{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:46Z","timestamp":1784557066560,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>\n                    Pituitary inhibin B, activin B, and follistatin are local regulators of FSH. Activin B is a homodimeric molecule (\u03b2\n                    <jats:sub>B<\/jats:sub>\n                    \u2013\u03b2\n                    <jats:sub>B<\/jats:sub>\n                    ), while inhibin B contains an \u03b1 and a \u03b2\n                    <jats:sub>B<\/jats:sub>\n                    subunit. The regulation of gene expression of \u03b1, \u03b2\n                    <jats:sub>B<\/jats:sub>\n                    , and follistatin by local and endocrine hormones was examined in pituitaries from female rats and in perifused pituitary cells by RT-PCR. Ovariectomy (OVX) induced an elevation in the mRNA level of \u03b1 and \u03b2\n                    <jats:sub>B<\/jats:sub>\n                    subunits and follistatin. Short-term (4\u200ah) treatment of pituitary cells with GnRH decreased both the inhibin \u03b1 and the inhibin\/activin \u03b2\n                    <jats:sub>B<\/jats:sub>\n                    subunit mRNA levels, while long-term treatment (20\u200ah) with 100\u200anM GnRH stimulated the expression of both subunits. In contrast, the mRNA level of follistatin was elevated after the short-term GnRH treatment. Long-term exposure of pituitary cells to estradiol and inhibin B suppressed the mRNA expression of \u03b2\n                    <jats:sub>B<\/jats:sub>\n                    and had no effect on the expression of \u03b1 subunit and follistatin. Our results demonstrate that the increased expressions of inhibin\/activin subunits and follistatin in the post-OVX period can be induced by the lack of gonadal negative feedback, resulting in a high GnRH environment in the pituitary. This study reports for the first time that GnRH administered in high doses and for a long period stimulates the gene expression of inhibin\/activin subunits and thereby may contribute to the stimulatory effect of OVX on the expression of these genes.\n                  <\/jats:p>","DOI":"10.1530\/joe-10-0485","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T21:10:39Z","timestamp":1302729039000},"page":"71-79","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of pituitary inhibin\/activin subunits and follistatin gene expression by GnRH in female rats"],"prefix":"10.1530","volume":"210","author":[{"given":"Petra","family":"Popovics","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Rekasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdolna","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/210\/1\/71.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/210\/1\/71.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:52:15Z","timestamp":1784555535000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/210\/1\/71-79\/22085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,13]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/joe-10-0485","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,13]]}}}