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These apparently independent symptoms have humoral factors secreted by the tumor as a common cause. Importantly, the hypothalamus has emerged as an organ that senses the peripheral signals emanating from the tumoral environment, and not only elicits anorexia but also contributes to the development of muscle and adipose tissue loss. Herein, we review the roles of factors secreted by the tumor and its effects on the hypothalamus, muscle and adipose tissue, as well as highlighting the key targets that are being exploited for cancer cachexia treatment.<\/jats:p>","DOI":"10.1530\/joe-15-0170","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:20:19Z","timestamp":1435278019000},"page":"R29-R43","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":77,"title":["Molecular and neuroendocrine mechanisms of cancer cachexia"],"prefix":"10.1530","volume":"226","author":[{"given":"Maria Carolina S","family":"Mendes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo D","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe O","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 B C","family":"Carvalheira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2015082118490588000_226.3.R29.1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420174"},{"key":"2015082118490588000_226.3.R29.2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4585"},{"key":"2015082118490588000_226.3.R29.3","unstructured":"Anand BK Brobeck JR 1951 Hypothalamic control of food intake in rats and cats. 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