{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:33:24Z","timestamp":1792172004572,"version":"4.4.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is a complex syndrome involving both endocrine and metabolic disorders. Gut microbiota and the intestinal immune factor IL-22 play an important role in the pathogenesis of PCOS. However, the therapeutic role of IL-22 in high androgen-induced PCOS mice is not clear. We aimed to determine the therapeutic effects of IL-22 on the DHEA-induced PCOS mouse model and to explore the possible mechanism of IL-22 in regulating hyperandrogenism-associated PCOS. Insulin resistance levels and ovarian functions were investigated in DHEA-induced PCOS mice with or without additional IL-22 treatment. We found that IL-22 could reverse insulin resistance, disturbed estrous cycle, abnormal ovary morphology, and decreased embryo number in DHEA mice. Mechanistically, IL-22 upregulated the browning of white adipose tissue in DHEA mice. This study demonstrated that IL-22-associated browning of white adipose tissue regulated insulin sensitivity and ovarian functions in PCOS, suggesting that IL-22 may be of value for the treatment of PCOS with a hyperandrogenism phenotype.<\/jats:p>","DOI":"10.1530\/joe-19-0589","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T19:06:21Z","timestamp":1584126381000},"page":"281-289","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":47,"title":["The therapeutic effect of interleukin-22 in high androgen-induced polycystic ovary syndrome"],"prefix":"10.1530","volume":"245","author":[{"given":"Xinyu","family":"Qi","sequence":"first","affiliation":[{"name":"1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China"},{"name":"3Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyu","family":"Yun","sequence":"additional","affiliation":[{"name":"2Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, School of Basic Medical Sciences, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Liao","sequence":"additional","affiliation":[{"name":"1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China"},{"name":"3Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China"},{"name":"4Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[{"name":"1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China"},{"name":"3Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China"},{"name":"4Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China"},{"name":"5National Clinical Research Center for Obstetrics and Gynecology, Beijing, China"},{"name":"6Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Pang","sequence":"additional","affiliation":[{"name":"1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China"},{"name":"3Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China"},{"name":"4Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/245\/2\/JOE-19-0589.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/245\/2\/JOE-19-0589.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:57:05Z","timestamp":1784555825000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/245\/2\/281-289\/5341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/joe-19-0589","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}