{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:15:23Z","timestamp":1791497723836,"version":"4.3.4"},"reference-count":50,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>\n                    This study elucidates the role of metabolic remodeling in cardiac dysfunction induced by hyperthyroidism. Cardiac hypertrophy, structural remodeling, and expression of the genes associated with fatty acid metabolism were examined in rats treated with triiodothyronine (T\n                    <jats:sub>3<\/jats:sub>\n                    ) alone (8\u200a\u03bcg\/100\u200ag body weight (BW), i.p.) for 15 days or along with a peroxisome proliferator-activated receptor alpha agonist bezafibrate (Bzf; 30\u200a\u03bcg\/100\u200ag BW, oral) and were found to improve in the Bzf co-treated condition. Ultrastructure of mitochondria was damaged in T\n                    <jats:sub>3<\/jats:sub>\n                    -treated rat heart, which was prevented by Bzf co-administration. Hyperthyroidism-induced oxidative stress, reduction in cytochrome\n                    <jats:italic>c<\/jats:italic>\n                    oxidase activity, and myocardial ATP concentration were also significantly checked by Bzf. Heart function studied at different time points during the course of T\n                    <jats:sub>3<\/jats:sub>\n                    treatment shows an initial improvement and then a gradual but progressive decline with time, which is prevented by Bzf co-treatment. In summary, the results demonstrate that hyperthyroidism inflicts structural and functional damage to mitochondria, leading to energy depletion and cardiac dysfunction.\n                  <\/jats:p>","DOI":"10.1530\/joe-12-0304","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T02:16:40Z","timestamp":1361326600000},"page":"215-228","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":25,"title":["Hyperthyroidism causes cardiac dysfunction by mitochondrial impairment and energy 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