{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:48:32Z","timestamp":1790866112478,"version":"4.1.0"},"reference-count":48,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    The human ovarian surface epithelium (hOSE) is a mesothelial layer that surrounds the ovary and undergoes injury and repair cycles after ovulation-associated inflammation. We previously showed that IL4 is a key regulator of progesterone bioavailability during post-ovulatory hOSE repair as it differentially up-regulated\n                    <jats:italic>3<\/jats:italic>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:italic>-HSD1<\/jats:italic>\n                    and\n                    <jats:italic>3<\/jats:italic>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:italic>-HSD2<\/jats:italic>\n                    mRNA transcripts and total 3\u03b2-hydroxysteroid dehydrogenase activity whereas it inhibited androgen receptor (AR) expression. We now show that the pro-inflammatory effect of IL1\u03b1 on\n                    <jats:italic>3<\/jats:italic>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:italic>-HSD1<\/jats:italic>\n                    expression is mediated by nuclear factor-\u03baB (NF-\u03baB), whereas its anti-inflammatory action on\n                    <jats:italic>3<\/jats:italic>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:italic>-HSD2<\/jats:italic>\n                    expression is exerted via p38 mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K) and NF-\u03baB signalling pathways. The anti-inflammatory IL4 effects on\n                    <jats:italic>3<\/jats:italic>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:italic>-HSD1<\/jats:italic>\n                    and\n                    <jats:italic>3<\/jats:italic>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:italic>-HSD2<\/jats:italic>\n                    mRNA expression are mediated through STAT6 and PI3K signalling networks. IL4 effects on\n                    <jats:italic>AR<\/jats:italic>\n                    and\n                    <jats:italic>3<\/jats:italic>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    <jats:italic>-HSD2<\/jats:italic>\n                    expression involve the p38 MAPK pathway. We also document that IL4 up-regulates lysyl oxidase (\n                    <jats:italic>LOX<\/jats:italic>\n                    ) mRNA transcripts, a key gene for extracellular matrix (ECM) deposition and inhibits IL1\u03b1-induced expression of cyclooxygenase-2 (\n                    <jats:italic>COX-2<\/jats:italic>\n                    ) mRNA, a gene involved in breakdown of ECM, showing a further role in post-ovulatory wound healing. We conclude that IL1\u03b1 and IL4 actions in the post-ovulatory wound healing of hOSE cells are mediated by different signalling transduction pathways. The p38 MAPK signalling pathway may have possible therapeutic benefit in inflammation-associated disorders of the ovary, including cancer.\n                  <\/jats:p>","DOI":"10.1530\/joe-11-0081","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T09:49:26Z","timestamp":1315561766000},"page":"273-283","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":22,"title":["IL1\u03b1 and IL4 signalling in human ovarian surface epithelial cells"],"prefix":"10.1530","volume":"211","author":[{"given":"Georgia","family":"Papacleovoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary O D","family":"Critchley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G","family":"Hillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J 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