{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:33Z","timestamp":1784557113531,"version":"3.55.0"},"reference-count":45,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>We investigated the influence of sex hormones on the expression of \u03b1- and \u03b2-cardiac myosin heavy chain isoforms (\u03b1-MHC and \u03b2-MHC) in C57bl\/6 mice of both sexes under physiological and pathological conditions. In the left ventricles (LVs) of fertile female mice, \u03b2-MHC expression was tenfold higher compared with the age-matched males, whereas no difference was found in \u03b1-MHC expression. These differences disappeared after ovariectomy or in immature mice. We also found a sex-related difference in expression of \u03b2-adrenoceptors (\u03b21-AR), as mRNA levels of this gene were 40% lower in fertile females compared with males of the same age but did not differ in prepubertal or ovariectomized animals. Interestingly, the deletion of both \u03b21- and \u03b22-ARs abolished sex difference of \u03b2-MHC expression, as mRNA levels in the LVs of knockout males were increased and reached values comparable to those of knockout females. Moreover, the \u03b21-AR antagonist metoprolol induced about a threefold increase in \u03b2-MHC expression in adult male mice. The capability of gender to regulate \u03b2-MHC expression was also evaluated in the presence of hemodynamic overload. Thoracic aortic coarctation (TAC) produced cardiac hypertrophy along with a 12-fold increase in \u03b2-MHC and a 50% decrease in \u03b21-AR expression in males but not in females, thus abolishing the gender difference observed in sham animals for such genes. By contrast, TAC did not change \u03b22-AR expression. In conclusion, our results show that the expression of \u03b2-MHC and \u03b21-AR in the LVs undergo gender-related and correlated changes under both physiological and pathological conditions and suggest a role of \u03b21-AR-mediated signaling.<\/jats:p>","DOI":"10.1530\/joe-12-0201","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T20:26:32Z","timestamp":1353702392000},"page":"287-296","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":12,"title":["Hormonal regulation of \u03b2-myosin heavy chain expression in the mouse left 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