{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:58:36Z","timestamp":1785862716022,"version":"3.56.0"},"reference-count":44,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    Anorexigenic neuropeptides produced and acting in the brain have the potential to decrease food intake and ameliorate obesity, but are ineffective after peripheral application, owing to a limited ability to cross the blood\u2013brain barrier. We have designed lipidized analogs of prolactin-releasing peptide (PrRP), which is involved in energy balance regulation as demonstrated by obesity phenotypes of both\n                    <jats:italic>Prrp<\/jats:italic>\n                    -knockout and\n                    <jats:italic>Prrp<\/jats:italic>\n                    receptor-knockout mice. The aim of this study was to characterize the subchronic effect of a palmitoylated PrRP analog in two rat models of obesity and diabetes: diet-induced obese Sprague\u2013Dawley rats and leptin receptor-deficient Zucker diabetic (ZDF) rats. In the rats with diet-induced obesity (DIO), a two-week intraperitoneal treatment with palmitoylated PrRP lowered food intake by 24% and body weight by 8%. This treatment also improved glucose tolerance and tended to decrease leptin levels and adipose tissue masses in a dose-dependent manner. In contrast, in ZDF rats, the same treatment with palmitoylated PrRP lowered food intake but did not significantly affect body weight or glucose tolerance, probably in consequence of severe leptin resistance due to a nonfunctional leptin receptor. Our data indicate a good efficacy of lipidized PrRP in DIO rats. Thus, the strong anorexigenic, body weight-reducing, and glucose tolerance-improving effects make palmitoylated PrRP an attractive candidate for anti-obesity treatment.\n                  <\/jats:p>","DOI":"10.1530\/joe-15-0519","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T23:09:14Z","timestamp":1456268954000},"page":"85-96","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":22,"title":["Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats"],"prefix":"10.1530","volume":"229","author":[{"given":"Martina","family":"Holubov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Zemenov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"Mikul\u00e1\u0161kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edra","family":"Panajotova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"St\u00f6hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Haluz\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Kune\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanka","family":"\u017delezn\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Malet\u00ednsk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2016060718191419000_229.2.85.1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00121.2014"},{"key":"2016060718191419000_229.2.85.2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s13679-015-0177-4","article-title":"Horizons in the pharmacotherapy of obesity","volume":"4","author":"Arch","year":"2015","journal-title":"Current Obesity Reports"},{"key":"2016060718191419000_229.2.85.3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.peptides.2012.09.033","article-title":"New analogs of the CART peptide with anorexigenic potency: the importance of individual disulfide bridges","volume":"39","author":"Blechov\u00e1","year":"2013","journal-title":"Peptides"},{"key":"2016060718191419000_229.2.85.4","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12328"},{"key":"2016060718191419000_229.2.85.5","doi-asserted-by":"crossref","unstructured":"Dodd GT Luckman SM 2013 Physiological roles of GPR10 and PrRP signaling. 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