{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:43:21Z","timestamp":1790603001543,"version":"4.1.0"},"reference-count":254,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n                    Chronic stress is a known suppressor of female reproductive function. However, attempts to isolate single causal links between stress and reproductive dysfunction have not yet been successful due to their multi-faceted aetiologies. The gut-derived hormone ghrelin regulates stress and reproductive function and may therefore be pivotal in the neuroendocrine integration of the hypothalamic\u2013pituitary\u2013adrenal (HPA) and \u2013gonadal (HPG) axes. Here, we hypothesised that chronic stress disrupts ovarian follicle maturation and that this effect is mediated by a stress-induced increase in acyl ghrelin and activation of the growth hormone secretatogue receptor (GHSR). We gave C57BL\/6J female mice 30\u2009min daily chronic predator stress for 4 weeks, or no stress, and gave them daily GHSR antagonist (\n                    <jats:sc>d<\/jats:sc>\n                    -Lys3-GHRP-6) or saline. Exposure to chronic predator stress reduced circulating corticosterone, elevated acyl ghrelin levels and led to significantly depleted primordial follicle numbers. GHSR antagonism stress-dependently altered the expression of genes regulating ovarian responsiveness to gonadotropins and was able to attenuate the stress-induced depletion of primordial follicles. These findings suggest that chronic stress-induced elevations of acyl ghrelin may be detrimental for ovarian follicle maturation.\n                  <\/jats:p>","DOI":"10.1530\/joe-19-0109","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T12:48:07Z","timestamp":1554382087000},"page":"201-219","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":15,"title":["Chronic predator stress in female mice reduces primordial follicle numbers: implications for the role of ghrelin"],"prefix":"10.1530","volume":"241","author":[{"given":"Madeleine R","family":"Di Natale","sequence":"first","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alita","family":"Soch","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilvana","family":"Ziko","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone N","family":"De Luca","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J","family":"Spencer","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luba","family":"Sominsky","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"ref1831","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","year":"2001","journal-title":"Methods"},{"key":"ref2541","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.expneurol.2016.06.003","article-title":"Predator-based psychosocial stress animal model of PTSD: preclinical assessment of traumatic stress at cognitive, hormonal, pharmacological, cardiovascular and epigenetic levels of analysis","volume":"284","year":"2016","journal-title":"Experimental Neurology"},{"key":"ref2001","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1477-7827-3-60","article-title":"Immunohistochemical evidence for an endocrine\/paracrine role for ghrelin in the reproductive tissues of 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