{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:06:33Z","timestamp":1790661993434,"version":"4.1.0"},"reference-count":120,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    Euthyroid status is essential for normal skeletal development and the maintenance of adult bone structure and strength. Established thyrotoxicosis has long been recognised as a cause of high bone turnover osteoporosis and fracture but more recent studies have suggested that subclinical hyperthyroidism and long-term suppressive doses of thyroxine (T\n                    <jats:sub>4<\/jats:sub>\n                    ) may also result in decreased bone mineral density (BMD) and an increased risk of fragility fracture, particularly in postmenopausal women. Furthermore, large population studies of euthyroid individuals have demonstrated that a hypothalamic\u2013pituitary\u2013thyroid axis set point at the upper end of the normal reference range is associated with reduced BMD and increased fracture susceptibility. Despite these findings, the cellular and molecular mechanisms of thyroid hormone action in bone remain controversial and incompletely understood. In this review, we discuss the role of thyroid hormones in bone and the skeletal consequences of hyperthyroidism.\n                  <\/jats:p>","DOI":"10.1530\/joe-12-0059","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T23:19:14Z","timestamp":1332890354000},"page":"209-221","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":102,"title":["The skeletal consequences of thyrotoxicosis"],"prefix":"10.1530","volume":"213","author":[{"given":"Jonathan J","family":"Nicholls","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jane","family":"Brassill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham R","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H Duncan","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"2","key":"1_17865467","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0092-8674(03)00771-2","volume":"115","author":"Abe","year":"2003","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"8","key":"2_11115140","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1172\/JCI10858","volume":"107","author":"Abel","year":"2001","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"1","key":"3_19150810","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00198-005-1892-6","volume":"17","author":"Ahmed","year":"2006","journal-title":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","ISSN":"https:\/\/id.crossref.org\/issn\/0937-941X","issn-type":"print"},{"key":"4_42617582","first-page":"121","volume":"12","year":"2006","journal-title":"ENDOCRINE PRACTICE"},{"issue":"3","key":"5_9877330","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1677\/joe.0.1330327","volume":"133","author":"Allain","year":"1992","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"12","key":"6_19675761","doi-asserted-by":"publisher","first-page":"5568","DOI":"10.1210\/en.2005-0762","volume":"146","year":"2005","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"key":"7_34082335","first-page":"418","volume":"43","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1873-2763","issn-type":"print"},{"issue":"4","key":"8_33079898","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1677\/JME-08-0142","volume":"42","year":"2009","journal-title":"Journal of Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0952-5041","issn-type":"print"},{"issue":"1","key":"9_21065457","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/en.2005-0485","volume":"147","year":"2006","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"8","key":"10_28537158","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1210\/me.2007-0157","volume":"21","year":"2007","journal-title":"Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0888-8809","issn-type":"print"},{"issue":"5","key":"11_23695596","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1210\/me.2007-0033","volume":"21","year":"2007","journal-title":"Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0888-8809","issn-type":"print"},{"issue":"2","key":"12_29608070","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1210\/me.2007-0221","volume":"22","year":"2008","journal-title":"Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0888-8809","issn-type":"print"},{"issue":"16","key":"13_36961224","doi-asserted-by":"publisher","first-page":"7604","DOI":"10.1073\/pnas.0911346107","volume":"107","year":"2010","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"9","key":"14_5723938","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1210\/jc.82.9.2931","volume":"82","author":"Bauer","year":"1997","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"7","key":"15_17435095","doi-asserted-by":"crossref","first-page":"561","DOI":"10.7326\/0003-4819-134-7-200104030-00009","volume":"134","author":"Bauer","year":"2001","journal-title":"Annals of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"key":"16_42617583","first-page":"62","volume":"6","year":"2007","journal-title":"Hormones","ISSN":"https:\/\/id.crossref.org\/issn\/0018-5051","issn-type":"print"},{"issue":"10","key":"17_22634538","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1172\/JCI29812","volume":"116","author":"Bianco","year":"2006","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"5","key":"18_16304735","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/BF01955262","volume":"155","author":"Boersma","year":"1996","journal-title":"European journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6199","issn-type":"print"},{"issue":"4","key":"19_22531931","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.cell.2006.06.049","volume":"126","author":"Bookout","year":"2006","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"1","key":"20_14664533","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1210\/en.134.1.169","volume":"134","author":"Britto","year":"1994","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"3","key":"21_28721135","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/BF03347430","volume":"30","author":"Buscemi","year":"2007","journal-title":"Journal of endocrinological investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0391-4097","issn-type":"print"},{"issue":"2","key":"22_16316404","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1089\/thy.1996.6.75","volume":"6","author":"Campbell","year":"1996","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"2","key":"23_36290452","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1210\/er.2009-0007","volume":"31","year":"2010","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"12","key":"24_15774037","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1056\/NEJM199503233321202","volume":"332","author":"Cummings","year":"1995","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"2","key":"25_17150446","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1172\/JCI200216234","volume":"110","author":"Davies","year":"2002","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"6","key":"26_10159621","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000182315","volume":"37","author":"De Menis","year":"1992","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"7","key":"27_18961614","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/ncb1272","volume":"7","author":"Dentice","year":"2005","journal-title":"Nature Cell Biology","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4679","issn-type":"print"},{"issue":"2","key":"28_30302136","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2265.2007.03016.x","volume":"68","author":"van der Deure","year":"2008","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"1","key":"29_35078225","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1677\/JME-09-0042","volume":"44","year":"2010","journal-title":"Journal of Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0952-5041","issn-type":"print"},{"key":"30_35180055","first-page":"101","volume":"7","year":"1986","ISSN":"https:\/\/id.crossref.org\/issn\/1873-2763","issn-type":"print"},{"issue":"4","key":"31_15469120","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1530\/eje.0.1300350","volume":"130","author":"Faber","year":"1994","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"key":"32_39931970","first-page":"27","volume":"6","year":"1994","journal-title":"Thyroidology \/ A.P.R.I.M"},{"issue":"3","key":"33_5993240","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1046\/j.1365-2265.1998.00427.x","volume":"48","author":"Faber","year":"1998","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"1","key":"34_30201175","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1359\/jbmr.070814","volume":"23","author":"Finigan","year":"2008","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"5","key":"35_14530855","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2265.1993.tb02403.x","volume":"39","author":"F\u00a0\u00a0ldes","year":"1993","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"5","key":"36_23307876","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/j.1460-2075.1990.tb08270.x","volume":"9","author":"Forrest","year":"1990","journal-title":"The EMBO Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0261-4189","issn-type":"print"},{"issue":"8810","key":"37_9869954","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0140-6736(92)92423-D","volume":"340","author":"Franklyn","year":"1992","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"11","key":"38_5904156","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1056\/NEJM199803123381103","volume":"338","author":"Franklyn","year":"1998","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"4","key":"39_15465128","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1210\/jc.78.4.955","volume":"78","author":"Garnero","year":"1994","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"14","key":"40_11202097","doi-asserted-by":"publisher","first-page":"4748","DOI":"10.1128\/MCB.21.14.4748-4760.2001","volume":"21","author":"Gauthier","year":"2001","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"7","key":"41_39932117","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1210\/er.2008-0019","volume":"29","year":"2008","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"key":"42_42617584","doi-asserted-by":"crossref","first-page":"304","DOI":"10.14310\/horm.2002.1111026","volume":"6","year":"2007","journal-title":"Hormones","ISSN":"https:\/\/id.crossref.org\/issn\/0018-5051","issn-type":"print"},{"issue":"11","key":"43_32277052","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1089\/thy.2008.0158","volume":"18","author":"Grimnes","year":"2008","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"3","key":"44_16786121","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1046\/j.1365-2265.1997.1280950.x","volume":"46","author":"Guo","year":"1997","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"6","key":"45_10889905","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1089\/thy.1999.9.539","volume":"9","author":"G\u00a0\u00a0rlek","year":"1999","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"3","key":"46_18072106","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1210\/jc.2003-031641","volume":"89","author":"Hansen","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"47_17183769","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1089\/105072502760143791","volume":"12","author":"Harvey","year":"2002","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"6","key":"48_9448853","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1210\/jcem-72-6-1189","volume":"72","author":"HARVEY","year":"1991","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"34","key":"49_22484073","doi-asserted-by":"publisher","first-page":"12849","DOI":"10.1073\/pnas.0600427103","volume":"103","year":"2006","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"6","key":"50_22387241","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1089\/thy.2006.16.583","volume":"16","author":"Heemstra","year":"2006","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"1","key":"51_16955726","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/jcb.10109","volume":"85","author":"Heino","year":"2002","journal-title":"Journal of cellular biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0730-2312","issn-type":"print"},{"issue":"7","key":"52_17129280","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1359\/jbmr.2002.17.7.1297","volume":"17","author":"Himeno","year":"2002","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"2","key":"53_6495879","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1359\/jbmr.2000.15.2.188","volume":"15","author":"Huang","year":"2000","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"key":"54_42617585","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ejmg.2007.02.002","volume":"50","year":"2007","journal-title":"EUROPEAN JOURNAL OF MEDICAL GENETICS"},{"issue":"9","key":"55_6149662","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1359\/jbmr.1998.13.9.1398","volume":"13","author":"Ishikawa","year":"1998","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"5","key":"56_18922959","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/s00198-004-1718-y","volume":"16","author":"Jamal","year":"2005","journal-title":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","ISSN":"https:\/\/id.crossref.org\/issn\/0937-941X","issn-type":"print"},{"issue":"4","key":"57_6312796","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s001980050069","volume":"8","author":"J\u00a0\u00a0dar","year":"1998","journal-title":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA","ISSN":"https:\/\/id.crossref.org\/issn\/0937-941X","issn-type":"print"},{"issue":"1","key":"58_18275010","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/jcp.20041","volume":"201","author":"Kanatani","year":"2004","journal-title":"Journal of cellular physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9541","issn-type":"print"},{"issue":"4","key":"59_18464996","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1365-2265.2004.02110.x","volume":"61","author":"Karga","year":"2004","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"1","key":"60_35150599","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00774-009-0098-y","volume":"28","author":"Karga","year":"2010","journal-title":"Journal of bone and mineral metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0914-8779","issn-type":"print"},{"issue":"1","key":"61_21386389","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1365-2265.2005.02422.x","volume":"64","author":"Kim","year":"2006","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"11","key":"62_10561952","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1210\/jc.85.11.4157","volume":"85","author":"Kumeda","year":"2000","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"63_16368927","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1210\/jc.81.3.1232","volume":"81","author":"Kung","year":"1996","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"64_33703457","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/jcp.21704","volume":"219","author":"Lassova","year":"2009","journal-title":"Journal of cellular physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9541","issn-type":"print"},{"issue":"4","key":"65_22009035","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.arcmed.2005.09.009","volume":"37","author":"Lee","year":"2006","journal-title":"Archives of medical research","ISSN":"https:\/\/id.crossref.org\/issn\/0188-0128","issn-type":"print"},{"issue":"21","key":"66_38563470","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1001\/archinternmed.2010.424","volume":"170","author":"Lee","year":"2010","journal-title":"Archives of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"issue":"6","key":"67_10135239","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1365-2265.1992.tb01480.x","volume":"37","author":"Leese","year":"1992","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"1","key":"68_39088317","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/07435800.2010.514877","volume":"36","author":"Lin","year":"2011","journal-title":"Endocrine research","ISSN":"https:\/\/id.crossref.org\/issn\/0743-5800","issn-type":"print"},{"issue":"8","key":"69_40330796","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1089\/thy.2010.0457","volume":"21","author":"Ma","year":"2011","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"6","key":"70_17626249","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1210\/en.2002-220746","volume":"144","author":"Makihira","year":"2003","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"4","key":"71_30822353","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/thy.2007.0166","volume":"18","author":"Martini","year":"2008","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"3","key":"72_18716099","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1359\/JBMR.041126","volume":"20","author":"Mazziotti","year":"2005","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"3","key":"73_35944045","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.bone.2009.10.031","volume":"46","author":"Mazziotti","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1873-2763","issn-type":"print"},{"issue":"5","key":"74_39358945","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1530\/EJE-10-1130","volume":"164","year":"2011","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"key":"75_42617586","first-page":"83","volume":"88","year":"1980","journal-title":"ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA SECTION A PATHOLOGY"},{"key":"76_39272061","first-page":"695","volume":"27","year":"2000","ISSN":"https:\/\/id.crossref.org\/issn\/1873-2763","issn-type":"print"},{"key":"77_34319314","first-page":"1128","volume":"40","year":"2007","ISSN":"https:\/\/id.crossref.org\/issn\/1873-2763","issn-type":"print"},{"issue":"1-2","key":"78_4624168","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.0954-6820.1978.tb08406.x","volume":"204","author":"Mosekilde","year":"1978","journal-title":"Acta medica Scandinavica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6101","issn-type":"print"},{"issue":"1","key":"79_5676858","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0889-8529(18)30338-4","volume":"19","author":"Mosekilde","year":"1990","journal-title":"Endocrinology and metabolism clinics of North America","ISSN":"https:\/\/id.crossref.org\/issn\/0889-8529","issn-type":"print"},{"issue":"4","key":"80_15655211","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2265.1994.tb02571.x","volume":"41","author":"Mudde","year":"1994","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"3","key":"81_4068227","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1172\/JCI108497","volume":"58","author":"Mundy","year":"1976","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"3","key":"82_18429692","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1365-2265.2004.02053.x","volume":"61","author":"Murphy","year":"2004","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"7","key":"83_37139375","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1210\/jc.2009-2630","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"10","key":"84_40753695","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/nm.2452","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nature medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"issue":"7","key":"85_17697626","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1210\/me.2002-0296","volume":"17","year":"2003","journal-title":"Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0888-8809","issn-type":"print"},{"issue":"12","key":"86_19706526","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1210\/me.2005-0224","volume":"19","year":"2005","journal-title":"Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0888-8809","issn-type":"print"},{"issue":"4","key":"87_30644187","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/j.1365-2265.2007.03079.x","volume":"68","author":"Panicker","year":"2008","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"9","key":"88_31432269","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1210\/jc.2007-2650","volume":"93","year":"2008","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"89_29092882","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1530\/EJE-07-0247","volume":"157","author":"Papadimitriou","year":"2007","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"368","key":"90_10285191","first-page":"107","volume":"43","author":"Parle","year":"1993","journal-title":"The British journal of general practice : the journal of the Royal College of General Practitioners","ISSN":"https:\/\/id.crossref.org\/issn\/0960-1643","issn-type":"print"},{"issue":"14","key":"91_11202098","doi-asserted-by":"publisher","first-page":"4761","DOI":"10.1128\/MCB.21.14.4761-4772.2001","volume":"21","author":"Plateroti","year":"2001","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"1","key":"92_11455174","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/jso.10043","volume":"79","author":"Quan","year":"2002","journal-title":"Journal of surgical oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-4790","issn-type":"print"},{"issue":"33","key":"93_37352368","doi-asserted-by":"publisher","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","volume":"285","year":"2010","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"10","key":"95_4860870","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1056\/NEJM198803103181003","volume":"318","author":"Rivkees","year":"1988","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"10","key":"96_10493789","doi-asserted-by":"publisher","first-page":"3887","DOI":"10.1210\/en.141.10.3887","volume":"141","author":"Robson","year":"2000","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"6","key":"97_39436519","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1530\/EJE-10-1113","volume":"164","year":"2011","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"9","key":"98_33953413","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1590\/S0004-27302008000900007","volume":"52","author":"Rosario","year":"2008","journal-title":"Arquivos brasileiros de endocrinologia e metabologia","ISSN":"https:\/\/id.crossref.org\/issn\/0004-2730","issn-type":"print"},{"issue":"6","key":"99_28719834","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1359\/jbmr.070302","volume":"22","author":"Sampath","year":"2007","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"9","key":"100_16456534","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jbmr.5650110920","volume":"11","author":"Seeley","year":"1996","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"9","key":"101_10998162","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/thy.1999.9.871","volume":"9","author":"Segni","year":"1999","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"3","key":"102_16713309","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1210\/jc.82.3.753","volume":"82","author":"Siddiqi","year":"1997","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"12","key":"103_10599232","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1359\/jbmr.2000.15.12.2431","volume":"15","author":"Stevens","year":"2000","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"9","key":"104_17783839","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1210\/me.2003-0137","volume":"17","year":"2003","journal-title":"Molecular Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0888-8809","issn-type":"print"},{"issue":"3","key":"105_33733685","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1210\/en.2008-1588","volume":"150","year":"2009","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"11","key":"106_30593833","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1073\/pnas.0712395105","volume":"105","year":"2008","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"107_35188945","first-page":"299","volume":"48","year":"2004","ISSN":"https:\/\/id.crossref.org\/issn\/1873-4111","issn-type":"print"},{"issue":"6","key":"108_6090131","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1530\/eje.0.1380667","volume":"138","author":"Toivonen","year":"1998","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"5","key":"109_18366832","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s00223-003-0108-3","volume":"74","author":"Tsai","year":"2004","journal-title":"Calcified Tissue International","ISSN":"https:\/\/id.crossref.org\/issn\/1432-0827","issn-type":"print"},{"issue":"11","key":"110_22913513","first-page":"947","volume":"47","author":"Udayakumar","year":"2006","journal-title":"Singapore medical journal","ISSN":"https:\/\/id.crossref.org\/issn\/0037-5675","issn-type":"print"},{"issue":"4","key":"111_17962020","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1081\/ERC-120026945","volume":"29","author":"Ugur-Altun","year":"2003","journal-title":"Endocrine research","ISSN":"https:\/\/id.crossref.org\/issn\/0743-5800","issn-type":"print"},{"issue":"12","key":"112_16549443","doi-asserted-by":"publisher","first-page":"4278","DOI":"10.1210\/jc.81.12.4278","volume":"81","author":"Uzzan","year":"1996","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"5","key":"113_39275124","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1210\/jc.2010-2693","volume":"96","year":"2011","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"5","key":"114_17130787","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1089\/105072502760043503","volume":"12","author":"Vestergaard","year":"2002","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"6","key":"115_17777905","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1089\/105072503322238854","volume":"13","author":"Vestergaard","year":"2003","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"3","key":"116_19527970","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00223-005-0068-x","volume":"77","author":"Vestergaard","year":"2005","journal-title":"Calcified Tissue International","ISSN":"https:\/\/id.crossref.org\/issn\/1432-0827","issn-type":"print"},{"issue":"5","key":"117_36745737","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1002\/jbmr.5","volume":"25","author":"Wang","year":"2010","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"3","key":"118_15804925","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2796.1995.tb01172.x","volume":"237","author":"Wejda","year":"1995","journal-title":"Journal of internal medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0954-6820","issn-type":"print"},{"issue":"3","key":"119_39136619","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1530\/JOE-10-0448","volume":"209","year":"2011","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"3","key":"121_11212745","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1152\/physrev.2001.81.3.1097","volume":"81","author":"Yen","year":"2001","journal-title":"Physiological Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0031-9333","issn-type":"print"},{"issue":"4","key":"122_32620039","first-page":"121","volume":"42","author":"Zofkova","year":"2008","journal-title":"Endocrine regulations","ISSN":"https:\/\/id.crossref.org\/issn\/1210-0668","issn-type":"print"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/213\/3\/209.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/213\/3\/209.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:52:48Z","timestamp":1784555568000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/213\/3\/209-221\/22217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,27]]},"references-count":120,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/joe-12-0059","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,27]]}}}