{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:24:24Z","timestamp":1790839464061,"version":"4.1.0"},"reference-count":196,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    Life in seasonally changing environments is challenging. Biological systems have to not only respond directly to the environment, but also schedule life history events in anticipation of seasonal changes. The cellular and molecular basis of how these events are scheduled is unknown. Cellular decision-making processes in response to signals above certain thresholds regularly occur i.e. cellular fate determination, apoptosis and firing of action potentials. Binary\n                    <jats:italic>switches<\/jats:italic>\n                    , the result of cellular decision-making processes, are defined as a change in phenotype between two stable states. A recent study presents evidence of a binary\n                    <jats:italic>switch<\/jats:italic>\n                    operating in the pars tuberalis (PT) of the pituitary, seemingly timing seasonal reproduction in sheep. Though, how a binary switch would allow for anticipation of seasonal environmental changes, not just direct responsiveness, is unclear. The purpose of this review is to assess the evidence for a binary switching mechanism timing seasonal reproduction and to hypothesize how a binary switch would allow biological processes to be timed over weeks to years. I draw parallels with mechanisms used in development, cell fate determination and seasonal timing in plants. I propose that the adult PT is a plastic tissue, showing a seasonal cycle of cellular differentiation, and that the underlying processes are likely to be epigenetic. Therefore, considering the mechanisms behind adult cellular plasticity offers a framework to hypothesize how a long-term timer functions within the PT.\n                  <\/jats:p>","DOI":"10.1530\/joe-18-0177","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T14:06:04Z","timestamp":1533218764000},"page":"R13-R25","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":11,"title":["How can a binary switch within the pars tuberalis control seasonal timing of reproduction?"],"prefix":"10.1530","volume":"239","author":[{"given":"Shona H","family":"Wood","sequence":"first","affiliation":[{"name":"1Department of Arctic and Marine Biology, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"},{"name":"2Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, 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circannual timing","volume":"26","year":"2011","journal-title":"Journal of Biological Rhythms"},{"key":"ref1701","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ceb.2018.01.003","article-title":"The epigenetic basis of cellular plasticity","volume":"49","year":"2017","journal-title":"Current Opinion in Cell Biology"},{"key":"ref661","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0197-0186(94)90100-7","article-title":"Melatonin receptors: localization, molecular pharmacology and physiological significance","volume":"24","year":"1994","journal-title":"Neurochemistry International"},{"key":"ref1891","first-page":"222","article-title":"The pars tuberalis: the site of the circannual clock in mammals?","volume":"258","year":"2017","journal-title":"General and Comparative Endocrinology"},{"key":"ref1061","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1210\/endo-113-1-329","article-title":"Role of the pineal gland in ovine photoperiodism: regulation of seasonal breeding and negative feedback effects of estradiol upon luteinizing hormone secretion","volume":"113","year":"1983","journal-title":"Endocrinology"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/jne.12013","article-title":"Circannual variation in thyroid hormone deiodinases in a short-day breeder","volume":"25","year":"2013","journal-title":"Journal of Neuroendocrinology"},{"key":"ref821","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1242\/jcs.084764","article-title":"Vernalization \u2013 a cold-induced epigenetic switch","volume":"125","year":"2012","journal-title":"Journal of Cell Science"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1210\/en.2005-0132","article-title":"Photorefractoriness in mammals: dissociating a seasonal timer from the circadian-based photoperiod response","volume":"146","year":"2005","journal-title":"Endocrinology"},{"key":"ref1331","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/0748730413487974","article-title":"Exogenous T3 elicits long day-like alterations in testis size and the RFamides Kisspeptin and gonadotropin-inhibitory hormone in short-day Siberian hamsters","volume":"28","year":"2013","journal-title":"Journal of Biological Rhythms"},{"key":"ref951","doi-asserted-by":"crossref","first-page":"11974","DOI":"10.1073\/pnas.94.22.11974","article-title":"Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function","volume":"94","year":"1997","journal-title":"PNAS"},{"key":"ref981","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00441-016-2484-9","article-title":"Identification of marker genes for pars tuberalis morphogenesis in chick embryo: expression of Cytokine-like 1 and Gap junction protein alpha 5 in pars 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pituitary","volume":"50","year":"2002","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"ref1901","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.cub.2015.09.014","article-title":"Binary switching of calender cells in the pituitary defines the phase of the circannual cycle in mammals","volume":"25","year":"2015","journal-title":"Current Biology"},{"key":"ref171","first-page":"19","article-title":"Thyroid hormone and seasonal rhythmicity","volume":"5","year":"2014","journal-title":"Frontiers in Endocrinology"},{"key":"ref1611","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.cub.2010.11.038","article-title":"Acute induction of Eya3 by late-night light stimulation triggers TSH\u03b2 expression in photoperiodism","volume":"20","year":"2010","journal-title":"Current Biology"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"e12554","DOI":"10.1111\/jne.12554","article-title":"Diurnal and photoperiodic changes in thyrotrophin-stimulating hormone \u03b2 expression and associated regulation of deiodinase enzymes (DIO2, DIO3) in the female juvenile chicken hypothalamus","volume":"29","year":"2017","journal-title":"Journal of Neuroendocrinology"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"e08494","DOI":"10.7554\/eLife.08494","article-title":"Spatially coordinated dynamic gene transcription in living pituitary tissue","volume":"5","year":"2016","journal-title":"eLife"},{"key":"ref891","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cophys.2018.04.006","article-title":"Seasonal physiology: making the future a thing of the past","volume":"5","year":"2018","journal-title":"Current Opinion in Physiology"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.yhbeh.2006.06.004","article-title":"Driving reproduction: RFamide peptides behind the wheel","volume":"50","year":"2006","journal-title":"Hormones and 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development: conservation in vitro but context specificity in vivo","volume":"306","year":"2007","journal-title":"Developmental Biology"},{"key":"ref791","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/org.1.2.1409","article-title":"Transdifferentiation, metaplasia and tissue regeneration","volume":"1","year":"2004","journal-title":"Organogenesis"},{"key":"ref1171","doi-asserted-by":"crossref","first-page":"e12554","DOI":"10.1111\/jne.12554","article-title":"Diurnal and photoperiodic changes in thyrotrophin-stimulating hormone \u03b2 expression and associated regulation of deiodinase enzymes (DIO2, DIO3) in the female juvenile chicken hypothalamus","volume":"29","year":"2017","journal-title":"Journal of Neuroendocrinology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1210\/endo.143.7.8924","article-title":"Temporal requirements of thyroid hormones for seasonal changes in LH 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failure","volume":"150","year":"2012","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrg3291","article-title":"The genetic basis of flowering responses to seasonal cues","volume":"13","year":"2012","journal-title":"Nature Reviews Genetics"},{"key":"ref1511","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.eururo.2016.04.028","article-title":"SRRM4 drives neuroendocrine transdifferentiation of prostate adenocarcinoma under androgen receptor pathway inhibition","volume":"71","year":"2017","journal-title":"European Urology"},{"key":"ref1811","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.cub.2013.07.027","article-title":"SongJIrwinJDeanC Remembering the prolonged cold of winter https org","volume":"23","year":"2013","journal-title":"Current Biology"},{"key":"ref1561","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1210\/en.2005-0132","article-title":"Photorefractoriness in mammals: dissociating a seasonal timer from the circadian-based photoperiod response","volume":"146","year":"2005","journal-title":"Endocrinology"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature06738","article-title":"Thyrotrophin in the pars tuberalis triggers photoperiodic response","volume":"452","year":"2008","journal-title":"Nature"},{"key":"ref1251","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.cub.2008.06.076","article-title":"Ancestral TSH mechanism signals summer in a photoperiodic mammal","volume":"18","year":"2008","journal-title":"Current Biology"},{"key":"ref1591","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s00018-017-2667-x","article-title":"The impact of thyroid hormone in seasonal breeding has a restricted transcriptional signature","volume":"75","year":"2018","journal-title":"Cellular and Molecular Life 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Mechanisms"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/0748730411420812","article-title":"Hypothesis: cyclical histogenesis is the basis of circannual timing","volume":"26","year":"2011","journal-title":"Journal of Biological Rhythms"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2826.1994.tb00580.x","article-title":"Photoperiodically-lnduced cycles in the secretion of prolactin in hypothalamo-pituitary disconnected rams: evidence for translation of the melatonin signal in the pituitary gland","volume":"6","year":"1994","journal-title":"Journal of Neuroendocrinology"},{"key":"ref1131","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1365-2826.2003.01060.x","article-title":"MT1 melatonin receptor mRNA expressing cells in the pars tuberalis of the European hamster: effect of photoperiod","volume":"15","year":"2003","journal-title":"Journal of 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B"},{"key":"ref1411","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s004180050220","article-title":"Localization and development of chromogranin A and luteinizing hormone immunoreactivities in the secretory-specific cells of the hypophyseal pars tuberalis of the chicken","volume":"109","year":"1998","journal-title":"Histochemistry and Cell Biology"},{"key":"ref1081","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1641\/B570805","article-title":"Dedifferentiation: a new approach in stem cell research","volume":"57","year":"2007","journal-title":"BioScience"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1365-2826.2003.01060.x","article-title":"MT1 melatonin receptor mRNA expressing cells in the pars tuberalis of the European hamster: effect of photoperiod","volume":"15","year":"2003","journal-title":"Journal of Neuroendocrinology"},{"key":"ref1291","first-page":"1575","article-title":"Seasonal reproduction in 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neurons \u2013 the doorway to understanding seasonal reproduction in mammals","volume":"7","year":"2016","journal-title":"Frontiers in Endocrinology"},{"key":"ref1831","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00018-012-1144-9","article-title":"The eyes absent proteins in development and disease","volume":"70","year":"2013","journal-title":"Cellular and Molecular Life Sciences"},{"key":"ref321","first-page":"e12631","article-title":"Neuroendocrine correlates of the critical day length response in the Soay sheep","year":"2018","journal-title":"Journal of Neuroendocrinology"},{"key":"ref1941","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1210\/en.2004-0366","article-title":"Seasonal morphological changes in the neuro-glial interaction between gonadotropin-releasing hormone nerve terminals and glial endfeet in Japanese quail","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"ref1181","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chaos.2012.11.007","article-title":"Modelling a molecular calendar: the seasonal photoperiodic response in mammals","volume":"50","year":"2013","journal-title":"Chaos, Solitons and Fractals"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s00018-017-2667-x","article-title":"The impact of thyroid hormone in seasonal breeding has a restricted transcriptional signature","volume":"75","year":"2018","journal-title":"Cellular and Molecular Life Sciences"},{"key":"ref1101","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1210\/jc.2015-2860","article-title":"Evidence of \u03b2-cell dedifferentiation in human type 2 diabetes","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1177\/002215540205001209","article-title":"The mt1 melatonin receptor and RORbeta receptor are co-localized in specific TSH-immunoreactive cells in the pars tuberalis of the rat pituitary","volume":"50","year":"2002","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"ref921","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.cub.2015.09.014","article-title":"Binary switching of calender cells in the pituitary defines the phase of the circannual cycle in mammals","volume":"25","year":"2015","journal-title":"Current Biology"},{"key":"ref1871","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cophys.2018.04.006","article-title":"Seasonal physiology: making the future a thing of the past","volume":"5","year":"2018","journal-title":"Current Opinion in 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decisions","volume":"458","year":"2009","journal-title":"Nature"},{"key":"ref1761","doi-asserted-by":"crossref","first-page":"8408","DOI":"10.1073\/pnas.1702943114","article-title":"Maternal photoperiod programs hypothalamic thyroid status via the fetal pituitary gland","volume":"114","year":"2017","journal-title":"PNAS"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ygcen.2017.05.011","article-title":"Signaling pathways to and from the hypophysial pars tuberalis, an important center for the control of seasonal rhythms","volume":"258","year":"2018","journal-title":"General and Comparative Endocrinology"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.cub.2010.10.048","article-title":"A molecular switch for photoperiod responsiveness in mammals","volume":"20","year":"2010","journal-title":"Current 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signalling genes are regulated by photoperiod in the hypothalamus of F344 rats","volume":"6","year":"2011","journal-title":"PLoS ONE"},{"key":"ref1051","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1210\/endo.143.7.8924","article-title":"Temporal requirements of thyroid hormones for seasonal changes in LH secretion","volume":"143","year":"2002","journal-title":"Endocrinology"},{"key":"ref441","first-page":"a001503","article-title":"Forming patterns in development without morphogen gradients: scattered differentiation and sorting out","volume":"1","year":"2009","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"ref1421","first-page":"a001503","article-title":"Forming patterns in development without morphogen gradients: scattered differentiation and sorting out","volume":"1","year":"2009","journal-title":"Cold Spring Harbor Perspectives in 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circuits","volume":"467","year":"2010","journal-title":"Nature"},{"key":"ref1351","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10735-012-9479-y","article-title":"Detailed morphogenetic analysis of the embryonic chicken pars tuberalis as glycoprotein alpha subunit positive region","volume":"44","year":"2013","journal-title":"Journal of Molecular Histology"},{"key":"ref1651","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1210\/en.2011-1249","article-title":"Effects of manipulating hypothalamic triiodothyronine concentrations on seasonal body weight and torpor cycles in Siberian hamsters","volume":"153","year":"2012","journal-title":"Endocrinology"},{"key":"ref1921","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1677\/JOE-08-0221","article-title":"Spatio-temporal expression of chromogranin A during zebrafish embryogenesis","volume":"198","year":"2008","journal-title":"Journal of 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