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Moreover, FGF21 protects the myocardium and great arteries by attenuating remodeling, inflammation, oxidative stress and also promoting the energy supply to the heart through fatty acid \u03b2-oxidation. This growing evidence emphasizes the important roles of FGF21 in cardioprotection. This review comprehensively summarizes and discusses the consistent and inconsistent findings regarding the beneficial effects of FGF21 on the heart available from both basic research and clinical reports. The details of the signaling, biological and pharmacological effects of FGF21 with regard to its protection of the heart are also presented and discussed in this review.<\/jats:p>","DOI":"10.1530\/joe-15-0289","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T22:09:57Z","timestamp":1441404597000},"page":"R13-R30","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":58,"title":["Effects of fibroblast growth factor 21 on the heart"],"prefix":"10.1530","volume":"227","author":[{"given":"Pongpan","family":"Tanajak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2015110216231961000_227.2.R13.1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0532"},{"key":"2015110216231961000_227.2.R13.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2792"},{"key":"2015110216231961000_227.2.R13.3","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301599"},{"key":"2015110216231961000_227.2.R13.4","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2012-0441"},{"key":"2015110216231961000_227.2.R13.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.08.002"},{"key":"2015110216231961000_227.2.R13.6","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0193"},{"key":"2015110216231961000_227.2.R13.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.3.282"},{"key":"2015110216231961000_227.2.R13.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3528"},{"key":"2015110216231961000_227.2.R13.9","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1262"},{"key":"2015110216231961000_227.2.R13.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.02.019"},{"key":"2015110216231961000_227.2.R13.11","unstructured":"Heather LC Catchpole AF Stuckey DJ Cole MA Carr CA Clarke K 2009 Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart. 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