{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:50:02Z","timestamp":1790254202235,"version":"4.1.0"},"reference-count":40,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n                    Somatostatin analogs (SSA) are the mainstay of pharmacological treatment for pituitary adenomas. However, some patients escape from therapy with octreotide, a somatostatin receptor 2 (sst2)-preferring SSA, and pasireotide, a novel multi-sst-preferring SSA, may help to overcome this problem. It has been proposed that correspondence between sst1-sst5 expression pattern and SSA-binding profile could predict patient\u2019s response. To explore the cellular\/molecular features associated with octreotide\/pasireotide response, we performed a parallel comparison of their\n                    <jats:italic>in vitro<\/jats:italic>\n                    effects, evaluating sst1-sst5 expression, intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling ([Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    ), hormone secretion and cell viability, in a series of 85 pituitary samples. Somatotropinomas expressed sst5&gt;sst2, yet octreotide reduced [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    more efficiently than pasireotide, while both SSA similarly decreased growth hormone release\/expression and viability. Corticotropinomas predominantly expressed sst5, but displayed limited response to pasireotide, while octreotide reduced functional endpoints. Non-functioning adenomas preferentially expressed sst3 but, surprisingly, both SSA increased cell viability. Prolactinomas mainly expressed sst1 but were virtually unresponsive to SSA. Finally, both SSA decreased [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>i<\/jats:sub>\n                    in normal pituitaries. In conclusion, both SSA act\n                    <jats:italic>in vitro<\/jats:italic>\n                    on pituitary adenomas exerting both similar and distinct effects; however, no evident correspondence was found with the sst1-sst5 profile. Thus, it seems plausible that additional factors, besides the simple abundance of a given sst, critically influence the SSA response.\n                  <\/jats:p>","DOI":"10.1530\/joe-16-0332","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T21:55:47Z","timestamp":1472766947000},"page":"135-145","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":66,"title":["Octreotide and pasireotide (dis)similarly inhibit pituitary tumor cells in vitro"],"prefix":"10.1530","volume":"231","author":[{"given":"Alejandro","family":"Ib\u00e1\u00f1ez-Costa","sequence":"first","affiliation":[{"name":"1Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)C\u00f3rdoba, Spain"},{"name":"2Department of Cell BiologyPhysiology and Immunology, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"},{"name":"3Hospital Universitario Reina Sof\u00edaC\u00f3rdoba, Spain"},{"name":"4CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERObn)C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rivero-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"1Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)C\u00f3rdoba, Spain"},{"name":"2Department of Cell BiologyPhysiology and Immunology, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"},{"name":"3Hospital Universitario Reina Sof\u00edaC\u00f3rdoba, Spain"},{"name":"4CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERObn)C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari C","family":"V\u00e1zquez-Borrego","sequence":"additional","affiliation":[{"name":"1Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)C\u00f3rdoba, Spain"},{"name":"2Department of Cell BiologyPhysiology and Immunology, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"},{"name":"3Hospital Universitario Reina Sof\u00edaC\u00f3rdoba, Spain"},{"name":"4CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERObn)C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel D","family":"Gahete","sequence":"additional","affiliation":[{"name":"1Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)C\u00f3rdoba, Spain"},{"name":"2Department of Cell BiologyPhysiology and Immunology, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"},{"name":"3Hospital Universitario Reina Sof\u00edaC\u00f3rdoba, Spain"},{"name":"4CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERObn)C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Jim\u00e9nez-Reina","sequence":"additional","affiliation":[{"name":"1Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)C\u00f3rdoba, Spain"},{"name":"5Department of Morphological SciencesUniversidad de C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Venegas-Moreno","sequence":"additional","affiliation":[{"name":"6Metabolism and Nutrition UnitHospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"de la Riva","sequence":"additional","affiliation":[{"name":"7Service of NeurosurgeryHospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Arr\u00e1ez","sequence":"additional","affiliation":[{"name":"8Neurosurgical DepartmentCarlos Haya Hospital, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Gonz\u00e1lez-Molero","sequence":"additional","affiliation":[{"name":"9Department of Endocrinology and NutritionCarlos Haya Hospital, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert A","family":"Schmid","sequence":"additional","affiliation":[{"name":"10Novartis Pharma AGNovartis Institutes for Biomedical Research, Oncology, CH-4057 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Maraver-Selfa","sequence":"additional","affiliation":[{"name":"11Service of Endocrinology and NutritionHospital Cl\u00ednico Universitario Virgen de la Victoria, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Gavil\u00e1n-Villarejo","sequence":"additional","affiliation":[{"name":"12Endocrinology and Nutrition UnitHospital Universitario Puerta del Mar, C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Garc\u00eda-Arn\u00e9s","sequence":"additional","affiliation":[{"name":"9Department of Endocrinology and NutritionCarlos Haya Hospital, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A","family":"Jap\u00f3n","sequence":"additional","affiliation":[{"name":"13Department of PathologyHospital Universitario Virgen del Roc\u00edo, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Soto-Moreno","sequence":"additional","affiliation":[{"name":"6Metabolism and Nutrition UnitHospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A","family":"G\u00e1lvez","sequence":"additional","affiliation":[{"name":"1Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)C\u00f3rdoba, Spain"},{"name":"14Service of Endocrinology and NutritionHospital Universitario Reina Sof\u00eda, C\u00f3rdoba, 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