{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:23:34Z","timestamp":1784903014109,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"\n Vitamin D is important for gonadal function in rodents, and improvement of vitamin D status in men with low sperm counts increases live birth rate. Vitamin D is a regulator of transcellular calcium transport in the intestine and kidney and may influence the dramatic changes in the luminal calcium concentration in epididymis. Here, we show spatial expression in the male reproductive tract of vitamin D receptor (VDR)-regulated factors involved in calcium transport: transient receptor potential vanilloid 5\/6 , sodium\/calcium exchanger 1, plasma membrane calcium ATPase 1, calbindin D\n 9k<\/jats:sub>\n , calcium-sensing receptor (CaSR), and parathyroid hormone-related peptide (PTHrP) in mouse and human testis and epididymis. Testicular\n Casr<\/jats:italic>\n expression was lower in\n Vdr<\/jats:italic>\n ablated mice compared with controls. Moreover, expression levels of\n Casr<\/jats:italic>\n and\n Pthrp<\/jats:italic>\n were strongly correlated in both testis and epididymis and\n Pthrp<\/jats:italic>\n was suppressed by 1,25(OH)\n 2<\/jats:sub>\n D\n 3<\/jats:sub>\n in a spermatogonial cell line. The expression of CaSR in epididymis may be of greater importance than in the gonad in mice as germ cell-specific\n Casr<\/jats:italic>\n deficient mice had no major reproductive phenotype, and coincubation with a CaSR-agonist had no effect on human sperm\u2013oocyte binding. In humans, seminal calcium concentration between 5 and 10 mM was associated with a higher fraction of motile and morphologically normal sperm cells, and the seminal calcium concentration was not associated with serum calcium levels. In conclusion, VDR regulates CaSR and PTHrP, and both factors may be involved in the regulation of calcium transport in the male reproductive tract with possible implications for sperm function and storage.\n <\/jats:p>","DOI":"10.1530\/joe-20-0321","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T09:41:47Z","timestamp":1633513307000},"page":"207-222","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":21,"title":["Calcium transport in male reproduction is possibly influenced by vitamin D and CaSR"],"prefix":"10.1530","volume":"251","author":[{"given":"Ida Marie","family":"Boisen","sequence":"first","affiliation":[{"name":"1Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Erik","family":"Nielsen","sequence":"additional","affiliation":[{"name":"2Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-3662","authenticated-orcid":true,"given":"Lieve","family":"Verlinden","sequence":"additional","affiliation":[{"name":"3Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Lorenzen","sequence":"additional","affiliation":[{"name":"1Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Holt","sequence":"additional","affiliation":[{"name":"1Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Pinborg","sequence":"additional","affiliation":[{"name":"4The Fertility Clinic, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"5Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-6426","authenticated-orcid":true,"given":"Christine Hjorth","family":"Andreassen","sequence":"additional","affiliation":[{"name":"1Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Juul","sequence":"additional","affiliation":[{"name":"2Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"5Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Lanske","sequence":"additional","affiliation":[{"name":"6Division of Bone and Mineral Research, HSDM\/HMS Harvard University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Carmeliet","sequence":"additional","affiliation":[{"name":"3Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Blomberg Jensen","sequence":"additional","affiliation":[{"name":"1Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"6Division of Bone and Mineral Research, HSDM\/HMS Harvard University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/251\/3\/JOE-20-0321.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/251\/3\/JOE-20-0321.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:57:18Z","timestamp":1784555838000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/251\/3\/207-222\/5480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/joe-20-0321","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}