{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:14:59Z","timestamp":1791263699112,"version":"4.1.0"},"reference-count":23,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    The translocator protein (TSPO), formerly known as a peripheral benzodiazepine receptor, exerts pro-apoptotic function via regulation of mitochondrial membrane potential. We examined\n                    <jats:italic>TSPO<\/jats:italic>\n                    expression in human thyroid tumors (25 follicular adenomas (FA), 15 follicular cancers (FC), and 70 papillary cancers (PC)). The role of TSPO in the regulation of cell growth, migration, and apoptosis was examined in thyroid cancer cell lines after\n                    <jats:italic>TSPO<\/jats:italic>\n                    knockdown with siRNA and after treatment with TSPO antagonist (PK11195). Compared with normal thyroid, the level of\n                    <jats:italic>TSPO<\/jats:italic>\n                    expression was increased in FA, FC, and PC in 24, 26.6, and 55.7% of cases respectively. Thyroid cancer cell lines demonstrated variable levels of\n                    <jats:italic>TSPO<\/jats:italic>\n                    expression, without specific association with thyroid oncogene mutations. Treatment with inhibitors of PI3K\/AKT or MEK\/ERK signaling was not associated with changes in\n                    <jats:italic>TSPO<\/jats:italic>\n                    expression. Treatment with histone deacetylase inhibitor (valproic acid) increased\n                    <jats:italic>TSPO<\/jats:italic>\n                    expression in TSPO-deficient cell lines (FTC236 cells).\n                    <jats:italic>TSPO<\/jats:italic>\n                    gene silencing or treatment with PK11195 did not affect thyroid cancer cell growth and migration but prevented depolarization of mitochondrial membranes induced by oxidative stress. Induction of\n                    <jats:italic>TSPO<\/jats:italic>\n                    expression by valproic acid was associated with increased sensitivity of FTC236 to oxidative stress-inducible apoptosis. Overall, we showed that\n                    <jats:italic>TSPO<\/jats:italic>\n                    expression is frequently increased in PC.\n                    <jats:italic>In vitro<\/jats:italic>\n                    data suggested the role of epigenetic mechanism(s) in the regulation of TSPO in thyroid cells. Implication of TSPO in the thyroid cancer cell response to oxidative stress suggested its potential role in the regulation of thyroid cancer cell response to treatment with radioiodine and warrants further investigation.\n                  <\/jats:p>","DOI":"10.1530\/joe-12-0081","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T22:42:24Z","timestamp":1338331344000},"page":"207-216","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":23,"title":["The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress"],"prefix":"10.1530","volume":"214","author":[{"given":"Joanna","family":"Klubo-Gwiezdzinska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneeta","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D","family":"Burman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Wartofsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Hardwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasyl V","family":"Vasko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"1","key":"1_18923996","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbrc.2005.05.071","volume":"333","author":"Akech","year":"2005","journal-title":"Biochemical and biophysical research communications","ISSN":"https:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"issue":"23","key":"2_37310783","doi-asserted-by":"publisher","first-page":"4766","DOI":"10.1021\/bi100020e","volume":"49","author":"Batarseh","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"1","key":"3_40886773","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbagrm.2011.09.001","volume":"1819","author":"Batarseh","year":"2012","journal-title":"Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3002","issn-type":"print"},{"issue":"1","key":"4_18213069","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.bcp.2004.03.008","volume":"68","author":"Chelli","year":"2004","journal-title":"Biochemical pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-2952","issn-type":"print"},{"key":"5_43243576","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/157488408783329878","volume":"3","year":"2008","journal-title":"CURRENT CLINICAL PHARMACOLOGY"},{"issue":"19","key":"6_35666188","doi-asserted-by":"publisher","first-page":"6177","DOI":"10.1158\/1078-0432.CCR-09-0844","volume":"15","year":"2009","journal-title":"Clinical Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"issue":"4","key":"7_10732281","first-page":"831","volume":"59","author":"Hardwick","year":"1999","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"8_43243577","first-page":"435","volume":"30","year":"2008","journal-title":"CELLULAR ONCOLOGY"},{"issue":"8","key":"9_31136674","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1210\/jc.2008-0273","volume":"93","year":"2008","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"11","key":"10_11438590","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1054\/bjoc.2001.2181","volume":"85","author":"Maaser","year":"2001","journal-title":"British Journal of Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1532-1827","issn-type":"print"},{"issue":"5","key":"11_18725072","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1158\/1078-0432.CCR-04-1955","volume":"11","author":"Maaser","year":"2005","journal-title":"Clinical Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"issue":"42","key":"12_19570883","doi-asserted-by":"publisher","first-page":"43990","DOI":"10.1074\/jbc.M407503200","volume":"279","year":"2004","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"8","key":"13_22417331","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.tips.2006.06.005","volume":"27","author":"Papadopoulos","year":"2006","journal-title":"Trends in Pharmacological Sciences (Regular ed.)","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3735","issn-type":"print"},{"issue":"29","key":"14_35184344","doi-asserted-by":"publisher","first-page":"6909","DOI":"10.1021\/bi900854z","volume":"48","author":"Rone","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"3","key":"15_5797779","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/(SICI)1097-4547(19971101)50:3<413::AID-JNR7>3.0.CO;2-L","volume":"50","author":"Satoh","year":"1997","journal-title":"Journal of neuroscience research","ISSN":"https:\/\/id.crossref.org\/issn\/0360-4012","issn-type":"print"},{"issue":"12","key":"16_36298190","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1089\/thy.2009.1603","volume":"19","author":"Schlumberger","year":"2009","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"6","key":"17_21263885","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.surg.2005.09.019","volume":"138","author":"Shen","year":"2005","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"key":"18_43243578","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/FPC.0b013e3283117d52","volume":"18","year":"2008","journal-title":"PHARMACOGENETICS AND GENOMICS"},{"issue":"9","key":"19_18134919","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.bcp.2004.01.009","volume":"67","author":"Sutter","year":"2004","journal-title":"Biochemical pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-2952","issn-type":"print"},{"issue":"1","key":"20_29425960","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11060-007-9396-1","volume":"85","author":"Takaya","year":"2007","journal-title":"Journal of neuro-oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0167-594X","issn-type":"print"},{"issue":"3","key":"21_31639584","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10863-008-9142-1","volume":"40","author":"Veenman","year":"2008","journal-title":"Journal of bioenergetics and biomembranes","ISSN":"https:\/\/id.crossref.org\/issn\/0145-479X","issn-type":"print"},{"issue":"1","key":"22_22356306","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11060-006-9199-9","volume":"81","author":"Church","year":"2007","journal-title":"Journal of neuro-oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0167-594X","issn-type":"print"},{"issue":"21","key":"23_34571373","doi-asserted-by":"publisher","first-page":"4652","DOI":"10.1021\/bi900064t","volume":"48","author":"Zeno","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/214\/2\/207.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/214\/2\/207.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:52:49Z","timestamp":1784555569000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/214\/2\/207-216\/22236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,29]]},"references-count":23,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/joe-12-0081","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,29]]}}}