{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:42:49Z","timestamp":1792669369841,"version":"4.5.0"},"reference-count":81,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2]]},"abstract":"\n Luteinizing hormone (Lh) and follicle-stimulating hormone (Fsh) control reproduction in vertebrates. Using a transgenic line of medaka, in which green fluorescent protein expression is controlled by the endogenous\n lhb<\/jats:italic>\n promotor, we studied development and plasticity of Lh cells, comparing juveniles and adults of both genders. Confocal imaging and 3D reconstruction revealed hypertrophy and hyperplasia of Lh cells in both genders from juvenile to adult stages. We show that Lh cell hyperplasia may be caused by recruitment of existing pituitary cells that start to produce\n lhb<\/jats:italic>\n , as evidenced by time lapse recordings of primary pituitary cell cultures, and\/or through Lh cell proliferation, demonstrated through a combination of 5-bromo-2\u2032-deoxyuridine incubation experiments and proliferating cell nuclear antigen staining. Proliferating Lh cells do not belong to the classical type of multipotent stem cells, as they do not stain with anti-\n sox2<\/jats:italic>\n . Estradiol exposure\n in vivo<\/jats:italic>\n increased pituitary cell proliferation, particularly Lh cells, whereas pituitary\n lhb<\/jats:italic>\n and\n gpa<\/jats:italic>\n expression levels decreased. RNA-seq and\n in situ<\/jats:italic>\n hybridization showed that Lh cells express two estrogen receptors,\n esr1<\/jats:italic>\n and\n esr2b<\/jats:italic>\n , and the aromatase gene\n cyp19a1b<\/jats:italic>\n , suggesting a direct effect of estradiol, and possibly androgens, on Lh cell proliferation. In conclusion, our study reveals a high degree of plasticity in the medaka Lh cell population, resulting from a combination of recruitment and cell proliferation.\n <\/jats:p>","DOI":"10.1530\/joe-18-0412","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T18:54:34Z","timestamp":1546023274000},"page":"361-377","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":35,"title":["Plasticity of Lh cells caused by cell proliferation and recruitment of existing cells"],"prefix":"10.1530","volume":"240","author":[{"given":"Romain","family":"Fontaine","sequence":"first","affiliation":[{"name":"Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirill","family":"Ager-Wick","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjetil","family":"Hodne","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn-Arne","family":"Weltzien","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref411","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20971","article-title":"Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon NA NA https org","author":"CuifLStrahleU","year":"2010","journal-title":"Glia"},{"key":"ref81","article-title":"Medaka follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh): developmental profiles of pituitary protein and gene expression levels","year":"2018","journal-title":"General and Comparative Endocrinology"},{"key":"ref701","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1093\/nar\/gkm306","article-title":"Primer Plus an enhanced web interface to Primer https org","year":"2007","journal-title":"Nucleic Acids Research"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbagrm.2014.07.002","article-title":"Aromatase, estrogen receptors and brain development in fish and amphibians","volume":"1849","year":"2015","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","year":"2006","journal-title":"Genome Biology"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1242\/dev.058156","article-title":"Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate","volume":"138","year":"2011","journal-title":"Development"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0016-6480(90)90225-B","article-title":"Salmonid pituitary gonadotrophs. 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