{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:01:14Z","timestamp":1791460874822,"version":"4.3.4"},"reference-count":46,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Circadian disruption is associated with metabolic disturbances such as hepatic steatosis (HS), obesity and type 2 diabetes. We hypothesized that HS, resulting from constant light (LL) exposure is due to an inconsistency between signals related to food intake and endocrine-driven suprachiasmatic nucleus (SCN) outputs. Indeed, exposing rats to LL induced locomotor, food intake and hormone arrhythmicity together with the development of HS. We investigated whether providing temporal signals such as 12-h food availability or driving a corticosterone plus melatonin rhythm could restore rhythmicity and prevent the metabolic disturbances under LL conditions in male rats. Discrete metabolic improvements under these separate treatments stimulated us to investigate whether the combination of hormone treatment together with mealtime restriction (12-h food during four weeks) could prevent the metabolic alterations. LL exposed arrhythmic rats, received daily administration of corticosterone (2.5\u2009\u00b5g\/kg) and melatonin (2.5\u2009mg\/kg) in synchrony or out of synchrony with their 12-h meal. HS and other metabolic alterations were importantly ameliorated in LL-exposed rats receiving hormonal treatment in synchrony with 12-h restricted mealtime, while treatment out of phase with meal time did not. Interestingly, liver bile acids, a major indication for HS, were only normalized when animals received hormones in synchrony with food indicating that disrupted bile acid metabolism might be an important mechanism for the HS induction under LL conditions. We conclude that food-elicited signals, as well as hormonal signals, are necessary for liver synchronization and that HS arises when there is conflict between food intake and the normal pattern of melatonin and corticosterone.<\/jats:p>","DOI":"10.1530\/joe-17-0370","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T20:11:01Z","timestamp":1504037461000},"page":"167-178","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":22,"title":["Food in synchrony with melatonin and corticosterone relieves constant light disturbed metabolism"],"prefix":"10.1530","volume":"235","author":[{"given":"Adri\u00e1n","family":"B\u00e1ez-Ruiz","sequence":"first","affiliation":[{"name":"1Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, M\u00e9xico"},{"name":"2Department of Cellular Physiology, Faculty of Science, UASLP, San Luis Potos\u00ed, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natal\u00ed N","family":"Guerrero-Vargas","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, M\u00e9xico"},{"name":"3Department of Anatomy, Faculty of Medicine, UNAM, DF, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"C\u00e1zarez-M\u00e1rquez","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Sabath","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Carmen","family":"Basualdo","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Salgado-Delgado","sequence":"additional","affiliation":[{"name":"2Department of Cellular Physiology, Faculty of Science, UASLP, San Luis Potos\u00ed, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Escobar","sequence":"additional","affiliation":[{"name":"3Department of Anatomy, Faculty of Medicine, UNAM, DF, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud M","family":"Buijs","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Cellular Biology, Biomedical Research Institute, UNAM, DF, 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Targets"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cbf.1046","article-title":"Effect of melatonin on cholestatic oxidative stress under constant light exposure","volume":"21","year":"2003","journal-title":"Cell Biochemistry and Function"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"e1000181","DOI":"10.1371\/journal.pbio.1000181","article-title":"REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis","volume":"7","year":"2009","journal-title":"PloS Biology"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1210\/en.2009-1436","article-title":"Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse","volume":"151","year":"2010","journal-title":"Endocrinology"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-079X.2006.00346.x","article-title":"Melatonin ameliorates nonalcoholic fatty liver induced by high-fat diet in rats","volume":"41","year":"2006","journal-title":"Journal of Pineal Research"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3109\/07420528.2013.803196","article-title":"Dim light at night does not disrupt timing or quality of sleep in mice.","volume":"30","year":"2013","journal-title":"Chronobiology International"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/jpi.12137","article-title":"Melatonin energy metabolism and obesity: a review","volume":"56","year":"2014","journal-title":"Journal of Pineal Research"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3109\/07420528.2010.548615","article-title":"Hepatic, duodenal, and colonic circadian clocks differ in their persistence under conditions of constant light and in their entrainment by restricted feeding","volume":"28","year":"2011","journal-title":"Chronobiology 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rest phase promotes metabolic disruption and desynchrony of liver genes in male rats","volume":"8","year":"2013","journal-title":"PLoS ONE"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1210\/en.2003-0693","article-title":"Melatonin reduces body weight gain in Sprague Dawley rats with diet-induced obesity","volume":"144","year":"2003","journal-title":"Endocrinology"},{"key":"ref271","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1152\/ajpendo.00645.2007","article-title":"MuniyappaRLeeSChenHQuonMJ Current approaches for assessing insulin sensitivity and resistance in vivo advantages limitations and appropriate usage of and","year":"2008","journal-title":"American Journal Physiology Endocrinology Metabolism"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jsbmb.2015.07.020","article-title":"Glucocorticoids and non-alcoholic fatty liver disease","volume":"154","year":"2015","journal-title":"Journal of Steroid 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metabolism","volume":"2015","year":"2015","journal-title":"International Journal of Endocrinology"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1152\/physiol.00014.2014","article-title":"The gut-adipose-liver axis in the metabolic syndrome","volume":"29","year":"2014","journal-title":"Physiology"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-511X-11-2","article-title":"Dietary restriction, caloric value and the accumulation of hepatic fat","volume":"11","year":"2012","journal-title":"Lipids in Health and Disease"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"e0148214","DOI":"10.1371\/journal.pone.0148214","article-title":"Melatonin signaling controls the daily rhythm in blood glucose levels independent of peripheral clocks","volume":"11","year":"2016","journal-title":"PLoS ONE"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/bdi.12196","article-title":"Melatonin attenuates 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