{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:00Z","timestamp":1784557200843,"version":"3.55.0"},"reference-count":138,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>\n                    Many hormones\/cytokines are secreted in response to exercise and cytokine signaling may play a pivotal role in the training adaptations. To investigate the importance of cytokine signaling during vertical ladder climbing, a resistance exercise model, we produced mice lacking SOCS3 protein exclusively in steroidogenic factor-1 (SF1) cells (SF1 Socs3 KO mice). SF1 expression is found in steroidogenic cells of the adrenal cortex and gonads, as well as in neurons of the ventromedial nucleus of the hypothalamus. Histological markers of the fetal adrenal zone (or X-zone in rodents) were still present in adult males and postpartum SF1 Socs3 KO females, suggesting a previously unrecognized effect of SOCS3 on the terminal differentiation of the adrenal gland. This change led to a distinct distribution of lipid droplets along the adrenal cortex. Under basal conditions, adult SF1 Socs3 KO mice exhibited similar adrenal weight, and plasma ACTH and corticosterone concentrations. Nonetheless, SF1 Socs3 KO mice exhibited a blunted ACTH-induced corticosterone secretion. The overall metabolic responses induced by resistance training remained unaffected in SF1 Socs3 KO mice, including changes in body adiposity, glucose tolerance and energy expenditure. However, training performance and glucose control during intense resistance exercise were impaired in SF1 Socs3 KO mice. Furthermore, a reduced counter-regulatory response to 2-deoxy-\n                    <jats:sc>d<\/jats:sc>\n                    -glucose was observed in mutant mice. These findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects. Therefore, cytokine signaling in SF1 cells exerts an important role to sustain training performance possibly by promoting the necessary metabolic adjustments during exercise.\n                  <\/jats:p>","DOI":"10.1530\/joe-17-0255","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T21:00:18Z","timestamp":1505250018000},"page":"207-222","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":16,"title":["SOCS3 expression in SF1 cells regulates adrenal differentiation and exercise performance"],"prefix":"10.1530","volume":"235","author":[{"given":"Jo\u00e3o A B","family":"Pedroso","sequence":"first","affiliation":[{"name":"1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro O R","family":"de Mendonca","sequence":"additional","affiliation":[{"name":"2Department of Anatomy, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A S","family":"Fortes","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Tomaz","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor L","family":"Pecorali","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais B","family":"Auricino","sequence":"additional","affiliation":[{"name":"2Department of Anatomy, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael C","family":"Costa","sequence":"additional","affiliation":[{"name":"2Department of Anatomy, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro B","family":"Lima","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora C","family":"Furigo","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora N","family":"Bueno","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M","family":"Ramos-Lobo","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudimara F P","family":"Lotfi","sequence":"additional","affiliation":[{"name":"2Department of Anatomy, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Donato","sequence":"additional","affiliation":[{"name":"1Department 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Research"},{"key":"ref691","first-page":"260","article-title":"Altered sympathetic control of nutrient mobilization during physical exercise after lesions in the of","year":"1991","journal-title":"American Journal Physiology"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1538\/expanim.44.285","article-title":"Comparison of adrenocortical zonation in C57BL\/6J and DDD mice","volume":"44","year":"1995","journal-title":"Experimental Animals"},{"key":"ref51","first-page":"541","article-title":"Mechanisms of the development of obesity in animals with hypothalamic lesions","volume":"25","year":"1946","journal-title":"Physiological Reviews"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2013.11.050","article-title":"Possible crosstalk between leptin and prolactin during pregnancy","volume":"259","year":"2014","journal-title":"Neuroscience"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1210\/en.2014-1276","article-title":"Leptin resistance is not the primary cause of weight gain associated with reduced sex hormone levels in female mice","volume":"155","year":"2014","journal-title":"Endocrinology"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tem.2006.09.007","article-title":"Attenuation of leptin and insulin signaling by SOCS proteins","volume":"17","year":"2006","journal-title":"Trends Endocrinology and Metabolism"},{"key":"ref1291","first-page":"38","article-title":"Neural pathways that control the glucose counterregulatory response","volume":"8","year":"2014","journal-title":"Frontiers in Neuroscience"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0026-0495(86)90132-0","article-title":"Magnitude and duration of excess postexercise oxygen consumption in healthy young subjects","volume":"35","year":"1986","journal-title":"Metabolism"},{"key":"ref01","first-page":"260","article-title":"Altered sympathetic control of nutrient mobilization during physical exercise after lesions in the of","year":"1991","journal-title":"American Journal Physiology"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1440-2440(99)80172-8","article-title":"Physiological determinants of endurance exercise performance","volume":"2","year":"1999","journal-title":"Journal of Science and Medicine in Sport"},{"key":"ref1011","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1002\/cne.23338","article-title":"Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain","volume":"521","year":"2013","journal-title":"Journal of Comparative 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Endocrinology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1440-2440(99)80172-8","article-title":"Physiological determinants of endurance exercise performance","volume":"2","year":"1999","journal-title":"Journal of Science and Medicine in Sport"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1152\/japplphysiol.00805.2010","article-title":"Is sprint exercise a leptin signaling mimetic in human skeletal muscle?","volume":"111","year":"2011","journal-title":"Journal of Applied Physiology"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"e12457","DOI":"10.14814\/phy2.12457","article-title":"Overload-induced skeletal muscle hypertrophy is not impaired in STZ-diabetic rats","volume":"3","year":"2015","journal-title":"Physiological Reports"},{"key":"ref881","doi-asserted-by":"crossref","first-page":"28012","DOI":"10.1038\/srep28012","article-title":"IL-6 mediates differentiation disorder during spermatogenesis in 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