{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:17Z","timestamp":1784557217299,"version":"3.55.0"},"reference-count":196,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>\n                    Organ transplantation is a useful therapeutic tool for patients with end-stage organ failure; however, graft rejection is a major obstacle in terms of a successful treatment. Rejection is usually a consequence of a complex immunological and nonimmunological antigen-independent cascade of events, including free radical-mediated ischemia-reperfusion injury (IRI). To reduce the frequency of this outcome, continuing improvements in the efficacy of antirejection drugs are a top priority to enhance the long-term survival of transplant recipients. Melatonin (\n                    <jats:italic>N<\/jats:italic>\n                    -acetyl-5-methoxytryptamine) is a powerful antioxidant and ant-inflammatory agent synthesized from the essential amino acid\n                    <jats:sc>l<\/jats:sc>\n                    -tryptophan; it is produced by the pineal gland as well as by many other organs including ovary, testes, bone marrow, gut, placenta, and liver. Melatonin has proven to be a potentially useful therapeutic tool in the reduction of graft rejection. Its benefits are based on its direct actions as a free radical scavenger as well as its indirect antioxidative actions in the stimulation of the cellular antioxidant defense system. Moreover, it has significant anti-inflammatory activity. Melatonin has been found to improve the beneficial effects of preservation fluids when they are enriched with the indoleamine. This article reviews the experimental evidence that melatonin is useful in reducing graft failure, especially in cardiac, bone, otolaryngology, ovarian, testicular, lung, pancreas, kidney, and liver transplantation.\n                  <\/jats:p>","DOI":"10.1530\/joe-16-0117","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:19:39Z","timestamp":1460420379000},"page":"R129-R146","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":33,"title":["Potential benefits of melatonin in organ transplantation: a review"],"prefix":"10.1530","volume":"229","author":[{"given":"Eduardo","family":"Esteban-Zubero","sequence":"first","affiliation":[{"name":"1Department of Pharmacology and PhysiologyUniversity of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Agust\u00edn","family":"Garc\u00eda-Gil","sequence":"additional","affiliation":[{"name":"2Department of SurgeryGynaecology and Obstetrics, University of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"L\u00f3pez-Pingarr\u00f3n","sequence":"additional","affiliation":[{"name":"3Department of MedicinePsychiatry and Dermatology, University of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s Alejandro","family":"Alatorre-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"4Department of Cellular and Structural BiologyUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"I\u00f1igo-Gil","sequence":"additional","affiliation":[{"name":"3Department of MedicinePsychiatry and Dermatology, University of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun-Xian","family":"Tan","sequence":"additional","affiliation":[{"name":"4Department of Cellular and Structural BiologyUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Joaqu\u00edn","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"1Department of Pharmacology and PhysiologyUniversity of Zaragoza, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russel J","family":"Reiter","sequence":"additional","affiliation":[{"name":"4Department of Cellular and Structural BiologyUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2016062318390947000_229.3.R129.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.06.032"},{"key":"2016062318390947000_229.3.R129.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1579-2"},{"key":"2016062318390947000_229.3.R129.3","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13060"},{"key":"2016062318390947000_229.3.R129.4","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880020073018"},{"key":"2016062318390947000_229.3.R129.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.09.018"},{"key":"2016062318390947000_229.3.R129.6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jncimonographs\/lgi005","article-title":"Disruption of spermatogenesis by the cancer disease process","volume":"34","author":"Agarwal","year":"2005","journal-title":"Journal of the National Cancer Institution Monographs"},{"key":"2016062318390947000_229.3.R129.7","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00590F"},{"key":"2016062318390947000_229.3.R129.8","doi-asserted-by":"publisher","DOI":"10.1002\/path.1250"},{"key":"2016062318390947000_229.3.R129.9","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26753"},{"key":"2016062318390947000_229.3.R129.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00214-015-1755-y"},{"key":"2016062318390947000_229.3.R129.11","doi-asserted-by":"publisher","DOI":"10.1177\/1553350610381088"},{"key":"2016062318390947000_229.3.R129.12","first-page":"794","article-title":"Effect of melatonin on kidney cold ischemic preservation injury","volume":"6","author":"Aslaner","year":"2013","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"2016062318390947000_229.3.R129.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.09.149"},{"key":"2016062318390947000_229.3.R129.14","first-page":"2849","article-title":"Cyclosporin A sensitivity of allo-specific precursor and committed cytotoxic T lymphocytes after clinical heart transplantation","volume":"26","author":"Baan","year":"1994","journal-title":"Transplantation Proceedings"},{"key":"2016062318390947000_229.3.R129.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.12.045"},{"key":"2016062318390947000_229.3.R129.16","doi-asserted-by":"publisher","DOI":"10.1038\/nature03434"},{"key":"2016062318390947000_229.3.R129.17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09225.x"},{"key":"2016062318390947000_229.3.R129.18","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(94)00154-M"},{"key":"2016062318390947000_229.3.R129.19","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12154"},{"key":"2016062318390947000_229.3.R129.20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i2.396"},{"key":"2016062318390947000_229.3.R129.21","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198803000-00041"},{"key":"2016062318390947000_229.3.R129.22","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.29"},{"key":"2016062318390947000_229.3.R129.23","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-1044-0"},{"key":"2016062318390947000_229.3.R129.24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01228.x"},{"key":"2016062318390947000_229.3.R129.25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/TP.0b013e3181e7a3aa","article-title":"AMP-activated protein kinase as a target for preconditioning in transplantation medicine","volume":"90","author":"Bouma","year":"2010","journal-title":"Transplantation"},{"key":"2016062318390947000_229.3.R129.26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.0954-6820.1988.tb17690.x","article-title":"Melatonin secretion related to side-effects of beta-blockers from the central nervous system","volume":"223","author":"Brismar","year":"1988","journal-title":"Acta Medica Scandinavica"},{"key":"2016062318390947000_229.3.R129.27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2141.2005.05740.x","article-title":"Subfertility in children and young people treated for solid and haematological malignancies","volume":"131","author":"Brougham","year":"2005","journal-title":"British Journal of Haematology"},{"key":"2016062318390947000_229.3.R129.28","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12443"},{"key":"2016062318390947000_229.3.R129.29","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38731.532766.F6"},{"key":"2016062318390947000_229.3.R129.30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/clr.12364","article-title":"New bone formation in bone defects after melatonin and porcine bone grafts: experimental study in rabbits","volume":"26","author":"Calvo-Guirado","year":"2015","journal-title":"Clinical Oral Implants Research"},{"key":"2016062318390947000_229.3.R129.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00521.x"},{"key":"2016062318390947000_229.3.R129.32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001026"},{"key":"2016062318390947000_229.3.R129.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.02.145"},{"key":"2016062318390947000_229.3.R129.34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00546.x"},{"key":"2016062318390947000_229.3.R129.35","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12198"},{"key":"2016062318390947000_229.3.R129.36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.00959.x"},{"key":"2016062318390947000_229.3.R129.37","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12234"},{"key":"2016062318390947000_229.3.R129.38","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/ajg.2009.171","article-title":"Melatonin arrhythmia is corrected after liver transplantation","volume":"104","author":"Cordoba","year":"2009","journal-title":"American Journal of Gastroenterology"},{"key":"2016062318390947000_229.3.R129.39","doi-asserted-by":"publisher","DOI":"10.1042\/bj3410233"},{"key":"2016062318390947000_229.3.R129.40","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-670SO"},{"key":"2016062318390947000_229.3.R129.41","first-page":"7","article-title":"A randomized study comparing IGL-1 to the University of Wisconsin preservation solution in liver transplantation","volume":"15","author":"Donder\u00f3","year":"2010","journal-title":"Annals of Transplantation"},{"key":"2016062318390947000_229.3.R129.42","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-005-0031-3"},{"key":"2016062318390947000_229.3.R129.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.03.016"},{"key":"2016062318390947000_229.3.R129.44","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1044401"},{"key":"2016062318390947000_229.3.R129.45","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20715"},{"key":"2016062318390947000_229.3.R129.46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03113.x"},{"key":"2016062318390947000_229.3.R129.47","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.201590"},{"key":"2016062318390947000_229.3.R129.48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02152.x"},{"key":"2016062318390947000_229.3.R129.49","doi-asserted-by":"publisher","DOI":"10.1139\/Y07-087"},{"key":"2016062318390947000_229.3.R129.50","first-page":"229","article-title":"In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia","volume":"20","author":"Freitas","year":"2006","journal-title":"In Vivo"},{"key":"2016062318390947000_229.3.R129.51","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der385"},{"key":"2016062318390947000_229.3.R129.52","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0990"},{"key":"2016062318390947000_229.3.R129.53","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12196"},{"key":"2016062318390947000_229.3.R129.54","doi-asserted-by":"publisher","DOI":"10.1007\/BF02829430"},{"key":"2016062318390947000_229.3.R129.55","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12128"},{"key":"2016062318390947000_229.3.R129.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.08.030"},{"key":"2016062318390947000_229.3.R129.57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00908.x"},{"key":"2016062318390947000_229.3.R129.58","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-012-9459-7"},{"key":"2016062318390947000_229.3.R129.59","first-page":"93","article-title":"Melatonin improves spermatogonial stem cells transplantation efficiency in azoospermic mice","volume":"17","author":"Gholami","year":"2014","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"2016062318390947000_229.3.R129.60","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02690707"},{"key":"2016062318390947000_229.3.R129.61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00006534-197201000-00005","article-title":"The fate of amputated tissues of the head and neck following replacement","volume":"48","author":"Grabb","year":"1972","journal-title":"Plastic and Reconstructive Surgery"},{"key":"2016062318390947000_229.3.R129.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.019"},{"key":"2016062318390947000_229.3.R129.63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00378.x"},{"key":"2016062318390947000_229.3.R129.64","first-page":"1906","article-title":"HTK solution is more effective than UW solution for cardiac preservation","volume":"28","author":"Gu","year":"1996","journal-title":"Transplantation Proceedings"},{"key":"2016062318390947000_229.3.R129.65","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:27:2:119"},{"key":"2016062318390947000_229.3.R129.66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2009.00701.x"},{"key":"2016062318390947000_229.3.R129.67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01087.x"},{"key":"2016062318390947000_229.3.R129.68","doi-asserted-by":"publisher","DOI":"10.1111\/and.12110"},{"key":"2016062318390947000_229.3.R129.69","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890100049008"},{"key":"2016062318390947000_229.3.R129.70","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1023\/A:1015952926016","article-title":"Role of nitric oxide in liver ischemia and reperfusion injury","volume":"234\u2013235","author":"Hines","year":"2002","journal-title":"Molecular and Cellular Biochemistry"},{"key":"2016062318390947000_229.3.R129.71","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(99)00037-6"},{"key":"2016062318390947000_229.3.R129.72","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200204000-00007"},{"key":"2016062318390947000_229.3.R129.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2007.03.009"},{"key":"2016062318390947000_229.3.R129.74","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000251723.97483.16"},{"key":"2016062318390947000_229.3.R129.75","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20280"},{"key":"2016062318390947000_229.3.R129.76","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03101-0"},{"key":"2016062318390947000_229.3.R129.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.12.011"},{"key":"2016062318390947000_229.3.R129.78","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80253-4"},{"key":"2016062318390947000_229.3.R129.79","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i45.16902"},{"key":"2016062318390947000_229.3.R129.80","first-page":"423","article-title":"Melatonin influences pancreatic cancerogenesis","volume":"29","author":"Jaworek","year":"2014","journal-title":"Histology Histopathology"},{"key":"2016062318390947000_229.3.R129.81","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/jpi.12089","article-title":"Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats","volume":"55","author":"Jim\u00e9nez-Aranda","year":"2013","journal-title":"Journal of Pineal Research"},{"key":"2016062318390947000_229.3.R129.82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2004.00133.x"},{"key":"2016062318390947000_229.3.R129.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.05.005"},{"key":"2016062318390947000_229.3.R129.84","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01481.x"},{"key":"2016062318390947000_229.3.R129.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.08.019"},{"key":"2016062318390947000_229.3.R129.86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2004.00178.x"},{"key":"2016062318390947000_229.3.R129.87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00504.x"},{"key":"2016062318390947000_229.3.R129.88","doi-asserted-by":"publisher","DOI":"10.1530\/REP-08-0226"},{"key":"2016062318390947000_229.3.R129.89","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.11.038"},{"key":"2016062318390947000_229.3.R129.90","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.06.012"},{"key":"2016062318390947000_229.3.R129.91","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2119\/molmed.2008.00117","article-title":"Melatonin: an established antioxidant worthy of use in clinical trials","volume":"15","author":"Korkmaz","year":"2009","journal-title":"Molecular Medicine"},{"key":"2016062318390947000_229.3.R129.92","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.7.1219"},{"key":"2016062318390947000_229.3.R129.93","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.23913"},{"key":"2016062318390947000_229.3.R129.94","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199904150-00022"},{"key":"2016062318390947000_229.3.R129.95","doi-asserted-by":"publisher","DOI":"10.1080\/713609354"},{"key":"2016062318390947000_229.3.R129.96","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000153160.82975.86"},{"key":"2016062318390947000_229.3.R129.97","doi-asserted-by":"publisher","DOI":"10.1007\/BF00410198"},{"key":"2016062318390947000_229.3.R129.98","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.4.370"},{"key":"2016062318390947000_229.3.R129.99","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150915924"},{"key":"2016062318390947000_229.3.R129.100","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2002.01869.x"},{"key":"2016062318390947000_229.3.R129.101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2009.00672.x"},{"key":"2016062318390947000_229.3.R129.102","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2014.934275"},{"key":"2016062318390947000_229.3.R129.103","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70177-4"},{"key":"2016062318390947000_229.3.R129.104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2009.00712.x"},{"key":"2016062318390947000_229.3.R129.105","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3892\/mmr.2014.2382","article-title":"Melatonin synergized with cyclosporine A improves cardiac allograft survival by suppressing inflammation and apoptosis","volume":"10","author":"Liu","year":"2014","journal-title":"Molecular Medicine Reports"},{"key":"2016062318390947000_229.3.R129.106","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.06.053"},{"key":"2016062318390947000_229.3.R129.107","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-7-27"},{"key":"2016062318390947000_229.3.R129.108","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12267"},{"key":"2016062318390947000_229.3.R129.109","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21372"},{"key":"2016062318390947000_229.3.R129.110","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12116"},{"key":"2016062318390947000_229.3.R129.111","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5638"},{"key":"2016062318390947000_229.3.R129.112","doi-asserted-by":"publisher","DOI":"10.1016\/1010-7940(94)90117-1"},{"key":"2016062318390947000_229.3.R129.113","first-page":"235","article-title":"Measurement of melatonin and 6-sulphatoxymelatonin","volume":"324","author":"Middleton","year":"2006","journal-title":"Methods in Molecular Biology"},{"key":"2016062318390947000_229.3.R129.114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2006.00651.x"},{"key":"2016062318390947000_229.3.R129.115","first-page":"67","article-title":"The protective effects of melatonin on the histological changes of testis in busulfan-treated adult mice","volume":"11","author":"Mohammadghasemi","year":"2010","journal-title":"Journal of Reproduction & Infertility"},{"key":"2016062318390947000_229.3.R129.116","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.06.032"},{"key":"2016062318390947000_229.3.R129.117","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-010-0668-4"},{"key":"2016062318390947000_229.3.R129.118","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00291.x"},{"key":"2016062318390947000_229.3.R129.119","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2010.498478"},{"key":"2016062318390947000_229.3.R129.120","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1140341"},{"key":"2016062318390947000_229.3.R129.121","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01643-1"},{"key":"2016062318390947000_229.3.R129.122","unstructured":"Orwig KE Schlatt S 2005 Cryopreservation and transplantation of spermatogonia and testicular tissue for preservation of male fertility. Journal of the National Cancer Institute Monographs 51\u201356. (doi:10.1093\/jncimonographs\/lgbib29)"},{"key":"2016062318390947000_229.3.R129.123","first-page":"117","article-title":"Melatonin, the RANKL\/RANK\/OPG system, and bone metabolism in girls with anorexia nervosa","volume":"61","author":"Ostrowska","year":"2010","journal-title":"Endokrynologia Polska"},{"key":"2016062318390947000_229.3.R129.124","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(97)00043-0"},{"key":"2016062318390947000_229.3.R129.125","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110093"},{"key":"2016062318390947000_229.3.R129.126","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1999.tb00619.x"},{"key":"2016062318390947000_229.3.R129.127","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.09.001"},{"key":"2016062318390947000_229.3.R129.128","doi-asserted-by":"crossref","unstructured":"Petrowsky H Clavien PA 2014 Principles of liver transplantation. In Transplantation of the Liver, edn 3 pp 582\u2013600. Eds Bulsuttil R Klintmalm G . Philadelphia, PA, USA: Elsevier Saunders.","DOI":"10.1016\/B978-1-4557-0268-8.00044-0"},{"key":"2016062318390947000_229.3.R129.129","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-015-1240-9"},{"key":"2016062318390947000_229.3.R129.130","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20913"},{"key":"2016062318390947000_229.3.R129.131","first-page":"336","article-title":"Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction","volume":"294","author":"Quiroz","year":"2008","journal-title":"American Journal of Physiology: Renal Physiology"},{"key":"2016062318390947000_229.3.R129.132","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502006000700012"},{"key":"2016062318390947000_229.3.R129.133","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.3.449"},{"key":"2016062318390947000_229.3.R129.134","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.124.1.1"},{"key":"2016062318390947000_229.3.R129.135","doi-asserted-by":"publisher","DOI":"10.1016\/1010-7940(93)90005-V"},{"key":"2016062318390947000_229.3.R129.136","doi-asserted-by":"publisher","DOI":"10.1007\/BF02253360"},{"key":"2016062318390947000_229.3.R129.137","doi-asserted-by":"publisher","DOI":"10.1080\/10409230903044914"},{"key":"2016062318390947000_229.3.R129.138","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.075655"},{"key":"2016062318390947000_229.3.R129.139","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)81008-4"},{"key":"2016062318390947000_229.3.R129.140","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14047231"},{"key":"2016062318390947000_229.3.R129.141","first-page":"373","article-title":"The universal nature, unequal distribution and antioxidant function of melatonin and its derivatives","volume":"13","author":"Reiter","year":"2014","journal-title":"Mini-Reviews in Medicinal Chemistry"},{"key":"2016062318390947000_229.3.R129.142","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-079X.2003.00092.x"},{"key":"2016062318390947000_229.3.R129.143","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6185"},{"key":"2016062318390947000_229.3.R129.144","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12132"},{"key":"2016062318390947000_229.3.R129.145","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.22041"},{"key":"2016062318390947000_229.3.R129.146","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.05.023"},{"key":"2016062318390947000_229.3.R129.147","doi-asserted-by":"publisher","DOI":"10.1159\/000369308"},{"key":"2016062318390947000_229.3.R129.148","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/01.tp.0000232310.49237.06","article-title":"Human islet isolation outcomes from pancreata preserved with Histidine-Tryptophan Ketoglutarate versus University of Wisconsin solution","volume":"82","author":"Salehi","year":"2006","journal-title":"Transplantation"},{"key":"2016062318390947000_229.3.R129.149","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-011-9287-2"},{"key":"2016062318390947000_229.3.R129.150","first-page":"350","article-title":"Effects of melatonin and oxytetracycline in autologous intraperitoneal ovary transplantation in rats","volume":"24","author":"Sapmaz","year":"2003","journal-title":"Neuroendocrinology Letters"},{"key":"2016062318390947000_229.3.R129.151","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2003.00073.x"},{"key":"2016062318390947000_229.3.R129.152","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12933"},{"key":"2016062318390947000_229.3.R129.153","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00573-0"},{"key":"2016062318390947000_229.3.R129.154","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.36244"},{"key":"2016062318390947000_229.3.R129.155","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500010311"},{"key":"2016062318390947000_229.3.R129.156","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000157773.96534.29"},{"key":"2016062318390947000_229.3.R129.157","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.04.014"},{"key":"2016062318390947000_229.3.R129.158","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00788.x"},{"key":"2016062318390947000_229.3.R129.159","doi-asserted-by":"publisher","DOI":"10.1159\/000433521"},{"key":"2016062318390947000_229.3.R129.160","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(97)00999-8"},{"key":"2016062318390947000_229.3.R129.161","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20021"},{"key":"2016062318390947000_229.3.R129.162","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199202010-00007"},{"key":"2016062318390947000_229.3.R129.163","first-page":"456","article-title":"Improved heart preservation with UW preservation solution","volume":"7","author":"Swanson","year":"1988","journal-title":"Journal of Heart Transplantation"},{"key":"2016062318390947000_229.3.R129.164","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-008-3416-3"},{"key":"2016062318390947000_229.3.R129.165","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.05.016"},{"key":"2016062318390947000_229.3.R129.166","first-page":"57","article-title":"Melatonin: a potent, endogenous hydroxyl radical scavenger","volume":"1","author":"Tan","year":"1993","journal-title":"Endocrine Journal"},{"key":"2016062318390947000_229.3.R129.167","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0304-4165(99)00125-7","article-title":"Identification of highly elevated levels of melatonin in bone marrow: its origin and significance","volume":"1472","author":"Tan","year":"1999","journal-title":"Biochimica et Biophysica Acta"},{"key":"2016062318390947000_229.3.R129.168","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03056.x"},{"key":"2016062318390947000_229.3.R129.169","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1515\/hmbci-2013-0041","article-title":"Beneficial effect of melatonin treatment on age-related insulin resistance and on the development of type 2 diabetes","volume":"16","author":"Tresguerres","year":"2013","journal-title":"Hormone Molecular Biology and Clinical Investigation"},{"key":"2016062318390947000_229.3.R129.170","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-003-0528-9"},{"key":"2016062318390947000_229.3.R129.171","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2004.00193.x"},{"key":"2016062318390947000_229.3.R129.172","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2823"},{"key":"2016062318390947000_229.3.R129.173","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00931.x"},{"key":"2016062318390947000_229.3.R129.174","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.108506"},{"key":"2016062318390947000_229.3.R129.175","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.01.036"},{"key":"2016062318390947000_229.3.R129.176","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.01.026"},{"key":"2016062318390947000_229.3.R129.177","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.08.024"},{"key":"2016062318390947000_229.3.R129.178","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1659-3"},{"key":"2016062318390947000_229.3.R129.179","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12189"},{"key":"2016062318390947000_229.3.R129.180","doi-asserted-by":"publisher","DOI":"10.1159\/000086079"},{"key":"2016062318390947000_229.3.R129.181","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00215.x"},{"key":"2016062318390947000_229.3.R129.182","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.08.005"},{"key":"2016062318390947000_229.3.R129.183","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/01.sla.0000080830.77437.4f","article-title":"Endothelin(A) receptor blockade reduces ischemia\/reperfusion injury in pig pancreas transplantation","volume":"238","author":"Witzigmann","year":"2003","journal-title":"Annals of Surgery"},{"key":"2016062318390947000_229.3.R129.184","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000100683.92689.27"},{"key":"2016062318390947000_229.3.R129.185","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2009.01047.x"},{"key":"2016062318390947000_229.3.R129.186","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.10.003"},{"key":"2016062318390947000_229.3.R129.187","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667"},{"key":"2016062318390947000_229.3.R129.188","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903547836"},{"key":"2016062318390947000_229.3.R129.189","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i45.5693"},{"key":"2016062318390947000_229.3.R129.190","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i28.3499"},{"key":"2016062318390947000_229.3.R129.191","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2012.12.005"},{"key":"2016062318390947000_229.3.R129.192","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12051"},{"key":"2016062318390947000_229.3.R129.193","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.11.601"},{"key":"2016062318390947000_229.3.R129.194","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1097\/TP.0b013e31819e04c3","article-title":"Primary graft dysfunction in lung transplantation: the role of CD26\/dipeptidylpeptidase IV and vasoactive intestinal peptide","volume":"27","author":"Zhai","year":"2009","journal-title":"Transplantation"},{"key":"2016062318390947000_229.3.R129.195","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03579.x"},{"key":"2016062318390947000_229.3.R129.196","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12162"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/229\/3\/R129.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/229\/3\/R129.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:55:24Z","timestamp":1784555724000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/229\/3\/R129-R146\/22855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":196,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/joe-16-0117","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}