{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:42Z","timestamp":1784557242764,"version":"3.55.0"},"reference-count":76,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    Multiple crosstalk between peripheral organs and the nervous system are required to maintain physiological and metabolic homeostasis. Using Vav3-deficient mice as a model for chronic sympathoexcitation-associated disorders, we report here that afferent fibers of the hepatic branch of the vagus nerve are needed for the development of the peripheral sympathoexcitation, tachycardia, tachypnea, insulin resistance, liver steatosis and adipose tissue thermogenesis present in those mice. This neuronal pathway contributes to proper activity of the rostral ventrolateral medulla, a sympathoregulatory brainstem center hyperactive in\n                    <jats:italic>\n                      Vav3\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Vagal afferent inputs are also required for the development of additional pathophysiological conditions associated with deregulated rostral ventrolateral medulla activity. By contrast, they are dispensable for other peripheral sympathoexcitation-associated disorders sparing metabolic alterations in liver.\n                  <\/jats:p>","DOI":"10.1530\/joe-18-0623","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T09:13:58Z","timestamp":1548926038000},"page":"483-496","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":14,"title":["Vagal afferents contribute to sympathoexcitation-driven metabolic dysfunctions"],"prefix":"10.1530","volume":"240","author":[{"given":"L Francisco","family":"Lorenzo-Mart\u00edn","sequence":"first","affiliation":[{"name":"1Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"2Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"3Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Menacho-M\u00e1rquez","sequence":"additional","affiliation":[{"name":"1Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"2Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"3Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Fabbiano","sequence":"additional","affiliation":[{"name":"1Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"2Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Al-Massadi","sequence":"additional","affiliation":[{"name":"4Departamento de Fisiolox\u00eda, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"5Centro de Investigaci\u00f3n en Medicina Molecular e Enfermidades Cr\u00f3nicas, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"6Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer sobre la Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Abad","sequence":"additional","affiliation":[{"name":"1Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"2Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"3Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), CSIC-University of Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Rodr\u00edguez-Fdez","sequence":"additional","affiliation":[{"name":"1Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"2Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A","family":"Sevilla","sequence":"additional","affiliation":[{"name":"1Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"2Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J","family":"Montero","sequence":"additional","affiliation":[{"name":"1Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"2Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Di\u00e9guez","sequence":"additional","affiliation":[{"name":"4Departamento de Fisiolox\u00eda, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"5Centro de Investigaci\u00f3n en Medicina Molecular e Enfermidades Cr\u00f3nicas, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"6Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer sobre la Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Nogueiras","sequence":"additional","affiliation":[{"name":"4Departamento de Fisiolox\u00eda, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"5Centro de Investigaci\u00f3n en Medicina Molecular e Enfermidades Cr\u00f3nicas, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"6Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer sobre la Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xos\u00e9 R","family":"Bustelo","sequence":"additional","affiliation":[{"name":"1Centro de Investigaci\u00f3n del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, Spain"},{"name":"2Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-University of Salamanca, Salamanca, 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