{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:52Z","timestamp":1784557252041,"version":"3.55.0"},"reference-count":53,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Adverse cardiac remodeling after myocardial infarction (MI) leads to progressive heart failure. Obese-insulin resistance increases risks of MI and heart failure. Although dipeptidyl peptidase-4 (DPP4) inhibitor is known to exert cardioprotection, its effects on adverse remodeling after MI in obese-insulin-resistant rats are unclear. We hypothesized that DPP4 inhibitor reduces adverse left ventricular (LV) remodeling and LV dysfunction in obese-insulin-resistant rats with MI. Rats were fed either normal diet (ND) or high-fat diet (HFD) for 12 weeks to induce obese-insulin resistance, followed by left anterior descending coronary artery ligation to induce MI. Then, rats in each dietary group were divided into five subgroups to receive vehicle, enalapril (10mg\/kg\/day), metformin (30mg\/kg\/day), DPP4 inhibitor vildagliptin (3mg\/kg\/day), or combined metformin and vildagliptin for 8 weeks. Heart rate variability (HRV), LV function, pathological and biochemical studies for LV remodeling, and cardiomyocyte apoptosis were determined. Obese-insulin-resistant rats had severe insulin resistance and LV dysfunction. HFD rats had a higher mortality rate than ND rats, and all treatments reduced the mortality rate in obese-insulin-resistant rats. Although all drugs improved insulin resistance, HRV, LV function as well as reduced cardiac hypertrophy and fibrosis, vildagliptin effectively reduced cardiomyocyte cross-sectional areas more than enalapril and was related to markedly decreased ERK1\/2 phosphorylation. In ND rats with MI, metformin neither improved LV ejection fraction nor reduced cardiac fibrosis. The infarct size and transforming growth factor-\u03b2 expression were not different among groups. In obese-insulin-resistant rats with chronic MI, DPP4 inhibitor vildagliptin exerts better cardioprotection than enalapril in attenuating adverse LV remodeling.<\/jats:p>","DOI":"10.1530\/joe-16-0096","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T21:49:28Z","timestamp":1459806568000},"page":"245-258","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":26,"title":["Effects of dipeptidyl peptidase-4 inhibitor in insulin-resistant rats with myocardial infarction"],"prefix":"10.1530","volume":"229","author":[{"given":"Nattayaporn","family":"Apaijai","sequence":"first","affiliation":[{"name":"1Cardiac Electrophysiology Research and Training CenterFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Cardiac Electrophysiology UnitDepartment of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"3Center of Excellence in Cardiac Electrophysiology ResearchChiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharnwimol","family":"Inthachai","sequence":"additional","affiliation":[{"name":"1Cardiac Electrophysiology Research and Training CenterFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suree","family":"Lekawanvijit","sequence":"additional","affiliation":[{"name":"1Cardiac Electrophysiology Research and Training CenterFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"4Department of PathologyFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C","family":"Chattipakorn","sequence":"additional","affiliation":[{"name":"1Cardiac Electrophysiology Research and Training CenterFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"3Center of Excellence in Cardiac Electrophysiology ResearchChiang Mai University, Chiang Mai, Thailand"},{"name":"5Department of Oral Biology and Diagnostic SciencesFaculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[{"name":"1Cardiac Electrophysiology Research and Training CenterFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Cardiac Electrophysiology UnitDepartment of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"3Center of Excellence in Cardiac Electrophysiology ResearchChiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2016062318390953000_229.3.245.1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1262"},{"key":"2016062318390953000_229.3.245.2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12176"},{"key":"2016062318390953000_229.3.245.3","doi-asserted-by":"crossref","unstructured":"Apaijai N Chinda K Palee S Chattipakorn S Chattipakorn N 2014 Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats. 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