{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:58:28Z","timestamp":1791615508573,"version":"4.3.4"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>\n                    The embryonic M\u00fcllerian ducts give rise to the female reproductive tract (fallopian tubes, uterus and upper vagina in humans, the oviducts in birds). Embryonic M\u00fcllerian ducts initially develop in both sexes, but later regress in males under the influence of anti-M\u00fcllerian hormone. While the molecular and endocrine control of duct regression in males have been well studied, early development of the ducts in both sexes is less well understood. Here, we describe a novel role for the adhesion G protein-coupled receptor, GPR56, in development of the M\u00fcllerian ducts in the chicken embryo.\n                    <jats:italic>GPR56<\/jats:italic>\n                    is expressed in the ducts of both sexes from early stages. The mRNA is present during the elongation phase of duct formation, and it is restricted to the inner M\u00fcllerian duct epithelium. The putative ligand, Collagen III, is abundantly expressed in the M\u00fcllerian duct at the same developmental stages. Knockdown of\n                    <jats:italic>GPR56<\/jats:italic>\n                    expression using\n                    <jats:italic>in ovo<\/jats:italic>\n                    electroporation results in variably truncated ducts, with a loss of expression of both epithelial and mesenchymal markers of duct development. Over-expression of GPR56\n                    <jats:italic>in vitro<\/jats:italic>\n                    results in enhanced cell proliferation and cell migration. These results show that GPR56 plays an essential role in avian M\u00fcllerian duct development through the regulation of duct elongation.\n                  <\/jats:p>","DOI":"10.1530\/joe-19-0419","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T13:12:42Z","timestamp":1576069962000},"page":"395-413","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":18,"title":["Adhesion G-protein-coupled receptor, GPR56, is required for M\u00fcllerian duct development in the chick"],"prefix":"10.1530","volume":"244","author":[{"given":"Zahida Yesmin","family":"Roly","sequence":"first","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T","family":"Major","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Fulcher","sequence":"additional","affiliation":[{"name":"2Monash Micro Imaging, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A","family":"Estermann","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E","family":"Hirst","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A","family":"Smith","sequence":"additional","affiliation":[{"name":"1Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/244\/2\/JOE-19-0419.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/244\/2\/JOE-19-0419.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:56:58Z","timestamp":1784555818000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/244\/2\/395-413\/5221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/joe-19-0419","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}