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However, although it is established that hyperglycemia requires \u03b2 cell dysfunction to develop, the role of testosterone in \u03b2 cell function is less understood. This review discusses recent evidence that the androgen receptor (AR) is present in male and female \u03b2 cells. In males, testosterone action on AR in \u03b2 cells enhances glucose-stimulated insulin secretion by potentiating the insulinotropic action of glucagon-like peptide-1. In females, excess testosterone action via AR in \u03b2 cells promotes insulin hypersecretion leading to oxidative injury, which in turn predisposes to T2D.<\/jats:p>","DOI":"10.1530\/joe-18-0573","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T12:44:56Z","timestamp":1546433096000},"page":"R97-R105","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":78,"title":["Emerging role of testosterone in pancreatic \u03b2 cell function and insulin secretion"],"prefix":"10.1530","volume":"240","author":[{"given":"Weiwei","family":"Xu","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Metabolism","department":["Department of Medicine, Diabetes Discovery Research and Gender Medicine Laboratory, Tulane University Health Sciences Center, School of Medicine, and Southeast Louisiana Veterans Healthcare System Medical Center, New Orleans, Louisiana, 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