{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:58Z","timestamp":1784557258791,"version":"3.55.0"},"reference-count":124,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>\n                    The mechanisms of vascular alterations resulting from early thyroid hormones deficiency are poorly understood. We tested the hypothesis that antenatal\/early postnatal hypothyroidism would alter the activity of endothelial NO pathway and Rho-kinase pathway, which are specific for developing vasculature. Dams were treated with propylthiouracil (PTU, 7\u2009ppm) in drinking water during gestation and 2 weeks after delivery, and their progeny had normal body weight but markedly reduced blood levels of thyroid hormones (ELISA). Small arteries from 2-week-old male pups were studied using wire myography, qPCR and Western blotting. Mesenteric arteries of PTU pups, compared to controls, demonstrated smaller maximum response to \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -adrenergic agonist methoxamine and reduced mRNA contents of smooth muscle differentiation markers \u03b1-actin and SERCA2A. Inhibition of basal NO synthesis by\n                    <jats:sc>l<\/jats:sc>\n                    -NNA led to tonic contraction of mesenteric arteries and augmented their contractile responses to methoxamine; both\n                    <jats:sc>l<\/jats:sc>\n                    -NNA effects were impaired in PTU pups. PTU pups demonstrated lower blood level of NO metabolites compared to control group (Griess reaction). Rho-kinase inhibitor Y27632 strongly reduced mesenteric arteries responses to methoxamine in PTU pups, that was accompanied by elevated Rho-kinase content in their arteries in comparison to control ones. Unlike mesenteric, saphenous arteries of PTU pups, compared to controls, had no changes in \u03b1-actin and SERCA2A contents and in responses to\n                    <jats:sc>l<\/jats:sc>\n                    -NNA and Y27632. In conclusion, thyroid hormones deficiency suppresses the anticontractile effect of NO and potentiates the procontractile Rho-kinase effects in mesenteric arteries of 2-week-old pups. Such alterations disturb perinatal cardiovascular homeostasis and might lead to cardiovascular pathologies in adulthood.\n                  <\/jats:p>","DOI":"10.1530\/joe-17-0225","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T20:30:17Z","timestamp":1502310617000},"page":"137-151","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":10,"title":["Antenatal\/early postnatal hypothyroidism alters arterial tone regulation in 2-week-old rats"],"prefix":"10.1530","volume":"235","author":[{"given":"Svetlana I","family":"Sofronova","sequence":"first","affiliation":[{"name":"1Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia"},{"name":"2Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina K","family":"Gaynullina","sequence":"additional","affiliation":[{"name":"1Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia"},{"name":"2Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia"},{"name":"3Department of Physiology, Russian National Research Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia A","family":"Shvetsova","sequence":"additional","affiliation":[{"name":"1Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia"},{"name":"2Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A","family":"Borzykh","sequence":"additional","affiliation":[{"name":"1Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina K","family":"Selivanova","sequence":"additional","affiliation":[{"name":"1Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia"},{"name":"2Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria S","family":"Kostyunina","sequence":"additional","affiliation":[{"name":"1Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia"},{"name":"2Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna P","family":"Sharova","sequence":"additional","affiliation":[{"name":"1Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey A","family":"Martyanov","sequence":"additional","affiliation":[{"name":"1Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia"},{"name":"2Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga S","family":"Tarasova","sequence":"additional","affiliation":[{"name":"1Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia"},{"name":"2Faculty of Biology, M.V. 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