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The adrenal glands of rats treated with DES (340\u200a\u03bcg\/kg body weight every 2 days) for 2 weeks showed increased weight and size and a decreased fat droplet size. Following 1 week of treatment with DES, the blood and adrenal corticosterone levels were substantially decreased without any histological alterations. The levels of the precursors for corticosteroid biosynthesis in the adrenal glands were also decreased, as determined using mass spectroscopy. Cholesterol, the principal material of corticosteroid biosynthesis, decreased substantially in the adrenal glands after only 1 week of treatment with DES. In conclusion, cholesterol insufficiency results in a reduction in adrenal corticosterone biosynthesis, which may lead to endocrine dysfunction, such as reproductive toxicity.<\/jats:p>","DOI":"10.1530\/joe-13-0460","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:18:59Z","timestamp":1393546739000},"page":"261-272","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":7,"title":["Diethylstilbestrol decreased adrenal cholesterol and corticosterone in 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