{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:29:13Z","timestamp":1790270953163,"version":"4.1.0"},"reference-count":37,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n                    Germline mutations in the aryl hydrocarbon receptor-interacting protein (\n                    <jats:italic>AIP<\/jats:italic>\n                    ) gene predispose humans to pituitary adenomas, particularly of the somatotroph lineage. Mice with global heterozygous inactivation of\n                    <jats:italic>Aip<\/jats:italic>\n                    (\n                    <jats:italic>Aip<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    ) also develop pituitary adenomas but differ from\n                    <jats:italic>AIP<\/jats:italic>\n                    -mutated patients by the high penetrance of pituitary disease. The endocrine phenotype of these mice is unknown. The aim of this study was to determine the endocrine phenotype of\n                    <jats:italic>Aip<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice by assessing the somatic growth, ultradian pattern of GH secretion and IGF1 concentrations of longitudinally followed male mice at 3 and 12\u2009months of age. As the early stages of pituitary tumorigenesis are controversial, we also studied the pituitary histology and somatotroph cell proliferation in these mice.\n                    <jats:italic>Aip<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice did not develop gigantism but exhibited a leaner phenotype than wild-type mice. Analysis of GH pulsatility by deconvolution in 12-month-old\n                    <jats:italic>Aip<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice showed a mild increase in total GH secretion, a conserved GH pulsatility pattern, but a normal IGF1 concentration. No pituitary adenomas were detected up to 12\u2009months of age. An increased\n                    <jats:italic>ex vivo<\/jats:italic>\n                    response to GHRH of pituitary explants from 3-month-old\n                    <jats:italic>Aip<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice, together with areas of enlarged acini identified on reticulin staining in the pituitary of some\n                    <jats:italic>Aip<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice, was suggestive of somatotroph hyperplasia. Global heterozygous\n                    <jats:italic>Aip<\/jats:italic>\n                    deficiency in mice is accompanied by subtle increase in GH secretion, which does not result in gigantism. The absence of pituitary adenomas in 12-month-old\n                    <jats:italic>Aip<\/jats:italic>\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice in our experimental conditions demonstrates the important phenotypic variability of this congenic mouse model.\n                  <\/jats:p>","DOI":"10.1530\/joe-16-0190","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T20:50:29Z","timestamp":1473713429000},"page":"59-69","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":18,"title":["Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice"],"prefix":"10.1530","volume":"231","author":[{"given":"Anne-Lise","family":"Lecoq","sequence":"first","affiliation":[{"name":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm) U1185Le Kremlin-Bic\u00eatre, France"},{"name":"2Universit\u00e9 Paris-SudFacult\u00e9 de M\u00e9decine Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Zizzari","sequence":"additional","affiliation":[{"name":"3Inserm U894Centre de Psychiatrie et Neurosciences, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Hage","sequence":"additional","affiliation":[{"name":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm) U1185Le Kremlin-Bic\u00eatre, France"},{"name":"2Universit\u00e9 Paris-SudFacult\u00e9 de M\u00e9decine Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyvianne","family":"Decourtye","sequence":"additional","affiliation":[{"name":"4Sorbonne Universit\u00e9sUniv Paris 06 UMRS 938, Inserm U938, CDR Saint-Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clovis","family":"Adam","sequence":"additional","affiliation":[{"name":"5Assistance Publique-H\u00f4pitaux de ParisService d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Bic\u00eatre, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Say","family":"Viengchareun","sequence":"additional","affiliation":[{"name":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm) U1185Le Kremlin-Bic\u00eatre, France"},{"name":"2Universit\u00e9 Paris-SudFacult\u00e9 de M\u00e9decine Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes D","family":"Veldhuis","sequence":"additional","affiliation":[{"name":"6Department of MedicineEndocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Geoffroy","sequence":"additional","affiliation":[{"name":"7Inserm U1132H\u00f4pital Lariboisi\u00e8re, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lomb\u00e8s","sequence":"additional","affiliation":[{"name":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm) U1185Le Kremlin-Bic\u00eatre, France"},{"name":"2Universit\u00e9 Paris-SudFacult\u00e9 de M\u00e9decine Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Tolle","sequence":"additional","affiliation":[{"name":"3Inserm U894Centre de Psychiatrie et Neurosciences, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Guillou","sequence":"additional","affiliation":[{"name":"8Unit\u00e9 Mixte de Recherche-5203Centre National de la Recherche Scientifique, Institut de Ge\u0301nomique Fonctionnelle, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auli","family":"Karhu","sequence":"additional","affiliation":[{"name":"9Department of Medical GeneticsGenome-Scale Biology Research Program Biomedicum, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Kappeler","sequence":"additional","affiliation":[{"name":"4Sorbonne Universit\u00e9sUniv Paris 06 UMRS 938, Inserm U938, CDR Saint-Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[{"name":"1Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 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