{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:47:02Z","timestamp":1789022822569,"version":"build-2803163510"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Exogenous treatment of a neurotensin receptor 1 (NTR1) agonist exerted the neuroprotection in an obese and Alzheimer\u2019s model. However, the effects of NTR1 modulation on peripheral\/hippocampal impairment and cognitive deficit following sustained HFD consumption are poorly understood. Forty rats received a normal diet (ND) or HFD for 16 weeks. At week 13, the ND group received a vehicle (\n                    <jats:italic>n<\/jats:italic>\n                    = 8). Thirty-two HFD-fed group were randomized into four subgroups (\n                    <jats:italic>n<\/jats:italic>\n                    = 8\/subgroup) with a vehicle, 1 mg\/kg of NTR1 agonist, 1 mg\/kg of NTR antagonist, and combined treatment (NTR1 agonist-NTR antagonist) for 2 weeks, s.c. injection. Then, the cognitive tests and peripheral\/hippocampal parameters were determined. Our findings demonstrated that NTR1 activator reversed obesity and attenuated metabolic impairment in pre-diabetic rats. It also alleviated hippocampal pathologies and synaptic dysplasticity, leading to deceleration or prevention of cognitive impairment progression. Therefore, NTR1 activation would be a possible novel therapy to decelerate or prevent progression of neuropathology and cognitive impairment in the pre-diabetes.\n                  <\/jats:p>","DOI":"10.1530\/joe-20-0439","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T11:39:05Z","timestamp":1603712345000},"page":"59-74","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":21,"title":["Neurotensin receptor 1 agonist provides neuroprotection in pre-diabetic rats"],"prefix":"10.1530","volume":"248","author":[{"given":"Napatsorn","family":"Saiyasit","sequence":"first","affiliation":[{"name":"1Neurophysiology Unit, Cardiac Electrophysiology Research, and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titikorn","family":"Chunchai","sequence":"additional","affiliation":[{"name":"1Neurophysiology Unit, Cardiac Electrophysiology Research, and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thidarat","family":"Jaiwongkam","sequence":"additional","affiliation":[{"name":"1Neurophysiology Unit, Cardiac Electrophysiology Research, and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasiwan","family":"Kerdphoo","sequence":"additional","affiliation":[{"name":"1Neurophysiology Unit, Cardiac Electrophysiology Research, and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattayaporn","family":"Apaijai","sequence":"additional","affiliation":[{"name":"1Neurophysiology Unit, Cardiac Electrophysiology Research, and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasana","family":"Pratchayasakul","sequence":"additional","affiliation":[{"name":"1Neurophysiology Unit, Cardiac Electrophysiology Research, and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirapas","family":"Sripetchwandee","sequence":"additional","affiliation":[{"name":"1Neurophysiology Unit, Cardiac Electrophysiology Research, and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[{"name":"1Neurophysiology Unit, Cardiac Electrophysiology Research, and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C","family":"Chattipakorn","sequence":"additional","affiliation":[{"name":"1Neurophysiology Unit, Cardiac Electrophysiology Research, and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"},{"name":"2Center of Excellence in Cardiac Electrophysiology, Chiang Mai University, Chiang Mai, Thailand"},{"name":"3Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/248\/1\/JOE-20-0439.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/248\/1\/JOE-20-0439.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:57:21Z","timestamp":1784555841000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/248\/1\/59-74\/5411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/joe-20-0439","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}