{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:54:49Z","timestamp":1790816089762,"version":"4.1.0"},"reference-count":244,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>The X-zone is a transient cortical region enriched in eosinophilic cells located in the cortical\u2013medullary boundary of the mouse adrenal gland. Similar to the X-zone, the fetal zone in human adrenals is also a transient cortical compartment, comprising the majority of the human fetal adrenal gland. During adrenal development, fetal cortical cells are gradually replaced by newly formed adult cortical cells that develop into outer definitive zones. In mice, the regression of this fetal cell population is sexually dimorphic. Many mouse models with mutations associated with endocrine factors have been reported with X-zone phenotypes. Increasing findings indicate that the cell fate of this aged cell population of the adrenal cortex can be manipulated by many hormonal and nonhormonal factors. This review summarizes the current knowledge of this transient adrenocortical zone with an emphasis on genes and signaling pathways that affect X-zone cells.<\/jats:p>","DOI":"10.1530\/joe-18-0632","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T10:04:17Z","timestamp":1551175457000},"page":"R51-R63","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":53,"title":["The transient cortical zone in the adrenal gland: the mystery of the adrenal X-zone"],"prefix":"10.1530","volume":"241","author":[{"given":"Chen-Che Jeff","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology, College of 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regulates adrenocortical apoptosis and modeling","year":"2000","journal-title":"Endocrine Society Annual Meeting Abstracts"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1679\/aohc1950.23.213","article-title":"Preliminary report on the function of the X-zone of the mouse adrenal cortex","volume":"23","year":"1963","journal-title":"Archivum Histologicum Japonicum"},{"key":"ref1611","first-page":"159","article-title":"X-zone degeneration in adrenal glands of adult and immature female mice","volume":"108","year":"1971b","journal-title":"Journal of Anatomy"},{"key":"ref2331","first-page":"294","article-title":"The adrenals: the experimental and clinical evidence as to their influence exerted upon the genital system","volume":"25","year":"1917","journal-title":"Surgery, Gynecology and Obstetrics"},{"key":"ref831","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1177\/002215540305101103","article-title":"Sex-related expression of 20alpha-hydroxysteroid 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Biology"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0016-6480(86)90253-4","article-title":"The X zone of the mouse adrenal cortex of the Swiss albino strain","volume":"61","year":"1986","journal-title":"General and Comparative Endocrinology"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1128\/MCB.00378-12","article-title":"Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor","volume":"32","year":"2012b","journal-title":"Molecular and Cellular Biology"},{"key":"ref2281","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1538\/expanim.44.127","article-title":"Strain difference of the adrenal cortex between A\/J and SM\/J mice, progenitors of SMXA recombinant inbred group","volume":"44","year":"1995","journal-title":"Experimental Animals"},{"key":"ref641","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.devcel.2011.06.028","article-title":"Eliminating SF-1 (NR5A1) SUMOylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development","volume":"21","year":"2011","journal-title":"Developmental Cell"},{"key":"ref1861","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.devcel.2011.06.028","article-title":"Eliminating SF-1 (NR5A1) SUMOylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development","volume":"21","year":"2011","journal-title":"Developmental Cell"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/endo.139.10.6217","article-title":"DAX-1 blocks steroid production at multiple levels","volume":"139","year":"1998","journal-title":"Endocrinology"},{"key":"ref1191","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/372635a0","article-title":"An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita","volume":"372","year":"1994","journal-title":"Nature"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1210\/en.2012-1258","article-title":"Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression","volume":"153","year":"2012","journal-title":"Endocrinology"},{"key":"ref2381","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/B978-0-12-416021-7.00007-9","article-title":"Adrenocortical development, maintenance, and disease.","volume":"106","year":"2013","journal-title":"Current Topics in Developmental Biology"},{"key":"ref1541","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/bmj.2.3128.886","article-title":"The effect of pregnancy upon the size and weight of some of the organs of the body","volume":"2","year":"1920a","journal-title":"BMJ"},{"key":"ref1671","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1210\/er.2010-0001","article-title":"Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit.","volume":"32","year":"2011","journal-title":"Endocrine Reviews"},{"key":"ref2421","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1128\/MCB.00222-06","article-title":"Two-step regulation of Ad4BP\/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP\/SF-1","volume":"26","year":"2006","journal-title":"Molecular and Cellular Biology"},{"key":"ref1431","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1210\/me.2003-0342","article-title":"GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1","volume":"18","year":"2004","journal-title":"Molecular 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vitro","volume":"82","year":"1968","journal-title":"Endocrinology"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1210\/jc.2017-00763","article-title":"Kisspeptin is a novel regulator of human fetal adrenocortical development and function: a finding with important implications for the human fetoplacental unit.","volume":"102","year":"2017","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref311","first-page":"121","article-title":"The androgen receptor in the testicular feminized (Tfm) mouse may be a product of internal translation initiation","volume":"4","year":"1994","journal-title":"Receptor"},{"key":"ref2161","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1677\/joe.0.0710445","article-title":"Degeneration of the adrenal X-zone in Tfm mice with inherited insensitivity to androgens","volume":"71","year":"1976","journal-title":"Journal of 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development","volume":"84","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/aja.1000400204","article-title":"A transitory zone in the adrenal cortex which shows age and sex relationships","volume":"40","year":"1927","journal-title":"American Journal of Anatomy"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/374354a0","article-title":"Functional analysis of activins during mammalian development","volume":"374","year":"1995","journal-title":"Nature"},{"key":"ref1211","doi-asserted-by":"crossref","first-page":"7030","DOI":"10.1128\/MCB.00900-08","article-title":"Developmental links between the fetal and adult zones of the adrenal cortex revealed by lineage tracing","volume":"28","year":"2008","journal-title":"Molecular and Cellular 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tracing","volume":"28","year":"2008","journal-title":"Molecular and Cellular Biology"},{"key":"ref1831","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1101\/gr.168801","article-title":"Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs","volume":"11","year":"2001","journal-title":"Genome Research"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1042\/bj0291424","article-title":"Effect of androsterone and of male hormone concentrates on the accessory reproductive organs of castrated rats, mice and guinea-pigs","volume":"29","year":"1935","journal-title":"Biochemical Journal"},{"key":"ref1591","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mce.2011.06.005","article-title":"Inhibins and activins: their roles in the adrenal gland and the development of adrenocortical tumors.","volume":"359","year":"2012","journal-title":"Molecular and Cellular 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Research"},{"key":"ref961","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0016-6480(68)90092-0","article-title":"A strain difference in the time and mode of regression of the adrenal X zone in female mice","volume":"11","year":"1968","journal-title":"General and Comparative Endocrinology"},{"key":"ref2271","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1538\/expanim.44.285","article-title":"Comparison of adrenocortical zonation in C57BL\/6J and DDD mice","volume":"44","year":"1995","journal-title":"Experimental Animals"},{"key":"ref1941","first-page":"55","article-title":"The effect of gonadectomy on the structure of the suprarenal glands of mice, with special reference to the functional relation between this gland and the sex gland of female","volume":"1","year":"1924","journal-title":"Japanese Journal of Zootechnical Science"},{"key":"ref1451","article-title":"Androgen receptor signalling is essential for regression of the adrenal x-zone and regulation of the adrenal cortex in the male mouse","volume":"49","year":"2017","journal-title":"Endocrine Abstracts"},{"key":"ref881","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1006\/geno.1998.5621","article-title":"cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12","volume":"54","year":"1998","journal-title":"Genomics"},{"key":"ref681","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1210\/me.2011-1150","article-title":"Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression","volume":"26","year":"2012a","journal-title":"Molecular Endocrinology"},{"key":"ref2021","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1679\/aohc1950.23.213","article-title":"Preliminary report on the function of the X-zone of the mouse adrenal cortex","volume":"23","year":"1963","journal-title":"Archivum Histologicum Japonicum"},{"key":"ref2181","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0016-6480(68)90092-0","article-title":"A strain difference in the time and mode of regression of the adrenal X zone in female mice","volume":"11","year":"1968","journal-title":"General and Comparative Endocrinology"},{"key":"ref1011","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1210\/endo-23-3-339","article-title":"The effect of testosterone-propionate on the X-zone of the mouse adrenal","volume":"23","year":"1938","journal-title":"Endocrinology"},{"key":"ref1631","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/aja.1000400204","article-title":"A transitory zone in the adrenal cortex which shows age and sex relationships","volume":"40","year":"1927","journal-title":"American Journal of Anatomy"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1152\/ajplegacy.1924.68.3.517","article-title":"The influence of pregnancy and lactation on the weight of the adrenal gland in the albino rat","volume":"68","year":"1924","journal-title":"American Journal of Physiology: Legacy Content"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/aja.1000400204","article-title":"A transitory zone in the adrenal cortex which shows age and sex relationships","volume":"40","year":"1927","journal-title":"American Journal of Anatomy"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.devcel.2013.07.016","article-title":"Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells","volume":"26","year":"2013","journal-title":"Developmental Cell"},{"key":"ref2401","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/3822","article-title":"Role of Ahch in gonadal development and gametogenesis","volume":"20","year":"1998","journal-title":"Nature Genetics"},{"key":"ref1981","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/aja.1000400204","article-title":"A transitory zone in the adrenal cortex which shows age and sex relationships","volume":"40","year":"1927","journal-title":"American Journal of Anatomy"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ar.1090750203","article-title":"The nature of the X-zone of the adrenal gland of the mouse","volume":"75","year":"1939","journal-title":"Anatomical Record"},{"key":"ref1581","first-page":"119","article-title":"Electron microscopic observations on the castration-induced X zone in the adrenal cortex of male mice","volume":"162","year":"1975","journal-title":"Cell and Tissue Research"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1530\/jrf.0.0250111","article-title":"The effect on the mouse adrenal X-zone of blastocysts transplanted under the kidney capsule","volume":"25","year":"1971a","journal-title":"Journal of Reproduction and Fertility"},{"key":"ref1321","first-page":"883","article-title":"A comparison of the X-zone of the adrenal cortex in two inbred strains of mice","volume":"1","year":"1941","journal-title":"Cancer Research"},{"key":"ref2201","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1172\/JCI115827","article-title":"Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells","volume":"90","year":"1992","journal-title":"Journal of Clinical Investigation"},{"key":"ref1221","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/ar.1091370107","article-title":"A histochemical study of 3(beta)-sterol dehydrogenase in the adrenal cortex of the developing mouse","volume":"137","year":"1960","journal-title":"Anatomical Record"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1095\/biolreprod61.1.142","article-title":"Functional capacity of fetal zone cells of the baboon fetal adrenal gland: a major source of alpha-inhibin.","volume":"61","year":"1999","journal-title":"Biology of Reproduction"},{"key":"ref1131","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1677\/joe.0.0030123","article-title":"Effect of hormones on degeneration of the x-zone in the mouse adrenal","volume":"3","year":"1942","journal-title":"Journal of Endocrinology"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.mce.2008.10.045","article-title":"A transgenic mouse line with specific Cre recombinase expression in the adrenal cortex","volume":"300","year":"2009","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref2131","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/gene.10235","article-title":"Pbx1 is essential for adrenal development and urogenital differentiation","volume":"37","year":"2003","journal-title":"Genesis"},{"key":"ref1901","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1210\/me.2011-1150","article-title":"Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression","volume":"26","year":"2012a","journal-title":"Molecular Endocrinology"},{"key":"ref1891","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1210\/me.2006-0182","article-title":"Origin and identity of adrenocortical tumors in inhibin knockout mice: implications for cellular plasticity in the adrenal cortex.","volume":"20","year":"2006","journal-title":"Molecular Endocrinology"},{"key":"ref951","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1677\/joe.0.1020277","article-title":"Adrenal changes in genetically hypothyroid mice","volume":"102","year":"1984","journal-title":"Journal of Endocrinology"},{"key":"ref1991","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1006\/bbrc.1998.8294","article-title":"Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain","volume":"244","year":"1998","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref1491","first-page":"898","article-title":"La capsule surrenale chez la femelle du cobaye en gestation","volume":"51","year":"1899","journal-title":"Comptes Rendus des s\u00e9ances de la Soci\u00e9t\u00e9 de Biologie et de ses 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ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor","volume":"32","year":"2012b","journal-title":"Molecular and Cellular Biology"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"21185","DOI":"10.1073\/pnas.0909471106","article-title":"Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages","volume":"106","year":"2009","journal-title":"PNAS"},{"key":"ref1881","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/en.2006-0681","article-title":"Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis","volume":"148","year":"2007","journal-title":"Endocrinology"},{"key":"ref671","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1210\/me.2006-0182","article-title":"Origin and identity of adrenocortical tumors in inhibin knockout mice: implications for cellular plasticity in the adrenal cortex.","volume":"20","year":"2006","journal-title":"Molecular Endocrinology"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1210\/endo-82-3-527","article-title":"20-Alpha-hydroxysteroid dehydrogenase and reductive pathways in mouse adrenal glands in vitro","volume":"82","year":"1968","journal-title":"Endocrinology"},{"key":"ref1921","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/2271217a0","article-title":"X-linked gene for testicular feminization in the mouse","volume":"227","year":"1970","journal-title":"Nature"},{"key":"ref2141","doi-asserted-by":"crossref","first-page":"97128","DOI":"10.1172\/jci.insight.97128","article-title":"The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion","volume":"2","year":"2017","journal-title":"JCI Insight"},{"key":"ref2171","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1677\/joe.0.1020277","article-title":"Adrenal 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in the adrenal gland that displays sexually dimorphic expression of thyroid hormone receptor-beta","volume":"156","year":"2015","journal-title":"Endocrinology"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1210\/er.2010-0001","article-title":"Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit.","volume":"32","year":"2011","journal-title":"Endocrine Reviews"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1172\/JCI7716","article-title":"Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex","volume":"105","year":"2000","journal-title":"Journal of Clinical Investigation"},{"key":"ref1151","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1242\/dev.150516","article-title":"Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and 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embryo","volume":"136","year":"1995","journal-title":"Endocrinology"},{"key":"ref2151","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1677\/joe.0.0620173","article-title":"Endocrine genetics of the adrenal gland","volume":"62","year":"1974","journal-title":"Journal of Endocrinology"},{"key":"ref1031","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/35799","article-title":"Dax1 antagonizes Sry action in mammalian sex determination","volume":"391","year":"1998","journal-title":"Nature"},{"key":"ref271","first-page":"898","article-title":"La capsule surrenale chez la femelle du cobaye en gestation","volume":"51","year":"1899","journal-title":"Comptes Rendus des s\u00e9ances de la Soci\u00e9t\u00e9 de Biologie et de ses filiales"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/bmj.2.3128.886","article-title":"The effect of pregnancy upon the size and weight of some of the organs of the body","volume":"2","year":"1920a","journal-title":"BMJ"},{"key":"ref1531","first-page":"121","article-title":"The androgen receptor in the testicular feminized (Tfm) mouse may be a product of internal translation initiation","volume":"4","year":"1994","journal-title":"Receptor"},{"key":"ref1601","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1530\/jrf.0.0250111","article-title":"The effect on the mouse adrenal X-zone of blastocysts transplanted under the kidney capsule","volume":"25","year":"1971a","journal-title":"Journal of Reproduction and Fertility"},{"key":"ref2051","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1177\/002215540305101103","article-title":"Sex-related expression of 20alpha-hydroxysteroid dehydrogenase mRNA in the adult mouse","volume":"51","year":"2003","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"ref231","article-title":"Androgen receptor signalling is essential for regression of the adrenal x-zone and regulation of the adrenal cortex in the male mouse","volume":"49","year":"2017","journal-title":"Endocrine Abstracts"},{"key":"ref1331","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1093\/hmg\/ddu265","article-title":"mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD)","volume":"23","year":"2014","journal-title":"Human Molecular Genetics"},{"key":"ref2191","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1210\/jcem-71-6-1678","article-title":"Human recombinant activin-A inhibits proliferation of human fetal adrenal cells in vitro","volume":"71","year":"1990","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref661","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/en.2006-0681","article-title":"Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis","volume":"148","year":"2007","journal-title":"Endocrinology"},{"key":"ref1551","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1210\/endo-4-4-577","article-title":"The influence of the thyroids on the functions of the suprarenals","volume":"4","year":"1920b","journal-title":"Endocrinology"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1530\/jrf.0.0180227","article-title":"Effectiveness of 6\u03b1-methyl-17-acetoxyprogesterone, in combination with oestradiol benzoate, in inducing delayed implantation in the mouse","volume":"18","year":"1969","journal-title":"Journal of Reproduction and Fertility"},{"key":"ref391","first-page":"159","article-title":"X-zone degeneration in adrenal glands of adult and immature female mice","volume":"108","year":"1971b","journal-title":"Journal of Anatomy"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1128\/MCB.23.11.3951-3964.2003","article-title":"Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice","volume":"23","year":"2003","journal-title":"Molecular and Cellular Biology"},{"key":"ref1021","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng0496-404","article-title":"Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function","volume":"12","year":"1996","journal-title":"Nature Genetics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1530\/acta.0.0580191","article-title":"Genetic variation in adrenal weight: strain differences in the development of the adrenal glands of mice.","volume":"58","year":"1968","journal-title":"Acta Endocrinologica"},{"key":"ref721","first-page":"55","article-title":"The effect of gonadectomy on the structure of the suprarenal glands of mice, with special reference to the functional relation between this gland and the sex gland of female","volume":"1","year":"1924","journal-title":"Japanese Journal of Zootechnical Science"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/182262a0","article-title":"Secretion of androgens by the adrenal cortex of the mouse","volume":"182","year":"1958","journal-title":"Nature"},{"key":"ref1961","doi-asserted-by":"crossref","first-page":"8817","DOI":"10.1073\/pnas.91.19.8817","article-title":"Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice","volume":"91","year":"1994","journal-title":"PNAS"},{"key":"ref2211","first-page":"1110","article-title":"Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling.","volume":"84","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1210\/en.2017-00098","article-title":"Targeted disruption of 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Abstracts"},{"key":"ref1201","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1128\/MCB.00222-06","article-title":"Two-step regulation of Ad4BP\/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP\/SF-1","volume":"26","year":"2006","journal-title":"Molecular and Cellular Biology"},{"key":"ref1171","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/nm.2928","article-title":"Endothelial PI3K-C2\u03b1, a class II PI3K, has an essential role in angiogenesis and vascular barrier function","volume":"18","year":"2012","journal-title":"Nature Medicine"},{"key":"ref251","first-page":"412","article-title":"Structur und enibryonale entwickelung der nebennieren bei saugethieren","volume":"9","year":"1883","journal-title":"Archiv fur Anatomie und Physiologie"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1042\/BJ20040276","article-title":"Characterization and 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in ceramide synthase 2 null mice","volume":"22","year":"2015","journal-title":"Endocrine-Related Cancer"},{"key":"ref1381","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/MCB.22.7.2294-2303.2002","article-title":"The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice","volume":"22","year":"2002","journal-title":"Molecular and Cellular Biology"},{"key":"ref741","doi-asserted-by":"crossref","first-page":"8817","DOI":"10.1073\/pnas.91.19.8817","article-title":"Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice","volume":"91","year":"1994","journal-title":"PNAS"},{"key":"ref1801","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/BF01986752","article-title":"Ver\u00e4nderungen der nebenniere bei schwangerschaft und nach kastration","volume":"99","year":"1913","journal-title":"Archiv f\u00fcr Gynaekologie"},{"key":"ref891","doi-asserted-by":"crossref","first-page":"e1000980","DOI":"10.1371\/journal.pgen.1000980","article-title":"Cushing\u2019s syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice","volume":"6","year":"2010","journal-title":"PLoS Genetics"},{"key":"ref1251","article-title":"Kisspeptin and kisspeptin receptor may be involved in the regulation of adrenocortical development and steroid hormone secretion","year":"2018","journal-title":"Endocrine Society Annual Meeting Abstracts"},{"key":"ref971","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1210\/jcem-71-6-1678","article-title":"Human recombinant activin-A inhibits proliferation of human fetal adrenal cells in vitro","volume":"71","year":"1990","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref911","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/gene.10235","article-title":"Pbx1 is essential for adrenal development and urogenital differentiation","volume":"37","year":"2003","journal-title":"Genesis"},{"key":"ref1641","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1210\/en.2009-0814","article-title":"Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog","volume":"151","year":"2010","journal-title":"Endocrinology"},{"key":"ref1771","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1210\/endo.143.8.8939","article-title":"Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue","volume":"143","year":"2002","journal-title":"Endocrinology"},{"key":"ref991","first-page":"1110","article-title":"Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling.","volume":"84","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref1471","first-page":"412","article-title":"Structur und enibryonale entwickelung der nebennieren bei saugethieren","volume":"9","year":"1883","journal-title":"Archiv fur Anatomie und Physiologie"},{"key":"ref1461","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ar.1090750203","article-title":"The nature of the X-zone of the adrenal gland of the mouse","volume":"75","year":"1939","journal-title":"Anatomical Record"},{"key":"ref1371","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1530\/jrf.0.0180227","article-title":"Effectiveness of 6\u03b1-methyl-17-acetoxyprogesterone, in combination with oestradiol benzoate, in inducing delayed implantation in the mouse","volume":"18","year":"1969","journal-title":"Journal of Reproduction and Fertility"},{"key":"ref101","first-page":"883","article-title":"A comparison of the X-zone of the adrenal cortex in two inbred strains of mice","volume":"1","year":"1941","journal-title":"Cancer Research"},{"key":"ref2231","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1210\/endo-23-3-339","article-title":"The effect of testosterone-propionate on the X-zone of the mouse adrenal","volume":"23","year":"1938","journal-title":"Endocrinology"},{"key":"ref1481","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1136\/jmg.2004.028043","article-title":"A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions","volume":"41","year":"2004","journal-title":"Journal of Medical Genetics"},{"key":"ref2361","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1016\/S0021-9258(18)69633-4","article-title":"Conversion of progesterone to 4-pregnen-20 alpha-ol-3-one by rat ovarian tissue in vitro","volume":"234","year":"1959","journal-title":"Journal of Biological Chemistry"},{"key":"ref1931","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1210\/me.2004-0257","article-title":"GATA factors and the nuclear receptors, steroidogenic factor 1\/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter","volume":"19","year":"2005","journal-title":"Molecular Endocrinology"},{"key":"ref1411","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1055\/s-0033-1349881","article-title":"Genomic analysis of sexual dimorphism of gene expression in the mouse adrenal gland","volume":"45","year":"2013","journal-title":"Hormone and Metabolic Research"},{"key":"ref1081","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1210\/jc.2007-1253","article-title":"Identification of potential gene markers and insights into the pathophysiology of pheochromocytoma malignancy","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref2001","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/372672a0","article-title":"Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism","volume":"372","year":"1994","journal-title":"Nature"},{"key":"ref471","first-page":"217","article-title":"The adrenal X-zone of mice: genetic analysis of its development with recombinant-inbred strains","volume":"46","year":"1987","journal-title":"Experimental Biology"},{"key":"ref1111","first-page":"294","article-title":"The adrenals: the experimental and clinical evidence as to their influence exerted upon the genital system","volume":"25","year":"1917","journal-title":"Surgery, Gynecology and Obstetrics"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1210\/endo-4-4-577","article-title":"The influence of the thyroids on the functions of the 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Communications"},{"key":"ref821","first-page":"4362","article-title":"Heritable disorders of pituitary development","volume":"84","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/aja.1000150104","article-title":"On the weights of the abdominal and the thoracic viscera, the sex glands, ductless glands and the eyeballs of the albino rat (Mus norvegicus Albinus) according to body weight","volume":"15","year":"1913","journal-title":"American Journal of Anatomy"},{"key":"ref981","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1172\/JCI115827","article-title":"Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells","volume":"90","year":"1992","journal-title":"Journal of Clinical Investigation"},{"key":"ref1301","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1042\/bj0291424","article-title":"Effect of androsterone and of male hormone concentrates on the accessory reproductive organs of castrated rats, mice and guinea-pigs","volume":"29","year":"1935","journal-title":"Biochemical Journal"},{"key":"ref1821","first-page":"4","article-title":"The relation between the adrenal cortex and sexual development","volume":"114","year":"1921","journal-title":"New York Medical Journal"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1210\/en.2003-0472","article-title":"GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis","volume":"144","year":"2003","journal-title":"Endocrinology"},{"key":"ref1951","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF00215195","article-title":"Morphological-changes in the submandibular glands and in the X-zone of the adrenal-gland following ovariectomy in mice","volume":"246","year":"1986","journal-title":"Cell and Tissue Research"},{"key":"ref1281","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1095\/biolreprod61.1.142","article-title":"Functional capacity of fetal zone cells of the baboon fetal adrenal gland: a major source of alpha-inhibin.","volume":"61","year":"1999","journal-title":"Biology of Reproduction"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1006\/bbrc.1998.8294","article-title":"Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain","volume":"244","year":"1998","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref1351","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/182262a0","article-title":"Secretion of androgens by the adrenal cortex of the mouse","volume":"182","year":"1958","journal-title":"Nature"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"98394","DOI":"10.1172\/jci.insight.98394","article-title":"PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal","volume":"3","year":"2018","journal-title":"JCI Insight"},{"key":"ref941","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1677\/joe.0.0710445","article-title":"Degeneration of the adrenal X-zone in Tfm mice with inherited insensitivity to androgens","volume":"71","year":"1976","journal-title":"Journal of Endocrinology"},{"key":"ref1851","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.mce.2008.10.045","article-title":"A transgenic mouse line with specific Cre recombinase expression in the adrenal cortex","volume":"300","year":"2009","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/aja.1000650105","article-title":"Effects of castration on the seminal vesicles as influenced by age, considered in relation to the degree of development of the adrenal X zone","volume":"65","year":"1939","journal-title":"American Journal of Anatomy"},{"key":"ref2031","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1530\/ERC-15-0058","article-title":"Development of pheochromocytoma in ceramide synthase 2 null mice","volume":"22","year":"2015","journal-title":"Endocrine-Related Cancer"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1128\/MCB.00468-10","article-title":"Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function","volume":"31","year":"2011","journal-title":"Molecular and Cellular 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molecular determinants of adrenocortical growth and steroidogenesis.","volume":"28","year":"2002","journal-title":"Endocrine Research"},{"key":"ref2091","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1677\/joe.0.1660077","article-title":"Long-term testosterone treatment prevents gonadal and adrenal tumorigenesis of mice transgenic for the mouse inhibin-alpha subunit promoter\/simian virus 40 T-antigen fusion gene","volume":"166","year":"2000","journal-title":"Journal of Endocrinology"},{"key":"ref841","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1210\/en.2012-1892","article-title":"Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice","volume":"154","year":"2013","journal-title":"Endocrinology"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1210\/me.2003-0342","article-title":"GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1","volume":"18","year":"2004","journal-title":"Molecular Endocrinology"},{"key":"ref2311","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0022-4731(80)90109-0","article-title":"20 Alpha-hydroxysteroid dehydrogenase activity and the X-zone of the female mouse adrenal","volume":"13","year":"1980","journal-title":"Journal of Steroid Biochemistry"},{"key":"ref2111","doi-asserted-by":"crossref","first-page":"e1000980","DOI":"10.1371\/journal.pgen.1000980","article-title":"Cushing\u2019s syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice","volume":"6","year":"2010","journal-title":"PLoS Genetics"},{"key":"ref1501","doi-asserted-by":"crossref","first-page":"11122","DOI":"10.1128\/MCB.25.24.11122-11130.2005","article-title":"The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation","volume":"25","year":"2005","journal-title":"Molecular and Cellular 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formation in inhibin-deficient mice","volume":"23","year":"2003","journal-title":"Molecular and Cellular Biology"},{"key":"ref1781","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mce.2005.01.012","article-title":"Transcription factors GATA-6, SF-1, and cell proliferation in human adrenocortical tumors","volume":"233","year":"2005","journal-title":"Molecular and Cellular Endocrinology"},{"key":"ref31","article-title":"Kisspeptin and kisspeptin receptor may be involved in the regulation of adrenocortical development and steroid hormone secretion","year":"2018","journal-title":"Endocrine Society Annual Meeting Abstracts"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"11122","DOI":"10.1128\/MCB.25.24.11122-11130.2005","article-title":"The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation","volume":"25","year":"2005","journal-title":"Molecular and Cellular 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congenita","volume":"372","year":"1994","journal-title":"Nature"},{"key":"ref1091","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0022-4731(80)90109-0","article-title":"20 Alpha-hydroxysteroid dehydrogenase activity and the X-zone of the female mouse adrenal","volume":"13","year":"1980","journal-title":"Journal of Steroid Biochemistry"},{"key":"ref1521","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/aja.1000150104","article-title":"On the weights of the abdominal and the thoracic viscera, the sex glands, ductless glands and the eyeballs of the albino rat (Mus norvegicus Albinus) according to body weight","volume":"15","year":"1913","journal-title":"American Journal of Anatomy"},{"key":"ref2251","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/35799","article-title":"Dax1 antagonizes Sry action in mammalian sex determination","volume":"391","year":"1998","journal-title":"Nature"},{"key":"ref1241","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1677\/joe.0.1410033","article-title":"Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency.","volume":"141","year":"1994","journal-title":"Journal of Endocrinology"},{"key":"ref1711","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1210\/endo-45-5-514","article-title":"The relationship of the mouse adrenal cortex to the pituitary","volume":"45","year":"1949","journal-title":"Endocrinology"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1055\/s-0033-1349881","article-title":"Genomic analysis of sexual dimorphism of gene expression in the mouse adrenal gland","volume":"45","year":"2013","journal-title":"Hormone and Metabolic Research"},{"key":"ref601","first-page":"4","article-title":"The relation between the adrenal cortex and sexual development","volume":"114","year":"1921","journal-title":"New York Medical Journal"},{"key":"ref1511","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1128\/MCB.00468-10","article-title":"Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and function","volume":"31","year":"2011","journal-title":"Molecular and Cellular Biology"},{"key":"ref1621","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/aja.1000650105","article-title":"Effects of castration on the seminal vesicles as influenced by age, considered in relation to the degree of development of the adrenal X zone","volume":"65","year":"1939","journal-title":"American Journal of Anatomy"},{"key":"ref2241","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng0496-404","article-title":"Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function","volume":"12","year":"1996","journal-title":"Nature Genetics"},{"key":"ref1001","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1210\/endo-86-5-1049","article-title":"An estrogen effect on 20 alpha-hydroxysteroid dehydrogenase activity in the mouse adrenal","volume":"86","year":"1970","journal-title":"Endocrinology"},{"key":"ref551","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1210\/endo.143.8.8939","article-title":"Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue","volume":"143","year":"2002","journal-title":"Endocrinology"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1210\/endo-45-5-514","article-title":"The relationship of the mouse adrenal cortex to the pituitary","volume":"45","year":"1949","journal-title":"Endocrinology"},{"key":"ref2071","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1210\/endo-12-3-323","article-title":"Effects of thyroxin injections on the suprarenal glands of the mouse","volume":"12","year":"1928","journal-title":"Endocrinology"},{"key":"ref2351","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1677\/joe.0.0030123","article-title":"Effect of hormones on degeneration of the x-zone in the mouse adrenal","volume":"3","year":"1942","journal-title":"Journal of Endocrinology"},{"key":"ref1651","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1210\/en.2012-1258","article-title":"Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression","volume":"153","year":"2012","journal-title":"Endocrinology"},{"key":"ref1071","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1210\/endo.132.6.8504754","article-title":"Gonadotropin secretion, synthesis, and gene expression in human growth hormone transgenic mice and in Ames dwarf 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