{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:36:25Z","timestamp":1789623385731,"version":"build-2803163510"},"reference-count":58,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    Mammals meet the increased nutritional demands of lactation through a combination of increased feed intake and a collection of adaptations known as adaptive metabolism (e.g., glucose sparing via insulin resistance, mobilization of endogenous reserves, and increased metabolic efficiency via reduced thyroid hormones). In the modern dairy cow, adaptive metabolism predominates over increased feed intake at the onset of lactation and develops concurrently with a reduction in plasma leptin. To address the role of leptin in the adaptive metabolism of early lactation, we asked which adaptations could be countered by a constant 96-h intravenous infusion of human leptin (hLeptin) starting on day 8 of lactation. Compared to saline infusion (Control), hLeptin did not alter energy intake or milk energy output but caused a modest increase in body weight loss. hLeptin reduced plasma glucose by 9% and hepatic glycogen content by 73%, and these effects were associated with a 17% increase in glucose disposal during an insulin tolerance test. hLeptin attenuated the accumulation of triglyceride in the liver by 28% in the absence of effects on plasma levels of the anti-lipolytic hormone insulin or plasma levels of free fatty acids, a marker of lipid mobilization from adipose tissue. Finally, hLeptin increased the plasma concentrations of T\n                    <jats:sub>4<\/jats:sub>\n                    and T\n                    <jats:sub>3<\/jats:sub>\n                    by nearly 50% without affecting other neurally regulated hormones (i.e., cortisol and luteinizing hormone (LH)). Overall these data implicate the periparturient reduction in plasma leptin as one of the signals promoting conservation of glucose and energy at the onset of lactation in the energy-deficient dairy cow.\n                  <\/jats:p>","DOI":"10.1530\/joe-16-0031","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T21:54:41Z","timestamp":1457474081000},"page":"145-157","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":35,"title":["Increased plasma leptin attenuates adaptive metabolism in early lactating dairy cows"],"prefix":"10.1530","volume":"229","author":[{"given":"Richard A","family":"Ehrhardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Foskolos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L","family":"Giesy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R","family":"Wesolowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S","family":"Krumm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Ronald","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Quirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R","family":"Waldron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves R","family":"Boisclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2016060718191416000_229.2.145.1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.5.1555"},{"key":"2016060718191416000_229.2.145.2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00397.2011"},{"key":"2016060718191416000_229.2.145.3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.13.070193.002253"},{"key":"2016060718191416000_229.2.145.4","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.2527\/1995.7392804x","article-title":"Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation","volume":"73","author":"Bell","year":"1995","journal-title":"Journal of Animal Science"},{"key":"2016060718191416000_229.2.145.5","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1128\/MCB.19.2.1401","article-title":"A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation","volume":"19","author":"Besser","year":"1999","journal-title":"Molecular and Cellular Biology"},{"key":"2016060718191416000_229.2.145.6","doi-asserted-by":"publisher","DOI":"10.1071\/RD00102"},{"key":"2016060718191416000_229.2.145.7","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1710339"},{"key":"2016060718191416000_229.2.145.8","doi-asserted-by":"crossref","first-page":"24892","DOI":"10.1016\/S0021-9258(19)74549-9","article-title":"Three clustered Sp1 sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor-binding protein-2 from the rat","volume":"268","author":"Boisclair","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"2016060718191416000_229.2.145.9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10028"},{"key":"2016060718191416000_229.2.145.10","doi-asserted-by":"crossref","unstructured":"Boisclair YR Wesolowski SR Kim JW Ehrhardt RA 2006 Roles of growth hormone and leptin in the periparturient dairy cow. 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