{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:19Z","timestamp":1784557219631,"version":"3.55.0"},"reference-count":64,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    Estradiol-17\u03b2 (E\n                    <jats:sub>2<\/jats:sub>\n                    ) plays critical roles in female maturation, sexual receptivity, ovulation and fertility. In many mammals, contact with males can similarly affect these female parameters, whereas male excretions contain significant quantities of E\n                    <jats:sub>2<\/jats:sub>\n                    . We administered radiolabeled estradiol ([\n                    <jats:sup>3<\/jats:sup>\n                    H]E\n                    <jats:sub>2<\/jats:sub>\n                    ) to male mice in doses representing a small fraction of their endogenous E\n                    <jats:sub>2<\/jats:sub>\n                    . These males were paired with sexually receptive females, and radioactivity was traced into the females\u2019 systems. In Experiment 1, males were given [\n                    <jats:sup>3<\/jats:sup>\n                    H]E\n                    <jats:sub>2<\/jats:sub>\n                    at 24 and 1\u2009h before mating. Male-to-female [\n                    <jats:sup>3<\/jats:sup>\n                    H]E\n                    <jats:sub>2<\/jats:sub>\n                    transfer intensified with increasing numbers of intromissions and spiked in the uterus after insemination. In Experiment 2, sexually experienced young males received [\n                    <jats:sup>3<\/jats:sup>\n                    H]E\n                    <jats:sub>2<\/jats:sub>\n                    at 72 and 24\u2009h before mating, and all mated to ejaculation. The copulatory plug deposited in the female reproductive tract contained substantial levels of radioactivity. The uteri, other tissues and blood serum of females displayed radioactivity indicative of E\n                    <jats:sub>2<\/jats:sub>\n                    transfer. In Experiment 3, radioactivity was observed 3 and 18\u2009h after insemination in the females\u2019 uteri and other tissues, including parts of the brain. In Experiment 4, we observed substantial levels of radioactivity in semen as well as the copulatory plugs retrieved from the females after mating. Transferred E\n                    <jats:sub>2<\/jats:sub>\n                    could directly affect abundant estrogen receptors in the female reproductive tract without potential metabolism by the liver. Sexually transferred E\n                    <jats:sub>2<\/jats:sub>\n                    may facilitate uterine preparation for blastocyst implantation. These data converge with several lines of evidence indicating that male-sourced E\n                    <jats:sub>2<\/jats:sub>\n                    can transfer to proximate females in bioactive form, contributing to various mammalian pheromonal effects.\n                  <\/jats:p>","DOI":"10.1530\/joe-16-0247","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T21:20:12Z","timestamp":1475788812000},"page":"245-257","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":13,"title":["Absorption and distribution of estradiol from male seminal emissions during mating"],"prefix":"10.1530","volume":"231","author":[{"given":"Denys","family":"deCatanzaro","sequence":"first","affiliation":[{"name":"Department of PsychologyNeuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of PsychologyNeuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2016110118350602000_231.3.245.1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-3-447"},{"key":"2016110118350602000_231.3.245.2","doi-asserted-by":"publisher","DOI":"10.1053\/beem.2002.0177"},{"key":"2016110118350602000_231.3.245.3","first-page":"435","article-title":"Uptake of radioactivity by body tissues and fluids in rhesus monkeys after intravenous injection or intranasal spray of tritium-labelled oestradiol and progesterone","volume":"43","author":"Anand Kumar","year":"1974","journal-title":"Current Science"},{"key":"2016110118350602000_231.3.245.4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0090-9556(25)08752-5","article-title":"Nasal absorption and metabolism of progesterone and 17\u03b2-estradiol in the rat","volume":"17","author":"Bawarshi-Nassar","year":"1989","journal-title":"Drug Metabolism and Disposition"},{"key":"2016110118350602000_231.3.245.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.03.001"},{"key":"2016110118350602000_231.3.245.6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-949521"},{"key":"2016110118350602000_231.3.245.7","doi-asserted-by":"publisher","DOI":"10.1210\/endo-96-2-511"},{"key":"2016110118350602000_231.3.245.8","doi-asserted-by":"publisher","DOI":"10.1210\/endo-94-6-1704"},{"key":"2016110118350602000_231.3.245.9","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(92)90031-L"},{"key":"2016110118350602000_231.3.245.10","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(87)90324-4"},{"key":"2016110118350602000_231.3.245.11","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod11.3.268"},{"key":"2016110118350602000_231.3.245.12","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.11.4613"},{"key":"2016110118350602000_231.3.245.13","doi-asserted-by":"publisher","DOI":"10.1210\/endo-105-5-1128"},{"key":"2016110118350602000_231.3.245.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.08.003"},{"key":"2016110118350602000_231.3.245.15","doi-asserted-by":"publisher","DOI":"10.1037\/h0077550"},{"key":"2016110118350602000_231.3.245.16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1037\/0735-7036.103.4.381","article-title":"Partial mediation of strange-male-induced pregnancy blocks by sexual activity in mice (Mus musculus)","volume":"13","author":"deCatanzaro","year":"1989","journal-title":"Journal of Comparative Psychology"},{"key":"2016110118350602000_231.3.245.17","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(91)90036-S"},{"key":"2016110118350602000_231.3.245.18","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1060269"},{"key":"2016110118350602000_231.3.245.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00554-8"},{"key":"2016110118350602000_231.3.245.20","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00965"},{"key":"2016110118350602000_231.3.245.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2008.10.013"},{"key":"2016110118350602000_231.3.245.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.12.046"},{"key":"2016110118350602000_231.3.245.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2014.09.011"},{"key":"2016110118350602000_231.3.245.24","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0020"},{"key":"2016110118350602000_231.3.245.25","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0500017"},{"key":"2016110118350602000_231.3.245.26","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod20.2.269"},{"key":"2016110118350602000_231.3.245.27","doi-asserted-by":"crossref","unstructured":"Freeman ME 2006 Neuroendocrine control of the ovarian cycle of the rat. 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