{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:40:59Z","timestamp":1787496059058,"version":"build-2736575974"},"reference-count":144,"publisher":"Bioscientifica","issue":"4","funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"crossref","award":["CPRR240322210479"],"award-info":[{"award-number":["CPRR240322210479"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jme.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Type 2 diabetes mellitus (DM) is closely associated with cellular senescence (SnC), a state of irreversible cell cycle arrest marked by functional decline. Preventing cellular senescence in already diagnosed DM patients is crucial for limiting disease progression and the onset of co-morbidities. The relationship between oxidative stress, DNA damage, and telomere shortening provides a mechanistic framework for elucidating the role of cellular senescence in the pathogenesis and progression of type 2 DM. This senescence-driven model of metabolic dysfunction not only accounts for impaired \u03b2-cell function and insulin resistance but also for the systemic complications observed in DM patients. The accumulation of senescent cells, particularly in metabolically active tissues such as adipose tissue, is increasingly recognised as both a cause and a consequence of the chronic inflammatory environment that characterises diabetes. Evidence from\n                    <jats:italic>in vitro<\/jats:italic>\n                    and preclinical studies highlights the detrimental effects of the senescence-associated secretory phenotype, reinforcing tissue damage through paracrine and autocrine signalling mechanisms. Despite its complexity, approaches targeting the senescent phenotype offer a promising avenue for adjunct therapies. Senotherapeutics, such as senomorphic agents that protect cells from cytotoxic damage and mitigate oxidative stress, can potentially protect against disease onset, whereas senolytic agents have the potential to eliminate senescent cells to limit metabolic disease progression, mitigate complications, and ultimately improve patient outcomes. There is, however, an urgent need to translate the preclinical findings into clinical trials to assess the safety, efficacy, and long-term effects of senotherapeutic agents.\n                  <\/jats:p>","DOI":"10.1530\/jme-25-0052","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:50:36Z","timestamp":1761911436000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":1,"title":["RISING STARS: Targeting premature cellular senescence using senomorphic or senolytic agents to impact diabetes"],"prefix":"10.1530","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0861-2939","authenticated-orcid":true,"given":"Mari","family":"van de Vyver","sequence":"first","affiliation":[{"name":"Experimental Medicine Research Group, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiuree","family":"Govender","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Group, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Petersen-Ross","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Group, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Howard","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Group, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Nat Cell Biol","first-page":"978","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta JC","year":"2013","unstructured":"Acosta JC\n, \nBanito A\n, \nWuestefeld T\n, et al.\n 2013 A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol 15 978\u2013990. (https:\/\/doi.org\/10.1038\/ncb2784)"},{"key":"bib2","series-title":"Cell Metab","first-page":"129","article-title":"Acceleration of \u03b2 cell aging determines diabetes and senolysis improves disease outcomes","volume":"30","author":"Aguayo-Mazzucato C","year":"2019","unstructured":"Aguayo-Mazzucato C\n, \nAndle J\n, \nLee TB\n, et al.\n 2019 Acceleration of \u03b2 cell aging determines diabetes and senolysis improves disease outcomes. Cell Metab 30 129\u2013142.e4. (https:\/\/doi.org\/10.1016\/j.cmet.2019.05.006)"},{"key":"bib3","series-title":"Pharmaceuticals","first-page":"921","article-title":"The potential protective role of naringenin against dasatinib-induced hepatotoxicity","volume":"16","author":"Alanazi AZ","year":"2023","unstructured":"Alanazi AZ\n, \nAlhazzani K\n, \nAlrewily SQ\n, et al.\n 2023 The potential protective role of naringenin against dasatinib-induced hepatotoxicity. Pharmaceuticals 16 921. (https:\/\/doi.org\/10.3390\/ph16070921)"},{"key":"bib4","series-title":"J Food Biochem","article-title":"A study of the molecular mechanism of quercetin and dasatinib combination as senolytic in alleviating age-related and kidney diseases","volume":"46","author":"Alharbi KS","year":"2022","unstructured":"Alharbi KS\n, \nAfzal O\n, \nAltamimi ASA\n, et al.\n 2022 A study of the molecular mechanism of quercetin and dasatinib combination as senolytic in alleviating age-related and kidney diseases. J Food Biochem 46 e14471. (https:\/\/doi.org\/10.1111\/jfbc.14471)"},{"key":"bib5","series-title":"J Diabetes Metab Disord","first-page":"1161","article-title":"Association of antidiabetic therapy with shortened telomere length in middle-aged type 2 diabetic patients","volume":"20","author":"Al-Thuwaini TM","year":"2021","unstructured":"Al-Thuwaini TM\n\n 2021 Association of antidiabetic therapy with shortened telomere length in middle-aged type 2 diabetic patients. J Diabetes Metab Disord 20 1161\u20131168. (https:\/\/doi.org\/10.1007\/s40200-021-00835-x)"},{"key":"bib6","series-title":"Nutrients","first-page":"428","article-title":"Protective effects of sulforaphane preventing inflammation and oxidative stress to enhance metabolic health: a narrative review","volume":"17","author":"Alves I","year":"2025","unstructured":"Alves I\n, \nAra\u00fajo EMQ\n, \nDalgaard LT\n, et al.\n 2025 Protective effects of sulforaphane preventing inflammation and oxidative stress to enhance metabolic health: a narrative review. Nutrients 17 428. (https:\/\/doi.org\/10.3390\/nu17030428)"},{"key":"bib7","series-title":"Cell","first-page":"132","article-title":"Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging","volume":"169","author":"Baar MP","year":"2017","unstructured":"Baar MP\n, \nBrandt RMC\n, \nPutavet DA\n, et al.\n 2017 Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell 169 132\u2013147.e16. (https:\/\/doi.org\/10.1016\/j.cell.2017.02.031)"},{"key":"bib8","series-title":"EMBO J","first-page":"4212","article-title":"Reversal of human cellular senescence: roles of the p53 and p16 pathways","volume":"22","author":"Beaus\u00e9jour CM","year":"2003","unstructured":"Beaus\u00e9jour CM\n, \nKrtolica A\n, \nGalimi F\n, et al.\n 2003 Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 22 4212\u20134222. (https:\/\/doi.org\/10.1093\/emboj\/cdg417)"},{"key":"bib9","series-title":"Nature","first-page":"569","article-title":"Structure and function of telomeres","volume":"350","author":"Blackburn EH","year":"1991","unstructured":"Blackburn EH\n\n 1991 Structure and function of telomeres. Nature 350 569\u2013573. (https:\/\/doi.org\/10.1038\/350569a0)"},{"key":"bib10","series-title":"Mutat Res","first-page":"297","article-title":"DNA damage and repair in type 2 diabetes mellitus","volume":"554","author":"Blasiak J","year":"2004","unstructured":"Blasiak J\n, \nArabski M\n, \nKrupa R\n, et al.\n 2004 DNA damage and repair in type 2 diabetes mellitus. Mutat Res 554 297\u2013304. (https:\/\/doi.org\/10.1016\/j.mrfmmm.2004.05.011)"},{"key":"bib11","series-title":"Biochem Biophys Res Commun","first-page":"1226","article-title":"Aspirin reduces endothelial cell senescence","volume":"334","author":"Bode-B\u00f6ger SM","year":"2005","unstructured":"Bode-B\u00f6ger SM\n, \nMartens-Lobenhoffer J\n, \nT\u00e4ger M\n, et al.\n 2005 Aspirin reduces endothelial cell senescence. Biochem Biophys Res Commun 334 1226\u20131232. (https:\/\/doi.org\/10.1016\/j.bbrc.2005.07.014)"},{"key":"bib12","series-title":"Oncotarget","first-page":"50835","article-title":"Leukocyte telomere length and mortality risk in patients with type 2 diabetes","volume":"7","author":"Bonfigli AR","year":"2016","unstructured":"Bonfigli AR\n, \nSpazzafumo L\n, \nPrattichizzo F\n, et al.\n 2016 Leukocyte telomere length and mortality risk in patients with type 2 diabetes. Oncotarget 7 50835\u201350844. (https:\/\/doi.org\/10.18632\/oncotarget.10615)"},{"key":"bib13","series-title":"Antioxidants Redox Signal","first-page":"2420","article-title":"Oxidative stress and the DNA mismatch repair pathway","volume":"18","author":"Brierley DJ","year":"2013","unstructured":"Brierley DJ\n & \nMartin SA\n\n 2013 Oxidative stress and the DNA mismatch repair pathway. Antioxidants Redox Signal 18 2420\u20132428. (https:\/\/doi.org\/10.1089\/ars.2012.4994)"},{"key":"bib14","series-title":"Pharmaceuticals","first-page":"982","article-title":"Plant polyphenols for aging health: implication from their autophagy modulating properties in age-associated diseases","volume":"14","author":"Brimson JM","year":"2021","unstructured":"Brimson JM\n, \nPrasanth MI\n, \nMalar DS\n, et al.\n 2021 Plant polyphenols for aging health: implication from their autophagy modulating properties in age-associated diseases. Pharmaceuticals 14 982. (https:\/\/doi.org\/10.3390\/ph14100982)"},{"key":"bib15","series-title":"Int J Mol Sci","first-page":"446","article-title":"Cell cycle and DNA repair regulation in the damage response: protein phosphatases take over the reins","volume":"21","author":"Campos A","year":"2020","unstructured":"Campos A\n & \nClemente-Blanco A\n\n 2020 Cell cycle and DNA repair regulation in the damage response: protein phosphatases take over the reins. Int J Mol Sci 21 446. (https:\/\/doi.org\/10.3390\/ijms21020446)"},{"key":"bib16","series-title":"Antioxidants","first-page":"142","article-title":"Redox signaling and advanced glycation endproducts (AGEs) in diet-related diseases","volume":"9","author":"Cepas V","year":"2020","unstructured":"Cepas V\n, \nCollino M\n, \nMayo JC\n, et al.\n 2020 Redox signaling and advanced glycation endproducts (AGEs) in diet-related diseases. Antioxidants 9 142. (https:\/\/doi.org\/10.3390\/antiox9020142)"},{"key":"bib17","series-title":"Pharmacol Res","first-page":"379","article-title":"A moderate decline in U937 cell GSH levels triggers PI3 kinase\/Akt-dependent bad phosphorylation, thereby preventing an otherwise prompt apoptotic response","volume":"65","author":"Cerioni L","year":"2012","unstructured":"Cerioni L\n, \nFiorani M\n, \nAzzolini C\n, et al.\n 2012 A moderate decline in U937 cell GSH levels triggers PI3 kinase\/Akt-dependent bad phosphorylation, thereby preventing an otherwise prompt apoptotic response. Pharmacol Res 65 379\u2013386. (https:\/\/doi.org\/10.1016\/j.phrs.2011.12.006)"},{"key":"bib18","series-title":"Curr Drug Targets","first-page":"460","article-title":"Is senescence reversible?","volume":"17","author":"Chakradeo S","year":"2016","unstructured":"Chakradeo S\n, \nElmore LW\n & \nGewirtz DA\n\n 2016 Is senescence reversible? Curr Drug Targets 17 460\u2013466. (https:\/\/doi.org\/10.2174\/1389450116666150825113500)"},{"key":"bib19","series-title":"Aging","first-page":"21547","article-title":"HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells","volume":"13","author":"Chen D-D","year":"2021","unstructured":"Chen D-D\n, \nPeng X\n, \nWang Y\n, et al.\n 2021 HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells. Aging 13 21547\u201321570. (https:\/\/doi.org\/10.18632\/aging.203496)"},{"key":"bib20","series-title":"Diabetes Care","first-page":"2257","article-title":"Shortened relative leukocyte telomere length is associated with prevalent and incident cardiovascular complications in type 2 diabetes: analysis from the Hong Kong diabetes register","volume":"43","author":"Cheng F","year":"2020","unstructured":"Cheng F\n, \nLuk AO\n, \nTam CHT\n, et al.\n 2020 Shortened relative leukocyte telomere length is associated with prevalent and incident cardiovascular complications in type 2 diabetes: analysis from the Hong Kong diabetes register. Diabetes Care 43 2257\u20132265. (https:\/\/doi.org\/10.2337\/dc20-0028)"},{"key":"bib21","series-title":"Diabetes Res Clin Pract","article-title":"Shortened relative leukocyte telomere length is associated with all-cause mortality in type 2 diabetes- analysis from the Hong Kong diabetes register","volume":"173","author":"Cheng F","year":"2021","unstructured":"Cheng F\n, \nLuk AO\n, \nWu H\n, et al.\n 2021 Shortened relative leukocyte telomere length is associated with all-cause mortality in type 2 diabetes- analysis from the Hong Kong diabetes register. Diabetes Res Clin Pract 173 108649. (https:\/\/doi.org\/10.1016\/j.diabres.2021.108649)"},{"key":"bib22","series-title":"Diabetes Care","first-page":"701","article-title":"Shortened leukocyte telomere length is associated with glycemic progression in type 2 diabetes: a prospective and mendelian randomization analysis","volume":"45","author":"Cheng F","year":"2022a","unstructured":"Cheng F\n, \nLuk AO\n, \nShi M\n, et al.\n 2022a Shortened leukocyte telomere length is associated with glycemic progression in type 2 diabetes: a prospective and mendelian randomization analysis. Diabetes Care 45 701\u2013709. (https:\/\/doi.org\/10.2337\/dc21-1609)"},{"key":"bib23","series-title":"Diabetologia","first-page":"375","article-title":"Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the Hong Kong diabetes register","volume":"65","author":"Cheng F","year":"2022b","unstructured":"Cheng F\n, \nLuk AO\n, \nWu H\n, et al.\n 2022b Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the Hong Kong diabetes register. Diabetologia 65 375\u2013386. (https:\/\/doi.org\/10.1007\/s00125-021-05613-1)"},{"key":"bib24","series-title":"J Physiol Invest","first-page":"107","article-title":"Protective effect of curcumin on the tight junction integrity and cellular senescence in human retinal pigment epithelium of early diabetic retinopathy","volume":"67","author":"Cheng Y-W","year":"2024","unstructured":"Cheng Y-W\n, \nHuang Y-C\n, \nChang K-F\n, et al.\n 2024 Protective effect of curcumin on the tight junction integrity and cellular senescence in human retinal pigment epithelium of early diabetic retinopathy. J Physiol Invest 67 107\u2013117. (https:\/\/doi.org\/10.4103\/ejpi.EJPI-D-23-00035)"},{"key":"bib25","series-title":"Biochemistry","first-page":"6102","article-title":"Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues","volume":"50","author":"Chetyrkin S","year":"2011","unstructured":"Chetyrkin S\n, \nMathis M\n, \nPedchenko V\n, et al.\n 2011 Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues. Biochemistry 50 6102\u20136112. (https:\/\/doi.org\/10.1021\/bi200757d)"},{"key":"bib26","series-title":"Genes Development","first-page":"2125","article-title":"Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity","volume":"25","author":"Chien Y","year":"2011","unstructured":"Chien Y\n, \nScuoppo C\n, \nWang X\n, et al.\n 2011 Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity. Genes Development 25 2125\u20132136. (https:\/\/doi.org\/10.1101\/gad.17276711)"},{"key":"bib27","series-title":"EMBO Rep","first-page":"1139","article-title":"Senescence and apoptosis: dueling or complementary cell fates?","volume":"15","author":"Childs BG","year":"2014","unstructured":"Childs BG\n, \nBaker DJ\n, \nKirkland JL\n, et al.\n 2014 Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep 15 1139\u20131153. (https:\/\/doi.org\/10.15252\/embr.201439245)"},{"key":"bib28","series-title":"PLoS Biol","first-page":"2853","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Copp\u00e9 J-P","year":"2008","unstructured":"Copp\u00e9 J-P\n, \nPatil CK\n, \nRodier F\n, et al.\n 2008 Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6 2853\u20132868. (https:\/\/doi.org\/10.1371\/journal.pbio.0060301)"},{"key":"bib29","series-title":"Annu Rev Pathol","first-page":"99","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9 J-P","year":"2010","unstructured":"Copp\u00e9 J-P\n, \nDesprez P-Y\n, \nKrtolica A\n, et al.\n 2010 The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 5 99\u2013118. (https:\/\/doi.org\/10.1146\/annurev-pathol-121808-102144)"},{"key":"bib30","series-title":"Neuropharmacology","first-page":"26","article-title":"A novel curcumin derivative for the treatment of diabetic neuropathy","volume":"129","author":"Daugherty DJ","year":"2018","unstructured":"Daugherty DJ\n, \nMarquez A\n, \nCalcutt NA\n, et al.\n 2018 A novel curcumin derivative for the treatment of diabetic neuropathy. Neuropharmacology 129 26\u201335. (https:\/\/doi.org\/10.1016\/j.neuropharm.2017.11.007)"},{"key":"bib31","series-title":"Mutat Res","first-page":"4","article-title":"Mechanism of oxidative DNA damage repair and relevance to human pathology","volume":"659","author":"D\u2019Errico M","year":"2008","unstructured":"D\u2019Errico M\n, \nParlanti E\n & \nDogliotti E\n\n 2008 Mechanism of oxidative DNA damage repair and relevance to human pathology. Mutat Res 659 4\u201314. (https:\/\/doi.org\/10.1016\/j.mrrev.2007.10.003)"},{"key":"bib32","series-title":"Ann Transl Med","first-page":"308","article-title":"Shorter leucocyte telomere length as a potential biomarker for nonalcoholic fatty liver disease-related advanced fibrosis in T2DM patients","volume":"8","author":"Dong K","year":"2020","unstructured":"Dong K\n, \nZhang Y\n, \nHuang J-J\n, et al.\n 2020 Shorter leucocyte telomere length as a potential biomarker for nonalcoholic fatty liver disease-related advanced fibrosis in T2DM patients. Ann Transl Med 8 308. (https:\/\/doi.org\/10.21037\/atm.2020.03.10)"},{"key":"bib33","series-title":"Oncotarget","first-page":"67699","article-title":"ATF6\u03b1 regulates morphological changes associated with senescence in human fibroblasts","volume":"7","author":"Druelle C","year":"2016","unstructured":"Druelle C\n, \nDrullion C\n, \nDesl\u00e9 J\n, et al.\n 2016 ATF6\u03b1 regulates morphological changes associated with senescence in human fibroblasts. Oncotarget 7 67699\u201367715. (https:\/\/doi.org\/10.18632\/oncotarget.11505)"},{"key":"bib34","series-title":"Int J Mol Sci","article-title":"The emerging role of p21 in diabetes and related metabolic disorders","volume":"25","author":"Elmitwalli O","year":"2024","unstructured":"Elmitwalli O\n, \nDarwish R\n, \nAl-Jabery L\n, et al.\n 2024 The emerging role of p21 in diabetes and related metabolic disorders. Int J Mol Sci 25 13209. (https:\/\/doi.org\/10.3390\/ijms252313209)"},{"key":"bib35","series-title":"Geroscience","first-page":"5169","article-title":"Frailty incidence by diabetes treatment regimens in older adults with diabetes mellitus in the ASPirin in reducing events in the elderly study","volume":"47","author":"Espinoza SE","year":"2025","unstructured":"Espinoza SE\n, \nBroder JC\n, \nWolfe R\n, et al.\n 2025 Frailty incidence by diabetes treatment regimens in older adults with diabetes mellitus in the ASPirin in reducing events in the elderly study. Geroscience 47 5169\u20135183. (https:\/\/doi.org\/10.1007\/s11357-025-01598-6)"},{"key":"bib36","series-title":"Geroscience","first-page":"2835","article-title":"Sexual dimorphic metabolic and cognitive responses of C57BL\/6 mice to fisetin or dasatinib and quercetin cocktail oral treatment","volume":"45","author":"Fang Y","year":"2023","unstructured":"Fang Y\n, \nMedina D\n, \nStockwell R\n, et al.\n 2023 Sexual dimorphic metabolic and cognitive responses of C57BL\/6 mice to fisetin or dasatinib and quercetin cocktail oral treatment. Geroscience 45 2835\u20132850. (https:\/\/doi.org\/10.1007\/s11357-023-00843-0)"},{"key":"bib37","series-title":"Ageing Res Rev","article-title":"(Poly)phenols and diabetes: from effects to mechanisms by systematic multigenomic analysis","volume":"102","author":"Farrim MI","year":"2024","unstructured":"Farrim MI\n, \nGomes A\n, \nMenezes R\n, et al.\n 2024 (Poly)phenols and diabetes: from effects to mechanisms by systematic multigenomic analysis. Ageing Res Rev 102 102557. (https:\/\/doi.org\/10.1016\/j.arr.2024.102557)"},{"key":"bib38","series-title":"FASEB Bioadv","first-page":"579","article-title":"Aspirin ameliorates the long-term adverse effects of doxorubicin through suppression of cellular senescence","volume":"1","author":"Feng M","year":"2019","unstructured":"Feng M\n, \nKim J\n, \nField K\n, et al.\n 2019 Aspirin ameliorates the long-term adverse effects of doxorubicin through suppression of cellular senescence. FASEB Bioadv 1 579\u2013590. (https:\/\/doi.org\/10.1096\/fba.2019-00041)"},{"key":"bib39","series-title":"Blood","first-page":"1813","article-title":"BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair","volume":"114","author":"Fernandes MS","year":"2009","unstructured":"Fernandes MS\n, \nReddy MM\n, \nGonneville JR\n, et al.\n 2009 BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair. Blood 114 1813\u20131819. (https:\/\/doi.org\/10.1182\/blood-2008-07-172148)"},{"key":"bib40","series-title":"Front Aging Neurosci","article-title":"Sex, senescence, senolytics, and cognition","volume":"17","author":"Foster TC","year":"2025","unstructured":"Foster TC\n & \nKumar A\n\n 2025 Sex, senescence, senolytics, and cognition. Front Aging Neurosci 17 1555872. (https:\/\/doi.org\/10.3389\/fnagi.2025.1555872)"},{"key":"bib41","series-title":"Nucleic Acids Res","article-title":"Broad repression of DNA repair genes in senescent cells identified by integration of transcriptomic data","volume":"53","author":"Frey Y","year":"2025","unstructured":"Frey Y\n, \nHaj M\n, \nZiv Y\n, et al.\n 2025 Broad repression of DNA repair genes in senescent cells identified by integration of transcriptomic data. Nucleic Acids Res 53 gkae1257. (https:\/\/doi.org\/10.1093\/nar\/gkae1257)"},{"key":"bib42","series-title":"Biochimie","first-page":"11","article-title":"Counteracting diabetes-induced adipose tissue derived-stromal cell senescence","volume":"220","author":"Govender S","year":"2024","unstructured":"Govender S\n, \nKruger MJ\n & \nvan de Vyver M\n\n 2024 Counteracting diabetes-induced adipose tissue derived-stromal cell senescence. Biochimie 220 11\u201321. (https:\/\/doi.org\/10.1016\/j.biochi.2023.12.001)"},{"key":"bib43","series-title":"Cardiovasc Diabetol","first-page":"214","article-title":"The tyrosine kinase inhibitor dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice","volume":"22","author":"Gu Y","year":"2023","unstructured":"Gu Y\n, \nAvolio E\n, \nAlvino VV\n, et al.\n 2023 The tyrosine kinase inhibitor dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice. Cardiovasc Diabetol 22 214. (https:\/\/doi.org\/10.1186\/s12933-023-01955-9)"},{"key":"bib44","series-title":"Phytomedicine","article-title":"Therapeutic application of natural products: NAD+ metabolism as potential target","volume":"114","author":"Guo C","year":"2023","unstructured":"Guo C\n, \nHuang Q\n, \nWang Y\n, et al.\n 2023 Therapeutic application of natural products: NAD+ metabolism as potential target. Phytomedicine 114 154768. (https:\/\/doi.org\/10.1016\/j.phymed.2023.154768)"},{"key":"bib45","series-title":"Phytomedicine","article-title":"Senolytic combination of dasatinib and quercetin attenuates renal damage in diabetic kidney disease","volume":"130","author":"Guo X","year":"2024","unstructured":"Guo X\n, \nWen S\n, \nWang J\n, et al.\n 2024 Senolytic combination of dasatinib and quercetin attenuates renal damage in diabetic kidney disease. Phytomedicine 130 155705. (https:\/\/doi.org\/10.1016\/j.phymed.2024.155705)"},{"key":"bib46","series-title":"Kidney Int Rep","first-page":"592","article-title":"Short leukocyte telomere length predicts albuminuria progression in individuals with type 2 diabetes","volume":"3","author":"Gurung RL","year":"2018","unstructured":"Gurung RL\n, \nM Y\n, \nLiu S\n, et al.\n 2018 Short leukocyte telomere length predicts albuminuria progression in individuals with type 2 diabetes. Kidney Int Rep 3 592\u2013601. (https:\/\/doi.org\/10.1016\/j.ekir.2017.12.005)"},{"key":"bib47","series-title":"Clin Kidney J","first-page":"2371","article-title":"Association of leukocyte telomere length with chronic kidney disease in East Asians with type 2 diabetes: a Mendelian randomization study","volume":"14","author":"Gurung RL","year":"2021","unstructured":"Gurung RL\n, \nDorajoo R\n, \nM Y\n, et al.\n 2021 Association of leukocyte telomere length with chronic kidney disease in East Asians with type 2 diabetes: a Mendelian randomization study. Clin Kidney J 14 2371\u20132376. (https:\/\/doi.org\/10.1093\/ckj\/sfab067)"},{"key":"bib48","series-title":"Exp Mol Med","first-page":"1626","article-title":"8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification","volume":"54","author":"Hahm JY","year":"2022","unstructured":"Hahm JY\n, \nPark J\n, \nJang E-S\n, et al.\n 2022 8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification. Exp Mol Med 54 1626\u20131642. (https:\/\/doi.org\/10.1038\/s12276-022-00822-z)"},{"key":"bib49","series-title":"Chin Med Sci J","first-page":"31","article-title":"NF-\u03baB inhibitor parthenolide promotes renal tubules albumin uptake in type 2 diabetic nephropathy","volume":"35","author":"Hao QF","year":"2020","unstructured":"Hao QF\n, \nWang BB\n, \nZhang W\n, et al.\n 2020 NF-\u03baB inhibitor parthenolide promotes renal tubules albumin uptake in type 2 diabetic nephropathy. Chin Med Sci J 35 31\u201342. (https:\/\/doi.org\/10.24920\/003573)"},{"key":"bib50","series-title":"Exp Cell Res","first-page":"585","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick L","year":"1961","unstructured":"Hayflick L\n & \nMoorhead PS\n\n 1961 The serial cultivation of human diploid cell strains. Exp Cell Res 25 585\u2013621. (https:\/\/doi.org\/10.1016\/0014-4827(61)90192-6)"},{"key":"bib51","series-title":"J Clin Endocrinol Metab","first-page":"e177","article-title":"The association between telomere length and diabetes mellitus: accumulated evidence from observational studies","volume":"110","author":"He X","year":"2024","unstructured":"He X\n, \nCao L\n, \nFu X\n, et al.\n 2024 The association between telomere length and diabetes mellitus: accumulated evidence from observational studies. J Clin Endocrinol Metab 110 e177\u2013e185. (https:\/\/doi.org\/10.1210\/clinem\/dgae536)"},{"key":"bib52","series-title":"Proc Natl Acad Sci U S A","first-page":"E3090","article-title":"Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins","volume":"110","author":"Hegde ML","year":"2013","unstructured":"Hegde ML\n, \nHegde PM\n, \nBellot LJ\n, et al.\n 2013 Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins. Proc Natl Acad Sci U S A 110 E3090\u2013E3099. (https:\/\/doi.org\/10.1073\/pnas.1304231110)"},{"key":"bib53","series-title":"Int J Mol Sci","first-page":"1148","article-title":"Deoxyribonucleic acid damage and repair: capitalizing on our understanding of the mechanisms of maintaining genomic integrity for therapeutic purposes","volume":"19","author":"Helena J","year":"2018","unstructured":"Helena J\n, \nJoubert A\n, \nGrobbelaar S\n, et al.\n 2018 Deoxyribonucleic acid damage and repair: capitalizing on our understanding of the mechanisms of maintaining genomic integrity for therapeutic purposes. Int J Mol Sci 19 1148. (https:\/\/doi.org\/10.3390\/ijms19041148)"},{"key":"bib54","series-title":"Oncogene","first-page":"3456","article-title":"Rb2\/p130 is the dominating pocket protein in the p53\u2013p21 DNA damage response pathway leading to senescence","volume":"28","author":"Helmbold H","year":"2009","unstructured":"Helmbold H\n, \nK\u00f6mm N\n, \nDeppert W\n, et al.\n 2009 Rb2\/p130 is the dominating pocket protein in the p53\u2013p21 DNA damage response pathway leading to senescence. Oncogene 28 3456\u20133467. (https:\/\/doi.org\/10.1038\/onc.2009.222)"},{"key":"bib55","series-title":"Diabetes Care","first-page":"1944","article-title":"Progression of retinopathy after improved metabolic control in type 2 diabetic patients. Relation to IGF-1 and hemostatic variables","volume":"22","author":"Henricsson M","year":"1999","unstructured":"Henricsson M\n, \nBerntorp K\n, \nBerntorp E\n, et al.\n 1999 Progression of retinopathy after improved metabolic control in type 2 diabetic patients. Relation to IGF-1 and hemostatic variables. Diabetes Care 22 1944\u20131949. (https:\/\/doi.org\/10.2337\/diacare.22.12.1944)"},{"key":"bib56","series-title":"Sci Rep","article-title":"MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice","volume":"14","author":"Hense JD","year":"2024","unstructured":"Hense JD\n, \nGarcia DN\n, \nZanini BM\n, et al.\n 2024 MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice. Sci Rep 14 17332. (https:\/\/doi.org\/10.1038\/s41598-024-67697-0)"},{"key":"bib57","series-title":"EBioMedicine","first-page":"446","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson LJ","year":"2019","unstructured":"Hickson LJ\n, \nLanghi Prata LGP\n, \nBobart SA\n, et al.\n 2019 Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. EBioMedicine 47 446\u2013456. (https:\/\/doi.org\/10.1016\/j.ebiom.2019.08.069)"},{"key":"bib58","series-title":"Front Cell Dev Biol","article-title":"Why senescent cells are resistant to apoptosis: an insight for senolytic development","volume":"10","author":"Hu L","year":"2022","unstructured":"Hu L\n, \nLi H\n, \nZi M\n, et al.\n 2022 Why senescent cells are resistant to apoptosis: an insight for senolytic development. Front Cell Dev Biol 10 822816. (https:\/\/doi.org\/10.3389\/fcell.2022.822816)"},{"key":"bib59","series-title":"Biomed Pharmacother","first-page":"656","article-title":"Molecular pathways associated with oxidative stress in diabetes mellitus","volume":"108","author":"Ighodaro OM","year":"2018","unstructured":"Ighodaro OM\n\n 2018 Molecular pathways associated with oxidative stress in diabetes mellitus. Biomed Pharmacother 108 656\u2013662. (https:\/\/doi.org\/10.1016\/j.biopha.2018.09.058)"},{"key":"bib60","series-title":"Curr Neurovascular Res","first-page":"232","article-title":"Triamcinolone acetonide suppresses inflammation and facilitates vascular barrier function in human retinal microvascular endothelial cells","volume":"14","author":"Imai S","year":"2017","unstructured":"Imai S\n, \nOtsuka T\n, \nNaito A\n, et al.\n 2017 Triamcinolone acetonide suppresses inflammation and facilitates vascular barrier function in human retinal microvascular endothelial cells. Curr Neurovascular Res 14 232\u2013241. (https:\/\/doi.org\/10.2174\/1567202614666170619081929)"},{"key":"bib61","series-title":"J Diabetes Invest","first-page":"830","article-title":"Relationship between the early initiation of insulin treatment and diabetic complications in patients newly diagnosed with type 2 diabetes mellitus in Korea: a nationwide cohort study","volume":"13","author":"Jeon H-L","year":"2022","unstructured":"Jeon H-L\n, \nKim W\n, \nKim B\n, et al.\n 2022 Relationship between the early initiation of insulin treatment and diabetic complications in patients newly diagnosed with type 2 diabetes mellitus in Korea: a nationwide cohort study. J Diabetes Invest 13 830\u2013838. (https:\/\/doi.org\/10.1111\/jdi.13719)"},{"key":"bib62","series-title":"J Fungi","first-page":"566","article-title":"Functional roles of homologous recombination and non-homologous end joining in DNA damage response and microevolution in cryptococcus neoformans","volume":"7","author":"Jung K-W","year":"2021","unstructured":"Jung K-W\n, \nJung J-H\n & \nPark H-Y\n\n 2021 Functional roles of homologous recombination and non-homologous end joining in DNA damage response and microevolution in cryptococcus neoformans. J Fungi 7 566. (https:\/\/doi.org\/10.3390\/jof7070566)"},{"key":"bib63","series-title":"Ann N Y Acad Sci","first-page":"278","article-title":"Mechanism of telomere shortening by oxidative stress","volume":"1019","author":"Kawanishi S","year":"2004","unstructured":"Kawanishi S\n & \nOikawa S\n\n 2004 Mechanism of telomere shortening by oxidative stress. Ann N Y Acad Sci 1019 278\u2013284. (https:\/\/doi.org\/10.1196\/annals.1297.047)"},{"key":"bib64","series-title":"Neuromolecular Med","first-page":"101","article-title":"Parthenolide, an NF-\u03baB inhibitor ameliorates diabetes-induced behavioural deficit, neurotransmitter imbalance and neuroinflammation in type 2 diabetes rat model","volume":"19","author":"Khare P","year":"2017","unstructured":"Khare P\n, \nDatusalia AK\n & \nSharma SS\n\n 2017 Parthenolide, an NF-\u03baB inhibitor ameliorates diabetes-induced behavioural deficit, neurotransmitter imbalance and neuroinflammation in type 2 diabetes rat model. Neuromolecular Med 19 101\u2013112. (https:\/\/doi.org\/10.1007\/s12017-016-8434-6)"},{"key":"bib65","series-title":"Pharmacol Res","article-title":"Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-induced inflammatory responses via the Nrf2\/Keap1 pathway","volume":"145","author":"Kim CY","year":"2019","unstructured":"Kim CY\n, \nKang B\n, \nSuh HJ\n, et al.\n 2019 Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-induced inflammatory responses via the Nrf2\/Keap1 pathway. Pharmacol Res 145 104259. (https:\/\/doi.org\/10.1016\/j.phrs.2019.104259)"},{"key":"bib66","series-title":"J Intern Med","first-page":"518","article-title":"Senolytic drugs: from discovery to translation","volume":"288","author":"Kirkland JL","year":"2020","unstructured":"Kirkland JL\n & \nTchkonia T\n\n 2020 Senolytic drugs: from discovery to translation. J Intern Med 288 518\u2013536. (https:\/\/doi.org\/10.1111\/joim.13141)"},{"key":"bib67","series-title":"Cell Metab","first-page":"5","article-title":"Targeting p21 for diabetes: another choice of senotherapy","volume":"34","author":"Kondoh H","year":"2022","unstructured":"Kondoh H\n & \nHara E\n\n 2022 Targeting p21 for diabetes: another choice of senotherapy. Cell Metab 34 5\u20137. (https:\/\/doi.org\/10.1016\/j.cmet.2021.12.008)"},{"key":"bib68","series-title":"Sci Rep","first-page":"920","article-title":"Impaired non-homologous end joining in human primary alveolar type II cells in emphysema","volume":"9","author":"Kosmider B","year":"2019","unstructured":"Kosmider B\n, \nLin C-R\n, \nVlasenko L\n, et al.\n 2019 Impaired non-homologous end joining in human primary alveolar type II cells in emphysema. Sci Rep 9 920. (https:\/\/doi.org\/10.1038\/s41598-018-37000-z)"},{"key":"bib69","series-title":"Antioxidants Redox Signal","first-page":"508","article-title":"Redox mechanisms of cytoprotection by Bcl-2","volume":"7","author":"Kowaltowski AJ","year":"2005","unstructured":"Kowaltowski AJ\n & \nFiskum G\n\n 2005 Redox mechanisms of cytoprotection by Bcl-2. Antioxidants Redox Signal 7 508\u2013514. (https:\/\/doi.org\/10.1089\/ars.2005.7.508)"},{"key":"bib70","series-title":"EMBO J","article-title":"Compromised DNA repair is responsible for diabetes-associated fibrosis","volume":"39","author":"Kumar V","year":"2020","unstructured":"Kumar V\n, \nAgrawal R\n, \nPandey A\n, et al.\n 2020 Compromised DNA repair is responsible for diabetes-associated fibrosis. EMBO J 39 e103477. (https:\/\/doi.org\/10.15252\/embj.2019103477)"},{"key":"bib71","series-title":"Nutrients","first-page":"1114","article-title":"GlyNAC (glycine and N-acetylcysteine) supplementation in mice increases length of life by correcting glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormalities in mitophagy and nutrient sensing, and genomic damage","volume":"14","author":"Kumar P","year":"2022","unstructured":"Kumar P\n, \nOsahon OW\n & \nSekhar RV\n\n 2022 GlyNAC (glycine and N-acetylcysteine) supplementation in mice increases length of life by correcting glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormalities in mitophagy and nutrient sensing, and genomic damage. Nutrients 14 1114. (https:\/\/doi.org\/10.3390\/nu14051114)"},{"key":"bib72","series-title":"Antioxidants","first-page":"1042","article-title":"GlyNAC (glycine and N-acetylcysteine) supplementation in old mice improves brain glutathione deficiency, oxidative stress, glucose uptake, mitochondrial dysfunction, genomic damage, inflammation and neurotrophic factors to reverse age-associated cognitive decline: implications for improving brain health in aging","volume":"12","author":"Kumar P","year":"2023","unstructured":"Kumar P\n, \nOsahon OW\n & \nSekhar RV\n\n 2023 GlyNAC (glycine and N-acetylcysteine) supplementation in old mice improves brain glutathione deficiency, oxidative stress, glucose uptake, mitochondrial dysfunction, genomic damage, inflammation and neurotrophic factors to reverse age-associated cognitive decline: implications for improving brain health in aging. Antioxidants 12 1042. (https:\/\/doi.org\/10.3390\/antiox12051042)"},{"key":"bib73","series-title":"Mol Cell Biochem","first-page":"689","article-title":"In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells","volume":"477","author":"Kurosaki Y","year":"2022","unstructured":"Kurosaki Y\n, \nImoto A\n, \nKawakami F\n, et al.\n 2022 In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells. Mol Cell Biochem 477 689\u2013699. (https:\/\/doi.org\/10.1007\/s11010-021-04295-y)"},{"key":"bib74","series-title":"Ter Arkh","first-page":"46","article-title":"Oxidative and carbonyl stress as a factors of the modification of proteins and DNA destruction in diabetes","volume":"90","author":"Lankin VZ","year":"2018","unstructured":"Lankin VZ\n, \nTikhaze AK\n, \nKonovalova GG\n, et al.\n 2018 Oxidative and carbonyl stress as a factors of the modification of proteins and DNA destruction in diabetes. Ter Arkh 90 46\u201350. (https:\/\/doi.org\/10.26442\/terarkh2018901046-50)"},{"key":"bib75","series-title":"Diabetes","first-page":"3600","article-title":"Targeting HSP90 ameliorates nephropathy and atherosclerosis through suppression of NF-\u03baB and STAT signaling pathways in diabetic mice","volume":"64","author":"Lazaro I","year":"2015","unstructured":"Lazaro I\n, \nOguiza A\n, \nRecio C\n, et al.\n 2015 Targeting HSP90 ameliorates nephropathy and atherosclerosis through suppression of NF-\u03baB and STAT signaling pathways in diabetic mice. Diabetes 64 3600\u20133613. (https:\/\/doi.org\/10.2337\/db14-1926)"},{"key":"bib76","series-title":"Cl\u00edn Invest Arterioscler","first-page":"51","article-title":"Interplay between HSP90 and Nrf2 pathways in diabetes-associated atherosclerosis","volume":"29","author":"Lazaro I","year":"2017","unstructured":"Lazaro I\n, \nOguiza A\n, \nRecio C\n, et al.\n 2017 Interplay between HSP90 and Nrf2 pathways in diabetes-associated atherosclerosis. Cl\u00edn Invest Arterioscler 29 51\u201359. (https:\/\/doi.org\/10.1016\/j.arteri.2016.10.003)"},{"key":"bib77","series-title":"Aging","first-page":"225","article-title":"Dietary curcumin restores insulin homeostasis in diet-induced obese aged mice","volume":"14","author":"Lee S-J","year":"2022","unstructured":"Lee S-J\n, \nChandrasekran P\n, \nMazucanti CH\n, et al.\n 2022 Dietary curcumin restores insulin homeostasis in diet-induced obese aged mice. Aging 14 225\u2013239. (https:\/\/doi.org\/10.18632\/aging.203821)"},{"key":"bib78","series-title":"J Biol Chem","first-page":"25665","article-title":"Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation","volume":"275","author":"Li C-Y","year":"2000","unstructured":"Li C-Y\n, \nLee J-S\n, \nKo Y-G\n, et al.\n 2000 Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem 275 25665\u201325671. (https:\/\/doi.org\/10.1074\/jbc.M906383199)"},{"key":"bib79","series-title":"Int Immunopharmacol","article-title":"Parthenolide ameliorates diabetic retinopathy by suppressing microglia-induced M\u00fcller cell gliosis and inflammation via the NF-\u03baB signalling","volume":"151","author":"Li Z","year":"2025","unstructured":"Li Z\n, \nXiong Q\n, \nLi Q\n, et al.\n 2025 Parthenolide ameliorates diabetic retinopathy by suppressing microglia-induced M\u00fcller cell gliosis and inflammation via the NF-\u03baB signalling. Int Immunopharmacol 151 114219. (https:\/\/doi.org\/10.1016\/j.intimp.2025.114219)"},{"key":"bib80","series-title":"Inflammation","first-page":"2018","article-title":"Inhibition of NF-\u03baB reduces renal inflammation and expression of PEPCK in type 2 diabetic mice","volume":"41","author":"Liu Q","year":"2018","unstructured":"Liu Q\n, \nZhang L\n, \nZhang W\n, et al.\n 2018 Inhibition of NF-\u03baB reduces renal inflammation and expression of PEPCK in type 2 diabetic mice. Inflammation 41 2018\u20132029. (https:\/\/doi.org\/10.1007\/s10753-018-0845-0)"},{"key":"bib81","series-title":"Cytokine","first-page":"15","article-title":"The senescence-associated secretory phenotype and its regulation","volume":"117","author":"Lopes-Paciencia S","year":"2019","unstructured":"Lopes-Paciencia S\n, \nSaint-Germain E\n, \nRowell M-C\n, et al.\n 2019 The senescence-associated secretory phenotype and its regulation. Cytokine 117 15\u201322. (https:\/\/doi.org\/10.1016\/j.cyto.2019.01.013)"},{"key":"bib82","series-title":"J Clin Investig","first-page":"653","article-title":"Increased single strand breaks in DNA of lymphocytes from diabetic subjects","volume":"79","author":"Lorenzi M","year":"1987","unstructured":"Lorenzi M\n, \nMontisano DF\n, \nToledo S\n, et al.\n 1987 Increased single strand breaks in DNA of lymphocytes from diabetic subjects. J Clin Investig 79 653\u2013656. (https:\/\/doi.org\/10.1172\/JCI112863)"},{"key":"bib83","series-title":"Diabetes","first-page":"1081","article-title":"Diabetes-induced cellular senescence and senescence-associated secretory phenotype impair cardiac regeneration and function independently of age","volume":"71","author":"Marino F","year":"2022","unstructured":"Marino F\n, \nScalise M\n, \nSalerno N\n, et al.\n 2022 Diabetes-induced cellular senescence and senescence-associated secretory phenotype impair cardiac regeneration and function independently of age. Diabetes 71 1081\u20131098. (https:\/\/doi.org\/10.2337\/db21-0536)"},{"key":"bib84","series-title":"Antioxidants","first-page":"1037","article-title":"Curcumin, polydatin and Quercetin synergistic activity protects from high-glucose-induced inflammation and oxidative stress","volume":"11","author":"Matacchione G","year":"2022","unstructured":"Matacchione G\n, \nValli D\n, \nSilvestrini A\n, et al.\n 2022 Curcumin, polydatin and Quercetin synergistic activity protects from high-glucose-induced inflammation and oxidative stress. Antioxidants 11 1037. (https:\/\/doi.org\/10.3390\/antiox11061037)"},{"key":"bib85","series-title":"Int J Mol Sci","first-page":"3367","article-title":"Therapeutic potential for regulation of the nuclear factor kappa-B transcription factor p65 to prevent cellular senescence and activation of pro-inflammatory in mesenchymal stem cells","volume":"22","author":"Mato-Basalo R","year":"2021","unstructured":"Mato-Basalo R\n, \nMorente-L\u00f3pez M\n, \nArntz OJ\n, et al.\n 2021 Therapeutic potential for regulation of the nuclear factor kappa-B transcription factor p65 to prevent cellular senescence and activation of pro-inflammatory in mesenchymal stem cells. Int J Mol Sci 22 3367. (https:\/\/doi.org\/10.3390\/ijms22073367)"},{"key":"bib86","series-title":"Immunol Rev","first-page":"132","article-title":"The DNA-dependent protein kinase: the director at the end","volume":"200","author":"Meek K","year":"2004","unstructured":"Meek K\n, \nGupta S\n, \nRamsden DA\n, et al.\n 2004 The DNA-dependent protein kinase: the director at the end. Immunol Rev 200 132\u2013141. (https:\/\/doi.org\/10.1111\/j.0105-2896.2004.00162.x)"},{"key":"bib87","series-title":"Cartilage","first-page":"1214S","article-title":"Resveratrol and curcumin attenuate ex vivo sugar-induced cartilage glycation, stiffening, senescence, and degeneration","volume":"13","author":"Mehta S","year":"2021","unstructured":"Mehta S\n, \nYoung CC\n, \nWarren MR\n, et al.\n 2021 Resveratrol and curcumin attenuate ex vivo sugar-induced cartilage glycation, stiffening, senescence, and degeneration. Cartilage 13 1214S\u20131228S. (https:\/\/doi.org\/10.1177\/1947603520988768)"},{"key":"bib88","series-title":"Biochem Res Int","article-title":"Role of p16(INK4A) in replicative senescence and DNA damage-induced premature senescence in p53-deficient human cells","volume":"2012","author":"Mirzayans R","year":"2012","unstructured":"Mirzayans R\n, \nAndrais B\n, \nHansen G\n, et al.\n 2012 Role of p16(INK4A) in replicative senescence and DNA damage-induced premature senescence in p53-deficient human cells. Biochem Res Int 2012 951574. (https:\/\/doi.org\/10.1155\/2012\/951574)"},{"key":"bib89","series-title":"Front Endocrinol","article-title":"Cellular senescence in diabetes mellitus: distinct senotherapeutic strategies for adipose tissue and pancreatic \u03b2 cells","volume":"13","author":"Murakami T","year":"2022","unstructured":"Murakami T\n, \nInagaki N\n & \nKondoh H\n\n 2022 Cellular senescence in diabetes mellitus: distinct senotherapeutic strategies for adipose tissue and pancreatic \u03b2 cells. Front Endocrinol 13 869414. (https:\/\/doi.org\/10.3389\/fendo.2022.869414)"},{"key":"bib90","series-title":"Cell Death Differ","first-page":"1654","article-title":"Hsp90 chaperones PPAR\u03b3 and regulates differentiation and survival of 3T3-L1 adipocytes","volume":"20","author":"Nguyen MT","year":"2013","unstructured":"Nguyen MT\n, \nCsermely P\n & \nS\u0151ti C\n\n 2013 Hsp90 chaperones PPAR\u03b3 and regulates differentiation and survival of 3T3-L1 adipocytes. Cell Death Differ 20 1654\u20131663. (https:\/\/doi.org\/10.1038\/cdd.2013.129)"},{"key":"bib91","series-title":"Antioxidants","first-page":"125","article-title":"Telomere maintenance is associated with type 2 diabetes remission in response to a long-term dietary intervention without non-weight loss in patients with coronary heart disease: from the CORDIOPREV randomized controlled trial","volume":"13","author":"Ojeda-Rodriguez A","year":"2024","unstructured":"Ojeda-Rodriguez A\n, \nAlcala-Diaz JF\n, \nRangel-Zu\u00f1iga OA\n, et al.\n 2024 Telomere maintenance is associated with type 2 diabetes remission in response to a long-term dietary intervention without non-weight loss in patients with coronary heart disease: from the CORDIOPREV randomized controlled trial. Antioxidants 13 125. (https:\/\/doi.org\/10.3390\/antiox13010125)"},{"key":"bib92","series-title":"Trends Mol Med","first-page":"1113","article-title":"Senescence and tissue fibrosis: opportunities for therapeutic targeting","volume":"30","author":"O\u2019Reilly S","year":"2024","unstructured":"O\u2019Reilly S\n, \nTsou P-S\n & \nVarga J\n\n 2024 Senescence and tissue fibrosis: opportunities for therapeutic targeting. Trends Mol Med 30 1113\u20131125. (https:\/\/doi.org\/10.1016\/j.molmed.2024.05.012)"},{"key":"bib93","series-title":"Aging Cell","article-title":"Targeting senescent cells alleviates obesity-induced metabolic dysfunction","volume":"18","author":"Palmer AK","year":"2019","unstructured":"Palmer AK\n, \nXu M\n, \nZhu Y\n, et al.\n 2019 Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell 18 e12950. (https:\/\/doi.org\/10.1111\/acel.12950)"},{"key":"bib94","series-title":"Biomedicines","first-page":"223","article-title":"Bcl-2 and Bcl-xL in diabetes: contributions to endocrine pancreas viability and function","volume":"13","author":"Perez-Serna AA","year":"2025","unstructured":"Perez-Serna AA\n, \nGuzman-Llorens D\n, \nDos Santos RS\n, et al.\n 2025 Bcl-2 and Bcl-xL in diabetes: contributions to endocrine pancreas viability and function. Biomedicines 13 223. (https:\/\/doi.org\/10.3390\/biomedicines13010223)"},{"key":"bib95","series-title":"J Thorac Oncol","first-page":"473","article-title":"Throwing more cold water on heat shock protein 90 inhibitors in NSCLC","volume":"13","author":"Pillai RN","year":"2018","unstructured":"Pillai RN\n & \nRamalingam SS\n\n 2018 Throwing more cold water on heat shock protein 90 inhibitors in NSCLC. J Thorac Oncol 13 473\u2013474. (https:\/\/doi.org\/10.1016\/j.jtho.2018.02.010)"},{"key":"bib96","series-title":"Indian Heart J","first-page":"S173","article-title":"Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease","volume":"70","author":"Piplani S","year":"2018","unstructured":"Piplani S\n, \nAlemao NN\n, \nPrabhu M\n, et al\n. 2018 Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease. Indian Heart J 70(Supp. 3) S173\u2013S176. (https:\/\/doi.org\/10.1016\/j.ihj.2018.09.007)"},{"key":"bib97","series-title":"Front Oncol","article-title":"The role of BCL-2 family proteins in regulating apoptosis and cancer therapy","volume":"12","author":"Qian S","year":"2022","unstructured":"Qian S\n, \nWei Z\n, \nYang W\n, et al.\n 2022 The role of BCL-2 family proteins in regulating apoptosis and cancer therapy. Front Oncol 12 985363. (https:\/\/doi.org\/10.3389\/fonc.2022.985363)"},{"key":"bib98","series-title":"Diabetes Metab Syndr Obes","first-page":"3739","article-title":"Can antidiabetic medications affect telomere length in patients with type 2 diabetes? A mini-review","volume":"16","author":"Qin B","year":"2023","unstructured":"Qin B\n\n 2023 Can antidiabetic medications affect telomere length in patients with type 2 diabetes? A mini-review. Diabetes Metab Syndr Obes 16 3739\u20133750. (https:\/\/doi.org\/10.2147\/DMSO.S428560)"},{"key":"bib99","series-title":"Ann N Y Acad Sci","first-page":"88","article-title":"Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications","volume":"1243","author":"Ramasamy R","year":"2011","unstructured":"Ramasamy R\n, \nYan SF\n & \nSchmidt AM\n\n 2011 Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y Acad Sci 1243 88\u2013102. (https:\/\/doi.org\/10.1111\/j.1749-6632.2011.06320.x)"},{"key":"bib100","series-title":"Nat Cell Biol","first-page":"973","article-title":"Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion","volume":"11","author":"Rodier F","year":"2009","unstructured":"Rodier F\n, \nCopp\u00e9 J-P\n, \nPatil CK\n, et al.\n 2009 Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 11 973\u2013979. (https:\/\/doi.org\/10.1038\/ncb1909)"},{"key":"bib101","series-title":"Mol Biol Cell","first-page":"402","article-title":"Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress","volume":"17","author":"Rodriguez R","year":"2006","unstructured":"Rodriguez R\n & \nMeuth M\n\n 2006 Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell 17 402\u2013412. (https:\/\/doi.org\/10.1091\/mbc.e05-07-0594)"},{"key":"bib102","series-title":"Free Radical Biol Med","first-page":"S47","article-title":"Polyphenols protect against protein glycoxidation","volume":"75","author":"Sadowska-Bartosz I","year":"2014","unstructured":"Sadowska-Bartosz I\n, \nGaliniak S\n & \nBartosz G\n\n 2014 Polyphenols protect against protein glycoxidation. Free Radical Biol Med 75(Supp. 1) S47. (https:\/\/doi.org\/10.1016\/j.freeradbiomed.2014.10.810)"},{"key":"bib103","series-title":"Mayo Clin Proc","first-page":"3021","article-title":"Antidiabetic effects of the senolytic agent dasatinib","volume":"96","author":"Salaami O","year":"2021","unstructured":"Salaami O\n, \nKuo C-L\n, \nDrake MT\n, et al.\n 2021 Antidiabetic effects of the senolytic agent dasatinib. Mayo Clin Proc 96 3021\u20133029. (https:\/\/doi.org\/10.1016\/j.mayocp.2021.06.025)"},{"key":"bib104","series-title":"Cell Signal","first-page":"835","article-title":"Emerging role of NF-\u03baB signaling in the induction of senescence-associated secretory phenotype (SASP)","volume":"24","author":"Salminen A","year":"2012","unstructured":"Salminen A\n, \nKauppinen A\n & \nKaarniranta K\n\n 2012 Emerging role of NF-\u03baB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 24 835\u2013845. (https:\/\/doi.org\/10.1016\/j.cellsig.2011.12.006)"},{"key":"bib105","series-title":"Exp Gerontol","article-title":"Regulation of senescence and the SASP by the transcription factor C\/EBP\u03b2","volume":"128","author":"Salotti J","year":"2019","unstructured":"Salotti J\n & \nJohnson PF\n\n 2019 Regulation of senescence and the SASP by the transcription factor C\/EBP\u03b2. Exp Gerontol 128 110752. (https:\/\/doi.org\/10.1016\/j.exger.2019.110752)"},{"key":"bib106","series-title":"Theranostics","first-page":"5429","article-title":"Clearance of senescent cells enhances skin wound healing in type 2 diabetic mice","volume":"14","author":"Samarawickrama PN","year":"2024","unstructured":"Samarawickrama PN\n, \nZhang G\n, \nZhu E\n, et al.\n 2024 Clearance of senescent cells enhances skin wound healing in type 2 diabetic mice. Theranostics 14 5429\u20135442. (https:\/\/doi.org\/10.7150\/thno.100991)"},{"key":"bib107","series-title":"Int J Mol Sci","first-page":"290","article-title":"Leukocyte telomere length as a marker of chronic complications in type 2 diabetes patients: a risk assessment study","volume":"26","author":"Sawicki K","year":"2024","unstructured":"Sawicki K\n, \nMatysiak-Kucharek M\n, \nGorczyca-Siudak D\n, et al.\n 2024 Leukocyte telomere length as a marker of chronic complications in type 2 diabetes patients: a risk assessment study. Int J Mol Sci 26 290. (https:\/\/doi.org\/10.3390\/ijms26010290)"},{"key":"bib108","series-title":"Curr Biol","first-page":"R453","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber M","year":"2014","unstructured":"Schieber M\n & \nChandel NS\n\n 2014 ROS function in redox signaling and oxidative stress. Curr Biol 24 R453\u2013R462. (https:\/\/doi.org\/10.1016\/j.cub.2014.03.034)"},{"key":"bib109","series-title":"Antioxidants","first-page":"154","article-title":"GlyNAC (glycine and N-acetylcysteine) supplementation improves impaired mitochondrial fuel oxidation and lowers insulin resistance in patients with type 2 diabetes: results of a pilot study","volume":"11","author":"Sekhar RV","year":"2022","unstructured":"Sekhar RV\n\n 2022 GlyNAC (glycine and N-acetylcysteine) supplementation improves impaired mitochondrial fuel oxidation and lowers insulin resistance in patients with type 2 diabetes: results of a pilot study. Antioxidants 11 154. (https:\/\/doi.org\/10.3390\/antiox11010154)"},{"key":"bib110","series-title":"Med Res Rev","first-page":"235","article-title":"The entrancing role of dietary polyphenols against the most frequent aging-associated diseases","volume":"44","author":"Shah MA","year":"2024","unstructured":"Shah MA\n, \nFaheem HI\n, \nHamid A\n, et al.\n 2024 The entrancing role of dietary polyphenols against the most frequent aging-associated diseases. Med Res Rev 44 235\u2013274. (https:\/\/doi.org\/10.1002\/med.21985)"},{"key":"bib111","series-title":"Aging","first-page":"11337","article-title":"Transient metabolic improvement in obese mice treated with navitoclax or dasatinib\/quercetin","volume":"12","author":"Sierra-Ramirez A","year":"2020","unstructured":"Sierra-Ramirez A\n, \nL\u00f3pez-Aceituno JL\n, \nCosta-Machado LF\n, et al.\n 2020 Transient metabolic improvement in obese mice treated with navitoclax or dasatinib\/quercetin. Aging 12 11337\u201311348. (https:\/\/doi.org\/10.18632\/aging.103607)"},{"key":"bib112","series-title":"Immun Ageing","first-page":"20","article-title":"NF-\u03baB, a culprit of both inflamm-ageing and declining immunity?","volume":"19","author":"Songkiatisak P","year":"2022","unstructured":"Songkiatisak P\n, \nRahman SMT\n, \nAqdas M\n, et al.\n 2022 NF-\u03baB, a culprit of both inflamm-ageing and declining immunity? Immun Ageing 19 20. (https:\/\/doi.org\/10.1186\/s12979-022-00277-w)"},{"key":"bib113","series-title":"J Biochem","first-page":"177","article-title":"Targeting senescent cells for the treatment of age-associated diseases","volume":"177","author":"Suda M","year":"2025","unstructured":"Suda M\n, \nTchkonia T\n, \nKirkland JL\n, et al.\n 2025 Targeting senescent cells for the treatment of age-associated diseases. J Biochem 177 177\u2013187. (https:\/\/doi.org\/10.1093\/jb\/mvae091)"},{"key":"bib114","series-title":"Biochim Biophys Acta Mol Basis Dis","article-title":"Apigenin enhancing oxidative resistance and proteostasis to extend lifespan via PTEN-mediated AKT signalling pathway","volume":"1871","author":"Sun Z","year":"2025","unstructured":"Sun Z\n, \nLi L\n & \nZhang L\n\n 2025 Apigenin enhancing oxidative resistance and proteostasis to extend lifespan via PTEN-mediated AKT signalling pathway. Biochim Biophys Acta Mol Basis Dis 1871 167670. (https:\/\/doi.org\/10.1016\/j.bbadis.2025.167670)"},{"key":"bib115","series-title":"Nat Cell Biol","first-page":"1291","article-title":"Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence","volume":"8","author":"Takahashi A","year":"2006","unstructured":"Takahashi A\n, \nOhtani N\n, \nYamakoshi K\n, et al.\n 2006 Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 8 1291\u20131297. (https:\/\/doi.org\/10.1038\/ncb1491)"},{"key":"bib116","series-title":"Cell Div","first-page":"10","article-title":"Irreversibility of cellular senescence: dual roles of p16INK4a\/Rb-pathway in cell cycle control","volume":"2","author":"Takahashi A","year":"2007","unstructured":"Takahashi A\n, \nOhtani N\n & \nHara E\n\n 2007 Irreversibility of cellular senescence: dual roles of p16INK4a\/Rb-pathway in cell cycle control. Cell Div 2 10. (https:\/\/doi.org\/10.1186\/1747-1028-2-10)"},{"key":"bib117","series-title":"J Clin Endocrinol Metab","first-page":"2771","article-title":"\u03b2-cell telomere attrition in diabetes: inverse correlation between HbA1c and telomere length","volume":"99","author":"Tamura Y","year":"2014","unstructured":"Tamura Y\n, \nIzumiyama-Shimomura N\n, \nKimbara Y\n, et al.\n 2014 \u03b2-cell telomere attrition in diabetes: inverse correlation between HbA1c and telomere length. J Clin Endocrinol Metab 99 2771\u20132777. (https:\/\/doi.org\/10.1210\/jc.2014-1222)"},{"key":"bib118","series-title":"Sci Rep","article-title":"Increased double strand breaks in diabetic \u03b2-cells with a p21 response that limits apoptosis","volume":"9","author":"Tay VSY","year":"2019","unstructured":"Tay VSY\n, \nDevaraj S\n, \nKoh T\n, et al.\n 2019 Increased double strand breaks in diabetic \u03b2-cells with a p21 response that limits apoptosis. Sci Rep 9 19341. (https:\/\/doi.org\/10.1038\/s41598-019-54554-8)"},{"key":"bib119","series-title":"Clin Sci","first-page":"309","article-title":"Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury","volume":"138","author":"Tesch GH","year":"2024","unstructured":"Tesch GH\n, \nMa FY\n, \nOzols E\n, et al.\n 2024 Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury. Clin Sci 138 309\u2013326. (https:\/\/doi.org\/10.1042\/CS20231698)"},{"key":"bib120","series-title":"Cell Metab","first-page":"1045","article-title":"Targeted elimination of senescent beta cells prevents type 1 diabetes","volume":"29","author":"Thompson PJ","year":"2019","unstructured":"Thompson PJ\n, \nShah A\n, \nNtranos V\n, et al.\n 2019 Targeted elimination of senescent beta cells prevents type 1 diabetes. Cell Metab 29 1045\u20131060.e10. (https:\/\/doi.org\/10.1016\/j.cmet.2019.01.021)"},{"key":"bib121","series-title":"J Clin Investig","first-page":"2601","article-title":"NF-\u03baB inhibition delays DNA damage-induced senescence and aging in mice","volume":"122","author":"Tilstra JS","year":"2012","unstructured":"Tilstra JS\n, \nRobinson AR\n, \nWang J\n, et al.\n 2012 NF-\u03baB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Investig 122 2601\u20132612. (https:\/\/doi.org\/10.1172\/JCI45785)"},{"key":"bib122","series-title":"Curr Mol Med","first-page":"506","article-title":"Legacy effect of antioxidant N-acetylcysteine in cellular senescence of diet-induced obesity mice","volume":"21","author":"Tsao C-F","year":"2021","unstructured":"Tsao C-F\n, \nChang Y-H\n, \nShen F-C\n, et al.\n 2021 Legacy effect of antioxidant N-acetylcysteine in cellular senescence of diet-induced obesity mice. Curr Mol Med 21 506\u2013525. (https:\/\/doi.org\/10.2174\/1566524020999201113101738)"},{"key":"bib123","series-title":"Cells","first-page":"1312","article-title":"Advanced glycation end-products (AGEs): formation, chemistry, classification, receptors, and diseases related to AGEs","volume":"11","author":"Twarda-Clapa A","year":"2022","unstructured":"Twarda-Clapa A\n, \nOlczak A\n, \nBia\u0142kowska AM\n, et al.\n 2022 Advanced glycation end-products (AGEs): formation, chemistry, classification, receptors, and diseases related to AGEs. Cells 11 1312. (https:\/\/doi.org\/10.3390\/cells11081312)"},{"key":"bib124","series-title":"Oncogene","first-page":"5683","article-title":"Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage","volume":"25","author":"Vakifahmetoglu H","year":"2006","unstructured":"Vakifahmetoglu H\n, \nOlsson M\n, \nOrrenius S\n, et al.\n 2006 Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene 25 5683\u20135692. (https:\/\/doi.org\/10.1038\/sj.onc.1209569)"},{"key":"bib125","series-title":"Nutr Metabol Cardiovasc Dis","first-page":"1236","article-title":"Advanced glycation end products, leukocyte telomere length, and mitochondrial DNA copy number in patients with coronary artery disease and alterations of glucose homeostasis: from the GENOCOR study","volume":"32","author":"Vecoli C","year":"2022","unstructured":"Vecoli C\n, \nBasta G\n, \nBorghini A\n, et al.\n 2022 Advanced glycation end products, leukocyte telomere length, and mitochondrial DNA copy number in patients with coronary artery disease and alterations of glucose homeostasis: from the GENOCOR study. Nutr Metabol Cardiovasc Dis 32 1236\u20131244. (https:\/\/doi.org\/10.1016\/j.numecd.2022.01.021)"},{"key":"bib126","series-title":"Biochim Biophys Acta","first-page":"29","article-title":"Genetic analysis of cellular senescence","volume":"1242","author":"Vojta PJ","year":"1995","unstructured":"Vojta PJ\n & \nBarrett JC\n\n 1995 Genetic analysis of cellular senescence. Biochim Biophys Acta 1242 29\u201341. (https:\/\/doi.org\/10.1016\/0304-419x(95)00002-w)"},{"key":"bib127","series-title":"J Endocrinol","article-title":"Immunology of chronic low-grade inflammation: relationship with metabolic function","volume":"257","author":"van de Vyver M","year":"2023","unstructured":"van de Vyver M\n\n 2023 Immunology of chronic low-grade inflammation: relationship with metabolic function. J Endocrinol 257 e220271. (https:\/\/doi.org\/10.1530\/JOE-22-0271)"},{"key":"bib128","series-title":"Cell Metab","first-page":"75","article-title":"Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity","volume":"34","author":"Wang L","year":"2022","unstructured":"Wang L\n, \nWang B\n, \nGasek NS\n, et al.\n 2022 Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab 34 75\u201389.e8. (https:\/\/doi.org\/10.1016\/j.cmet.2021.11.002)"},{"key":"bib129","series-title":"Nat Med","first-page":"1246","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu M","year":"2018","unstructured":"Xu M\n, \nPirtskhalava T\n, \nFarr JN\n, et al.\n 2018 Senolytics improve physical function and increase lifespan in old age. Nat Med 24 1246\u20131256. (https:\/\/doi.org\/10.1038\/s41591-018-0092-9)"},{"key":"bib130","series-title":"Science","first-page":"1129","article-title":"Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked","volume":"275","author":"Yang J","year":"1997","unstructured":"Yang J\n, \nLiu X\n, \nBhalla K\n, et al.\n 1997 Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275 1129\u20131132. (https:\/\/doi.org\/10.1126\/science.275.5303.1129)"},{"key":"bib131","series-title":"Aging","first-page":"10370","article-title":"Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells","volume":"12","author":"Yang J-L","year":"2020","unstructured":"Yang J-L\n, \nSun M-Y\n, \nYuan Q\n, et al.\n 2020 Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells. Aging 12 10370\u201310380. (https:\/\/doi.org\/10.18632\/aging.103263)"},{"key":"bib132","series-title":"Nat Commun","article-title":"Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL","volume":"7","author":"Yosef R","year":"2016","unstructured":"Yosef R\n, \nPilpel N\n, \nTokarsky-Amiel R\n, et al.\n 2016 Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nat Commun 7 11190. (https:\/\/doi.org\/10.1038\/ncomms11190)"},{"key":"bib133","series-title":"Stem Cell Res Ther","first-page":"182","article-title":"Curcumin induces therapeutic angiogenesis in a diabetic mouse hindlimb ischemia model via modulating the function of endothelial progenitor cells","volume":"8","author":"You J","year":"2017","unstructured":"You J\n, \nSun J\n, \nMa T\n, et al.\n 2017 Curcumin induces therapeutic angiogenesis in a diabetic mouse hindlimb ischemia model via modulating the function of endothelial progenitor cells. Stem Cell Res Ther 8 182. (https:\/\/doi.org\/10.1186\/s13287-017-0636-9)"},{"key":"bib134","series-title":"Eur J Pharmacol","article-title":"Alleviative effects of the parthenolide derivative ACT001 on insulin resistance induced by sodium propionate combined with a high-fat diet and its potential mechanisms","volume":"971","author":"Yu Q","year":"2024","unstructured":"Yu Q\n, \nZuo X\n, \nBai H\n, et al.\n 2024 Alleviative effects of the parthenolide derivative ACT001 on insulin resistance induced by sodium propionate combined with a high-fat diet and its potential mechanisms. Eur J Pharmacol 971 176529. (https:\/\/doi.org\/10.1016\/j.ejphar.2024.176529)"},{"key":"bib135","series-title":"J Diabetes Complicat","first-page":"363","article-title":"Insulin treatment affects leukocyte telomere length in patients with type 2 diabetes: 6-year longitudinal study","volume":"33","author":"Zeng J","year":"2019","unstructured":"Zeng J\n, \nLiu H\n, \nPing F\n, et al.\n 2019 Insulin treatment affects leukocyte telomere length in patients with type 2 diabetes: 6-year longitudinal study. J Diabetes Complicat 33 363\u2013367. (https:\/\/doi.org\/10.1016\/j.jdiacomp.2019.02.003)"},{"key":"bib136","series-title":"Am J Physiol Cell Physiol","first-page":"C1786","article-title":"Hsp90 regulates O-linked \u03b2-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked \u03b2-N-acetylglucosamine modification in endothelial cells","volume":"302","author":"Zhang F","year":"2012","unstructured":"Zhang F\n, \nSnead CM\n & \nCatravas JD\n\n 2012 Hsp90 regulates O-linked \u03b2-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked \u03b2-N-acetylglucosamine modification in endothelial cells. Am J Physiol Cell Physiol 302 C1786\u2013C1796. (https:\/\/doi.org\/10.1152\/ajpcell.00004.2012)"},{"key":"bib137","series-title":"J Nutr Health Aging","first-page":"835","article-title":"A study on neuroprotective effects of curcumin on the diabetic rat brain","volume":"20","author":"Zhang L","year":"2016","unstructured":"Zhang L\n, \nKong X-J\n, \nWang Z-Q\n, et al.\n 2016 A study on neuroprotective effects of curcumin on the diabetic rat brain. J Nutr Health Aging 20 835\u2013840. (https:\/\/doi.org\/10.1007\/s12603-016-0723-0)"},{"key":"bib138","series-title":"Biochem Biophys Res Commun","article-title":"Targeting senescent HDF with the USP7 inhibitor P5091 to enhance DFU wound healing through the p53 pathway","volume":"722","author":"Zhang S","year":"2024","unstructured":"Zhang S\n, \nMeng N\n, \nLiu S\n, et al.\n 2024 Targeting senescent HDF with the USP7 inhibitor P5091 to enhance DFU wound healing through the p53 pathway. Biochem Biophys Res Commun 722 150149. (https:\/\/doi.org\/10.1016\/j.bbrc.2024.150149)"},{"key":"bib139","series-title":"PLoS Biol","article-title":"Development of novel NEMO-binding domain mimetics for inhibiting IKK\/NF-\u03baB activation","volume":"16","author":"Zhao J","year":"2018","unstructured":"Zhao J\n, \nZhang L\n, \nMu X\n, et al.\n 2018 Development of novel NEMO-binding domain mimetics for inhibiting IKK\/NF-\u03baB activation. PLoS Biol 16 e2004663. (https:\/\/doi.org\/10.1371\/journal.pbio.2004663)"},{"key":"bib140","series-title":"Aging Cell","first-page":"644","article-title":"The Achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu Y","year":"2015","unstructured":"Zhu Y\n, \nTchkonia T\n, \nPirtskhalava T\n, et al.\n 2015 The Achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14 644\u2013658. (https:\/\/doi.org\/10.1111\/acel.12344)"},{"key":"bib141","series-title":"Aging Cell","first-page":"428","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu Y","year":"2016","unstructured":"Zhu Y\n, \nTchkonia T\n, \nFuhrmann-Stroissnigg H\n, et al.\n 2016 Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell 15 428\u2013435. (https:\/\/doi.org\/10.1111\/acel.12445)"},{"key":"bib142","series-title":"Aging","first-page":"955","article-title":"New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463","volume":"9","author":"Zhu Y","year":"2017","unstructured":"Zhu Y\n, \nDoornebal EJ\n, \nPirtskhalava T\n, et al.\n 2017 New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging 9 955\u2013963. (https:\/\/doi.org\/10.18632\/aging.101202)"},{"key":"bib143","series-title":"Int J Mol Med","first-page":"26","article-title":"Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the Notch pathway","volume":"53","author":"Zhu X","year":"2024","unstructured":"Zhu X\n, \nZhang C\n, \nLiu L\n, et al.\n 2024 Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the Notch pathway. Int J Mol Med 53 26. (https:\/\/doi.org\/10.3892\/ijmm.2024.5350)"},{"key":"bib144","series-title":"Lancet Diabetes Endocrinol","first-page":"98","article-title":"Daily low-dose aspirin and incident type 2 diabetes in community-dwelling healthy older adults: a post-hoc analysis of efficacy and safety in the ASPREE randomised placebo-controlled trial","volume":"12","author":"Zoungas S","year":"2024","unstructured":"Zoungas S\n, \nZhou Z\n, \nOwen AJ\n, et al.\n 2024 Daily low-dose aspirin and incident type 2 diabetes in community-dwelling healthy older adults: a post-hoc analysis of efficacy and safety in the ASPREE randomised placebo-controlled trial. Lancet Diabetes Endocrinol 12 98\u2013106. 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