{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:37:07Z","timestamp":1787963827622,"version":"build-2784847793"},"reference-count":98,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    We examined the long-term effects of protein restriction during puberty on the function of hypothalamic\u2013pituitary\u2013adrenal (HPA) and hypothalamic\u2013pituitary\u2013gonadal (HPG) axes in male rats. Male Wistar rats from the age of 30 to 60 days were fed a low-protein diet (4%, LP). A normal-protein diet (20.5%) was reintroduced to rats from the age of 60 to 120 days. Control rats were fed a normal-protein diet throughout life (NP). Rats of 60 or 120 days old were killed. Food consumption, body weight, visceral fat deposits, lipid profile, glycemia, insulinemia, corticosteronemia, adrenocorticotropic hormone (ACTH), testosteronemia and leptinemia were evaluated. Glucose-insulin homeostasis, pancreatic-islet insulinotropic response, testosterone production and hypothalamic protein expression of the androgen receptor (AR), glucocorticoid receptor (GR) and leptin signaling pathway were also determined. LP rats were hypophagic, leaner, hypoglycemic, hypoinsulinemic and hypoleptinemic at the age of 60 days (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). These rats exhibited hyperactivity of the HPA axis, hypoactivity of the HPG axis and a weak insulinotropic response (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01). LP rats at the age of 120 days were hyperphagic and exhibited higher visceral fat accumulation, hyperleptinemia and dyslipidemia; lower blood ACTH, testosterone and testosterone release; and reduced hypothalamic expression of AR, GR and SOCS3, with a higher pSTAT3\/STAT3 ratio (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Glucose-insulin homeostasis was disrupted and associated with hyperglycemia, hyperinsulinemia and increased insulinotropic response of the pancreatic islets. The cholinergic and glucose pancreatic-islet responses were small in 60-day-old LP rats but increased in 120-day-old LP rats. The hyperactivity of the HPA axis and the suppression of the HPG axis caused by protein restriction at puberty contributed to energy and metabolic disorders as long-term consequences.\n                  <\/jats:p>","DOI":"10.1530\/joe-17-0606","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T12:30:30Z","timestamp":1522326630000},"page":"243-254","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":34,"title":["Low-protein diet in puberty impairs testosterone output and energy metabolism in male rats"],"prefix":"10.1530","volume":"237","author":[{"given":"J\u00falio Cezar","family":"de Oliveira","sequence":"first","affiliation":[{"name":"1Laborat\u00f3rio de Biologia Celular da Secre\u00e7\u00e3o, Departamento de Biotecnologia, Gen\u00e9tica e Biologia Celular, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"},{"name":"2Departamento de Ci\u00eancias Fisiol\u00f3gicas, Laborat\u00f3rio de Fisiologia End\u00f3crina, Instituto de Biologia Roberto Alc\u00e2ntara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"3Instituto de Ci\u00eancias da Sa\u00fade, Universidade Federal de Mato Grosso, Sinop, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egberto Gaspar","family":"de Moura","sequence":"additional","affiliation":[{"name":"2Departamento de Ci\u00eancias Fisiol\u00f3gicas, Laborat\u00f3rio de Fisiologia End\u00f3crina, Instituto de Biologia Roberto Alc\u00e2ntara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosiane Aparecida","family":"Miranda","sequence":"additional","affiliation":[{"name":"1Laborat\u00f3rio de Biologia Celular da Secre\u00e7\u00e3o, Departamento de Biotecnologia, Gen\u00e9tica e Biologia Celular, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"},{"name":"4Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Praxedes","family":"de Moraes","sequence":"additional","affiliation":[{"name":"1Laborat\u00f3rio de Biologia Celular da Secre\u00e7\u00e3o, Departamento de Biotecnologia, Gen\u00e9tica e Biologia Celular, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Felipe","family":"Barella","sequence":"additional","affiliation":[{"name":"1Laborat\u00f3rio de Biologia Celular da Secre\u00e7\u00e3o, Departamento de Biotecnologia, Gen\u00e9tica e Biologia Celular, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Paula Santos","family":"da Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"2Departamento de Ci\u00eancias Fisiol\u00f3gicas, Laborat\u00f3rio de Fisiologia End\u00f3crina, Instituto de Biologia Roberto Alc\u00e2ntara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Mello","family":"Gomes","sequence":"additional","affiliation":[{"name":"5Departamento de Ci\u00eancias Fisiol\u00f3gicas, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane Aparecida","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"1Laborat\u00f3rio de Biologia Celular da Secre\u00e7\u00e3o, Departamento de Biotecnologia, Gen\u00e9tica e Biologia Celular, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda","family":"Malta","sequence":"additional","affiliation":[{"name":"1Laborat\u00f3rio de Biologia Celular da Secre\u00e7\u00e3o, Departamento de Biotecnologia, Gen\u00e9tica e Biologia Celular, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Peixoto","family":"Martins","sequence":"additional","affiliation":[{"name":"1Laborat\u00f3rio de Biologia Celular da Secre\u00e7\u00e3o, Departamento de Biotecnologia, Gen\u00e9tica e Biologia Celular, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudin\u00e9ia Conationi da Silva","family":"Franco","sequence":"additional","affiliation":[{"name":"1Laborat\u00f3rio de Biologia Celular da Secre\u00e7\u00e3o, Departamento de Biotecnologia, Gen\u00e9tica e Biologia Celular, Universidade Estadual de Maring\u00e1, Maring\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Cristina","family":"Lisboa","sequence":"additional","affiliation":[{"name":"2Departamento de Ci\u00eancias Fisiol\u00f3gicas, Laborat\u00f3rio de 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