{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:33:23Z","timestamp":1790940803382,"version":"4.1.0"},"reference-count":30,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>The aim of this study was to explore the involvement of retinoids in the hypoactivity and hyporeactivity to stress of the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis in LOU\/C rats. We measured the effects of vitamin A deficiency administered or not with retinoic acid (RA) on plasma corticosterone in standard conditions and in response to restraint stress and on hypothalamic and hippocampal expression of corticosteroid receptors, corticotropin-releasing hormone and 11\u03b2-hydroxysteroid dehydrogenase type 1 (11\u03b2-HSD1) in LOU\/C rats. Interestingly, under control conditions, we measured a higher plasma concentration of retinol in LOU\/C than in Wistar rats, which could contribute to the lower basal activity of the HPA axis in LOU\/C rats. Vitamin A deficiency induced an increased HPA axis activity in LOU\/C rats, normalized by RA administration. Compared with LOU\/C control rats, vitamin A-deficient rats showed a delayed and heightened corticosterone response to restraint stress. The expression of corticosteroid receptors was strongly decreased by vitamin A deficiency in the hippocampus, which could contribute to a less efficient feedback by corticosterone on HPA axis tone. The expression of 11\u03b2-HSD1 was increased by vitamin A deficiency in the hypothalamus (+62.5%) as in the hippocampus (+104.7%), which could lead to a higher production of corticosterone locally and contribute to alteration of the hippocampus. RA supplementation treatment restored corticosterone concentrations and 11\u03b2-HSD1 expression to control levels. The high vitamin A status of LOU\/C rats could contribute to their low HPA axis activity\/reactivity and to a protective effect against 11\u03b2-HSD1-mediated deleterious action on cognitive performances during ageing.<\/jats:p>","DOI":"10.1530\/joe-13-0062","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T22:54:31Z","timestamp":1373583271000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin A regulates hypothalamic\u2013pituitary\u2013adrenal axis status in LOU\/C rats"],"prefix":"10.1530","volume":"219","author":[{"given":"Nathalie","family":"Marissal-Arvy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Hamiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Moisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Pallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"1_27173638","doi-asserted-by":"crossref","first-page":"B312","DOI":"10.1093\/gerona\/57.8.B312","volume":"57","year":"2002","journal-title":"JOURNALS OF GERONTOLOGY SERIES A BIOLOGICAL SCIENCES AND MEDICAL SCIENCES"},{"issue":"6","key":"2_33733693","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1210\/en.2008-1618","volume":"150","year":"2009","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"12","key":"3_17408420","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1016\/S0531-5565(02)00174-2","volume":"37","author":"Boghossian","year":"2002","journal-title":"Experimental gerontology","ISSN":"https:\/\/id.crossref.org\/issn\/0531-5565","issn-type":"print"},{"issue":"10","key":"4_32339426","doi-asserted-by":"publisher","first-page":"e3487","DOI":"10.1371\/journal.pone.0003487","volume":"3","author":"Bonnet","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"key":"5_46456753","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/jnc.12192","volume":"125","year":"2013","journal-title":"Journal of neurochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3042","issn-type":"print"},{"issue":"12","key":"6_37719246","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.euroneuro.2010.06.019","volume":"20","author":"Cai","year":"2010","journal-title":"European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0924-977X","issn-type":"print"},{"issue":"16","key":"7_11265352","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1523\/JNEUROSCI.21-16-06423.2001","volume":"21","author":"Etchamendy","year":"2001","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"4","key":"8_33863549","doi-asserted-by":"publisher","first-page":"696","DOI":"10.3945\/jn.108.102988","volume":"139","year":"2009","journal-title":"The Journal of Nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3166","issn-type":"print"},{"issue":"1","key":"9_18730543","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/oby.2005.3","volume":"13","author":"Helies","year":"2005","journal-title":"Obesity","ISSN":"https:\/\/id.crossref.org\/issn\/1071-7323","issn-type":"print"},{"issue":"16","key":"10_9542433","doi-asserted-by":"publisher","first-page":"7276","DOI":"10.1073\/pnas.88.16.7276","volume":"88","author":"Holland","year":"1991","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"20","key":"11_37293974","doi-asserted-by":"publisher","first-page":"6916","DOI":"10.1523\/JNEUROSCI.0731-10.2010","volume":"30","author":"Holmes","year":"2010","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"1","key":"12_17707572","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1079\/BJN2003877","volume":"90","author":"Husson","year":"2003","journal-title":"The British journal of nutrition","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1145","issn-type":"print"},{"key":"13_46456754","first-page":"1","volume":"23","year":"2006","journal-title":"NEUROBIOLOGICAL DISORDERS"},{"issue":"1","key":"14_7259248","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1042\/bj0990138","volume":"99","author":"Juneja","year":"1966","journal-title":"The Biochemical journal","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"issue":"1","key":"15_33422305","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.neurobiolaging.2008.03.010","volume":"31","author":"Kollen","year":"2010","journal-title":"Neurobiology of aging","ISSN":"https:\/\/id.crossref.org\/issn\/0197-4580","issn-type":"print"},{"issue":"4","key":"16_18850121","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.pneurobio.2005.03.002","volume":"75","author":"Lane","year":"2005","journal-title":"Progress in neurobiology","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0082","issn-type":"print"},{"key":"17_18698810","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0083-6729(05)70007-8","volume":"70","author":"Lefebvre","year":"2005","journal-title":"Vitamins and hormones","ISSN":"https:\/\/id.crossref.org\/issn\/0083-6729","issn-type":"print"},{"issue":"6","key":"18_34711463","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nrn2639","volume":"10","author":"Lupien","year":"2009","journal-title":"Nature reviews. Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/1471-003X","issn-type":"print"},{"issue":"3","key":"19_29860959","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1677\/JOE-07-0077","volume":"195","author":"Marissal-Arvy","year":"2007","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"5","key":"20_37957588","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.metabol.2010.07.005","volume":"60","author":"Marissal-Arvy","year":"2011","journal-title":"Metabolism: clinical and experimental","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"11","key":"21_22376788","doi-asserted-by":"publisher","first-page":"5325","DOI":"10.1210\/en.2006-0760","volume":"147","year":"2006","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"1","key":"22_30150405","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1523\/JNEUROSCI.4065-07.2008","volume":"28","author":"Mingaud","year":"2008","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"8","key":"23_11360027","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1172\/JCI200111098","volume":"108","author":"Paez-Pereda","year":"2001","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"2","key":"24_36213242","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1210\/en.2009-0862","volume":"151","year":"2010","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"key":"25_46456755","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1475-2891-10-70","volume":"10","year":"2011","journal-title":"NUTRITION JOURNAL"},{"key":"26_46456756","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1385\/ENDO:30:1:113","volume":"30","year":"2006","journal-title":"Endocrine","ISSN":"https:\/\/id.crossref.org\/issn\/0969-711X","issn-type":"print"},{"issue":"16","key":"27_5997649","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/S0024-3205(98)00080-0","volume":"62","author":"Sarrieau","year":"1998","journal-title":"Life sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0024-3205","issn-type":"print"},{"issue":"41","key":"28_38264310","doi-asserted-by":"publisher","first-page":"13867","DOI":"10.1523\/JNEUROSCI.2783-10.2010","volume":"30","author":"Sooy","year":"2010","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"key":"29_35379098","first-page":"267","volume":"573574","year":"2006","journal-title":"Analytica Chimica Acta","ISSN":"https:\/\/id.crossref.org\/issn\/1873-4324","issn-type":"print"},{"issue":"6","key":"30_28844796","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/nm1587","volume":"13","author":"Ziouzenkova","year":"2007","journal-title":"Nature medicine","ISSN":"https:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/219\/1\/21.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/219\/1\/21.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:53:37Z","timestamp":1784555617000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/219\/1\/21-27\/22489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,11]]},"references-count":30,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/joe-13-0062","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,11]]}}}