{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:38:43Z","timestamp":1789785523613,"version":"4.0.1"},"reference-count":51,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>\n                    Hypocalcemia is a metabolic disorder that affects dairy cows during the transition from pregnancy to lactation. Twelve multiparous Holstein cows and twelve multiparous Jersey cows were intravenously infused daily for approximately 7 days prepartum with either saline or 1.0mg\/kg bodyweight of the immediate precursor to serotonin synthesis, 5hydroxy-\n                    <jats:sc>l<\/jats:sc>\n                    -tryptophan (5-HTP). On infusion days, blood was collected before, after, and at 2, 4, and 8h postinfusion. Blood and urine were collected daily before the infusion period, for 14 days postpartum and on day 30 postpartum. Milk was collected daily during the postpartum period. Feed intake and milk yield were unaffected by 5-HTP infusion postpartum. Cows infused with 5-HTP had elevated circulating serotonin concentrations prepartum. Infusion with 5-HTP induced a transient hypocalcemia in Jersey cows prepartum, but not in any other treatment. Holstein cows infused with saline had the highest milk calcium on the day of and day after parturition. Postpartum, circulating total calcium tended to be elevated, and urine deoxypyridinoline (DPD) concentrations were elevated in Holstein cows infused with 5-HTP. Overall, Jerseys had higher urine DPD concentrations postpartum when compared with Holsteins. Taken together, these data warrant further investigation of the potential therapeutic benefit of 5-HTP administration prepartum for prevention of hypocalcemia. Further research should focus on delineation of mechanisms associated with 5-HTP infusion that control calcium homeostasis during the peripartum period in Holstein and Jersey cows.\n                  <\/jats:p>","DOI":"10.1530\/joe-16-0038","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T21:59:24Z","timestamp":1467928764000},"page":"105-123","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":42,"title":["Elevation of circulating serotonin improves calcium dynamics in the peripartum dairy cow"],"prefix":"10.1530","volume":"230","author":[{"given":"Samantha R","family":"Weaver","sequence":"first","affiliation":[{"name":"1Department of Dairy ScienceUniversity of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin P","family":"Prichard","sequence":"additional","affiliation":[{"name":"1Department of Dairy ScienceUniversity of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L","family":"Endres","sequence":"additional","affiliation":[{"name":"1Department of Dairy ScienceUniversity of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie A","family":"Newhouse","sequence":"additional","affiliation":[{"name":"1Department of Dairy ScienceUniversity of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonia L","family":"Peters","sequence":"additional","affiliation":[{"name":"1Department of Dairy ScienceUniversity of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Crump","sequence":"additional","affiliation":[{"name":"2Department of Animal SciencesUniversity of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S","family":"Akins","sequence":"additional","affiliation":[{"name":"3Department of Dairy ScienceUniversity of Wisconsin-Madison, Marshfield, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D","family":"Crenshaw","sequence":"additional","affiliation":[{"name":"2Department of Animal SciencesUniversity of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert M","family":"Bruckmaier","sequence":"additional","affiliation":[{"name":"4Department of Veterinary PhysiologyVetsuisse Faculty, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L","family":"Hernandez","sequence":"additional","affiliation":[{"name":"1Department of Dairy ScienceUniversity of Wisconsin-Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2016070718585458000_230.1.105.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.11.009"},{"key":"2016070718585458000_230.1.105.2","doi-asserted-by":"publisher","DOI":"10.1017\/S002202990002714X"},{"key":"2016070718585458000_230.1.105.3","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010-4075"},{"key":"2016070718585458000_230.1.105.4","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(06)72116-6"},{"key":"2016070718585458000_230.1.105.5","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b14-00273"},{"key":"2016070718585458000_230.1.105.6","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731111002461"},{"key":"2016070718585458000_230.1.105.7","first-page":"61","article-title":"Comparison of some physiochemical properties of milk from Holstein-Friesian and Jersey cows","volume":"15","author":"Czerniewicz","year":"2006","journal-title":"Polish Journal of Food and Nutrition Sciences"},{"key":"2016070718585458000_230.1.105.8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tvjl.2007.12.029","article-title":"Milk fever in dairy cows: a review of pathophysiology and control principles","volume":"176","author":"DeGaris","year":"2009","journal-title":"Veterinary Journal"},{"key":"2016070718585458000_230.1.105.9","unstructured":"Drackley JK Guretzky NAJ 2007 Controlled energy diets for dry cows. 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