{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:15Z","timestamp":1790620995765,"version":"4.1.0"},"reference-count":46,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    We investigated the potential anorectic action of peripherally administered glucagon-like peptide 2 (GLP2) in lean and diet-induced obese (DIO) mice. Mice, fasted for 16\u200ah, were injected i.p. with native GLP2 or [Gly\n                    <jats:sup>2<\/jats:sup>\n                    ]GLP2, stable analog of GLP2, before or after GLP2 (3\u201333), a GLP2 receptor (GLP2R) antagonist, or exendin (9\u201339), a GLP1R antagonist. Food intake was measured at intervals 1, 2, 4, 8, and 24\u200ah postinjection. In addition, we tested in lean mice the influence of [Gly\n                    <jats:sup>2<\/jats:sup>\n                    ]GLP2 on gastric emptying and the effects of GLP1 alone or in combination with [Gly\n                    <jats:sup>2<\/jats:sup>\n                    ]GLP2 on food intake. [Gly\n                    <jats:sup>2<\/jats:sup>\n                    ]GLP2 dose dependently and significantly inhibited food intake in lean and DIO mice. The reduction of food intake occurred in the first hour postinjection and it was sustained until 4\u200ah postinjection in lean mice while it was sustained until 2\u200ah postinjection in DIO mice. GLP2 significantly inhibited food intake in both lean and DIO mice but only in the first hour postinjection. The efficiency of [Gly\n                    <jats:sup>2<\/jats:sup>\n                    ]GLP2 or GLP2 in suppressing food intake was significantly weaker in DIO mice compared with lean animals. The [Gly\n                    <jats:sup>2<\/jats:sup>\n                    ]GLP2 anorectic actions were blocked by the GLP2R antagonist GLP2 (3\u201333) or by the GLP1R antagonist exendin (9\u201339). The coadministration of [Gly\n                    <jats:sup>2<\/jats:sup>\n                    ]GLP2 and GLP1 did not cause additive effects. [Gly\n                    <jats:sup>2<\/jats:sup>\n                    ]GLP2 decreased the gastric emptying rate. Results suggest that GLP2 can reduce food intake in mice in the short term, likely acting at a peripheral level. DIO mice are less sensitive to the anorectic effect of the peptide.\n                  <\/jats:p>","DOI":"10.1530\/joe-12-0092","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T00:37:23Z","timestamp":1332981443000},"page":"277-284","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":36,"title":["Food intake in lean and obese mice after peripheral administration of glucagon-like peptide 2"],"prefix":"10.1530","volume":"213","author":[{"given":"Sara","family":"Baldassano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Lisa","family":"Bellanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Mul\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"3","key":"1_33025056","doi-asserted-by":"publisher","first-page":"G678","DOI":"10.1152\/ajpgi.90587.2008","volume":"296","year":"2009","journal-title":"American Journal of Physiology - 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