{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:47:09Z","timestamp":1791172029738,"version":"4.1.0"},"reference-count":72,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>\n                    Estrogens are thought to promote labor by increasing the expression of pro-contraction genes in myometrial cells. The specific estrogen receptors ((ERs: ER\u03b1 and ER\u03b2 (also known as ESR1 and ESR2)) and G protein-coupled receptor 30 (GPR30; also known as G protein-coupled estrogen receptor 1)) and signaling pathways that mediate these actions are not clearly understood. In this study, we identified the ERs expressed in the pregnant human myometrium and determined a key extranuclear signaling pathway through which estradiol (E\n                    <jats:sub>2<\/jats:sub>\n                    ) modulates expression of the gene encoding the oxytocin receptor (OXTR), a major pro-contraction protein. Using quantitative RT-PCR, we found that\n                    <jats:italic>ER<\/jats:italic>\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and\n                    <jats:italic>GPR30<\/jats:italic>\n                    mRNAs were expressed in the human pregnant myometrium while\n                    <jats:italic>ER<\/jats:italic>\n                    <jats:italic>\u03b2<\/jats:italic>\n                    mRNA was virtually undetectable. While mRNA encoding ER\u03b1 was the predominant ER transcript in the pregnant myometrium, ER\u03b1 protein was largely undetectable in myometrial tissue by immunoblotting. Pharmacological inhibition of 26S proteasome activity increased ER\u03b1 protein abundance to detectable levels in term myometrial explants, however, indicating rapid turnover of ER\u03b1 protein by proteasomal processing in the pregnant myometrium. E\n                    <jats:sub>2<\/jats:sub>\n                    stimulated rapid extranuclear signaling in myometrial explants, as evidenced by increased extracellularly regulated kinase (ERK1\/2) phosphorylation within 10\u200amin. This effect was inhibited by pre-treatment with an ER antagonist, ICI 182\u200a780, indicating the involvement of ER\u03b1. Inhibition of ERK signaling abrogated the ability of E\n                    <jats:sub>2<\/jats:sub>\n                    to stimulate\n                    <jats:italic>OXTR<\/jats:italic>\n                    gene expression in myometrial explants. We conclude that estrogenic actions in the human myometrium during pregnancy, including the stimulation of contraction-associated gene expression, can be mediated by extranuclear signaling through ER\u03b1 via activation of the ERK\/mitogen-activated protein kinase pathway.\n                  <\/jats:p>","DOI":"10.1530\/joe-11-0358","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T02:45:01Z","timestamp":1320806701000},"page":"227-238","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":55,"title":["Estrogen receptor (ER) expression and function in the pregnant human myometrium: estradiol via ER\u03b1 activates ERK1\/2 signaling in term myometrium"],"prefix":"10.1530","volume":"212","author":[{"given":"Toni","family":"Welsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matrika","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roksana","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Merlino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Zakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Mesiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"7","key":"1_18224647","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1210\/en.2003-1676","volume":"145","year":"2004","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"5","key":"2_18361326","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1210\/me.2003-0335","volume":"18","year":"2004","journal-title":"Molecular 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