{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:59:07Z","timestamp":1791071947685,"version":"4.1.0"},"reference-count":35,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>\n                    The novel adipokine chemerin plays a role in the regulation of lipid and carbohydrate metabolism, and recent reports of elevated chemerin levels in polycystic ovarian syndrome and preeclampsia have pointed to an emerging role of chemerin in reproduction. We hypothesised that chemerin, like other adipokines, may function to regulate male gonadal steroidogenesis. In this study, we show that chemerin and its three receptors chemokine-like receptor 1 (CMKLR1), G-protein-coupled receptor 1 (GPR1) and chemokine (C-C motif) receptor-like 2 were expressed in male reproductive tracts, liver and white adipose tissue. CMKLR1 and GPR1 proteins were localised specifically in the Leydig cells of human and rat testes by immunohistochemistry. The expression of\n                    <jats:italic>chemerin<\/jats:italic>\n                    and its receptors in rat testes was developmentally regulated and highly expressed in Leydig cells.\n                    <jats:italic>In vitro<\/jats:italic>\n                    treatment with chemerin suppressed the human chorionic gonadotropin (hCG)-induced testosterone production from primary Leydig cells, which was accompanied by the inhibition of 3\u03b2-hydroxysteroid dehydrogenase gene and protein expression. The hCG-activated p44\/42 MAPK (Erk1\/2) pathway in Leydig cells was also inhibited by chemerin cotreatment. Together, these data suggest that chemerin is a novel regulator of male gonadal steroidogenesis.\n                  <\/jats:p>","DOI":"10.1530\/joe-13-0275","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T20:56:54Z","timestamp":1386104214000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":59,"title":["Expression of chemerin and its receptors in rat testes and its action on testosterone 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