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After that, flow-mediated dilation (FMD) as an indicator of endothelial function was measured by high-resolution ultrasound in the femoral artery of living rats. ELD ameliorated the reduction of FMD in OVX rats. ELD inhibited the increase in NOX4, nitrotyrosine, and p65 and the decrease in dimer\/monomer ratio of nitric oxide synthase in OVX rat femoral arteries. ELD also prevented the decrease in peroxisome proliferator-activated receptor gamma (PPAR\u03b3) in femoral arteries and cultured endothelial cells. Although PPAR\u03b3 is known to inhibit osteoblastogenesis, ELD understandably increased bone mineral density of OVX rats without increase in PPAR\u03b3 in bone marrow. These results suggest that ELD prevented the deterioration of endothelial function under condition of preventing bone loss in OVX rats. This endothelial protective effect of ELD might be exerted through improvement of endothelial nitric oxide synthase uncoupling, which is mediated by an antioxidative effect through normalization of vascular PPAR\u03b3\/NF-\u03baB signaling.<\/jats:p>","DOI":"10.1530\/joe-15-0332","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T22:23:36Z","timestamp":1446675816000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":12,"title":["Eldecalcitol prevents endothelial dysfunction in postmenopausal osteoporosis model rats"],"prefix":"10.1530","volume":"228","author":[{"given":"Kenichi","family":"Serizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Yogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2015121719381957000_228.2.75.1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0735"},{"key":"2015121719381957000_228.2.75.2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406486200"},{"key":"2015121719381957000_228.2.75.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.8.2496"},{"key":"2015121719381957000_228.2.75.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.176339"},{"key":"2015121719381957000_228.2.75.5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.206078"},{"key":"2015121719381957000_228.2.75.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.10.023"},{"key":"2015121719381957000_228.2.75.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01746-6"},{"key":"2015121719381957000_228.2.75.8","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.12.1340"},{"key":"2015121719381957000_228.2.75.9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr459"},{"key":"2015121719381957000_228.2.75.10","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.12"},{"key":"2015121719381957000_228.2.75.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2003.11.008"},{"key":"2015121719381957000_228.2.75.12","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1782"},{"key":"2015121719381957000_228.2.75.13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036617"},{"key":"2015121719381957000_228.2.75.14","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-7-34"},{"key":"2015121719381957000_228.2.75.15","doi-asserted-by":"publisher","DOI":"10.1038\/320454a0"},{"key":"2015121719381957000_228.2.75.16","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs536"},{"key":"2015121719381957000_228.2.75.17","doi-asserted-by":"crossref","unstructured":"Horwitz KB McGuire WL 1978 Estrogen control of progesterone receptor in human breast cancer. 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