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The last 30 years of research have demonstrated that MR is a functional hormone-activated transcription factor in vascular smooth muscle cells and endothelial cells. This review summarizes advances in our understanding of the role of vascular MR in regulating blood pressure and vascular function, and its contribution to vascular disease. Specifically, vascular MR contributes directly to blood pressure control and to vascular dysfunction and remodeling in response to hypertension, obesity and vascular injury. The literature is summarized with respect to the role of vascular MR in conditions including: pulmonary hypertension; cerebral vascular remodeling and stroke; vascular inflammation, atherosclerosis and myocardial infarction; acute kidney injury; and vascular pathology in the eye. Considerations regarding the impact of age and sex on the function of vascular MR are also described. Further investigation of the precise molecular mechanisms by which MR contributes to these processes will aid in the identification of novel therapeutic targets to reduce cardiovascular disease (CVD)-related morbidity and mortality.<\/jats:p>","DOI":"10.1530\/joe-17-0009","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T20:10:21Z","timestamp":1497989421000},"page":"T67-T82","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":95,"title":["30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature"],"prefix":"10.1530","volume":"234","author":[{"given":"Jennifer J","family":"DuPont","sequence":"first","affiliation":[{"name":"Molecular Cardiology Research InstituteTufts Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris Z","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Molecular Cardiology Research InstituteTufts Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2017062017101032000_234.1.T67.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.5.1099"},{"key":"2017062017101032000_234.1.T67.2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.312"},{"key":"2017062017101032000_234.1.T67.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037703"},{"key":"2017062017101032000_234.1.T67.4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/HYPERTENSIONAHA.115.06054","article-title":"Rac1-mediated activation of mineralocorticoid receptor in pressure overload-induced cardiac injury","volume":"67","author":"Ayuzawa","year":"2016","journal-title":"Hypertension"},{"key":"2017062017101032000_234.1.T67.5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014121216"},{"key":"2017062017101032000_234.1.T67.6","doi-asserted-by":"crossref","unstructured":"Barrera-Chimal J Andr\u00e9-Gr\u00e9goire G Nguyen Dinh Cat A Lechner SM Cau J Prince S Kolkhof P Loirand G Sauzeau V Hauet T 2017 Benefit of mineralocorticoid receptor antagonism in AKI: Role of vascular smooth muscle Rac1. 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