{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:09:58Z","timestamp":1792919398508,"version":"4.5.0"},"reference-count":488,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2]]},"abstract":"\n While 95% of pituitary adenomas arise sporadically without a known inheritable predisposing mutation, in about 5% of the cases they can arise in a familial setting, either isolated (familial isolated pituitary adenoma or FIPA) or as part of a syndrome. FIPA is caused, in 15\u201330% of all kindreds, by inactivating mutations in the\n AIP<\/jats:italic>\n gene, encoding a co-chaperone with a vast array of interacting partners and causing most commonly growth hormone excess. While the mechanisms linking AIP with pituitary tumorigenesis have not been fully understood, they are likely to involve several pathways, including the cAMP-dependent protein kinase A pathway via defective G inhibitory protein signalling or altered interaction with phosphodiesterases. The cAMP pathway is also affected by other conditions predisposing to pituitary tumours, including X-linked acrogigantism caused by duplications of the\n GPR101<\/jats:italic>\n gene, encoding an orphan G stimulatory protein-coupled receptor. Activating mosaic mutations in the\n GNAS<\/jats:italic>\n gene, coding for the G\u03b1 stimulatory protein, cause McCune\u2013Albright syndrome, while inactivating mutations in the regulatory type 1\u03b1 subunit of protein kinase A represent the most frequent genetic cause of Carney complex, a syndromic condition with multi-organ manifestations also involving the pituitary gland. In this review, we discuss the genetic and molecular aspects of isolated and syndromic familial pituitary adenomas due to germline or mosaic mutations, including those secondary to\n AIP<\/jats:italic>\n and\n GPR101<\/jats:italic>\n mutations, multiple endocrine neoplasia type 1 and 4, Carney complex, McCune\u2013Albright syndrome, DICER1 syndrome and mutations in the\n SDHx<\/jats:italic>\n genes underlying the association of familial paragangliomas and phaeochromocytomas with pituitary adenomas.\n <\/jats:p>","DOI":"10.1530\/joe-18-0446","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T06:39:11Z","timestamp":1545115151000},"page":"R21-R45","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":49,"title":["Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects"],"prefix":"10.1530","volume":"240","author":[{"given":"Sara","family":"Pepe","sequence":"first","affiliation":[{"name":"1Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK"},{"name":"2Department of Medical Biotechnologies, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Korbonits","sequence":"additional","affiliation":[{"name":"1Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Iacovazzo","sequence":"additional","affiliation":[{"name":"1Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref51","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1210\/jc.2008-1451","article-title":"MicroRNAs differentially expressed in ACTH-secreting pituitary tumors","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref821","first-page":"2172","article-title":"Epidemiology of pituitary adenoma: results of the first Swiss study","volume":"5","year":"2009","journal-title":"Revue M\u00e9dicale Suisse"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2265.2009.03667.x","article-title":"Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK)","volume":"72","year":"2010","journal-title":"Clinical Endocrinology"},{"key":"ref2661","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/jc.2005-1862","article-title":"Clinical presentation and penetrance of pheochromocytoma\/paraganglioma syndromes","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3401","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/onc.2014.3","article-title":"MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2","volume":"34","year":"2015","journal-title":"Oncogene"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"214","DOI":"10.12688\/f1000research.6746.1","article-title":"Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma\/DICER1 syndrome: a unique variant of the two-hit tumor suppression model","volume":"4","year":"2015","journal-title":"F1000Research"},{"key":"ref3751","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1093\/hmg\/9.20.3037","article-title":"Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex","volume":"9","year":"2000b","journal-title":"Human Molecular Genetics"},{"key":"ref4801","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1210\/jc.2011-1179","article-title":"la SierraMMatroJBallEAzevedoM dehydrogenase subunit inactivation in a growth - hormone - producing pituitary tumor : a new association for SDH of and https org","author":"Luz","year":"2012","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref2071","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000079049","article-title":"Pathology and molecular genetics of the pituitary gland in patients with the \u2018complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas\u2019 (Carney complex)","volume":"32","year":"2004","journal-title":"Frontiers of Hormone Research"},{"key":"ref2611","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","article-title":"Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma","volume":"287","year":"2000","journal-title":"Science"},{"key":"ref841","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mce.2014.05.004","article-title":"cAMP signalling in the normal and tumorigenic pituitary gland","volume":"392","year":"2014","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref3171","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1056\/NEJMc1406028","article-title":"Breast-cancer predisposition in multiple endocrine neoplasia type 1","volume":"371","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"ref2001","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/onc.2014.171","article-title":"Cables1 controls p21\/Cip1 protein stability by antagonizing proteasome subunit alpha type 3","volume":"34","year":"2015","journal-title":"Oncogene"},{"key":"ref1811","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2353\/ajpath.2010.100138","article-title":"Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression","volume":"177","year":"2010","journal-title":"American Journal of Pathology"},{"key":"ref1741","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-13-0623","article-title":"Non-pheochromocytoma (PCC)\/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis","volume":"170","year":"2014","journal-title":"European Journal of Endocrinology"},{"key":"ref4231","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0092-8674(94)90513-4","article-title":"Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras","volume":"76","year":"1994","journal-title":"Cell"},{"key":"ref1391","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/JOE-16-0190","article-title":"Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice","volume":"231","year":"2016b","journal-title":"Journal of Endocrinology"},{"key":"ref3981","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s40618-017-0725-8","article-title":"Frequency of familial pituitary adenoma syndromes among patients with functioning pituitary adenomas in a reference outpatient clinic","volume":"40","year":"2017","journal-title":"Journal of Endocrinological Investigation"},{"key":"ref4001","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1158\/1078-0432.CCR-16-0435","article-title":"Translational diagnostics and therapeutics in pancreatic neuroendocrine tumors","volume":"22","year":"2016","journal-title":"Clinical Cancer Research"},{"key":"ref1261","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1158\/2159-8290.CD-13-0092","article-title":"Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor","volume":"3","year":"2013","journal-title":"Cancer Discovery"},{"key":"ref3761","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1158\/0008-5472.CAN-05-0580","article-title":"A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues","volume":"65","year":"2005","journal-title":"Cancer Research"},{"key":"ref1531","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s40618-017-0725-8","article-title":"Frequency of familial pituitary adenoma syndromes among patients with functioning pituitary adenomas in a reference outpatient clinic","volume":"40","year":"2017","journal-title":"Journal of Endocrinological Investigation"},{"key":"ref3101","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00401-014-1285-z","article-title":"Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations","volume":"128","year":"2014","journal-title":"Acta Neuropathologica"},{"key":"ref4061","doi-asserted-by":"crossref","first-page":"e53339","DOI":"10.1371\/journal.pone.0053339","article-title":"Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal alpha-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition","volume":"7","year":"2012","journal-title":"PLoS ONE"},{"key":"ref4271","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng.3166","article-title":"Mutations in the deubiquitinase gene USP8 cause Cushing\u2019s disease","volume":"47","year":"2015","journal-title":"Nature Genetics"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1086\/321282","article-title":"Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma","volume":"69","year":"2001","journal-title":"American Journal of Human Genetics"},{"key":"ref4841","doi-asserted-by":"crossref","first-page":"e1005242","DOI":"10.1371\/journal.pgen.1005242","article-title":"Fibroblast growth factor 9 regulation by microRNAs controls lung development and links DICER1 loss to the pathogenesis of pleuropulmonary blastoma","volume":"11","year":"2015","journal-title":"PLoS Genetics"},{"key":"ref2241","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/onc.2014.50","article-title":"AIP inactivation leads to pituitary tumorigenesis through defective Galphai-cAMP signaling","volume":"34","year":"2015","journal-title":"Oncogene"},{"key":"ref2581","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1086\/301729","article-title":"Characterization of mutations in patients with multiple endocrine neoplasia type 1","volume":"62","year":"1998","journal-title":"American Journal of Human Genetics"},{"key":"ref3221","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1038\/sj.onc.1205428","article-title":"Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas","volume":"21","year":"2002","journal-title":"Oncogene"},{"key":"ref2561","first-page":"250","article-title":"Reduced expression levels of the cell-cycle inhibitor p27Kip1 in human pituitary adenomas","volume":"140","year":"1999","journal-title":"European Journal of Endocrinology"},{"key":"ref1171","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/EJE-15-0832","article-title":"Factors predicting pasireotide responsiveness in somatotroph pituitary adenomas resistant to first-generation somatostatin analogues: an immunohistochemical study","volume":"174","year":"2016a","journal-title":"European Journal of Endocrinology"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1158\/0008-5472.CAN-07-5580","article-title":"Cells silenced for SDHB expression display characteristic features of the tumor phenotype","volume":"68","year":"2008","journal-title":"Cancer Research"},{"key":"ref3341","first-page":"249","article-title":"Loss of heterozygosity on chromosome 11q13 in two families with acromegaly\/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene","volume":"84","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4471","doi-asserted-by":"crossref","first-page":"7615","DOI":"10.1158\/0008-5472.CAN-06-0833","article-title":"Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability","volume":"66","year":"2006","journal-title":"Cancer Research"},{"key":"ref2621","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1210\/er.2012-1013","article-title":"Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene","volume":"34","year":"2013","journal-title":"Endocrine Reviews"},{"key":"ref831","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1056\/NEJMc1309730","article-title":"PRKACB and Carney complex","volume":"370","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1158\/0008-5472.CAN-10-1887","article-title":"Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells","volume":"70","year":"2010","journal-title":"Cancer Research"},{"key":"ref4291","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1210\/jc.2015-4366","article-title":"Somatic GPR101 duplication causing X-linked acrogigantism (XLAG)-diagnosis and management","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1211","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0954-6820.1952.tb13837.x","article-title":"Acromegaly associated with phaeochromocytoma","volume":"142","year":"1952","journal-title":"Acta Medica Scandinavica"},{"key":"ref3351","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1210\/jc.2006-0561","article-title":"McCune-Albright syndrome and acromegaly: effects of hypothalamopituitary radiotherapy and\/or pegvisomant in somatostatin analog-resistant patients","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1191","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/humu.21292","article-title":"Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families","volume":"31","year":"2010","journal-title":"Human Mutation"},{"key":"ref2461","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0092-8674(00)80967-8","article-title":"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription","volume":"96","year":"1999","journal-title":"Cell"},{"key":"ref2601","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1470-2045(10)70007-3","article-title":"SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma","volume":"11","year":"2010","journal-title":"Lancet Oncology"},{"key":"ref901","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1210\/jc.2006-0561","article-title":"McCune-Albright syndrome and acromegaly: effects of hypothalamopituitary radiotherapy and\/or pegvisomant in somatostatin analog-resistant patients","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1251","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/EJE-17-0227","article-title":"mutation causing pituitary - dependent Cushing disease in a patient with complex of https org","author":"PRKAR","year":"2017","journal-title":"European Journal Endocrinology"},{"key":"ref1551","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1158\/1078-0432.CCR-16-0435","article-title":"Translational diagnostics and therapeutics in pancreatic neuroendocrine tumors","volume":"22","year":"2016","journal-title":"Clinical Cancer Research"},{"key":"ref1691","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1046\/j.1365-2265.2003.01921.x","article-title":"Fibrous bodies are associated with lower GH production and decreased expression of E-cadherin in GH-producing pituitary adenomas","volume":"59","year":"2003","journal-title":"Clinical Endocrinology"},{"key":"ref2421","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-005-9017-9","article-title":"Anti-apoptotic action by hypoxia inducible factor 1-alpha in human pituitary adenoma cell line, HP-75 in hypoxic condition","volume":"78","year":"2006","journal-title":"Journal of Neurooncology"},{"key":"ref3791","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archsurg.137.6.641","article-title":"Genotype-phenotype analysis in multiple endocrine neoplasia type 1","volume":"137","year":"2002","journal-title":"Archives of Surgery"},{"key":"ref711","article-title":"DICER1-related disorders","year":"1993","journal-title":"GeneReviews."},{"key":"ref1631","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0092-8674(00)81237-4","article-title":"Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors","volume":"85","year":"1996","journal-title":"Cell"},{"key":"ref4541","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1210\/jc.2012-1230","article-title":"Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4621","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/ijc.2910590521","article-title":"Differential effects of protein kinase A sub-units on Chinese-hamster-ovary cell cycle and proliferation","volume":"59","year":"1994b","journal-title":"International Journal of Cancer"},{"key":"ref3731","doi-asserted-by":"crossref","first-page":"654","DOI":"10.4161\/cbt.4.6.1732","article-title":"Increased growth rate, delayed senescense and decreased serum dependence characterize cables-deficient cells","volume":"4","year":"2005","journal-title":"Cancer Biology and Therapy"},{"key":"ref2881","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1056\/NEJMoa1008020","article-title":"AIP mutation in pituitary adenomas in the 18th century and today","volume":"364","year":"2011","journal-title":"New England Journal of Medicine"},{"key":"ref621","first-page":"161","article-title":"GHRH excess and blockade in X-LAG syndrome","volume":"23","year":"2016a","journal-title":"Endocrine-Related Cancer"},{"key":"ref1341","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archsurg.137.6.641","article-title":"Genotype-phenotype analysis in multiple endocrine neoplasia type 1","volume":"137","year":"2002","journal-title":"Archives of Surgery"},{"key":"ref2841","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-0042-100733","article-title":"GPR101 mutations are not a frequent cause of congenital isolated growth hormone deficiency","volume":"48","year":"2016","journal-title":"Hormone and Metabolic Research"},{"key":"ref4051","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJM199008023230507","article-title":"Gigantism due to pituitary mammosomatotroph hyperplasia","volume":"323","year":"1990","journal-title":"New England Journal of Medicine"},{"key":"ref4391","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000079041","article-title":"Down-regulation of E-cadherin and catenins in human pituitary growth hormone-producing adenomas","volume":"32","year":"2004","journal-title":"Frontiers of Hormone Research"},{"key":"ref1021","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/MCB.01338-07","article-title":"Loss of the SdhB, but not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis","volume":"28","year":"2008","journal-title":"Molecular and Cellular Biology"},{"key":"ref3201","first-page":"5902","article-title":"Hypermethylation-associated inactivation of the cellular retinol-binding-protein 1 gene in human cancer","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"ref3971","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ecl.2017.01.004","article-title":"Genetic aspects of pituitary adenomas","volume":"46","year":"2017","journal-title":"Endocrinology and Metabolism Clinics of North America"},{"key":"ref4301","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1530\/EJE-15-1064","article-title":"Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas","volume":"174","year":"2016","journal-title":"European Journal of Endocrinology"},{"key":"ref1701","doi-asserted-by":"crossref","first-page":"e1003350","DOI":"10.1371\/journal.pgen.1003350","article-title":"A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype","volume":"9","year":"2013","journal-title":"PLoS Genetics"},{"key":"ref2111","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1002\/ijc.24602","article-title":"Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly","volume":"125","year":"2009","journal-title":"International Journal of Cancer"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/cncr.20412","article-title":"The prevalence of pituitary adenomas: a systematic review","volume":"101","year":"2004","journal-title":"Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0092-8674(00)80967-8","article-title":"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription","volume":"96","year":"1999","journal-title":"Cell"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1210\/jc.2006-1668","article-title":"High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium","volume":"91","year":"2006a","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3041","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1210\/jc.2006-2513","article-title":"Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4151","doi-asserted-by":"crossref","first-page":"e1003350","DOI":"10.1371\/journal.pgen.1003350","article-title":"A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype","volume":"9","year":"2013","journal-title":"PLoS Genetics"},{"key":"ref4771","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S1097-2765(00)00109-X","article-title":"JunD protects cells from p53-dependent senescence and apoptosis","volume":"6","year":"2000","journal-title":"Molecular Cell"},{"key":"ref1651","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1530\/EJE-07-0533","article-title":"Variable pathological and clinical features of a large Brazilian family harboring a mutation in the aryl hydrocarbon receptor-interacting protein gene","volume":"157","year":"2007","journal-title":"European Journal of Endocrinology"},{"key":"ref4681","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12022-017-9474-7","article-title":"Pituitary carcinoma in a patient with an SDHB mutation","volume":"28","year":"2017","journal-title":"Endocrine Pathology"},{"key":"ref1951","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00401-008-0388-9","article-title":"Pituitary blastoma","volume":"116","year":"2008","journal-title":"Acta Neuropathologica"},{"key":"ref1971","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1158\/1078-0432.CCR-17-3089","article-title":"DICER1 and associated conditions: identification of at-risk individuals and recommended surveillance strategies","volume":"24","year":"2018","journal-title":"Clinical Cancer Research"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1210\/er.2012-1013","article-title":"Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene","volume":"34","year":"2013","journal-title":"Endocrine Reviews"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1530\/EJE-10-0465","article-title":"Increased prevalence of acromegaly in a highly polluted area","volume":"163","year":"2010","journal-title":"European Journal of Endocrinology"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00401-014-1285-z","article-title":"Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations","volume":"128","year":"2014","journal-title":"Acta Neuropathologica"},{"key":"ref2871","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1158\/0008-5472.CAN-07-5580","article-title":"Cells silenced for SDHB expression display characteristic features of the tumor phenotype","volume":"68","year":"2008","journal-title":"Cancer Research"},{"key":"ref3811","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/332085a0","article-title":"Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma","volume":"332","year":"1988","journal-title":"Nature"},{"key":"ref4201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EC-14-0116","article-title":"Functional characterization of a CDKN1B mutation in a Sardinian kindred with multiple endocrine neoplasia type 4 (MEN4)","volume":"4","year":"2015","journal-title":"Endocrine Connections"},{"key":"ref2721","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/83667","article-title":"Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D","volume":"27","year":"2001","journal-title":"Nature Genetics"},{"key":"ref1471","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1074\/jbc.272.14.8878","article-title":"A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"272","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"ref4431","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","article-title":"Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase","volume":"7","year":"2005","journal-title":"Cancer Cell"},{"key":"ref641","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1530\/ERC-18-0065","article-title":"der Pheochromocytomas and pituitary adenomas in three patients with MAX exon deletions - Related https org","author":"LelyAJBoursV","year":"2018","journal-title":"Endocrine Cancer"},{"key":"ref3051","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2009.05.008","article-title":"The epidemiology and genetics of pituitary adenomas","volume":"23","year":"2009","journal-title":"Best Practice and Research Clinical Endocrinology and Metabolism"},{"key":"ref3901","doi-asserted-by":"crossref","first-page":"32955","DOI":"10.18632\/oncotarget.5106","article-title":"Deciphering the molecular basis of invasiveness in Sdhb-deficient cells","volume":"6","year":"2015","journal-title":"Oncotarget"},{"key":"ref4491","article-title":"Familial isolated pituitary adenoma.","volume-title":"Endotext","year":"2011"},{"key":"ref4511","article-title":"Carney complex","year":"1993","journal-title":"GeneReviews."},{"key":"ref3651","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1158\/0008-5472.203.65.1","article-title":"A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis","volume":"65","year":"2005","journal-title":"Cancer Research"},{"key":"ref3911","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1210\/jc.2003-031225","article-title":"Activating Gsalpha mutations: analysis of 113 patients with signs of McCune-Albright syndrome \u2013 a European Collaborative Study","volume":"89","year":"2004","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3251","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/s12020-016-0862-4","article-title":"Analysis of GPR101 and AIP genes mutations in acromegaly: a multicentric study","volume":"54","year":"2016","journal-title":"Endocrine"},{"key":"ref3891","doi-asserted-by":"crossref","first-page":"35924","DOI":"10.1074\/jbc.M705471200","article-title":"Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality","volume":"282","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"ref1711","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1530\/EJE-12-0457","article-title":"Germline mutations of AIP gene in somatotropinomas resistant to somatostatin analogues","volume":"168","year":"2013","journal-title":"European Journal of Endocrinology"},{"key":"ref4241","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/modpathol.2008.202","article-title":"Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas","volume":"22","year":"2009","journal-title":"Modern Pathology"},{"key":"ref4311","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1530\/ERC-15-0320","article-title":"Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients","volume":"22","year":"2015","journal-title":"Endocrine-Related Cancer"},{"key":"ref4821","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1210\/jc.2014-4297","article-title":"adenoma with paraganglioma PAs succinate dehydrogenase defects in humans and mice of and https org","journal-title":"Pituitary pheochromocytoma Journal Clinical Endocrinology Metabolism"},{"key":"ref1051","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI11887","article-title":"Imprinting of the alpha gene in the pathogenesis of acromegaly of Investigation https org","author":"GNAS","year":"2001","journal-title":"Journal Clinical"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1530\/ERC-16-0082","article-title":"Somatic mosaicism underlies X-linked acrogigantism syndrome in sporadic male subjects","volume":"23","year":"2016b","journal-title":"Endocrine-Related Cancer"},{"key":"ref2251","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1210\/jc.2015-3129","article-title":"Whole-genome sequencing of growth hormone (GH)-secreting pituitary adenomas","volume":"100","year":"2015","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1093\/hmg\/ddq206","article-title":"SDHA is a tumor suppressor gene causing paraganglioma","volume":"19","year":"2010","journal-title":"Human Molecular Genetics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1210\/jc.2008-2083","article-title":"Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2411","first-page":"43","article-title":"Elevated cell invasion is induced by hypoxia in a human pituitary adenoma cell line","year":"2007","journal-title":"Cell Adhesion and Migration"},{"key":"ref1581","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1073\/pnas.0408836102","article-title":"Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors","volume":"102","year":"2005","journal-title":"PNAS"},{"key":"ref1731","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11060-004-6150-9","article-title":"Magnetic resonance imaging and biological markers in pituitary adenomas with invasion of the cavernous sinus space","volume":"74","year":"2005","journal-title":"Journal of Neurooncology"},{"key":"ref1611","doi-asserted-by":"crossref","first-page":"e53339","DOI":"10.1371\/journal.pone.0053339","article-title":"Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal alpha-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition","volume":"7","year":"2012","journal-title":"PLoS ONE"},{"key":"ref1781","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0092-8674(94)90513-4","article-title":"Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras","volume":"76","year":"1994","journal-title":"Cell"},{"key":"ref2201","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1530\/JME-16-0045","article-title":"Characterization of GPR101 transcript structure and expression patterns","volume":"57","year":"2016a","journal-title":"Journal of Molecular Endocrinology"},{"key":"ref2761","article-title":"Fibrous dysplasia\/McCune\u2013Albright syndrome","year":"1993","journal-title":"GeneReviews"},{"key":"ref1321","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0092-8674(00)81238-6","article-title":"Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)","volume":"85","year":"1996","journal-title":"Cell"},{"key":"ref4711","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.endonu.2012.02.009","article-title":"Coexistence of a pituitary macroadenoma and multicentric paraganglioma: a strange coincidence","volume":"60","year":"2013","journal-title":"Endocrinolog\u00eda y Nutrici\u00f3n"},{"key":"ref1961","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1093\/hmg\/ddy166","article-title":"Interaction of AIP with protein kinase A (cAMP-dependent protein kinase)","volume":"27","year":"2018","journal-title":"Human Molecular Genetics"},{"key":"ref3621","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/EJE-15-0832","article-title":"Factors predicting pasireotide responsiveness in somatotroph pituitary adenomas resistant to first-generation somatostatin analogues: an immunohistochemical study","volume":"174","year":"2016a","journal-title":"European Journal of Endocrinology"},{"key":"ref3801","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","year":"2010","journal-title":"Nature Reviews Genetics"},{"key":"ref1031","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0014-5793(79)80519-0","article-title":"Altered cellular ratio of type I and type II cyclic AMP-dependent protein kinase in human mammary tumors","volume":"106","year":"1979","journal-title":"FEBS Letters"},{"key":"ref3091","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1530\/ERC-18-0065","article-title":"der Pheochromocytomas and pituitary adenomas in three patients with MAX exon deletions - Related https org","author":"LelyAJBoursV","year":"2018","journal-title":"Endocrine Cancer"},{"key":"ref2541","doi-asserted-by":"crossref","first-page":"10217","DOI":"10.1073\/pnas.92.22.10217","article-title":"Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner","volume":"92","year":"1995","journal-title":"PNAS"},{"key":"ref2911","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.3892\/or.2013.2689","article-title":"HIF-1alpha inhibition sensitizes pituitary adenoma cells to temozolomide by regulating MGMT expression","volume":"30","year":"2013","journal-title":"Oncology Reports"},{"key":"ref4181","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11060-004-6150-9","article-title":"Magnetic resonance imaging and biological markers in pituitary adenomas with invasion of the cavernous sinus space","volume":"74","year":"2005","journal-title":"Journal of Neurooncology"},{"key":"ref2391","doi-asserted-by":"crossref","first-page":"e1005242","DOI":"10.1371\/journal.pgen.1005242","article-title":"Fibroblast growth factor 9 regulation by microRNAs controls lung development and links DICER1 loss to the pathogenesis of pleuropulmonary blastoma","volume":"11","year":"2015","journal-title":"PLoS Genetics"},{"key":"ref2051","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11154-016-9400-1","article-title":"Carney complex: a familial lentiginosis predisposing to a variety of tumors","volume":"17","year":"2016","journal-title":"Reviews in Endocrine and Metabolic Disorders"},{"key":"ref2531","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1086\/321282","article-title":"Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma","volume":"69","year":"2001","journal-title":"American Journal of Human Genetics"},{"key":"ref111","first-page":"250","article-title":"Reduced expression levels of the cell-cycle inhibitor p27Kip1 in human pituitary adenomas","volume":"140","year":"1999","journal-title":"European Journal of Endocrinology"},{"key":"ref611","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1210\/jc.2009-2556","article-title":"Clinical characteristics and therapeutic responses in patients with germ - line AIP mutations and pituitary adenomas : an international collaborative study of and https org","year":"2010","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref2511","doi-asserted-by":"crossref","first-page":"27294","DOI":"10.1074\/jbc.M200302200","article-title":"Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"ref3781","article-title":"Case report of bilateral pheochromocytomas due to a novel MAX mutation in a patient known to have a pituitary prolactinoma","year":"2018","journal-title":"AACE Clinical Case Reports"},{"key":"ref2491","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/ERC-17-0243","article-title":"ShmouniFStratakisCA MEN mutations the latest of the MEN syndromes - Related https org","volume":"24","author":"AlrezkRHannah","year":"2017","journal-title":"Endocrine Cancer"},{"key":"ref4651","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1530\/JME-16-0045","article-title":"Characterization of GPR101 transcript structure and expression patterns","volume":"57","year":"2016a","journal-title":"Journal of Molecular Endocrinology"},{"key":"ref981","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s11102-016-0743-0","article-title":"Childhood acromegaly due to X-linked acrogigantism: long term follow-up","volume":"19","year":"2016","journal-title":"Pituitary"},{"key":"ref1301","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1093\/hmg\/9.20.3037","article-title":"Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex","volume":"9","year":"2000b","journal-title":"Human Molecular Genetics"},{"key":"ref951","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/onc.2014.3","article-title":"MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2","volume":"34","year":"2015","journal-title":"Oncogene"},{"key":"ref4331","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.beem.2010.03.003","article-title":"Clinical and molecular genetics of Carney complex","volume":"24","year":"2010","journal-title":"Best Practice and Research Clinical Endocrinology and Metabolism"},{"key":"ref4091","doi-asserted-by":"crossref","first-page":"e60525","DOI":"10.1371\/journal.pone.0060525","article-title":"Quantitative and sensitive detection of GNAS mutations causing mccune-albright syndrome with next generation sequencing","volume":"8","year":"2013","journal-title":"PLoS ONE"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"10217","DOI":"10.1073\/pnas.92.22.10217","article-title":"Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner","volume":"92","year":"1995","journal-title":"PNAS"},{"key":"ref2181","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1530\/JOE-11-0054","article-title":"AIP and its interacting partners","volume":"210","year":"2011","journal-title":"Journal of Endocrinology"},{"key":"ref2941","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ng.861","article-title":"Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma","volume":"43","year":"2011","journal-title":"Nature Genetics"},{"key":"ref1841","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1210\/jc.2015-4366","article-title":"Somatic GPR101 duplication causing X-linked acrogigantism (XLAG)-diagnosis and management","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3331","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1210\/jc.2010-1048","article-title":"Pituitary incidentaloma: an endocrine society clinical practice guideline","volume":"96","year":"2011","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1491","first-page":"18-0078","article-title":"A patient with a germline SDHB mutation presenting with an isolated pituitary macroprolactinoma","volume":"2018","year":"2018","journal-title":"Endocrinology, Diabetes and Metabolism Case Reports"},{"key":"ref2291","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.1126100","article-title":"Pituitary adenoma predisposition caused by germline mutations in the AIP gene","volume":"312","year":"2006","journal-title":"Science"},{"key":"ref4661","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1530\/ERC-16-0091","article-title":"Screening for GPR101 defects in pediatric pituitary corticotropinomas","volume":"23","year":"2016b","journal-title":"Endocrine-Related Cancer"},{"key":"ref1981","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","article-title":"Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase","volume":"7","year":"2005","journal-title":"Cancer Cell"},{"key":"ref1621","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4161\/cbt.7.5.5665","article-title":"The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration","volume":"7","year":"2008","journal-title":"Cancer Biology and Therapy"},{"key":"ref2081","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2013.08.002","article-title":"Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)","volume":"386","year":"2014","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref871","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.beem.2018.01.005","article-title":"The kisspeptin receptor: a key G-protein-coupled receptor in the control of the reproductive axis","volume":"32","year":"2018","journal-title":"Best Practice and Research Clinical Endocrinology and Metabolism"},{"key":"ref4581","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1530\/EJE-11-0304","article-title":"High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas","volume":"165","year":"2011","journal-title":"European Journal of Endocrinology"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cancergen.2015.12.002","article-title":"Multiple endocrine neoplasia type 1 (MEN1): an update of 208 new germline variants reported in the last nine years","volume":"209","year":"2016","journal-title":"Cancer Genetics"},{"key":"ref2211","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1530\/ERC-16-0091","article-title":"Screening for GPR101 defects in pediatric pituitary corticotropinomas","volume":"23","year":"2016b","journal-title":"Endocrine-Related Cancer"},{"key":"ref2651","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2265.2011.04269.x","article-title":"Novel mutations in MEN1, CDKN1B and AIP genes in patients with multiple endocrine neoplasia type 1 syndrome in Spain","volume":"76","year":"2012","journal-title":"Clinical Endocrinology"},{"key":"ref1441","doi-asserted-by":"crossref","first-page":"35924","DOI":"10.1074\/jbc.M705471200","article-title":"Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality","volume":"282","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"ref3111","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/jmedgenet-2015-103428","article-title":"High-sensitivity sequencing reveals multi-organ somatic mosaicism causing DICER1 syndrome","volume":"53","year":"2016","journal-title":"Journal of Medical Genetics"},{"key":"ref3461","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1261\/rna.032680.112","article-title":"In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs","volume":"18","year":"2012","journal-title":"RNA"},{"key":"ref4261","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2353\/ajpath.2010.100138","article-title":"Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression","volume":"177","year":"2010","journal-title":"American Journal of Pathology"},{"key":"ref4341","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1210\/jc.2015-3324","article-title":"The Cables1 gene in glucocorticoid regulation of pituitary corticotrope growth and cushing disease","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4831","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1210\/me.2006-0428","article-title":"Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis","volume":"22","year":"2008","journal-title":"Molecular Endocrinology"},{"key":"ref671","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1210\/JC.2015-2015","article-title":"Long-term natural course of pituitary tumors in patients with MEN1: results from the DutchMEN1 Study Group (DMSG)","volume":"100","year":"2015","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref741","first-page":"510985","article-title":"Early onset primary hyperparathyroidism associated with a novel germline mutation in CDKN1B","volume":"2015","year":"2015","journal-title":"Case Reports in Endocrinology"},{"key":"ref931","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1210\/jc.2008-1003","article-title":"Large genomic deletions in AIP in pituitary adenoma predisposition","volume":"93","year":"2008","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1158\/1078-0432.CCR-16-0452","article-title":"Novel genetic causes of pituitary adenomas","volume":"22","year":"2016","journal-title":"Clinical Cancer Research"},{"key":"ref3821","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jmedgenet-2011-100468","article-title":"Comprehensive sequence analysis of nine Usher syndrome genes in the UK National Collaborative Usher Study","volume":"49","year":"2012","journal-title":"Journal of Medical Genetics"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2265.2011.04269.x","article-title":"Novel mutations in MEN1, CDKN1B and AIP genes in patients with multiple endocrine neoplasia type 1 syndrome in Spain","volume":"76","year":"2012","journal-title":"Clinical Endocrinology"},{"key":"ref2671","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1210\/jc.2008-2333","article-title":"Mutations in regulatory subunit type 1A of cyclic adenosine 5\u2032-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1038\/sj.onc.1205428","article-title":"Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas","volume":"21","year":"2002","journal-title":"Oncogene"},{"key":"ref3541","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1210\/jc.2016-1307","article-title":"Rapid proteasomal degradation of mutant proteins is the primary mechanism leading to tumorigenesis in patients with missense AIP mutations","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3071","first-page":"161","article-title":"GHRH excess and blockade in X-LAG syndrome","volume":"23","year":"2016a","journal-title":"Endocrine-Related Cancer"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1073\/pnas.98.3.1118","article-title":"A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors","volume":"98","year":"2001","journal-title":"PNAS"},{"key":"ref4251","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1210\/jc.2010-0537","article-title":"Incidence of pituitary adenomas in Northern Finland in 1992\u20132007","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4741","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.1126100","article-title":"Pituitary adenoma predisposition caused by germline mutations in the AIP gene","volume":"312","year":"2006","journal-title":"Science"},{"key":"ref4121","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/81551","article-title":"Mutations in SDHC cause autosomal dominant paraganglioma, type 3","volume":"26","year":"2000","journal-title":"Nature Genetics"},{"key":"ref3361","doi-asserted-by":"crossref","first-page":"15736","DOI":"10.1074\/jbc.271.26.15736","article-title":"The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo","volume":"271","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"ref1891","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1210\/jc.2015-3324","article-title":"The Cables1 gene in glucocorticoid regulation of pituitary corticotrope growth and cushing disease","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s12020-016-0941-6","article-title":"Loss of p27 expression is associated with MEN1 gene mutations in sporadic parathyroid adenomas","volume":"55","year":"2017","journal-title":"Endocrine"},{"key":"ref2831","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI10841","article-title":"Mutations in the protein kinase alpha regulatory subunit cause familial cardiac myxomas and complex of Investigation https org","author":"Carney","year":"2000","journal-title":"Journal Clinical"},{"key":"ref661","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/jmedgenet-2015-103428","article-title":"High-sensitivity sequencing reveals multi-organ somatic mosaicism causing DICER1 syndrome","volume":"53","year":"2016","journal-title":"Journal of Medical Genetics"},{"key":"ref2501","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1210\/jc.2008-1451","article-title":"MicroRNAs differentially expressed in ACTH-secreting pituitary tumors","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1821","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng.3166","article-title":"Mutations in the deubiquitinase gene USP8 cause Cushing\u2019s disease","volume":"47","year":"2015","journal-title":"Nature Genetics"},{"key":"ref1921","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1530\/EJE-17-0293","article-title":"In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism","volume":"177","year":"2017","journal-title":"European Journal of Endocrinology"},{"key":"ref791","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/24179","article-title":"The murine gene p27Kip1 is haplo-insufficient for tumour suppression","volume":"396","year":"1998","journal-title":"Nature"},{"key":"ref3081","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1530\/ERC-16-0082","article-title":"Somatic mosaicism underlies X-linked acrogigantism syndrome in sporadic male subjects","volume":"23","year":"2016b","journal-title":"Endocrine-Related Cancer"},{"key":"ref3711","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1158\/2159-8290.CD-13-0092","article-title":"Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor","volume":"3","year":"2013","journal-title":"Cancer Discovery"},{"key":"ref1061","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1056\/NEJMoa1102903","article-title":"Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers","volume":"366","year":"2012","journal-title":"New England Journal of Medicine"},{"key":"ref1541","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1055\/s-0042-118613","article-title":"P27\/CDKN1B translational regulators in pituitary tumorigenesis","volume":"48","year":"2016","journal-title":"Hormone and Metabolic Research"},{"key":"ref2931","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1172\/JCI7308","article-title":"CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression","volume":"104","year":"1999","journal-title":"Journal of Clinical Investigation"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1086\/301729","article-title":"Characterization of mutations in patients with multiple endocrine neoplasia type 1","volume":"62","year":"1998","journal-title":"American Journal of Human Genetics"},{"key":"ref731","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1210\/jc.2013-1400","article-title":"Familial SDHA mutation associated with pituitary adenoma and paraganglioma of and https org","author":"BlighRJ","year":"2013","journal-title":"pheochromocytoma Journal Clinical Endocrinology Metabolism"},{"key":"ref1851","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1530\/EJE-15-1064","article-title":"Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas","volume":"174","year":"2016","journal-title":"European Journal of Endocrinology"},{"key":"ref4281","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1530\/EJE-16-0620","article-title":"Impact of AIP and inhibitory G protein alpha 2 proteins on clinical features of sporadic GH-secreting pituitary adenomas","volume":"176","year":"2017","journal-title":"European Journal of Endocrinology"},{"key":"ref3021","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1210\/jc.2006-1668","article-title":"High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium","volume":"91","year":"2006a","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref921","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1210\/jc.2006-2843","article-title":"Germline CDKN1B\/p27Kip1 mutation in multiple endocrine neoplasia","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3491","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1175689","article-title":"SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma","volume":"325","year":"2009","journal-title":"Science"},{"key":"ref4891","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mce.2013.09.006","article-title":"Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma","volume":"386","year":"2014","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref2401","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ccr.2008.05.003","article-title":"Menin critically links MLL proteins with LEDGF on cancer-associated target genes","volume":"14","year":"2008","journal-title":"Cancer Cell"},{"key":"ref3511","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1056\/NEJMoa1102903","article-title":"Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers","volume":"366","year":"2012","journal-title":"New England Journal of Medicine"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/js.2017-00364","article-title":"USP8 mutations in pituitary cushing adenomas-targeted analysis by next-generation sequencing","volume":"2","year":"2018","journal-title":"Journal of the Endocrine Society"},{"key":"ref1521","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ecl.2017.01.004","article-title":"Genetic aspects of pituitary adenomas","volume":"46","year":"2017","journal-title":"Endocrinology and Metabolism Clinics of North America"},{"key":"ref3211","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/cncr.20412","article-title":"The prevalence of pituitary adenomas: a systematic review","volume":"101","year":"2004","journal-title":"Cancer"},{"key":"ref3681","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMc1500340","article-title":"Gigantism, acromegaly, and GPR101 mutations","volume":"372","year":"2015","journal-title":"New England Journal of Medicine"},{"key":"ref891","first-page":"249","article-title":"Loss of heterozygosity on chromosome 11q13 in two families with acromegaly\/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene","volume":"84","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2821","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00005792-198507000-00007","article-title":"The complex of myxomas, spotty pigmentation, and endocrine overactivity","volume":"64","year":"1985","journal-title":"Medicine"},{"key":"ref2101","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yfrne.2013.07.005","article-title":"Somatostatin receptors: from signaling to clinical practice","volume":"34","year":"2013","journal-title":"Frontiers in Neuroendocrinology"},{"key":"ref3881","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1210\/jcem.84.10.6066","article-title":"Low expression of the cell cycle inhibitor p27Kip1 in normal corticotroph cells, corticotroph tumors, and malignant pituitary tumors","volume":"84","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4361","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1210\/jc.2013-3159","article-title":"Deletions of the locus at q q in complex genotype - phenotype correlations and implications for genetic testing of and https org","volume":"24","author":"PRKAR","year":"2014","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref861","first-page":"272","article-title":"Protein kinases in human renal cell carcinoma and renal cortex. A comparison of isozyme distribution and of responsiveness to adenosine 3\u2032:5\u2032-cyclic monophosphate","volume":"189","year":"1978","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"ref941","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/PAS.0000000000000149","article-title":"Succinate dehydrogenase deficiency is rare in pituitary adenomas","volume":"38","year":"2014","journal-title":"American Journal of Surgical Pathology"},{"key":"ref4701","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1210\/jc.2015-3129","article-title":"Whole-genome sequencing of growth hormone (GH)-secreting pituitary adenomas","volume":"100","year":"2015","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3501","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI11887","article-title":"Imprinting of the alpha gene in the pathogenesis of acromegaly of Investigation https org","author":"GNAS","year":"2001","journal-title":"Journal Clinical"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1038\/ncomms7044","article-title":"Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas","volume":"6","year":"2015","journal-title":"Nature Communication"},{"key":"ref4161","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1530\/EJE-12-0457","article-title":"Germline mutations of AIP gene in somatotropinomas resistant to somatostatin analogues","volume":"168","year":"2013","journal-title":"European Journal of Endocrinology"},{"key":"ref1481","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/cr.2015.20","article-title":"Recurrent gain-of-function USP8 mutations in Cushing\u2019s disease","volume":"25","year":"2015","journal-title":"Cell Research"},{"key":"ref2641","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1530\/ERC-16-0558","article-title":"Paleogenetic study of ancient DNA suggestive of linked acrogigantism - Related https org","volume":"24","year":"2017","journal-title":"Endocrine Cancer"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/s12020-016-0862-4","article-title":"Analysis of GPR101 and AIP genes mutations in acromegaly: a multicentric study","volume":"54","year":"2016","journal-title":"Endocrine"},{"key":"ref4551","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yfrne.2013.07.005","article-title":"Somatostatin receptors: from signaling to clinical practice","volume":"34","year":"2013","journal-title":"Frontiers in Neuroendocrinology"},{"key":"ref1291","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/79238","article-title":"Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex","volume":"26","year":"2000a","journal-title":"Nature Genetics"},{"key":"ref4481","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11102-005-5348-y","article-title":"Pituitary pathology in Carney complex patients","volume":"7","year":"2004","journal-title":"Pituitary"},{"key":"ref1371","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jmedgenet-2011-100468","article-title":"Comprehensive sequence analysis of nine Usher syndrome genes in the UK National Collaborative Usher Study","volume":"49","year":"2012","journal-title":"Journal of Medical Genetics"},{"key":"ref851","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1530\/ERC-13-0043","article-title":"Aip regulates cAMP signalling and GH secretion in GH3 cells","volume":"20","year":"2013","journal-title":"Endocrine-Related Cancer"},{"key":"ref1431","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1210\/jcem.84.10.6066","article-title":"Low expression of the cell cycle inhibitor p27Kip1 in normal corticotroph cells, corticotroph tumors, and malignant pituitary tumors","volume":"84","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4371","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1530\/EJE-17-0293","article-title":"In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism","volume":"177","year":"2017","journal-title":"European Journal of Endocrinology"},{"key":"ref2691","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mce.2018.04.014","article-title":"Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas","volume":"476","year":"2018","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref3671","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/359295a0","article-title":"Effects of an Rb mutation in the mouse","volume":"359","year":"1992","journal-title":"Nature"},{"key":"ref961","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/js.2016-1004","article-title":"Somatotroph-specific aip-deficient mice display pretumorigenic alterations in cell-cycle signaling","volume":"1","year":"2017","journal-title":"Journal of the Endocrine Society"},{"key":"ref1751","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EC-14-0116","article-title":"Functional characterization of a CDKN1B mutation in a Sardinian kindred with multiple endocrine neoplasia type 4 (MEN4)","volume":"4","year":"2015","journal-title":"Endocrine Connections"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1210\/jc.2005-2671","article-title":"Clinical characterization of familial isolated pituitary adenomas","volume":"91","year":"2006b","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4081","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0092-8674(00)81237-4","article-title":"Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors","volume":"85","year":"1996","journal-title":"Cell"},{"key":"ref1071","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1210\/jcem-71-6-1427","article-title":"Clonal origin of pituitary adenomas","volume":"71","year":"1990","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3321","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.beem.2018.01.005","article-title":"The kisspeptin receptor: a key G-protein-coupled receptor in the control of the reproductive axis","volume":"32","year":"2018","journal-title":"Best Practice and Research Clinical Endocrinology and Metabolism"},{"key":"ref1351","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","year":"2010","journal-title":"Nature Reviews Genetics"},{"key":"ref911","doi-asserted-by":"crossref","first-page":"15736","DOI":"10.1074\/jbc.271.26.15736","article-title":"The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo","volume":"271","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"ref4721","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4158\/EP11064.RA","article-title":"Familial pituitary tumor syndromes","volume":"17","year":"2011","journal-title":"Endocrine Practice"},{"key":"ref521","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1530\/EJE-15-0209","article-title":"CorreaRSalpeaPStratakisCA complex an update of https org","author":"Carney","journal-title":"European Journal Endocrinology"},{"key":"ref4351","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1210\/jc.2013-3826","article-title":"Acromegaly and McCune-Albright syndrome","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4141","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1046\/j.1365-2265.2003.01921.x","article-title":"Fibrous bodies are associated with lower GH production and decreased expression of E-cadherin in GH-producing pituitary adenomas","volume":"59","year":"2003","journal-title":"Clinical Endocrinology"},{"key":"ref1571","first-page":"1817","article-title":"Cellular retinol binding protein 1 could be a tumor suppressor gene in cervical cancer","volume":"6","year":"2013","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1530\/ERC-16-0558","article-title":"Paleogenetic study of ancient DNA suggestive of linked acrogigantism - Related https org","volume":"24","year":"2017","journal-title":"Endocrine Cancer"},{"key":"ref2341","first-page":"726","article-title":"Menin represses tumorigenesis via repressing cell proliferation","volume":"1","year":"2011","journal-title":"American Journal of Cancer Research"},{"key":"ref4791","first-page":"726","article-title":"Menin represses tumorigenesis via repressing cell proliferation","volume":"1","year":"2011","journal-title":"American Journal of Cancer Research"},{"key":"ref2591","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.02.123","article-title":"Characterization of Gpr101 expression and G-protein coupling selectivity","volume":"1087","year":"2006","journal-title":"Brain Research"},{"key":"ref1151","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1158\/1078-0432.CCR-07-1155","article-title":"Large deletions of the PRKAR1A gene in Carney complex","volume":"14","year":"2008","journal-title":"Clinical Cancer Research"},{"key":"ref2701","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1158\/0008-5472.CAN-10-1887","article-title":"Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells","volume":"70","year":"2010","journal-title":"Cancer Research"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/ERC-17-0243","article-title":"ShmouniFStratakisCA MEN mutations the latest of the MEN syndromes - Related https org","volume":"24","author":"AlrezkRHannah","year":"2017","journal-title":"Endocrine Cancer"},{"key":"ref3281","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1056\/NEJMc1309730","article-title":"PRKACB and Carney complex","volume":"370","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"ref1461","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1210\/jc.2003-031225","article-title":"Activating Gsalpha mutations: analysis of 113 patients with signs of McCune-Albright syndrome \u2013 a European Collaborative Study","volume":"89","year":"2004","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3301","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1530\/ERC-13-0043","article-title":"Aip regulates cAMP signalling and GH secretion in GH3 cells","volume":"20","year":"2013","journal-title":"Endocrine-Related Cancer"},{"key":"ref1101","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1530\/ERC-17-0131","article-title":"Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing\u2019s disease","volume":"24","year":"2017a","journal-title":"Endocrine-Related Cancer"},{"key":"ref1771","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1530\/JME-13-0172","article-title":"cAMP in the pituitary : an old messenger for multiple signals of https org","year":"2014","journal-title":"Journal Molecular Endocrinology"},{"key":"ref3391","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/PAS.0000000000000149","article-title":"Succinate dehydrogenase deficiency is rare in pituitary adenomas","volume":"38","year":"2014","journal-title":"American Journal of Surgical Pathology"},{"key":"ref2451","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11060-013-1354-5","article-title":"Epidemiology and etiopathogenesis of pituitary adenomas","volume":"117","year":"2014","journal-title":"Journal of Neurooncology"},{"key":"ref2521","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/path.4135","article-title":"Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage","volume":"229","year":"2013","journal-title":"Journal of Pathology"},{"key":"ref3141","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1365-2826.2008.01716.x","article-title":"An insight to pituitary folliculo-stellate cells","volume":"20","year":"2008","journal-title":"Journal of Neuroendocrinology"},{"key":"ref4811","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1530\/ERC-13-0218","article-title":"la Familial pituitary apoplexy as the only presentation of a novel AIP mutation - Related https org","volume":"20","author":"Luz","year":"2013","journal-title":"Endocrine Cancer"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ng.861","article-title":"Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma","volume":"43","year":"2011","journal-title":"Nature Genetics"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mce.2018.04.014","article-title":"Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas","volume":"476","year":"2018","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref3001","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1073\/pnas.98.3.1118","article-title":"A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors","volume":"98","year":"2001","journal-title":"PNAS"},{"key":"ref2851","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1038\/ncomms7044","article-title":"Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas","volume":"6","year":"2015","journal-title":"Nature Communication"},{"key":"ref4881","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ajhg.2017.03.011","article-title":"Germline mutations in CDH23, encoding cadherin-related 23, are associated with both familial and sporadic pituitary adenomas","volume":"100","year":"2017","journal-title":"American Journal of Human Genetics"},{"key":"ref3611","article-title":"X-linked acrogigantism","year":"2018","journal-title":"GeneReviews."},{"key":"ref371","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00005792-198507000-00007","article-title":"The complex of myxomas, spotty pigmentation, and endocrine overactivity","volume":"64","year":"1985","journal-title":"Medicine"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1365-2826.2008.01716.x","article-title":"An insight to pituitary folliculo-stellate cells","volume":"20","year":"2008","journal-title":"Journal of Neuroendocrinology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1530\/EJE-15-0189","article-title":"The epidemiology of pituitary adenomas in Iceland, 1955\u20132012: a nationwide population-based study","volume":"173","year":"2015","journal-title":"European Journal of Endocrinology"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/jcp.20832","article-title":"Identification of differentially expressed microRNAs by microarray: a possible role for microRNA genes in pituitary adenomas","volume":"210","year":"2007","journal-title":"Journal of Cellular Physiology"},{"key":"ref1931","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12020-015-0540-y","article-title":"Early onset acromegaly associated with a novel deletion in CDKN1B 5\u2032UTR region.","volume":"49","year":"2015","journal-title":"Endocrine"},{"key":"ref3771","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0092-8674(00)81238-6","article-title":"Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)","volume":"85","year":"1996","journal-title":"Cell"},{"key":"ref1161","article-title":"X-linked acrogigantism","year":"2018","journal-title":"GeneReviews."},{"key":"ref2471","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1210\/jc.2008-2083","article-title":"Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2231","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12022-017-9474-7","article-title":"Pituitary carcinoma in a patient with an SDHB mutation","volume":"28","year":"2017","journal-title":"Endocrine Pathology"},{"key":"ref3581","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1210\/endo.137.6.8641220","article-title":"Growth hormone-releasing factor (GRF) regulates expression of its own receptor","volume":"137","year":"1996","journal-title":"Endocrinology"},{"key":"ref4071","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4161\/cbt.7.5.5665","article-title":"The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration","volume":"7","year":"2008","journal-title":"Cancer Biology and Therapy"},{"key":"ref1001","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11102-012-0454-0","article-title":"Prevalence and incidence of pituitary adenomas: a population based study in Malta","volume":"16","year":"2013","journal-title":"Pituitary"},{"key":"ref2331","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/jc.2013-2868","article-title":"Clinical experience in the screening and management of a large kindred with familial isolated pituitary adenoma due to an aryl hydrocarbon receptor interacting protein (AIP) mutation","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.molmed.2008.07.001","article-title":"let-7 microRNAs in development, stem cells and cancer","volume":"14","year":"2008","journal-title":"Trends in Molecular Medicine"},{"key":"ref2681","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1128\/MCB.24.8.3125-3131.2004","article-title":"Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues","volume":"24","year":"2004","journal-title":"Molecular and Cellular Biology"},{"key":"ref3241","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/24179","article-title":"The murine gene p27Kip1 is haplo-insufficient for tumour suppression","volume":"396","year":"1998","journal-title":"Nature"},{"key":"ref1411","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1210\/jc.2007-2611","article-title":"The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas","volume":"93","year":"2008","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2161","first-page":"3233","article-title":"The RI alpha subunit of protein kinase A controls serum dependency and entry into cell cycle of human mammary epithelial cells","volume":"9","year":"1994a","journal-title":"Oncogene"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1210\/en.2004-0900","article-title":"Minireview: PRKAR1A: normal and abnormal functions","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"ref2041","article-title":"Familial isolated pituitary adenoma.","volume-title":"Endotext","year":"2011"},{"key":"ref1131","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1210\/endo.137.6.8641220","article-title":"Growth hormone-releasing factor (GRF) regulates expression of its own receptor","volume":"137","year":"1996","journal-title":"Endocrinology"},{"key":"ref311","article-title":"Fibrous dysplasia\/McCune\u2013Albright syndrome","year":"1993","journal-title":"GeneReviews"},{"key":"ref2381","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1210\/me.2006-0428","article-title":"Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis","volume":"22","year":"2008","journal-title":"Molecular Endocrinology"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/83667","article-title":"Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D","volume":"27","year":"2001","journal-title":"Nature Genetics"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1172\/JCI7308","article-title":"CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression","volume":"104","year":"1999","journal-title":"Journal of Clinical Investigation"},{"key":"ref4631","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1530\/JOE-11-0054","article-title":"AIP and its interacting partners","volume":"210","year":"2011","journal-title":"Journal of Endocrinology"},{"key":"ref2781","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1093\/hmg\/ddq206","article-title":"SDHA is a tumor suppressor gene causing paraganglioma","volume":"19","year":"2010","journal-title":"Human Molecular Genetics"},{"key":"ref3481","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0014-5793(79)80519-0","article-title":"Altered cellular ratio of type I and type II cyclic AMP-dependent protein kinase in human mammary tumors","volume":"106","year":"1979","journal-title":"FEBS Letters"},{"key":"ref2301","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1530\/ERC-11-0059","article-title":"Hyperplasia-adenoma sequence in pituitary tumorigenesis related to aryl hydrocarbon receptor interacting protein gene mutation","volume":"18","year":"2011","journal-title":"Endocrine-Related Cancer"},{"key":"ref1831","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1530\/EJE-16-0620","article-title":"Impact of AIP and inhibitory G protein alpha 2 proteins on clinical features of sporadic GH-secreting pituitary adenomas","volume":"176","year":"2017","journal-title":"European Journal of Endocrinology"},{"key":"ref2901","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia-type 1","volume":"276","year":"1997","journal-title":"Science"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"27294","DOI":"10.1074\/jbc.M200302200","article-title":"Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"ref721","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1056\/NEJMc1406028","article-title":"Breast-cancer predisposition in multiple endocrine neoplasia type 1","volume":"371","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/path.4135","article-title":"Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage","volume":"229","year":"2013","journal-title":"Journal of Pathology"},{"key":"ref1221","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/359295a0","article-title":"Effects of an Rb mutation in the mouse","volume":"359","year":"1992","journal-title":"Nature"},{"key":"ref751","first-page":"5902","article-title":"Hypermethylation-associated inactivation of the cellular retinol-binding-protein 1 gene in human cancer","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"ref2131","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1530\/EJE-11-0304","article-title":"High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas","volume":"165","year":"2011","journal-title":"European Journal of Endocrinology"},{"key":"ref3311","first-page":"272","article-title":"Protein kinases in human renal cell carcinoma and renal cortex. A comparison of isozyme distribution and of responsiveness to adenosine 3\u2032:5\u2032-cyclic monophosphate","volume":"189","year":"1978","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"ref3181","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1210\/jc.2013-1400","article-title":"Familial SDHA mutation associated with pituitary adenoma and paraganglioma of and https org","author":"BlighRJ","year":"2013","journal-title":"pheochromocytoma Journal Clinical Endocrinology Metabolism"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2009.05.008","article-title":"The epidemiology and genetics of pituitary adenomas","volume":"23","year":"2009","journal-title":"Best Practice and Research Clinical Endocrinology and Metabolism"},{"key":"ref2801","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1158\/1078-0432.CCR-16-0452","article-title":"Novel genetic causes of pituitary adenomas","volume":"22","year":"2016","journal-title":"Clinical Cancer Research"},{"key":"ref381","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI10841","article-title":"Mutations in the protein kinase alpha regulatory subunit cause familial cardiac myxomas and complex of Investigation https org","author":"Carney","year":"2000","journal-title":"Journal Clinical"},{"key":"ref4601","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1530\/EJE-14-0080","article-title":"heterozygous frameshift mutation in exon of gene in a patient affected by MEN syndrome of https org","author":"CDKN","journal-title":"European Journal Endocrinology"},{"key":"ref2321","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S1097-2765(00)00109-X","article-title":"JunD protects cells from p53-dependent senescence and apoptosis","volume":"6","year":"2000","journal-title":"Molecular Cell"},{"key":"ref3381","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1210\/jc.2008-1003","article-title":"Large genomic deletions in AIP in pituitary adenoma predisposition","volume":"93","year":"2008","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2271","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4158\/EP11064.RA","article-title":"Familial pituitary tumor syndromes","volume":"17","year":"2011","journal-title":"Endocrine Practice"},{"key":"ref1601","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJM199008023230507","article-title":"Gigantism due to pituitary mammosomatotroph hyperplasia","volume":"323","year":"1990","journal-title":"New England Journal of Medicine"},{"key":"ref2371","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1210\/jc.2014-4297","article-title":"adenoma with paraganglioma PAs succinate dehydrogenase defects in humans and mice of and https org","journal-title":"Pituitary pheochromocytoma Journal Clinical Endocrinology Metabolism"},{"key":"ref811","first-page":"2398","article-title":"The high mobility group A2 gene is amplified and overexpressed in human prolactinomas","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"ref4561","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1002\/ijc.24602","article-title":"Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly","volume":"125","year":"2009","journal-title":"International Journal of Cancer"},{"key":"ref3841","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/JOE-16-0190","article-title":"Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice","volume":"231","year":"2016b","journal-title":"Journal of Endocrinology"},{"key":"ref4401","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00401-008-0388-9","article-title":"Pituitary blastoma","volume":"116","year":"2008","journal-title":"Acta Neuropathologica"},{"key":"ref3831","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1530\/EJE-15-1044","article-title":"Very low frequency of germline GPR101 genetic variation and no biallelic defects with AIP in a large cohort of patients with sporadic pituitary adenomas","volume":"174","year":"2016a","journal-title":"European Journal of Endocrinology"},{"key":"ref4211","doi-asserted-by":"crossref","first-page":"15558","DOI":"10.1073\/pnas.0603877103","article-title":"Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans","volume":"103","year":"2006","journal-title":"PNAS"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.bbabio.2011.07.003","article-title":"SDH mutations in cancer","volume":"1807","year":"2011","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref4461","first-page":"678","article-title":"SkalheggBSTaskenK Specificity in the cAMP PKA signaling pathway Differential expression regulation and subcellular localization of subunits of PKA in","year":"2000","journal-title":"Frontiers Bioscience"},{"key":"ref1451","doi-asserted-by":"crossref","first-page":"32955","DOI":"10.18632\/oncotarget.5106","article-title":"Deciphering the molecular basis of invasiveness in Sdhb-deficient cells","volume":"6","year":"2015","journal-title":"Oncotarget"},{"key":"ref681","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1210\/jc.2014-3399","article-title":"Heterogeneous genetic background of the association of pheochromocytoma \/ paraganglioma and pituitary adenoma : results from a large patient cohort of and https org","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref1941","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000079041","article-title":"Down-regulation of E-cadherin and catenins in human pituitary growth hormone-producing adenomas","volume":"32","year":"2004","journal-title":"Frontiers of Hormone Research"},{"key":"ref2861","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1210\/jc.2011-2291","article-title":"AIP mutations in apparently sporadic pituitary adenomas : prevalence in a prospective single - center cohort of patients of and https org","author":"MantelAChansonP","year":"2012","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref1501","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1210\/jc.2004-0194","article-title":"Parental origin of Gsalpha mutations in the McCune-Albright syndrome and in isolated endocrine tumors","volume":"89","year":"2004","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3961","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1750-1172-1-38","article-title":"Multiple endocrine neoplasia type 1","volume":"1","year":"2006","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","article-title":"Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma","volume":"287","year":"2000","journal-title":"Science"},{"key":"ref1901","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1210\/jc.2013-3826","article-title":"Acromegaly and McCune-Albright syndrome","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4751","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1530\/ERC-11-0059","article-title":"Hyperplasia-adenoma sequence in pituitary tumorigenesis related to aryl hydrocarbon receptor interacting protein gene mutation","volume":"18","year":"2011","journal-title":"Endocrine-Related Cancer"},{"key":"ref2991","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s13244-012-0208-6","article-title":"The complex of myxomas, spotty skin pigmentation and endocrine overactivity (Carney complex): imaging findings with clinical and pathological correlation","volume":"4","year":"2013","journal-title":"Insights into Imaging"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1128\/MCB.24.8.3125-3131.2004","article-title":"Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues","volume":"24","year":"2004","journal-title":"Molecular and Cellular Biology"},{"key":"ref1311","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1158\/0008-5472.CAN-05-0580","article-title":"A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues","volume":"65","year":"2005","journal-title":"Cancer Research"},{"key":"ref2091","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1210\/jc.2012-1230","article-title":"Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)","volume":"97","year":"2012","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2731","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s12020-016-0941-6","article-title":"Loss of p27 expression is associated with MEN1 gene mutations in sporadic parathyroid adenomas","volume":"55","year":"2017","journal-title":"Endocrine"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11060-013-1354-5","article-title":"Epidemiology and etiopathogenesis of pituitary adenomas","volume":"117","year":"2014","journal-title":"Journal of Neurooncology"},{"key":"ref2361","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1530\/ERC-13-0218","article-title":"la Familial pituitary apoplexy as the only presentation of a novel AIP mutation - Related https org","volume":"20","author":"Luz","year":"2013","journal-title":"Endocrine Cancer"},{"key":"ref3931","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/cr.2015.20","article-title":"Recurrent gain-of-function USP8 mutations in Cushing\u2019s disease","volume":"25","year":"2015","journal-title":"Cell Research"},{"key":"ref4671","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/PAS.0b013e31815ade45","article-title":"Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): a case-control study in a series of 77 patients versus 2509 non-MEN1 patients","volume":"32","year":"2008","journal-title":"American Journal of Surgical Pathology"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1056\/NEJMoa1008020","article-title":"AIP mutation in pituitary adenomas in the 18th century and today","volume":"364","year":"2011","journal-title":"New England Journal of Medicine"},{"key":"ref1801","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1210\/jc.2010-0537","article-title":"Incidence of pituitary adenomas in Northern Finland in 1992\u20132007","volume":"95","year":"2010","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3471","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/MCB.01338-07","article-title":"Loss of the SdhB, but not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis","volume":"28","year":"2008","journal-title":"Molecular and Cellular Biology"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/jc.2005-1862","article-title":"Clinical presentation and penetrance of pheochromocytoma\/paraganglioma syndromes","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3941","first-page":"18-0078","article-title":"A patient with a germline SDHB mutation presenting with an isolated pituitary macroprolactinoma","volume":"2018","year":"2018","journal-title":"Endocrinology, Diabetes and Metabolism Case Reports"},{"key":"ref1861","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1530\/ERC-15-0320","article-title":"Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients","volume":"22","year":"2015","journal-title":"Endocrine-Related Cancer"},{"key":"ref2921","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc2347","article-title":"The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy","volume":"8","year":"2008","journal-title":"Nature Reviews Cancer"},{"key":"ref2141","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/ERC-11-0362","article-title":"Cyclin-dependent kinase inhibitor 1B (CDKN1B) gene variants in AIP mutation-negative familial isolated pituitary adenoma kindreds","volume":"19","year":"2012","journal-title":"Endocrine-Related Cancer"},{"key":"ref4861","first-page":"43","article-title":"Elevated cell invasion is induced by hypoxia in a human pituitary adenoma cell line","year":"2007","journal-title":"Cell Adhesion and Migration"},{"key":"ref3291","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mce.2014.05.004","article-title":"cAMP signalling in the normal and tumorigenic pituitary gland","volume":"392","year":"2014","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref2121","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1093\/hmg\/ddt039","article-title":"Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d\u2019etude des Tumeurs Endocrines (GTE) cohort study","volume":"22","year":"2013","journal-title":"Human Molecular Genetics"},{"key":"ref3131","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1210\/jc.2014-3399","article-title":"Heterogeneous genetic background of the association of pheochromocytoma \/ paraganglioma and pituitary adenoma : results from a large patient cohort of and https org","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref2811","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1530\/EJE-10-0465","article-title":"Increased prevalence of acromegaly in a highly polluted area","volume":"163","year":"2010","journal-title":"European Journal of Endocrinology"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1210\/jc.2006-2513","article-title":"Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2571","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.bbabio.2011.07.003","article-title":"SDH mutations in cancer","volume":"1807","year":"2011","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref2981","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jc.2010-1338","article-title":"mutation and germline sequence abnormalities in encoding Kip in sporadic parathyroid adenomas of and https org","volume":"27","author":"Costa","year":"2011","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref3991","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1055\/s-0042-118613","article-title":"P27\/CDKN1B translational regulators in pituitary tumorigenesis","volume":"48","year":"2016","journal-title":"Hormone and Metabolic Research"},{"key":"ref4571","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1093\/hmg\/ddt039","article-title":"Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d\u2019etude des Tumeurs Endocrines (GTE) cohort study","volume":"22","year":"2013","journal-title":"Human Molecular Genetics"},{"key":"ref3161","article-title":"DICER1-related disorders","year":"1993","journal-title":"GeneReviews."},{"key":"ref2961","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cancergen.2015.12.002","article-title":"Multiple endocrine neoplasia type 1 (MEN1): an update of 208 new germline variants reported in the last nine years","volume":"209","year":"2016","journal-title":"Cancer Genetics"},{"key":"ref4321","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1210\/js.2017-00135","article-title":"Case report of a prolactinoma in a patient with a novel MAX mutation and bilateral pheochromocytomas.","volume":"1","year":"2017","journal-title":"Journal of the Endocrine Society"},{"key":"ref3551","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1530\/ERC-17-0131","article-title":"Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing\u2019s disease","volume":"24","year":"2017a","journal-title":"Endocrine-Related Cancer"},{"key":"ref4421","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1158\/1078-0432.CCR-17-3089","article-title":"DICER1 and associated conditions: identification of at-risk individuals and recommended surveillance strategies","volume":"24","year":"2018","journal-title":"Clinical Cancer Research"},{"key":"ref4611","first-page":"3233","article-title":"The RI alpha subunit of protein kinase A controls serum dependency and entry into cell cycle of human mammary epithelial cells","volume":"9","year":"1994a","journal-title":"Oncogene"},{"key":"ref1671","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/81551","article-title":"Mutations in SDHC cause autosomal dominant paraganglioma, type 3","volume":"26","year":"2000","journal-title":"Nature Genetics"},{"key":"ref2431","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ajhg.2017.03.011","article-title":"Germline mutations in CDH23, encoding cadherin-related 23, are associated with both familial and sporadic pituitary adenomas","volume":"100","year":"2017","journal-title":"American Journal of Human Genetics"},{"key":"ref4871","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-005-9017-9","article-title":"Anti-apoptotic action by hypoxia inducible factor 1-alpha in human pituitary adenoma cell line, HP-75 in hypoxic condition","volume":"78","year":"2006","journal-title":"Journal of Neurooncology"},{"key":"ref4171","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11102-018-0876-4","article-title":"Germline mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene and somatostatin receptor 1\u20135 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues","volume":"21","year":"2018","journal-title":"Pituitary"},{"key":"ref2281","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1210\/jcem.87.2.8145","article-title":"Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study","volume":"87","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref4531","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2013.08.002","article-title":"Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)","volume":"386","year":"2014","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref3571","doi-asserted-by":"crossref","first-page":"9177","DOI":"10.18632\/oncotarget.24183","article-title":"Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland","volume":"9","year":"2018","journal-title":"Oncotarget"},{"key":"ref1421","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ccr.2013.04.018","article-title":"SDH mutations establish a hypermethylator phenotype in paraganglioma","volume":"23","year":"2013","journal-title":"Cancer Cell"},{"key":"ref3411","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/js.2016-1004","article-title":"Somatotroph-specific aip-deficient mice display pretumorigenic alterations in cell-cycle signaling","volume":"1","year":"2017","journal-title":"Journal of the Endocrine Society"},{"key":"ref3011","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1530\/EJE-12-0763","article-title":"Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don\u2019t forget MEN1 genetic analysis","volume":"168","year":"2013","journal-title":"European Journal of Endocrinology"},{"key":"ref2891","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jc.2012-1111","article-title":"Somatostatin analogs modulate AIP in somatotroph adenomas : the role of the pathway of and https org","year":"2012","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref3921","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1074\/jbc.272.14.8878","article-title":"A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"272","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"ref4591","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/ERC-11-0362","article-title":"Cyclin-dependent kinase inhibitor 1B (CDKN1B) gene variants in AIP mutation-negative familial isolated pituitary adenoma kindreds","volume":"19","year":"2012","journal-title":"Endocrine-Related Cancer"},{"key":"ref2771","doi-asserted-by":"crossref","first-page":"214","DOI":"10.12688\/f1000research.6746.1","article-title":"Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma\/DICER1 syndrome: a unique variant of the two-hit tumor suppression model","volume":"4","year":"2015","journal-title":"F1000Research"},{"key":"ref4101","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1530\/EJE-07-0533","article-title":"Variable pathological and clinical features of a large Brazilian family harboring a mutation in the aryl hydrocarbon receptor-interacting protein gene","volume":"157","year":"2007","journal-title":"European Journal of Endocrinology"},{"key":"ref2221","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/PAS.0b013e31815ade45","article-title":"Pituitary tumors and hyperplasia in multiple endocrine neoplasia type 1 syndrome (MEN1): a case-control study in a series of 77 patients versus 2509 non-MEN1 patients","volume":"32","year":"2008","journal-title":"American Journal of Surgical Pathology"},{"key":"ref2741","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1210\/en.2004-0900","article-title":"Minireview: PRKAR1A: normal and abnormal functions","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"ref4691","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/onc.2014.50","article-title":"AIP inactivation leads to pituitary tumorigenesis through defective Galphai-cAMP signaling","volume":"34","year":"2015","journal-title":"Oncogene"},{"key":"ref1181","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40478-016-0328-1","article-title":"Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study","volume":"4","year":"2016b","journal-title":"Acta Neuropathologica Communications"},{"key":"ref2031","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11102-005-5348-y","article-title":"Pituitary pathology in Carney complex patients","volume":"7","year":"2004","journal-title":"Pituitary"},{"key":"ref2311","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neo.2015.08.003","article-title":"The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors","volume":"17","year":"2015","journal-title":"Neoplasia"},{"key":"ref881","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1210\/jc.2010-1048","article-title":"Pituitary incidentaloma: an endocrine society clinical practice guideline","volume":"96","year":"2011","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1721","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11102-018-0876-4","article-title":"Germline mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene and somatostatin receptor 1\u20135 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues","volume":"21","year":"2018","journal-title":"Pituitary"},{"key":"ref4441","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1101\/gad.11.11.1464","article-title":"Cyclin E-CDK2 is a regulator of p27Kip1","volume":"11","year":"1997","journal-title":"Genes and Development"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/hmg\/ddt069","article-title":"Tumoral EPAS1 (HIF2A) mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis","volume":"22","year":"2013","journal-title":"Human Molecular Genetics"},{"key":"ref4031","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1073\/pnas.0408836102","article-title":"Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors","volume":"102","year":"2005","journal-title":"PNAS"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1470-2045(10)70007-3","article-title":"SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma","volume":"11","year":"2010","journal-title":"Lancet Oncology"},{"key":"ref4011","first-page":"307","article-title":"Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches","volume":"44","year":"1988","journal-title":"Recent Progress in Hormone Research"},{"key":"ref1791","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/modpathol.2008.202","article-title":"Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas","volume":"22","year":"2009","journal-title":"Modern Pathology"},{"key":"ref3451","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11102-012-0454-0","article-title":"Prevalence and incidence of pituitary adenomas: a population based study in Malta","volume":"16","year":"2013","journal-title":"Pituitary"},{"key":"ref1591","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/humu.21354","article-title":"UbertiECZatelliMCPellegataNS novel germline mutation causing multiple endocrine tumors clinical genetic and functional characterization https org","author":"CDKN","year":"2010","journal-title":"Human Mutation"},{"key":"ref1661","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3109\/10715762.2012.669041","article-title":"Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia","volume":"46","year":"2012","journal-title":"Free Radical Research"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1210\/jc.2008-2333","article-title":"Mutations in regulatory subunit type 1A of cyclic adenosine 5\u2032-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes","volume":"94","year":"2009","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1041","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1175689","article-title":"SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma","volume":"325","year":"2009","journal-title":"Science"},{"key":"ref1381","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1530\/EJE-15-1044","article-title":"Very low frequency of germline GPR101 genetic variation and no biallelic defects with AIP in a large cohort of patients with sporadic pituitary adenomas","volume":"174","year":"2016a","journal-title":"European Journal of Endocrinology"},{"key":"ref2441","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mce.2013.09.006","article-title":"Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma","volume":"386","year":"2014","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref4221","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1530\/JME-13-0172","article-title":"cAMP in the pituitary : an old messenger for multiple signals of https org","year":"2014","journal-title":"Journal Molecular Endocrinology"},{"key":"ref3721","first-page":"6135","article-title":"Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex","volume":"63","year":"2003","journal-title":"Cancer Research"},{"key":"ref3601","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1158\/1078-0432.CCR-07-1155","article-title":"Large deletions of the PRKAR1A gene in Carney complex","volume":"14","year":"2008","journal-title":"Clinical Cancer Research"},{"key":"ref4731","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1210\/jcem.87.2.8145","article-title":"Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study","volume":"87","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1111","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1210\/js.2017-00231","article-title":"Corticotropinoma as a component of carney complex","volume":"1","year":"2017b","journal-title":"Journal of the Endocrine Society"},{"key":"ref3531","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1210\/jc.2015-1869","article-title":"of familial isolated and young - onset pituitary adenomas : prospective diagnosis in AIP mutation carriers of and https org","author":"Hernandez","journal-title":"Landscape Journal Clinical Endocrinology Metabolism"},{"key":"ref3431","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s11102-016-0743-0","article-title":"Childhood acromegaly due to X-linked acrogigantism: long term follow-up","volume":"19","year":"2016","journal-title":"Pituitary"},{"key":"ref971","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1210\/jc.2011-1401","article-title":"Hereditary pituitary hyperplasia with infantile gigantism of and https org","year":"2011","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref2631","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1530\/ERC-15-0038","article-title":"X-linked acrogigantism syndrome: clinical profile and therapeutic responses","volume":"22","year":"2015","journal-title":"Endocrine-Related Cancer"},{"key":"ref4501","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11154-016-9400-1","article-title":"Carney complex: a familial lentiginosis predisposing to a variety of tumors","volume":"17","year":"2016","journal-title":"Reviews in Endocrine and Metabolic Disorders"},{"key":"ref2171","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/ijc.2910590521","article-title":"Differential effects of protein kinase A sub-units on Chinese-hamster-ovary cell cycle and proliferation","volume":"59","year":"1994b","journal-title":"International Journal of Cancer"},{"key":"ref4191","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-13-0623","article-title":"Non-pheochromocytoma (PCC)\/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis","volume":"170","year":"2014","journal-title":"European Journal of Endocrinology"},{"key":"ref4761","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neo.2015.08.003","article-title":"The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors","volume":"17","year":"2015","journal-title":"Neoplasia"},{"key":"ref1201","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1158\/0008-5472.203.65.1","article-title":"A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis","volume":"65","year":"2005","journal-title":"Cancer Research"},{"key":"ref1881","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.beem.2010.03.003","article-title":"Clinical and molecular genetics of Carney complex","volume":"24","year":"2010","journal-title":"Best Practice and Research Clinical Endocrinology and Metabolism"},{"key":"ref1991","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1101\/gad.11.11.1464","article-title":"Cyclin E-CDK2 is a regulator of p27Kip1","volume":"11","year":"1997","journal-title":"Genes and Development"},{"key":"ref3851","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/humu.20605","article-title":"Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene","volume":"29","year":"2008","journal-title":"Human Mutation"},{"key":"ref3261","first-page":"2398","article-title":"The high mobility group A2 gene is amplified and overexpressed in human prolactinomas","volume":"62","year":"2002","journal-title":"Cancer Research"},{"key":"ref4451","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/onc.2014.171","article-title":"Cables1 controls p21\/Cip1 protein stability by antagonizing proteasome subunit alpha type 3","volume":"34","year":"2015","journal-title":"Oncogene"},{"key":"ref1091","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1210\/jc.2016-1307","article-title":"Rapid proteasomal degradation of mutant proteins is the primary mechanism leading to tumorigenesis in patients with missense AIP mutations","volume":"101","year":"2016","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc2347","article-title":"The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy","volume":"8","year":"2008","journal-title":"Nature Reviews Cancer"},{"key":"ref1361","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/332085a0","article-title":"Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma","volume":"332","year":"1988","journal-title":"Nature"},{"key":"ref1641","doi-asserted-by":"crossref","first-page":"e60525","DOI":"10.1371\/journal.pone.0060525","article-title":"Quantitative and sensitive detection of GNAS mutations causing mccune-albright syndrome with next generation sequencing","volume":"8","year":"2013","journal-title":"PLoS ONE"},{"key":"ref3591","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s00595-012-0354-y","article-title":"Analysis of genotype-phenotype correlations and survival outcomes in patients with primary hyperparathyroidism caused by multiple endocrine neoplasia type 1: the experience at a single institution","volume":"43","year":"2013","journal-title":"Surgery Today"},{"key":"ref3151","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1210\/jcem.82.5.3944","article-title":"Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1","volume":"82","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2971","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1530\/EJE-15-0209","article-title":"CorreaRSalpeaPStratakisCA complex an update of https org","author":"Carney","journal-title":"European Journal Endocrinology"},{"key":"ref3561","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1210\/js.2017-00231","article-title":"Corticotropinoma as a component of carney complex","volume":"1","year":"2017b","journal-title":"Journal of the Endocrine Society"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1530\/ERC-15-0038","article-title":"X-linked acrogigantism syndrome: clinical profile and therapeutic responses","volume":"22","year":"2015","journal-title":"Endocrine-Related Cancer"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1530\/EJE-12-0763","article-title":"Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don\u2019t forget MEN1 genetic analysis","volume":"168","year":"2013","journal-title":"European Journal of Endocrinology"},{"key":"ref2061","article-title":"Carney complex","year":"1993","journal-title":"GeneReviews."},{"key":"ref2151","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1530\/EJE-14-0080","article-title":"heterozygous frameshift mutation in exon of gene in a patient affected by MEN syndrome of https org","author":"CDKN","journal-title":"European Journal Endocrinology"},{"key":"ref1331","article-title":"Case report of bilateral pheochromocytomas due to a novel MAX mutation in a patient known to have a pituitary prolactinoma","year":"2018","journal-title":"AACE Clinical Case Reports"},{"key":"ref4781","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/jc.2013-2868","article-title":"Clinical experience in the screening and management of a large kindred with familial isolated pituitary adenoma due to an aryl hydrocarbon receptor interacting protein (AIP) mutation","volume":"99","year":"2014","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1871","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1210\/js.2017-00135","article-title":"Case report of a prolactinoma in a patient with a novel MAX mutation and bilateral pheochromocytomas.","volume":"1","year":"2017","journal-title":"Journal of the Endocrine Society"},{"key":"ref1281","doi-asserted-by":"crossref","first-page":"654","DOI":"10.4161\/cbt.4.6.1732","article-title":"Increased growth rate, delayed senescense and decreased serum dependence characterize cables-deficient cells","volume":"4","year":"2005","journal-title":"Cancer Biology and Therapy"},{"key":"ref1271","first-page":"6135","article-title":"Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex","volume":"63","year":"2003","journal-title":"Cancer Research"},{"key":"ref1761","doi-asserted-by":"crossref","first-page":"15558","DOI":"10.1073\/pnas.0603877103","article-title":"Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans","volume":"103","year":"2006","journal-title":"PNAS"},{"key":"ref3191","first-page":"510985","article-title":"Early onset primary hyperparathyroidism associated with a novel germline mutation in CDKN1B","volume":"2015","year":"2015","journal-title":"Case Reports in Endocrinology"},{"key":"ref2791","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.molmed.2008.07.001","article-title":"let-7 microRNAs in development, stem cells and cancer","volume":"14","year":"2008","journal-title":"Trends in Molecular Medicine"},{"key":"ref3271","first-page":"2172","article-title":"Epidemiology of pituitary adenoma: results of the first Swiss study","volume":"5","year":"2009","journal-title":"Revue M\u00e9dicale Suisse"},{"key":"ref3121","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1210\/JC.2015-2015","article-title":"Long-term natural course of pituitary tumors in patients with MEN1: results from the DutchMEN1 Study Group (DMSG)","volume":"100","year":"2015","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1141","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s00595-012-0354-y","article-title":"Analysis of genotype-phenotype correlations and survival outcomes in patients with primary hyperparathyroidism caused by multiple endocrine neoplasia type 1: the experience at a single institution","volume":"43","year":"2013","journal-title":"Surgery Today"},{"key":"ref3521","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1210\/jcem-71-6-1427","article-title":"Clonal origin of pituitary adenomas","volume":"71","year":"1990","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2191","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1056\/NEJMoa1408028","article-title":"Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation","volume":"371","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"ref4851","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ccr.2008.05.003","article-title":"Menin critically links MLL proteins with LEDGF on cancer-associated target genes","volume":"14","year":"2008","journal-title":"Cancer Cell"},{"key":"ref2021","doi-asserted-by":"crossref","first-page":"7615","DOI":"10.1158\/0008-5472.CAN-06-0833","article-title":"Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability","volume":"66","year":"2006","journal-title":"Cancer Research"},{"key":"ref2751","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/jcp.20832","article-title":"Identification of differentially expressed microRNAs by microarray: a possible role for microRNA genes in pituitary adenomas","volume":"210","year":"2007","journal-title":"Journal of Cellular Physiology"},{"key":"ref1561","first-page":"307","article-title":"Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches","volume":"44","year":"1988","journal-title":"Recent Progress in Hormone Research"},{"key":"ref2551","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/js.2017-00364","article-title":"USP8 mutations in pituitary cushing adenomas-targeted analysis by next-generation sequencing","volume":"2","year":"2018","journal-title":"Journal of the Endocrine Society"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-0042-100733","article-title":"GPR101 mutations are not a frequent cause of congenital isolated growth hormone deficiency","volume":"48","year":"2016","journal-title":"Hormone and Metabolic Research"},{"key":"ref2711","doi-asserted-by":"crossref","first-page":"33351","DOI":"10.1074\/jbc.M303269200","article-title":"Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2","volume":"278","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"ref531","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jc.2010-1338","article-title":"mutation and germline sequence abnormalities in encoding Kip in sporadic parathyroid adenomas of and https org","volume":"27","author":"Costa","year":"2011","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref2351","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1210\/jc.2011-1179","article-title":"la SierraMMatroJBallEAzevedoM dehydrogenase subunit inactivation in a growth - hormone - producing pituitary tumor : a new association for SDH of and https org","author":"Luz","year":"2012","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia-type 1","volume":"276","year":"1997","journal-title":"Science"},{"key":"ref4641","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1056\/NEJMoa1408028","article-title":"Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation","volume":"371","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"ref3631","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40478-016-0328-1","article-title":"Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study","volume":"4","year":"2016b","journal-title":"Acta Neuropathologica Communications"},{"key":"ref3741","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/79238","article-title":"Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex","volume":"26","year":"2000a","journal-title":"Nature Genetics"},{"key":"ref701","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1210\/jcem.82.5.3944","article-title":"Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1","volume":"82","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1681","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2826.2006.01502.x","article-title":"G protein-coupled receptor 101 mRNA expression in the mouse brain: altered expression in the posterior hypothalamus and amygdala by energetic challenges","volume":"19","year":"2007","journal-title":"Journal of Neuroendocrinology"},{"key":"ref4411","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1093\/hmg\/ddy166","article-title":"Interaction of AIP with protein kinase A (cAMP-dependent protein kinase)","volume":"27","year":"2018","journal-title":"Human Molecular Genetics"},{"key":"ref1081","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1210\/jc.2015-1869","article-title":"of familial isolated and young - onset pituitary adenomas : prospective diagnosis in AIP mutation carriers of and https org","author":"Hernandez","journal-title":"Landscape Journal Clinical Endocrinology Metabolism"},{"key":"ref1241","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1530\/ERC-12-0020","article-title":"KasukiLVieira NetoLWildembergLEColliLMde CastroMTakiyaCMGadelhaMR expression in sporadic somatotropinomas is a predictor of the response to octreotide LAR therapy independent of expression - Related https org","author":"SSTR","year":"2012","journal-title":"Endocrine Cancer"},{"key":"ref3031","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1210\/jc.2005-2671","article-title":"Clinical characterization of familial isolated pituitary adenomas","volume":"91","year":"2006b","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2011","first-page":"678","article-title":"SkalheggBSTaskenK Specificity in the cAMP PKA signaling pathway Differential expression regulation and subcellular localization of subunits of PKA in","year":"2000","journal-title":"Frontiers Bioscience"},{"key":"ref4131","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2826.2006.01502.x","article-title":"G protein-coupled receptor 101 mRNA expression in the mouse brain: altered expression in the posterior hypothalamus and amygdala by energetic challenges","volume":"19","year":"2007","journal-title":"Journal of Neuroendocrinology"},{"key":"ref1231","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMc1500340","article-title":"Gigantism, acromegaly, and GPR101 mutations","volume":"372","year":"2015","journal-title":"New England Journal of Medicine"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"33351","DOI":"10.1074\/jbc.M303269200","article-title":"Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2","volume":"278","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"ref1401","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/humu.20605","article-title":"Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene","volume":"29","year":"2008","journal-title":"Human Mutation"},{"key":"ref4041","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/humu.21354","article-title":"UbertiECZatelliMCPellegataNS novel germline mutation causing multiple endocrine tumors clinical genetic and functional characterization https org","author":"CDKN","year":"2010","journal-title":"Human Mutation"},{"key":"ref4111","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3109\/10715762.2012.669041","article-title":"Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia","volume":"46","year":"2012","journal-title":"Free Radical Research"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.02.123","article-title":"Characterization of Gpr101 expression and G-protein coupling selectivity","volume":"1087","year":"2006","journal-title":"Brain Research"},{"key":"ref1011","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1261\/rna.032680.112","article-title":"In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs","volume":"18","year":"2012","journal-title":"RNA"},{"key":"ref1121","doi-asserted-by":"crossref","first-page":"9177","DOI":"10.18632\/oncotarget.24183","article-title":"Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland","volume":"9","year":"2018","journal-title":"Oncotarget"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.3892\/or.2013.2689","article-title":"HIF-1alpha inhibition sensitizes pituitary adenoma cells to temozolomide by regulating MGMT expression","volume":"30","year":"2013","journal-title":"Oncology Reports"},{"key":"ref1911","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1210\/jc.2013-3159","article-title":"Deletions of the locus at q q in complex genotype - phenotype correlations and implications for genetic testing of and https org","volume":"24","author":"PRKAR","year":"2014","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref441","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jc.2012-1111","article-title":"Somatostatin analogs modulate AIP in somatotroph adenomas : the role of the pathway of and https org","year":"2012","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref3661","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0954-6820.1952.tb13837.x","article-title":"Acromegaly associated with phaeochromocytoma","volume":"142","year":"1952","journal-title":"Acta Medica Scandinavica"},{"key":"ref4381","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12020-015-0540-y","article-title":"Early onset acromegaly associated with a novel deletion in CDKN1B 5\u2032UTR region.","volume":"49","year":"2015","journal-title":"Endocrine"},{"key":"ref3861","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1210\/jc.2007-2611","article-title":"The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas","volume":"93","year":"2008","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s13244-012-0208-6","article-title":"The complex of myxomas, spotty skin pigmentation and endocrine overactivity (Carney complex): imaging findings with clinical and pathological correlation","volume":"4","year":"2013","journal-title":"Insights into Imaging"},{"key":"ref3231","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2265.2009.03667.x","article-title":"Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK)","volume":"72","year":"2010","journal-title":"Clinical Endocrinology"},{"key":"ref4021","first-page":"1817","article-title":"Cellular retinol binding protein 1 could be a tumor suppressor gene in cervical cancer","volume":"6","year":"2013","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"ref3691","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1530\/ERC-12-0020","article-title":"KasukiLVieira NetoLWildembergLEColliLMde CastroMTakiyaCMGadelhaMR expression in sporadic somatotropinomas is a predictor of the response to octreotide LAR therapy independent of expression - Related https org","author":"SSTR","year":"2012","journal-title":"Endocrine Cancer"},{"key":"ref3701","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/EJE-17-0227","article-title":"mutation causing pituitary - dependent Cushing disease in a patient with complex of https org","author":"PRKAR","year":"2017","journal-title":"European Journal Endocrinology"},{"key":"ref1511","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1750-1172-1-38","article-title":"Multiple endocrine neoplasia type 1","volume":"1","year":"2006","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"ref3951","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1210\/jc.2004-0194","article-title":"Parental origin of Gsalpha mutations in the McCune-Albright syndrome and in isolated endocrine tumors","volume":"89","year":"2004","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref411","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1210\/jc.2011-2291","article-title":"AIP mutations in apparently sporadic pituitary adenomas : prevalence in a prospective single - center cohort of patients of and https org","author":"MantelAChansonP","year":"2012","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref2481","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1530\/EJE-15-0189","article-title":"The epidemiology of pituitary adenomas in Iceland, 1955\u20132012: a nationwide population-based study","volume":"173","year":"2015","journal-title":"European Journal of Endocrinology"},{"key":"ref2261","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.endonu.2012.02.009","article-title":"Coexistence of a pituitary macroadenoma and multicentric paraganglioma: a strange coincidence","volume":"60","year":"2013","journal-title":"Endocrinolog\u00eda y Nutrici\u00f3n"},{"key":"ref3371","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1210\/jc.2006-2843","article-title":"Germline CDKN1B\/p27Kip1 mutation in multiple endocrine neoplasia","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref3871","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ccr.2013.04.018","article-title":"SDH mutations establish a hypermethylator phenotype in paraganglioma","volume":"23","year":"2013","journal-title":"Cancer Cell"},{"key":"ref3421","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1210\/jc.2011-1401","article-title":"Hereditary pituitary hyperplasia with infantile gigantism of and https org","year":"2011","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref3641","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/humu.21292","article-title":"Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families","volume":"31","year":"2010","journal-title":"Human Mutation"},{"key":"ref3061","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1210\/jc.2009-2556","article-title":"Clinical characteristics and therapeutic responses in patients with germ - line AIP mutations and pituitary adenomas : an international collaborative study of and https org","year":"2010","journal-title":"Journal Clinical Endocrinology Metabolism"},{"key":"ref2951","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/hmg\/ddt069","article-title":"Tumoral EPAS1 (HIF2A) mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis","volume":"22","year":"2013","journal-title":"Human Molecular Genetics"},{"key":"ref4521","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000079049","article-title":"Pathology and molecular genetics of the pituitary gland in patients with the \u2018complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas\u2019 (Carney complex)","volume":"32","year":"2004","journal-title":"Frontiers of Hormone Research"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/240\/2\/JOE-18-0446.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/240\/2\/JOE-18-0446.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:56:29Z","timestamp":1784555789000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/240\/2\/R21-R45\/5191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":488,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/joe-18-0446","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}