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Characterisation of the physiological control of the axis was significantly advanced by frequent blood sampling studies in the 1980s and 1990s; the pulsatile pattern of GH secretion and the factors that influenced the frequency and amplitude of the pulses have been defined. Over the same time, spontaneously occurring and targeted mutations in the GH axis in rodents combined with the recognition of genetic causes of familial hypopituitarism demonstrated the key factors controlling pituitary development. As the understanding of the control of GH secretion advanced, developments of treatments for GH axis disorders have evolved. Administration of pituitary-derived human GH was followed by the introduction of recombinant human GH in the 1980s, and, more recently, by long-acting GH preparations. For GH excess disorders, dopamine agonists were used first followed by SST analogues, and in 2005 the GH receptor blocker pegvisomant was introduced. This review will cover the evolution of these discoveries and build a picture of our current understanding of the hypothalamo-GH axis.<\/jats:p>","DOI":"10.1530\/joe-15-0120","type":"journal-article","created":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T23:17:47Z","timestamp":1433373467000},"page":"T123-T140","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":72,"title":["60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-GH axis: the past 60 years"],"prefix":"10.1530","volume":"226","author":[{"given":"P G","family":"Murray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C E","family":"Higham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P E","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2015072420351668000_226.2.T123.1","doi-asserted-by":"crossref","unstructured":"Abu Dabrh AM Mohammed K Asi N Farah WH Wang Z Farah MH Prokop LJ Katznelson L Murad MH 2014 Surgical interventions and medical treatments in treatment-naive patients with acromegaly: systematic review and meta-analysis. 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