{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:15:52Z","timestamp":1787724952444,"version":"build-2784847793"},"reference-count":64,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    Impaired glucose-stimulated insulin secretion (GSIS) and increasing \u03b2-cell death are two typical dysfunctions of pancreatic \u03b2-cells in individuals that are destined to develop type 2 diabetes, and improvement of \u03b2-cell function through GSIS enhancement and\/or inhibition of \u03b2-cell death is a promising strategy for anti-diabetic therapy. In this study, we discovered that the small molecule,\n                    <jats:italic>N<\/jats:italic>\n                    -(2-benzoylphenyl)-5-bromo-2-thiophenecarboxamide (BBT), was effective in both potentiating GSIS and protecting \u03b2-cells from cytokine- or streptozotocin (STZ)-induced cell death. Results of further studies revealed that cAMP\/PKA and long-lasting (L-type) voltage-dependent Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    channel\/CaMK2 pathways were involved in the action of BBT against GSIS, and that the cAMP\/PKA pathway was essential for the protective action of BBT on \u03b2-cells. An assay using the model of type 2 diabetic mice induced by high-fat diet combined with STZ (STZ\/HFD) demonstrated that BBT administration efficiently restored \u03b2-cell functions as indicated by the increased plasma insulin level and decrease in the \u03b2-cell loss induced by STZ\/HFD. Moreover, the results indicated that BBT treatment decreased fasting blood glucose and HbA1c and improved oral glucose tolerance further highlighting the potential of BBT in anti-hyperglycemia research.\n                  <\/jats:p>","DOI":"10.1530\/joe-14-0721","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T01:42:40Z","timestamp":1420767760000},"page":"327-341","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["BBT improves glucose homeostasis by ameliorating \u03b2-cell dysfunction in type 2 diabetic mice"],"prefix":"10.1530","volume":"224","author":[{"given":"Xin-gang","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gai-hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-ling","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-hua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-pei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"issue":"4","key":"1_32771382","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1517\/14728210802584126","volume":"13","author":"Ahren","year":"2008","journal-title":"Expert opinion on emerging drugs","ISSN":"https:\/\/id.crossref.org\/issn\/1472-8214","issn-type":"print"},{"issue":"2","key":"2_11032293","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1006\/bbrc.2001.4361","volume":"281","author":"Andersson","year":"2001","journal-title":"Biochemical and biophysical research communications","ISSN":"https:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"issue":"35","key":"3_19563151","doi-asserted-by":"publisher","first-page":"32517","DOI":"10.1074\/jbc.M301174200","volume":"278","year":"2003","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"9","key":"4_31768587","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1211\/jpp.60.9.0008","volume":"60","author":"Arulmozhi","year":"2008","journal-title":"The Journal of pharmacy and pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3573","issn-type":"print"},{"key":"5_49765629","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1016\/j.bmcl.2004.03.058","volume":"14","year":"2004","journal-title":"BIOORGANIC MEDICINAL CHEMISTRY LETTERS"},{"key":"6_28588955","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/0264-6021:3400219","volume":"340","year":"1999","journal-title":"Biochemical Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"issue":"4","key":"7_17559035","doi-asserted-by":"publisher","first-page":"974","DOI":"10.2337\/diabetes.52.4.974","volume":"52","author":"Briaud","year":"2003","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"6","key":"8_18884195","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"1","key":"9_17459333","doi-asserted-by":"publisher","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"10","key":"10_31527335","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1210\/jc.2007-2109","volume":"93","year":"2008","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"9","key":"11_5589802","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1016\/S0021-9258(19)34116-X","volume":"265","author":"Chijiwa","year":"1990","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"12_49765630","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/BJ20121454","volume":"449","year":"2013","journal-title":"Biochemical Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"issue":"12","key":"13_16122914","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1016\/0006-2952(95)02102-7","volume":"50","author":"Delaney","year":"1995","journal-title":"Biochemical pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-2952","issn-type":"print"},{"issue":"7","key":"14_31575583","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s12325-008-0076-1","volume":"25","author":"Doupis","year":"2008","journal-title":"Advances in therapy","ISSN":"https:\/\/id.crossref.org\/issn\/0741-238X","issn-type":"print"},{"key":"15_49765631","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1016\/S0960-894X(98)00522-8","volume":"8","year":"1998","journal-title":"BIOORGANIC MEDICINAL CHEMISTRY LETTERS"},{"issue":"4","key":"16_10770486","doi-asserted-by":"publisher","first-page":"675","DOI":"10.2337\/diabetes.48.4.675","volume":"48","author":"Easom","year":"1999","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"17_46178806","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/S0168-8227(11)70015-8","volume":"93","year":"2011","journal-title":"Diabetes research and clinical practice","ISSN":"https:\/\/id.crossref.org\/issn\/0168-8227","issn-type":"print"},{"key":"18_49765632","doi-asserted-by":"crossref","first-page":"48e","DOI":"10.4158\/EP10383.CR","volume":"17","year":"2011","journal-title":"ENDOCRINE PRACTICE"},{"issue":"50","key":"19_19558638","doi-asserted-by":"publisher","first-page":"48146","DOI":"10.1074\/jbc.M209165200","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"3","key":"20_31619228","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000137662","volume":"70","author":"Han","year":"2008","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"2","key":"21_23539322","doi-asserted-by":"publisher","first-page":"438","DOI":"10.2337\/db06-0738","volume":"56","author":"de Heer","year":"2007","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"3","key":"22_10365045","doi-asserted-by":"publisher","first-page":"424","DOI":"10.2337\/diabetes.49.3.424","volume":"49","author":"Hohmeier","year":"2000","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"4","key":"23_17540840","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1210\/en.2002-220897","volume":"144","author":"Hui","year":"2003","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"key":"24_49765633","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1016\/j.bmcl.2008.05.016","volume":"18","year":"2008","journal-title":"BIOORGANIC MEDICINAL CHEMISTRY LETTERS"},{"issue":"5","key":"25_45036683","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.2337\/db12-1013","volume":"62","year":"2013","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"26_18168513","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1196\/annals.1293.017","volume":"1011","author":"KAJIMOTO","year":"2004","journal-title":"Annals of the New York Academy of Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0077-8923","issn-type":"print"},{"issue":"11","key":"27_16787932","doi-asserted-by":"publisher","first-page":"5599","DOI":"10.1073\/pnas.94.11.5599","volume":"94","author":"Khoo","year":"1997","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"9","key":"28_9206432","doi-asserted-by":"publisher","first-page":"992","DOI":"10.2337\/diacare.13.9.992","volume":"13","author":"Leahy","year":"1990","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"3","key":"29_9788432","doi-asserted-by":"publisher","first-page":"442","DOI":"10.2337\/diacare.15.3.442","volume":"15","author":"Leahy","year":"1992","journal-title":"Diabetes Care","ISSN":"https:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"7","key":"30_19344931","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1007\/s00125-005-1787-2","volume":"48","author":"Li","year":"2005","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"2","key":"31_18616489","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1210\/en.2004-0841","volume":"146","year":"2005","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"26","key":"32_9576719","doi-asserted-by":"crossref","first-page":"17067","DOI":"10.1016\/S0021-9258(19)47340-7","volume":"266","author":"Lytton","year":"1991","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"6","key":"33_17242149","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1172\/JCI200215318","volume":"110","author":"Maedler","year":"2002","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"4","key":"34_28302064","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1185\/030079906X167336","volume":"23","author":"Meece","year":"2007","journal-title":"Current medical research and opinion","ISSN":"https:\/\/id.crossref.org\/issn\/0300-7995","issn-type":"print"},{"issue":"7","key":"35_22334029","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1172\/JCI29103","volume":"116","author":"Prentki","year":"2006","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"3","key":"36_6121694","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1006\/nlme.1998.3822","volume":"69","author":"Quevedo","year":"1998","journal-title":"Neurobiology of learning and memory","ISSN":"https:\/\/id.crossref.org\/issn\/1074-7427","issn-type":"print"},{"key":"37_49575018","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1007\/s00125-014-3174-3","volume":"57","year":"2014","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"Pt_1","key":"38_27958447","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1469-7793.1997.105bl.x","volume":"502","author":"Renstrom","year":"1997","journal-title":"The Journal of Physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3751","issn-type":"print"},{"issue":"5708","key":"39_18629201","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1126\/science.1104345","volume":"307","author":"Rhodes","year":"2005","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"2","key":"40_18030958","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1210\/jc.2003-031120","volume":"89","author":"Ritzel","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"8","key":"41_16854251","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.2337\/diab.46.8.1305","volume":"46","author":"Rustenbeck","year":"1997","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"2","key":"42_41282312","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.tips.2011.10.006","volume":"33","author":"Seifert","year":"2012","journal-title":"Trends in Pharmacological Sciences (Regular ed.)","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3735","issn-type":"print"},{"issue":"5","key":"43_36745122","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1185\/03007991003672551","volume":"26","author":"Seino","year":"2010","journal-title":"Current medical research and opinion","ISSN":"https:\/\/id.crossref.org\/issn\/0300-7995","issn-type":"print"},{"issue":"6","key":"44_40054155","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1172\/JCI45680","volume":"121","author":"Seino","year":"2011","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"suppl_3","key":"45_18536919","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.2337\/diabetes.53.suppl_3.S59","volume":"53","author":"Shibasaki","year":"2004","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"46_49765634","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0968-0896(98)00210-7","volume":"7","year":"1999","journal-title":"BIOORGANIC MEDICINAL CHEMISTRY"},{"issue":"9","key":"47_22473480","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1007\/s00125-006-0307-3","volume":"49","author":"Stephan","year":"2006","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"3","key":"48_9686210","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/0006-291X(91)92031-E","volume":"181","author":"Sumi","year":"1991","journal-title":"Biochemical and biophysical research communications","ISSN":"https:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"issue":"10","key":"49_11002518","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1007\/s001250051293","volume":"42","author":"Suzuki","year":"1999","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"6","key":"50_16901802","doi-asserted-by":"crossref","first-page":"537","DOI":"10.33549\/physiolres.930111","volume":"50","author":"Szkudelski","year":"2001","journal-title":"Physiological research \/ Academia Scientiarum Bohemoslovaca","ISSN":"https:\/\/id.crossref.org\/issn\/0862-8408","issn-type":"print"},{"issue":"13","key":"51_19560039","doi-asserted-by":"publisher","first-page":"10908","DOI":"10.1074\/jbc.M213183200","volume":"278","year":"2003","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"1-2","key":"52_11420089","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0248-4900(01)01129-7","volume":"93","author":"Volmat","year":"2001","journal-title":"Biology of the cell \/ under the auspices of the European Cell Biology Organization","ISSN":"https:\/\/id.crossref.org\/issn\/0248-4900","issn-type":"print"},{"issue":"11","key":"53_10189996","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1016\/S0021-9258(18)53027-1","volume":"268","author":"Wang","year":"1993","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"54_49765635","first-page":"92","volume":"8","year":"2000","journal-title":"ACTA LABORATORIUM ANIMALIS SCIENTIA SINICA"},{"issue":"5","key":"55_23372657","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1002\/hep.510270519","volume":"27","author":"Anwer","year":"1998","journal-title":"Hepatology (Baltimore, Md.)","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"issue":"44","key":"56_37908975","doi-asserted-by":"publisher","first-page":"33623","DOI":"10.1074\/jbc.M109.085084","volume":"285","year":"2010","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"51","key":"57_19558834","doi-asserted-by":"publisher","first-page":"49676","DOI":"10.1074\/jbc.M208756200","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"2","key":"58_19406416","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/sj.bjp.0706306","volume":"146","author":"Wu","year":"2005","journal-title":"British journal of pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1188","issn-type":"print"},{"issue":"5240","key":"59_16096222","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","volume":"270","author":"Xia","year":"1995","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"60_49765636","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jep.2013.08.043","volume":"150","year":"2013","journal-title":"Journal of ethnopharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0378-8741","issn-type":"print"},{"issue":"9","key":"61_43799664","doi-asserted-by":"publisher","first-page":"e44988","DOI":"10.1371\/journal.pone.0044988","volume":"7","author":"Yeo","year":"2012","ISSN":"https:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"issue":"3","key":"62_17516385","doi-asserted-by":"publisher","first-page":"838","DOI":"10.2337\/diabetes.52.3.838","volume":"52","author":"Yokota","year":"2003","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"63_49765637","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1016\/j.bmc.2006.03.024","volume":"14","year":"2006","journal-title":"BIOORGANIC MEDICINAL CHEMISTRY"},{"issue":"6865","key":"64_11447732","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/414782a","volume":"414","author":"Zimmet","year":"2001","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/224\/3\/327.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/224\/3\/327.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:54:55Z","timestamp":1784555695000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/224\/3\/327-341\/22634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,8]]},"references-count":64,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/joe-14-0721","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,8]]}}}