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Discoveries of wide significance followed, including: the recognition of the importance of pulsatile hormone secretion; the recognition of the importance of stimulus-secretion coupling mechanisms in interpreting the patterned electrical activity of neurons; the physiological importance of peptide release in the brain; the recognition that peptide release comes substantially from dendrites and can be regulated independently of nerve terminal secretion; and the importance of dynamic morphological changes to neuronal function in the hypothalamus. All of these discoveries followed from the drive to understand the milk-ejection reflex. We also reflect on Harris's observations on vasopressin secretion, on the effects of stress, and on oxytocin secretion during sexual activity.<\/jats:p>","DOI":"10.1530\/joe-15-0087","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T21:52:32Z","timestamp":1429653152000},"page":"T173-T185","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":78,"title":["60 YEARS OF NEUROENDOCRINOLOGY: The posterior pituitary, from Geoffrey Harris to our present understanding"],"prefix":"10.1530","volume":"226","author":[{"given":"Gareth","family":"Leng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Sabatier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2015072420351671000_226.2.T173.1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(83)90041-4"},{"key":"2015072420351671000_226.2.T173.2","doi-asserted-by":"crossref","unstructured":"Antunes-Rodrigues J Favaretto AL Gutkowska J McCann SM 1997 The neuroendocrine control of atrial natriuretic peptide release. 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