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The aim of this study was to elucidate the occurrence of continuous angiogenesis and growth factor-dependent neurovascular reconstruction in the NH of adult mice. Active proliferation of endothelial cells and oligodendrocyte progenitor cells (OPCs) was observed using the immunohistochemistry of bromodeoxyuridine and Ki-67. Vascular endothelial growth factor A (VEGFA) and VEGF receptor 2 (VEGFR2 (KDR)) were highly expressed at pituicytes and endothelial cells respectively. Moreover, prominent expression of platelet-derived growth factor B (PDGFB) and PDGF receptor beta was observed at OXT-containing axonal terminals and pericytes respectively. Administration of the selective tyrosine kinase inhibitor AZD2171 for VEGFRs and STI571 for PDGFRs significantly decreased proliferation of endothelial cells and OPCs. Moreover, AZD2171 treatment decreased vascular density by facilitating apoptosis of endothelial cells and the withdrawal of its treatment led to remarkable rebound proliferation of endothelial cells, so that vascular density rapidly returned to normal levels. AZD2171 decreased the density of both AVP- and OXT-containing axonal terminals, whereas STI571 selectively decreased the density of AVP-containing ones. Thus, this study demonstrates that the signaling pathways of VEGF and PDGF are crucial mediators for determining proliferation of endothelial cells and OPCs and the density of AVP- and OXT-containing axonal terminals in the HNS.<\/jats:p>","DOI":"10.1530\/joe-14-0075","type":"journal-article","created":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T01:07:24Z","timestamp":1400893644000},"page":"161-179","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":46,"title":["VEGF-dependent and PDGF-dependent dynamic neurovascular reconstruction in the neurohypophysis of adult mice"],"prefix":"10.1530","volume":"222","author":[{"given":"Eriko","family":"Furube","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Mannari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"1","key":"1_35458637","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiology of disease","ISSN":"https:\/\/id.crossref.org\/issn\/0969-9961","issn-type":"print"},{"issue":"7323","key":"2_38321941","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nature09522","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"8","key":"3_23394567","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1093\/emboj\/21.8.1957","volume":"21","author":"Baron","year":"2002","journal-title":"The EMBO Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0261-4189","issn-type":"print"},{"issue":"15","key":"4_29091155","doi-asserted-by":"publisher","first-page":"4632s","DOI":"10.1158\/1078-0432.CCR-07-0212","volume":"13","author":"Bauman","year":"2007","journal-title":"Clinical Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"issue":"1","key":"5_13390485","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1523\/JNEUROSCI.05-01-00081.1985","volume":"5","author":"Ben-Barak","year":"1985","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"5","key":"6_41601939","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1523\/JNEUROSCI.5531-11.2012","volume":"32","author":"Bozoyan","year":"2012","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"1","key":"7_38325196","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1365-2990.2010.01139.x","volume":"37","author":"Brown","year":"2011","journal-title":"Neuropathology and applied neurobiology","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1846","issn-type":"print"},{"issue":"6573","key":"8_16187584","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/380435a0","volume":"380","author":"Carmeliet","year":"1996","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"9_47425747","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1016\/j.bbapap.2012.10.015","volume":"1834","year":"2013","journal-title":"Biochimica et Biophysica Acta. 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