cells. Diabetes652331\u20132341. (https:\/\/doi.org\/10.2337\/db15-1527)"},{"key":"bib3","series-title":"Endocrinology","first-page":"1620","article-title":"The forgotten lactogenic activity of growth hormone: important implications for rodent studies","volume":"156","author":"Bartke","year":"2015","unstructured":"Bartke A & Kopchick JJ2015The forgotten lactogenic activity of growth hormone: important implications for rodent studies. Endocrinology1561620\u20131622. (https:\/\/doi.org\/10.1210\/en.2015-1097)"},{"key":"bib4","series-title":"International Journal of Molecular Sciences","first-page":"1621","article-title":"Growth hormone\u2019s effect on adipose tissue: quality versus quantity","volume":"18","author":"Berryman","year":"2017","unstructured":"Berryman DE & List EO2017Growth hormone\u2019s effect on adipose tissue: quality versus quantity. International Journal of Molecular Sciences181621. (https:\/\/doi.org\/10.3390\/ijms18081621)"},{"key":"bib5","series-title":"Endocrinology","first-page":"879","article-title":"Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy","volume":"132","author":"Brelje","year":"1993","unstructured":"Brelje TCScharp DWLacy PEOgren LTalamantes FRobertson MFriesen HG & Sorenson RL1993Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy. Endocrinology132879\u2013887. (https:\/\/doi.org\/10.1210\/endo.132.2.8425500)"},{"key":"bib6","series-title":"Endocrinology","first-page":"4162","article-title":"Distinctive roles for prolactin and growth hormone in the activation of signal transducer and activator of transcription 5 in pancreatic islets of Langerhans","volume":"145","author":"Brelje","year":"2004","unstructured":"Brelje TCStout LEBhagroo NV & Sorenson RL2004Distinctive roles for prolactin and growth hormone in the activation of signal transducer and activator of transcription 5 in pancreatic islets of Langerhans. Endocrinology1454162\u20134175. (https:\/\/doi.org\/10.1210\/en.2004-0201)"},{"key":"bib7","series-title":"Nature Reviews","first-page":"515","article-title":"The growth hormone receptor: mechanism of activation and clinical implications","volume":"6","author":"Brooks","year":"2010","unstructured":"Brooks AJ & Waters MJ2010The growth hormone receptor: mechanism of activation and clinical implications. Nature Reviews6515\u2013525. (https:\/\/doi.org\/10.1038\/nrendo.2010.123)"},{"key":"bib8","series-title":"JCI Insight","first-page":"e160854","article-title":"\u03b2 cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood","volume":"7","author":"Castell","year":"2022","unstructured":"Castell ALGoubault CEthier MFergusson GTremblay CBaltz MDal Soglio DGhislain J & Poitout V2022\u03b2 cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood. JCI Insight7e160854. (https:\/\/doi.org\/10.1172\/jci.insight.160854)"},{"key":"bib9","series-title":"Growth Hormone and IGF Research","first-page":"58","article-title":"A useful model to compare human and mouse growth hormone gene chromosomal structure, expression and regulation, and immune tolerance of human growth hormone analogues","volume":"42\u201343","author":"Cattini","year":"2018","unstructured":"Cattini PABock MEJin YZanghi JA & Vakili H2018A useful model to compare human and mouse growth hormone gene chromosomal structure, expression and regulation, and immune tolerance of human growth hormone analogues. Growth Hormone and IGF Research42\u20134358\u201365. (https:\/\/doi.org\/10.1016\/j.ghir.2018.09.001)"},{"key":"bib10","series-title":"PNAS","first-page":"5061","article-title":"Expression of a mutated bovine growth hormone gene suppresses growth of transgenic mice","volume":"87","author":"Chen","year":"1990","unstructured":"Chen WYWight DCWagner TE & Kopchick JJ1990Expression of a mutated bovine growth hormone gene suppresses growth of transgenic mice. PNAS875061\u20135065. (https:\/\/doi.org\/10.1073\/pnas.87.13.5061)"},{"key":"bib11","series-title":"Williams Textbook of Endocrinology","first-page":"964","article-title":"Normal and aberrant growth in children","author":"Cooke","year":"2016","unstructured":"Cooke DWSara ADivall SA & Radovick S2016Normal and aberrant growth in children. In Williams Textbook of Endocrinology, pp. 964\u20131073. Eds Melmed SPolonsky KSLarsen PR & Kronenberg HM. Amsterdam, Netherlands: Elsevier. (https:\/\/doi.org\/10.1016\/B978-0-323-29738-7.00024-1)"},{"key":"bib12","series-title":"Lipids","first-page":"1025","article-title":"Dietary t10,c12-CLA but not c9,t11 CLA reduces adipocyte size in the absence of changes in the adipose renin-angiotensin system in fa\/fa Zucker rats","volume":"45","author":"DeClercq","year":"2010","unstructured":"DeClercq VZahradka P & Taylor CG2010Dietary t10,c12-CLA but not c9,t11 CLA reduces adipocyte size in the absence of changes in the adipose renin-angiotensin system in fa\/fa Zucker rats. Lipids451025\u20131033. (https:\/\/doi.org\/10.1007\/s11745-010-3469-1)"},{"key":"bib13","series-title":"Laboratory Animals","first-page":"230","article-title":"The breeding performance of CD1 stud male mice with some comparative data from BALB\/c, PSD and PSDI strains","volume":"17","author":"Eveleigh","year":"1983","unstructured":"Eveleigh JRJasdrow HH & Gunner M1983The breeding performance of CD1 stud male mice with some comparative data from BALB\/c, PSD and PSDI strains. Laboratory Animals17230\u2013234. (https:\/\/doi.org\/10.1258\/002367783781070669)"},{"key":"bib14","series-title":"Journal of Biological Chemistry","first-page":"19937","article-title":"Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism","volume":"284","author":"Fan","year":"2009","unstructured":"Fan YMenon RKCohen PHwang DClemens TDiGirolamo DJKopchick JJLe Roith DTrucco M & Sperling MA2009Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. Journal of Biological Chemistry28419937\u201319944. (https:\/\/doi.org\/10.1074\/jbc.M109.014308)"},{"key":"bib15","series-title":"Growth Hormone and IGF Research","first-page":"201","article-title":"Growth hormone signalling and its regulation: preventing too much of a good thing","volume":"11","author":"Frank","year":"2001","unstructured":"Frank SJ2001Growth hormone signalling and its regulation: preventing too much of a good thing. Growth Hormone and IGF Research11201\u2013212. (https:\/\/doi.org\/10.1054\/ghir.2001.0237)"},{"key":"bib16","series-title":"Endocrinology","first-page":"1378","article-title":"Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance","volume":"143","author":"Freemark","year":"2002","unstructured":"Freemark MAvril IFleenor DDriscoll PPetro AOpara EKendall WOden JBridges SBinart N, et al.2002Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. Endocrinology1431378\u20131385. (https:\/\/doi.org\/10.1210\/endo.143.4.8722)"},{"key":"bib17","series-title":"Molecular Endocrinology","first-page":"1841","article-title":"Human GH receptor-IGF-1 receptor interaction: implications for GH signaling","volume":"28","author":"Gan","year":"2014","unstructured":"Gan YBuckels ALiu YZhang YPaterson AJJiang JZinn KR & Frank SJ2014Human GH receptor-IGF-1 receptor interaction: implications for GH signaling. Molecular Endocrinology281841\u20131854. (https:\/\/doi.org\/10.1210\/me.2014-1174)"},{"key":"bib18","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"756","article-title":"Adiponectin gene expression and plasma values in obese women during very-low-calorie diet. Relationship with cardiovascular risk factors and insulin resistance","volume":"89","author":"Garaulet","year":"2004","unstructured":"Garaulet MViguerie NPorubsky SKlimcakova EClement KLangin D & Stich V2004Adiponectin gene expression and plasma values in obese women during very-low-calorie diet. Relationship with cardiovascular risk factors and insulin resistance. Journal of Clinical Endocrinology and Metabolism89756\u2013760. (https:\/\/doi.org\/10.1210\/jc.2003-031495)"},{"key":"bib19","series-title":"Journal of Clinical and Translational Endocrinology","first-page":"85","article-title":"The prolactin receptor: diverse and emerging roles in pathophysiology","volume":"2","author":"Gorvin","year":"2015","unstructured":"Gorvin CM2015The prolactin receptor: diverse and emerging roles in pathophysiology. Journal of Clinical and Translational Endocrinology285\u201391. (https:\/\/doi.org\/10.1016\/j.jcte.2015.05.001)"},{"key":"bib20","series-title":"Cells","first-page":"1207","article-title":"The neglected insulin: IGF-II, a metabolic regulator with implications for diabetes, obesity, and cancer","volume":"8","author":"Holly","year":"2019","unstructured":"Holly JMPBiernacka K & Perks CM2019The neglected insulin: IGF-II, a metabolic regulator with implications for diabetes, obesity, and cancer. Cells81207. (https:\/\/doi.org\/10.3390\/cells8101207)"},{"key":"bib21","series-title":"Endocrine Connections","first-page":"1135","article-title":"Sleep deprivation and diet affect human GH gene expression in transgenic mice in vivo","volume":"9","author":"Jarmasz","year":"2020","unstructured":"Jarmasz JSJin YVakili H & Cattini PA2020Sleep deprivation and diet affect human GH gene expression in transgenic mice in vivo. Endocrine Connections91135\u20131147. (https:\/\/doi.org\/10.1530\/EC-20-0354)"},{"key":"bib22","series-title":"Placenta","first-page":"226","article-title":"Differential placental hormone gene expression during pregnancy in a transgenic mouse containing the human growth hormone\/chorionic somatomammotropin locus","volume":"30","author":"Jin","year":"2009","unstructured":"Jin YLu SYFresnoza ADetillieux KADuckworth ML & Cattini PA2009Differential placental hormone gene expression during pregnancy in a transgenic mouse containing the human growth hormone\/chorionic somatomammotropin locus. Placenta30226\u2013235. (https:\/\/doi.org\/10.1016\/j.placenta.2008.12.011)"},{"key":"bib23","series-title":"DNA and Cell Biology","first-page":"543","article-title":"Dexamethasone rescues an acute high-fat diet-induced decrease in human growth hormone gene expression in male partially humanized CD-1 mice","volume":"40","author":"Jin","year":"2021","unstructured":"Jin YJarmasz JS & Cattini PA2021Dexamethasone rescues an acute high-fat diet-induced decrease in human growth hormone gene expression in male partially humanized CD-1 mice. DNA and Cell Biology40543\u2013552. (https:\/\/doi.org\/10.1089\/dna.2020.6293)"},{"key":"bib24","series-title":"Nature Reviews","first-page":"135","article-title":"The effects of growth hormone on adipose tissue: old observations, new mechanisms","volume":"16","author":"Kopchick","year":"2020","unstructured":"Kopchick JJBerryman DEPuri VLee KY & Jorgensen JOL2020The effects of growth hormone on adipose tissue: old observations, new mechanisms. Nature Reviews16135\u2013146. (https:\/\/doi.org\/10.1038\/s41574-019-0280-9)"},{"key":"bib25","series-title":"Pharmacology and Therapeutics","first-page":"591","article-title":"The biology of growth hormone","volume":"2","author":"Kostyo","year":"1976","unstructured":"Kostyo JL & Reagan CR1976The biology of growth hormone. Pharmacology and Therapeutics2591\u2013604. (https:\/\/doi.org\/10.1016\/0306-039x(7690009-x)"},{"key":"bib26","series-title":"Obesity","first-page":"336","article-title":"Visceral fat is an independent predictor of all-cause mortality in men","volume":"14","author":"Kuk","year":"2006","unstructured":"Kuk JLKatzmarzyk PTNichaman MZChurch TSBlair SN & Ross R2006Visceral fat is an independent predictor of all-cause mortality in men. Obesity14336\u2013341. (https:\/\/doi.org\/10.1038\/oby.2006.43)"},{"key":"bib27","series-title":"Arteriosclerosis, Thrombosis, and Vascular Biology","first-page":"349","article-title":"Growth hormone induces low-density lipoprotein clearance but not bile acid synthesis in humans","volume":"24","author":"Lind","year":"2004","unstructured":"Lind SRudling MEricsson SOlivecrona HEriksson MBorgstrom BEggertsen GBerglund L & Angelin B2004Growth hormone induces low-density lipoprotein clearance but not bile acid synthesis in humans. Arteriosclerosis, Thrombosis, and Vascular Biology24349\u2013356. (https:\/\/doi.org\/10.1161\/01.ATV.0000110657.67317.90)"},{"key":"bib28","series-title":"Journal of Molecular Endocrinology","first-page":"231","article-title":"Regulation of pancreatic beta-cell mass and proliferation by SOCS-3","volume":"35","author":"Lindberg","year":"2005","unstructured":"Lindberg KRonn SGTornehave DRichter HHansen JARomer JJackerott M & Billestrup N2005Regulation of pancreatic beta-cell mass and proliferation by SOCS-3. Journal of Molecular Endocrinology35231\u2013243. (https:\/\/doi.org\/10.1677\/jme.1.01840)"},{"key":"bib29","series-title":"Endocrinology","first-page":"3564","article-title":"Prolactin (PRL) receptor gene expression in mouse adipose tissue: increases during lactation and in PRL-transgenic mice","volume":"141","author":"Ling","year":"2000","unstructured":"Ling CHellgren GGebre-Medhin MDillner KWennbo HCarlsson B & Billig H2000Prolactin (PRL) receptor gene expression in mouse adipose tissue: increases during lactation and in PRL-transgenic mice. Endocrinology1413564\u20133572. (https:\/\/doi.org\/10.1210\/endo.141.10.7691)"},{"key":"bib30","series-title":"Endocrinology","first-page":"1743","article-title":"GH knockout mice have increased subcutaneous adipose tissue with decreased fibrosis and enhanced insulin sensitivity","volume":"160","author":"List","year":"2019","unstructured":"List EOBerryman DEBuchman MJensen EAFunk KDuran-Ortiz SQian YYoung JASlyby JMcKenna S, et al.2019GH knockout mice have increased subcutaneous adipose tissue with decreased fibrosis and enhanced insulin sensitivity. Endocrinology1601743\u20131756. (https:\/\/doi.org\/10.1210\/en.2019-00167)"},{"key":"bib31","series-title":"American Journal of Physiology","first-page":"E405","article-title":"Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice","volume":"287","author":"Liu","year":"2004","unstructured":"Liu JLCoschigano KTRobertson KLipsett MGuo YKopchick JJKumar U & Liu YL2004Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. American Journal of Physiology287E405\u2013E413. (https:\/\/doi.org\/10.1152\/ajpendo.00423.2003)"},{"key":"bib32","series-title":"Journal of Neuroendocrinology","first-page":"e13258","article-title":"Effect of high fat diet on maternal behavior, brain-derived neurotrophic factor and neural stem cell proliferation in mice expressing human placental lactogen during pregnancy","author":"Moazzam","year":"2023","unstructured":"Moazzam SNoorjahan NJin YNagy JIKardami E & Cattini PA2023Effect of high fat diet on maternal behavior, brain-derived neurotrophic factor and neural stem cell proliferation in mice expressing human placental lactogen during pregnancy. Journal of Neuroendocrinologye13258. (https:\/\/doi.org\/10.1111\/jne.13258)"},{"key":"bib33","series-title":"Diabetes","first-page":"4148","article-title":"Autocrine action of IGF2 regulates adult beta-cell mass and function","volume":"64","author":"Modi","year":"2015","unstructured":"Modi HJacovetti CTarussio DMetref SMadsen ODZhang FPRantakari PPoutanen MNef SGorman T, et al.2015Autocrine action of IGF2 regulates adult beta-cell mass and function. Diabetes644148\u20134157. (https:\/\/doi.org\/10.2337\/db14-1735)"},{"key":"bib34","series-title":"Metabolism","first-page":"33","article-title":"Metabolic effects of growth hormone in humans","volume":"44","author":"Moller","year":"1995","unstructured":"Moller NJorgensen JOMoller JOrskov LOvesen PSchmitz OChristiansen JS & Orskov H1995Metabolic effects of growth hormone in humans. Metabolism4433\u201336. (https:\/\/doi.org\/10.1016\/0026-0495(9590218-x)"},{"key":"bib35","series-title":"American Journal of Physiology","first-page":"R902","article-title":"Prolactin regulates liver growth during postnatal development in mice","volume":"314","author":"Moreno-Carranza","year":"2018","unstructured":"Moreno-Carranza BBravo-Manriquez MBaez ALedesma-Colunga MGRuiz-Herrera XReyes-Ortega Pde Los Rios EAMacotela YMartinez de la Escalera G & Clapp C2018Prolactin regulates liver growth during postnatal development in mice. American Journal of Physiology314R902\u2013R908. (https:\/\/doi.org\/10.1152\/ajpregu.00003.2018)"},{"key":"bib36","series-title":"Gastroenterology and Hepatology","first-page":"167","article-title":"Pathogenesis and prevention of hepatic steatosis","volume":"11","author":"Nassir","year":"2015","unstructured":"Nassir FRector RSHammoud GM & Ibdah JA2015Pathogenesis and prevention of hepatic steatosis. Gastroenterology and Hepatology11167\u2013175."},{"key":"bib37","series-title":"Endotext","article-title":"Normal physiology of growth hormone in adults","author":"Olarescu","year":"2000","unstructured":"Olarescu NCGunawardane KHansen TKMoller N & Jorgensen JOL2000Normal physiology of growth hormone in adults. In Endotext. Eds Feingold KRAnawalt BBlackman MRBoyce AChrousos GCorpas Ede Herder WWDhatariya KDungan KHofland J, et al.South Dartmouth,MA, USA: MDText.com, Inc. (available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279056\/)"},{"key":"bib38","series-title":"International Journal of Molecular Sciences","first-page":"2519","article-title":"Adiponectin, obesity, and cancer: clash of the bigwigs in health and disease","volume":"20","author":"Parida","year":"2019","unstructured":"Parida SSiddharth S & Sharma D2019Adiponectin, obesity, and cancer: clash of the bigwigs in health and disease. International Journal of Molecular Sciences202519. (https:\/\/doi.org\/10.3390\/ijms20102519)"},{"key":"bib39","series-title":"Clinics","first-page":"265","article-title":"Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient little mice","volume":"67","author":"Peroni","year":"2012","unstructured":"Peroni CNHayashida CYNascimento NLonguini VCToledo RABartolini PBowers CY & Toledo SP2012Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient little mice. Clinics67265\u2013272. (https:\/\/doi.org\/10.6061\/clinics\/2012(0311)"},{"key":"bib40","series-title":"Reviews in Endocrine and Metabolic Disorders","first-page":"13","article-title":"Leptin as a key regulator of the adipose organ","volume":"23","author":"Pico","year":"2022","unstructured":"Pico CPalou MPomar CARodriguez AM & Palou A2022Leptin as a key regulator of the adipose organ. Reviews in Endocrine and Metabolic Disorders2313\u201330. (https:\/\/doi.org\/10.1007\/s11154-021-09687-5)"},{"key":"bib41","series-title":"Pituitary","first-page":"1","article-title":"Mice with gene alterations in the GH and IGF family","volume":"25","author":"Qian","year":"2022","unstructured":"Qian YBerryman DEBasu RList EOOkada SYoung JAJensen EABell SRCKulkarni PDuran-Ortiz S, et al.2022Mice with gene alterations in the GH and IGF family. Pituitary251\u201351. (https:\/\/doi.org\/10.1007\/s11102-021-01191-y)"},{"key":"bib42","series-title":"Journal of Heredity","first-page":"49","article-title":"Predicting selection response for growth of channel catfish","volume":"67","author":"Reagan","year":"1976","unstructured":"Reagan REPardue GB & Eisen EJ1976Predicting selection response for growth of channel catfish. Journal of Heredity6749\u201353. (https:\/\/doi.org\/10.1093\/oxfordjournals.jhered.a108664)"},{"key":"bib43","series-title":"Clinical Diabetes and Endocrinology","first-page":"18","article-title":"Growth hormone: isoforms, clinical aspects and assays interference","volume":"4","author":"Ribeiro de Oliveira Longo Schweizer","year":"2018","unstructured":"Ribeiro de Oliveira Longo Schweizer JRibeiro-Oliveira AJr & Bidlingmaier M2018Growth hormone: isoforms, clinical aspects and assays interference. Clinical Diabetes and Endocrinology418. (https:\/\/doi.org\/10.1186\/s40842-018-0068-1)"},{"key":"bib44","series-title":"Nature Methods","first-page":"671","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","unstructured":"Schneider CARasband WS & Eliceiri KW2012NIH Image to ImageJ: 25 years of image analysis. Nature Methods9671\u2013675. (https:\/\/doi.org\/10.1038\/nmeth.2089)"},{"key":"bib45","series-title":"Pathologie-Biologie","first-page":"395","article-title":"Current data on growth hormone","volume":"23","author":"Segrestaa","year":"1975","unstructured":"Segrestaa JMGueris J & Lamotte M1975Current data on growth hormone. Pathologie-Biologie23395\u2013408."},{"key":"bib46","series-title":"American Journal of Physiology","first-page":"E34","article-title":"Growth hormone acts along the PPARgamma-FSP27 axis to stimulate lipolysis in human adipocytes","volume":"316","author":"Sharma","year":"2019","unstructured":"Sharma VMVestergaard ETJessen NKolind-Thomsen PNellemann BNielsen TSVendelbo MHMoller NSharma RLee KY, et al.2019Growth hormone acts along the PPARgamma-FSP27 axis to stimulate lipolysis in human adipocytes. American Journal of Physiology316E34\u2013E42. (https:\/\/doi.org\/10.1152\/ajpendo.00129.2018)"},{"key":"bib47","series-title":"Proceedings of the Society for Experimental Biology and Medicine","first-page":"465","article-title":"A \u201c20K\u201d form of growth hormone in the murine pituitary gland","volume":"177","author":"Sinha","year":"1984","unstructured":"Sinha YN & Gilligan TA1984A \u201c20K\u201d form of growth hormone in the murine pituitary gland. Proceedings of the Society for Experimental Biology and Medicine177465\u2013474. (https:\/\/doi.org\/10.3181\/00379727-177-41974)"},{"key":"bib48","series-title":"Growth Hormone and IGF Research","first-page":"59","article-title":"Effects of growth hormone-releasing hormone on visceral fat, metabolic, and cardiovascular indices in human studies","volume":"25","author":"Stanley","year":"2015","unstructured":"Stanley TL & Grinspoon SK2015Effects of growth hormone-releasing hormone on visceral fat, metabolic, and cardiovascular indices in human studies. Growth Hormone and IGF Research2559\u201365. (https:\/\/doi.org\/10.1016\/j.ghir.2014.12.005)"},{"key":"bib49","series-title":"Molecular and Cellular Endocrinology","first-page":"48","article-title":"Transgenic mice expressing the human growth hormone gene provide a model system to study human growth hormone synthesis and secretion in non-tumor-derived pituitary cells: differential effects of dexamethasone and thyroid hormone","volume":"345","author":"Vakili","year":"2011","unstructured":"Vakili HJin YNagy JI & Cattini PA2011Transgenic mice expressing the human growth hormone gene provide a model system to study human growth hormone synthesis and secretion in non-tumor-derived pituitary cells: differential effects of dexamethasone and thyroid hormone. Molecular and Cellular Endocrinology34548\u201357. (https:\/\/doi.org\/10.1016\/j.mce.2011.07.010)"},{"key":"bib50","series-title":"Journal of Biological Chemistry","first-page":"33282","article-title":"Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells","volume":"287","author":"Vakili","year":"2012","unstructured":"Vakili HJin Y & Cattini PA2012Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells. Journal of Biological Chemistry28733282\u201333292. (https:\/\/doi.org\/10.1074\/jbc.M112.380949)"},{"key":"bib51","series-title":"Journal of Biological Chemistry","first-page":"22849","article-title":"CCAAT-enhancer-binding protein beta (C\/EBPbeta) and downstream human placental growth hormone genes are targets for dysregulation in pregnancies complicated by maternal obesity","volume":"288","author":"Vakili","year":"2013","unstructured":"Vakili HJin YMenticoglou S & Cattini PA2013CCAAT-enhancer-binding protein beta (C\/EBPbeta) and downstream human placental growth hormone genes are targets for dysregulation in pregnancies complicated by maternal obesity. Journal of Biological Chemistry28822849\u201322861. (https:\/\/doi.org\/10.1074\/jbc.M113.474999)"},{"key":"bib52","series-title":"Journal of Clinical Investigation","first-page":"5002","article-title":"Energy homeostasis targets chromosomal reconfiguration of the human GH1 locus","volume":"124","author":"Vakili","year":"2014","unstructured":"Vakili HJin Y & Cattini PA2014Energy homeostasis targets chromosomal reconfiguration of the human GH1 locus. Journal of Clinical Investigation1245002\u20135012. (https:\/\/doi.org\/10.1172\/JCI77126)"},{"key":"bib53","series-title":"Journal of Biological Chemistry","first-page":"13823","article-title":"Evidence for a circadian effect on the reduction of human growth hormone gene expression in response to excess caloric intake","volume":"291","author":"Vakili","year":"2016","unstructured":"Vakili HJin Y & Cattini PA2016Evidence for a circadian effect on the reduction of human growth hormone gene expression in response to excess caloric intake. Journal of Biological Chemistry29113823\u201313833. (https:\/\/doi.org\/10.1074\/jbc.M116.722744)"},{"key":"bib54","series-title":"Diabetes","first-page":"2755","article-title":"Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence","volume":"59","author":"Villaret","year":"2010","unstructured":"Villaret AGalitzky JDecaunes PEsteve DMarques MASengenes CChiotasso PTchkonia TLafontan MKirkland JL, et al.2010Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence. Diabetes592755\u20132763. (https:\/\/doi.org\/10.2337\/db10-0398)"},{"key":"bib55","series-title":"American Journal of Physiology","first-page":"R226","article-title":"Determinants of leptin gene expression in fat depots of lean mice","volume":"282","author":"Zhang","year":"2002","unstructured":"Zhang YGuo KYDiaz PAHeo M & Leibel RL2002Determinants of leptin gene expression in fat depots of lean mice. American Journal of Physiology282R226\u2013R234. 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