{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:13:23Z","timestamp":1790061203256,"version":"4.0.1"},"reference-count":43,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Diabetes-induced injury of myocardium, defined as diabetic cardiomyopathy (DCM), accounts for significant mortality and morbidity in diabetic population. Alleviation of DCM by a potent drug remains considerable interests in experimental and clinical researches because hypoglycemic drugs cannot effectively control this condition. Here, we explored the beneficial effects of isosteviol sodium (STVNa) on type 1 diabetes-induced DCM and the potential mechanisms involved. Male Wistar rats were induced to diabetes by injection of streptozotocin (STZ). One week later, diabetic rats were randomly grouped to receive STVNa (STZ\/STVNa) or its vehicle (STZ). After 11 weeks of treatment or 11 weeks treatment following 4 weeks of removal of the treatment, the cardiac function and structure were evaluated and related mechanisms were investigated. In diabetic rats, oxidative stress, inflammation, blood glucose and plasma advanced glycation end products (AGEs) were significantly increased, whereas superoxide dismutase 2 (SOD-2) expression and activity were decreased. STVNa treatment inhibited cardiac hypertrophy, fibrosis and inflammation, showed similar ratio of heart to body weight and antioxidant capacities almost similar to the normal controls, which can be sustained at least 4 weeks. Moreover, STVNa inhibited diabetes-inducted stimulation of both extracellular signal-regulated kinase (ERK) and nuclear factor \u03baB (NF-\u03baB) signal pathways. However, blood glucose, plasma AGE and insulin levels were not altered by STVNa treatment. These results indicate that STVNa may be developed into a potent therapy for DCM. The mechanism underlying this therapeutic effect involves the suppression of oxidative stress and inflammation by inhibiting ERK and NF-\u03baB without changing blood glucose or AGEs.<\/jats:p>","DOI":"10.1530\/joe-17-0681","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T07:50:13Z","timestamp":1525247413000},"page":"47-60","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":50,"title":["Isosteviol ameliorates diabetic cardiomyopathy in rats by inhibiting ERK and NF-\u03baB signaling pathways"],"prefix":"10.1530","volume":"238","author":[{"given":"Sheng-Gao","family":"Tang","sequence":"first","affiliation":[{"name":"1School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"1School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Ming","family":"Ye","sequence":"additional","affiliation":[{"name":"2Molecular Pharmacology for Diabetes, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Hu","sequence":"additional","affiliation":[{"name":"1School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"1School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Han","sequence":"additional","affiliation":[{"name":"1School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tan","sequence":"additional","affiliation":[{"name":"3Institute of Biomedical & Pharmaceutical Science, Guangdong University of Technology, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref371","first-page":"1898","article-title":"Protective role of STVNa in myocardial ischemia reperfusion injury by inhibiting mitochondrial fission","volume":"9","year":"2017","journal-title":"Oncotarget"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1111\/j.1582-4934.2008.00547.x","article-title":"Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy","volume":"13","year":"2009","journal-title":"Journal of Cellular and Molecular 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