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C57BL\/6J mice were treated with corticosterone (100 or 25\u200a\u03bcg\/ml) or vehicle in their drinking water for 5 weeks after which they were subjected to insulin or glucose tolerance tests. GC-treated mice displayed increased food intake, body weight gain, and central fat deposit accumulations. In addition, the GC treatment led to dyslipidemia as well as accumulation of ectopic fat in the liver and skeletal muscle, having a substantial negative effect on insulin sensitivity. Also glucose intolerance and hypertension, both part of the metabolic syndrome, were evident in the GC-treated mice. However, the observed effects of corticosterone were reversed after drug removal. Furthermore, this study reveals insights into \u03b2-cell adaptation to the GC-induced insulin resistance. Increased pancreatic islet volume due to cell proliferation, increased insulin secretion capacity, and increased islet chaperone expression were found in GC-treated animals. This model mimics the human metabolic syndrome. It could be a valuable model for studying the complex mechanisms behind the development of the metabolic syndrome and type 2 diabetes, as well as the multifaceted relations between GC excess and disease.<\/jats:p>","DOI":"10.1530\/joe-13-0189","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T23:17:59Z","timestamp":1379546279000},"page":"231-241","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":59,"title":["\u03b2-cell adaptation in a mouse model of glucocorticoid-induced metabolic syndrome"],"prefix":"10.1530","volume":"219","author":[{"given":"Liselotte","family":"Fransson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Franz\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Rosengren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Wolbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"Sj\u00f6holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Orts\u00e4ter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"6","key":"1_38710587","doi-asserted-by":"publisher","first-page":"353","DOI":"10.4161\/isl.2.6.13619","volume":"2","author":"Ahren","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1938-2022","issn-type":"print"},{"issue":"8","key":"2_34918347","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1210\/jc.2009-0370","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"3_18508670","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s11906-004-0046-0","volume":"6","author":"Baid","year":"2004","journal-title":"Current hypertension reports","ISSN":"https:\/\/id.crossref.org\/issn\/1522-6417","issn-type":"print"},{"issue":"5","key":"4_36141310","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s00421-009-1272-6","volume":"108","author":"Barel","year":"2010","journal-title":"European journal of applied physiology","ISSN":"https:\/\/id.crossref.org\/issn\/1439-6319","issn-type":"print"},{"issue":"7","key":"5_17694461","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.2337\/diabetes.52.7.1716","volume":"52","author":"Bock","year":"2003","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"6","key":"6_30276812","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1096\/fj.07-094144","volume":"22","year":"2008","journal-title":"The FASEB Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0892-6638","issn-type":"print"},{"issue":"7","key":"7_19306814","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/oby.2005.137","volume":"13","author":"Duclos","year":"2005","journal-title":"Obesity","ISSN":"https:\/\/id.crossref.org\/issn\/1071-7323","issn-type":"print"},{"issue":"110","key":"8_36588962","doi-asserted-by":"publisher","first-page":"pe7","DOI":"10.1126\/scisignal.3110pe7","volume":"3","year":"2010","journal-title":"Science Signaling","ISSN":"https:\/\/id.crossref.org\/issn\/1945-0877","issn-type":"print"},{"issue":"3","key":"9_17520560","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nrm1052","volume":"4","author":"Ellgaard","year":"2003","journal-title":"Nature reviews. 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