{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:08:18Z","timestamp":1790158098961,"version":"4.1.0"},"reference-count":74,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>\n                    Leptin-deficient\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice are morbidly obese and exhibit low total bone mass and mild osteopetrosis. In order to disassociate the skeletal effects of leptin deficiency from those associated with morbid obesity, we evaluated bone mass, architecture, gene expression, and indices of bone turnover in WT mice,\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice allowed to feed\n                    <jats:italic>ad libitum<\/jats:italic>\n                    (\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    ), and\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice pair-fed equivalent to WT mice (pair-fed\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    ). Mice were maintained at 32\u200a\u00b0C (thermoneutral) from 6 to 18 weeks of age to minimize differences in resting energy expenditure.\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice were heavier, had more abdominal white adipose tissue (WAT), and were hyperglycemic compared with WT mice. Femur length, bone mineral content (BMC) and bone mineral density, and midshaft femur cortical thickness were lower in\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice than in WT mice. Cancellous bone volume (BV) fraction was higher but indices of bone formation and resorption were lower in\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice compared with WT mice; reduced bone resorption in\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice resulted in pathological retention of calcified cartilage. Pair-fed\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice were lighter and had lower WAT, uterine weight, and serum glucose than\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice. Similarly, femoral length, BMC, and cortical thickness were lower in pair-fed\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice compared with\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice, as were indices of cancellous bone formation and resorption. In contrast, bone marrow adiposity, calcified cartilage, and cancellous BV fraction were higher at one or more cancellous sites in pair-fed\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice compared with\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice. These findings indicate that the skeletal abnormalities caused by leptin deficiency are markedly attenuated in morbidly obese\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice.\n                  <\/jats:p>","DOI":"10.1530\/joe-14-0224","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T03:51:35Z","timestamp":1404359495000},"page":"M1-M15","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":40,"title":["Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice"],"prefix":"10.1530","volume":"223","author":[{"given":"Russell T","family":"Turner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A","family":"Philbrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen P","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn A","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J","family":"Branscum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula T","family":"Iwaniec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"6","key":"1_18124690","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1172\/JCI200419900","volume":"113","author":"Akune","year":"2004","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"2_18600833","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2271fje","year":"2004","journal-title":"The FASEB Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0892-6638","issn-type":"print"},{"issue":"8","key":"3_39805387","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1002\/jbmr.406","volume":"26","author":"Bartell","year":"2011","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"issue":"4","key":"4_4749933","first-page":"457","volume":"2","author":"Batt","year":"1978","journal-title":"International journal of obesity","ISSN":"https:\/\/id.crossref.org\/issn\/0307-0565","issn-type":"print"},{"key":"5_48531893","first-page":"29","volume":"16","year":"1992","journal-title":"INTERNATIONAL JOURNAL OF OBESITY AND RELATED METABOLIC DISORDERS"},{"issue":"7","key":"6_37429842","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/jbmr.141","volume":"25","author":"Bouxsein","year":"2010","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"key":"7_48531894","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/oby.2010.106","volume":"19","year":"2011","journal-title":"OBESITY"},{"issue":"10 Pt 2","key":"8_17303391","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1301\/002966402320634823","volume":"60","author":"Chehab","year":"2002","journal-title":"Nutrition Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0029-6643","issn-type":"print"},{"issue":"7","key":"9_42398057","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.bbagen.2012.04.001","volume":"1820","author":"Christiaens","year":"2012","journal-title":"Biochimica et Biophysica Acta. 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